ALIX and the multivesicular endosome: ALIX in Wonderland

Membrane vesicles as conveyors of immune responses

Théry, C., Ostrowski, M., & Segura, É. (2009) · Nature reviews. Immunology · doi:10.1038/nri2567 · Cited by 3,996

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

Trajković, K., Hsu, C., Chiantia, S., Rajendran, L., Wenzel, D., Wieland, F., Schwille, P., Brügger, B., & Simons, M. (2008) · Science · doi:10.1126/science.1153124 · Cited by 3,760

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

Baietti, M. F., Zhang, Z., Mortier, E., Melchior, A., Degeest, G., Geeraerts, A., Ivarsson, Y., Depoortere, F., Coomans, C., Vermeiren, E., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2502 · Cited by 1,899

The ESCRT Pathway

Henne, W. M., Buchkovich, N. J., & Emr, S. D. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.05.015 · Cited by 1,586

Ebola virus entry requires the cholesterol transporter Niemann–Pick C1

Carette, J. E., Raaben, M., Wong, A., Herbert, A. S., Obernosterer, G., Mulherkar, N., Kuehne, A. I., Kranzusch, P. J., Griffin, A. M., Ruthel, G. T., et al. (2011) · Nature · doi:10.1038/nature10348 · Cited by 1,327

Selective Enrichment of Tetraspan Proteins on the Internal Vesicles of Multivesicular Endosomes and on Exosomes Secreted by Human B-lymphocytes

Escola, J.-M., Kleijmeer, M. J., Stoorvogel, W., Griffith, J. M., Yoshie, O., & Geuze, H. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.32.20121 · Cited by 1,228

Hydration forces between phospholipid bilayers

Rand, R. P., & Parsegian, V. A. (1989) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(89)90010-5 · Cited by 1,125

ExoCarta 2012: database of exosomal proteins, RNA and lipids

Mathivanan, S., Fahner, C. J., Reid, G. E., & Simpson, R. J. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr828 · Cited by 1,096

Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells

Gillooly, D. J., Morrow, I. C., Lindsay, M., Gould, R., Bryant, N. J., Gaullier, J., Parton, R. G., & Stenmark, H. (2000) · The EMBO Journal · doi:10.1093/emboj/19.17.4577 · Cited by 1,031

The Golgi apparatus (complex)-(1954-1981)-from artifact to center stage.

Farquhar, M. G., & Palade, G. E. (1981) · The Journal of Cell Biology · doi:10.1083/jcb.91.3.77s · Cited by 999

Why Cells and Viruses Cannot Survive without an ESCRT

Calistri, A., Reale, A., Palù, G., & Parolin, C. (2021) · Cells · doi:10.3390/cells10030483 · Cited by 54

Extracellular Vesicles and the Stress System

Makrygianni, E. A., & Chrousos, G. P. (2022) · Neuroendocrinology · doi:10.1159/000527182 · Cited by 59

Light-Triggerable Liposomes for Enhanced Endolysosomal Escape and Gene Silencing in PC12 Cells

Chen, W., Deng, W., & Goldys, E. M. (2017) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2017.04.015 · Cited by 53

Urinary excretion pattern of exosomal aquaporin-2 in rats that received gentamicin

Abdeen, A., Sonoda, H., El-Shawarby, R. M., Takahashi, S., & Ikeda, M. (2014) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00140.2014 · Cited by 52

Host microRNAs and exosomes that modulate influenza virus infection

Zheng, B., Zhou, J., & Wang, H. (2020) · Virus Research · doi:10.1016/j.virusres.2020.197885 · Cited by 54

Modulating intracellular pathways to improve non-viral delivery of RNA therapeutics

de Vyver, T. V., Smedt, S. C. D., & Raemdonck, K. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.114041 · Cited by 51

Discovery of novel membrane binding structures and functions

Kufareva, I., Lenoir, M., Dancea, F., Sridhar, P., Raush, E., Bissig, C., Grüenberg, J., Abagyan, R. A., & Overduin, M. (2014) · Biochemistry and Cell Biology · doi:10.1139/bcb-2014-0074 · Cited by 53

Host and Viral Proteins Modulating Ebola and Marburg Virus Egress

Gordon, T. B., Hayward, J. A., Marsh, G. A., Baker, M. L., & Tachedjian, G. (2019) · Viruses · doi:10.3390/v11010025 · Cited by 47

Proteolysis mediated by cysteine cathepsins and legumain—recent advances and cell biological challenges

Brix, K., McInnes, J., Al-Hashimi, A., Rehders, M., Tamhane, T., & Haugen, M. H. (2014) · PROTOPLASMA · doi:10.1007/s00709-014-0730-0 · Cited by 47

Alix is required during development for normal growth of the mouse brain

Laporte, M. H., Chatellard, C., Vauchez, V., Hemming, F. J., Deloulme, J., Vossier, F., Blot, B., Fraboulet, S., & Sadoul, R. (2017) · Scientific Reports · doi:10.1038/srep44767 · Cited by 49

The role of ESCRT during development and functioning of the nervous system

Sadoul, R., Laporte, M. H., Chassefeyre, R., Il, K., Goldberg, Y., Chatellard, C., Hemming, F. J., & Fraboulet, S. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.08.013 · Cited by 45

Extracellular vesicles and melanoma: New perspectives on tumor microenvironment and metastasis

Benito‐Martín, A., Jasiulionis, M. G., & Garcı́a-Silva, S. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1061982 · Cited by 48

Plasma membrane and cytoskeleton dynamics during single-cell wound healing

Boucher, É. L., & Mandato, C. A. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.07.012 · Cited by 43

Best practice of identification and proteomic analysis of extracellular vesicles in human health and disease

Sódar, B. W., Kovács, Á. F., Visnovitz, T., Pállinger, É., Vékey, K., Pòcsfalvi, G., Turiák, L., & Buzás, E. I. (2017) · Expert Review of Proteomics · doi:10.1080/14789450.2017.1392244 · Cited by 45

Multiple Roles of Exosomal Long Noncoding RNAs in Cancers

Zhao, W., Liu, Y., Zhang, C., & Duan, C. (2019) · BioMed Research International · doi:10.1155/2019/1460572 · Cited by 46

Extracellular Vesicles in Immune System Regulation and Type 1 Diabetes: Cell-to-Cell Communication Mediators, Disease Biomarkers, and Promising Therapeutic Tools

Grieco, G. E., Fignani, D., Formichi, C., Nigi, L., Licata, G., Maccora, C., Brusco, N., Sebastiani, G., & Dotta, F. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.682948 · Cited by 46

The Regulation of Flavivirus Infection by Hijacking Exosome-Mediated Cell–Cell Communication: New Insights on Virus–Host Interactions

Reyes-Ruíz, J. M., Osuna‐Ramos, J. F., Jesús‐González, L. A. D., Palacios-Rápalo, S. N., Cordero‐Rivera, C. D., Farfán-Morales, C. N., Hurtado-Monzón, A. M., Gallardo-Flores, C. E., Alcaráz‐Estrada, S. L., Salas-Benito, J. S., et al. (2020) · Viruses · doi:10.3390/v12070765 · Cited by 45

Interest of extracellular vesicles in regards to lipid nanoparticle based systems for intracellular protein delivery

Saux, S. L., Aubert‐Pouëssel, A., Mohamed, K. E., Martineau, P., Guglielmi, L., Devoisselle, J., Legrand, P., Chopineau, J., & Morille, M. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113837 · Cited by 48

Exosomes in colorectal carcinoma formation: ALIX under the magnifying glass

Valcz, G., Galamb, O., Krenács, T., Spisák, S., Kalmár, A., Patai, Á. V., Wichmann, B., Dede, K., Tulassay, Z., & Molnár, B. (2016) · Modern Pathology · doi:10.1038/modpathol.2016.72 · Cited by 42

ALG-2 interacting protein-X (Alix) is essential for clathrin-independent endocytosis and signaling

Mercier, V., Laporte, M. H., Destaing, O., Blot, B., Blouin, C. M., Pernet‐Gallay, K., Chatellard, C., Saoudi, Y., Albigès‐Rizo, C., Lamaze, C., et al. (2016) · Scientific Reports · doi:10.1038/srep26986 · Cited by 45

ESCRT machinery components are required for Orthobunyavirus particle production in Golgi compartments

Barbosa, N. S., de Mendonça, L. R., Dias, M. V. S., Pontelli, M. C., da Silva, E. Z. M., Criado, M. F., da Silva-Januário, M. E., Schindler, M., Jamur, M. C., Oliver, C., et al. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1007047 · Cited by 43

Extracellular Vesicles and Ebola Virus: A New Mechanism of Immune Evasion

Pleet, M. L., DeMarino, C., Stonier, S. W., Dye, J. M., Jacobson, S., Aman, M. J., & Kashanchi, F. (2019) · Viruses · doi:10.3390/v11050410 · Cited by 41

Suppression of protein tyrosine phosphatase N23 predisposes to breast tumorigenesis via activation of FYN kinasePreprint

Zhang, S., Fan, G., Yuan, H., Hammell, M., Wilkinson, J. E., & Tonks, N. K. (2017) · Genes & Development · doi:10.1101/gad.304261.117 · Cited by 42

Interaction network of extracellular vesicles building universal analysis via eye tears: iNEBULA

Hu, L., Liu, X., Zheng, Q., Chen, W., Xu, H. Y., Li, H., Luo, J., Yang, R., Mao, X., Wang, S., et al. (2023) · Science Advances · doi:10.1126/sciadv.adg1137 · Cited by 40

Interaction of HIV-1 Nef Protein with the Host Protein Alix Promotes Lysosomal Targeting of CD4 Receptor

Amorim, N. A., da Silva, E. M. L., de Castro, R. O., da Silva-Januário, M. E., Mendonça, L., Bonifacino, J. S., da Costa, L. J., & daSilva, L. L. P. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.560193 · Cited by 41

Regulation of Notch Signaling Through Intracellular Transport

Conner, S. D. (2016) · International review of cytology · doi:10.1016/bs.ircmb.2015.12.002 · Cited by 40

Cloaked Viruses and Viral Factors in Cutting Edge Exosome-Based Therapies

Dogrammatzis, C., Waisner, H., & Kalamvoki, M. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00376 · Cited by 39

Cellular ESCRT components are recruited to regulate the endocytic trafficking and RNA replication compartment assembly during classical swine fever virus infection

Liu, C., Liu, Y., Zhou, J., Chen, X., Chen, H., Hu, J.-H., Chen, J., Zhang, J., Sun, R., Wei, J., et al. (2022) · PLoS Pathogens · doi:10.1371/journal.ppat.1010294 · Cited by 39

Redundant Late Domain Functions of Tandem VP2 YPX 3 L Motifs in Nonlytic Cellular Egress of Quasi-enveloped Hepatitis A Virus

González‐López, O., Rivera-Serrano, E. E., Hu, F., Hensley, L., McKnight, K. L., Ren, J., Stuart, D. I., Fry, E. E., & Lemon, S. M. (2018) · Journal of Virology · doi:10.1128/jvi.01308-18 · Cited by 39

Unravelling the pivotal role of Alix in MVB sorting and silencing of the activated EGFR

Sun, S., Zhou, X., Zhang, W., Gallick, G. E., & Kuang, J. (2015) · Biochemical Journal · doi:10.1042/bj20141156 · Cited by 37

Bis(monoacylglycero)phosphate, an important actor in the host endocytic machinery hijacked by SARS-CoV-2 and related viruses

Luquain‐Costaz, C., Rabia, M., Hullin‐Matsuda, F., & Delton-v, I. (2020) · Biochimie · doi:10.1016/j.biochi.2020.10.018 · Cited by 37

Syntenin-knock out reduces exosome turnover and viral transduction

Kashyap, R. S., Balzano, M., Lechat, B., Lambaerts, K., Egea-Jiménez, A. L., Lembo, F., Fares, J., Meeussen, S., Kügler, S., Roebroek, A., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-81697-4 · Cited by 38

Network biology and artificial intelligence drive the understanding of the multidrug resistance phenotype in cancer

Bueschbell, B., Caniceiro, A. B., Suzano, P. M. S., Machuqueiro, M., Rosário‐Ferreira, N., & Moreira, I. S. (2022) · Drug Resistance Updates · doi:10.1016/j.drup.2022.100811 · Cited by 38

Extracellular vesicles as vital players in drug delivery: a focus on clinical disease treatment

Chen, T., Chen, D., Su, W., Liang, J., Liu, X., & Cai, M. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2025.1600227 · Cited by 42

Phosphorylation-Dependent Activation of the ESCRT Function of ALIX in Cytokinetic Abscission and Retroviral Budding

Sun, S., Sun, L., Zhou, X., Wu, C., Wang, R., Lin, S.-H., & Kuang, J. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.01.001 · Cited by 36

The Role of Extracellular Vesicles in Melanoma Progression

Lattmann, E., & Levesque, M. P. (2022) · Cancers · doi:10.3390/cancers14133086 · Cited by 35

ALG-2 activates the MVB sorting function of ALIX through relieving its intramolecular interaction

Sun, S., Zhou, X., Corvera, J., Gallick, G. E., Lin, S.-H., & Kuang, J. (2015) · Cell Discovery · doi:10.1038/celldisc.2015.18 · Cited by 38

Circulating Exosome Cargoes Contain Functionally Diverse Cancer Biomarkers: From Biogenesis and Function to Purification and Potential Translational Utility

Mitchell, M. I., Ma, J., Carter, C. L., & Loudig, O. D. (2022) · Cancers · doi:10.3390/cancers14143350 · Cited by 34

Insights into the function of ESCRT and its role in enveloped virus infection

Wang, C., Chen, Y., Hu, S., & Liu, X. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1261651 · Cited by 36

The vacuolar protein sorting genes in insects: A comparative genome view

Li, Z., & Blissard, G. W. (2014) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2014.11.007 · Cited by 34

Centralspindlin Recruits ALIX to the Midbody during Cytokinetic Abscission in Drosophila via a Mechanism Analogous to Virus Budding

Lie-Jensen, A., Ivanauskiene, K., Malerød, L., Jain, A., Tan, K. W., Laerdahl, J. K., Liestøl, K., Stenmark, H., & Haglund, K. (2019) · Current Biology · doi:10.1016/j.cub.2019.09.025 · Cited by 36

Small extracellular vesicles released from germinated kiwi pollen (pollensomes) present characteristics similar to mammalian exosomes and carry a plant homolog of ALIX

Suanno, C., Tonoli, E., Fornari, E., Savoca, M. P., Aloisi, I., Parrotta, L., Faleri, C., Cai, G., Coveney, C., Boocock, D. J., et al. (2023) · Frontiers in Plant Science · doi:10.3389/fpls.2023.1090026 · Cited by 33

Arabidopsis CaLB1 undergoes phase separation with the ESCRT protein ALIX and modulates autophagosome maturation

Mosesso, N., Lerner, N. S., Bläske, T., Groh, F., Maguire, S., Niedermeier, M. L., Landwehr, E., Vogel, K., Meergans, K., Nagel, M.-K., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-49485-6 · Cited by 35

Dancing with Trojan horses: an interplay between the extracellular vesicles and viruses

Badierah, R., Uversky, V. N., & Redwan, E. M. M. M. (2020) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2020.1756409 · Cited by 34

The Beginning of the End: Initial Steps in the Degradation of Plasma Membrane Proteins

Schwihla, M., & Korbei, B. (2020) · Frontiers in Plant Science · doi:10.3389/fpls.2020.00680 · Cited by 33

Identification of a Novel Regulatory Mechanism of Nutrient Transport Controlled by TORC1-Npr1-Amu1/Par32

Boeckstaens, M., Merhi, A., Llinares, E., Vooren, P. V., Springael, J., Wintjens, R. T., & Marini, A. M. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005382 · Cited by 36

Advancements in extracellular vesicles biomanufacturing: a comprehensive overview of large-scale production and clinical research

Li, Z., Yan, J., Li, X., Chen, H., Chen, L., Zhang, Y., Gao, T., Zhang, Y., Shu, Y. L., Pan, S.-Y., et al. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2025.1487627 · Cited by 40

Enhanced generation of intraluminal vesicles in neuronal late endosomes in the brain of a Down syndrome mouse model with endosomal dysfunction

D’Acunzo, P., Hargash, T., Pawlik, M., Goulbourne, C. N., Pérez‐González, R., & Levy, E. (2019) · Developmental Neurobiology · doi:10.1002/dneu.22708 · Cited by 32

Cellular Targeting of Oligonucleotides by Conjugation with Small Molecules

Hawner, M., & Ducho, C. (2020) · Molecules · doi:10.3390/molecules25245963 · Cited by 31

Exosomes to exosome-functionalized scaffolds: a novel approach to stimulate bone regeneration

Deng, L., Liu, Y., Wu, Q., Lai, S., Yang, Q., Mu, Y., & Dong, M. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-04024-4 · Cited by 32

Distinct molecular properties and functions of small EV subpopulations isolated from human umbilical cord MSCs using tangential flow filtration combined with size exclusion chromatography

Liu, W. Y., Wang, X., Chen, Y., Yuan, J., Zhang, H., Jin, X., Jiang, Y., Cao, J., Wang, Z., Yang, S., et al. (2025) · Journal of Extracellular Vesicles · doi:10.1002/jev2.70029 · Cited by 30

Dissecting the role of His domain protein tyrosine phosphatase/PTPN23 and ESCRTs in sorting activated epidermal growth factor receptor to the multivesicular body

Tabernero, L., & Woodman, P. G. (2018) · Biochemical Society Transactions · doi:10.1042/bst20170443 · Cited by 30

Exosomes and extracellular vesicles as liquid biopsy biomarkers in diffuse large B‐cell lymphoma: Current state of the art and unmet clinical needs

Ofori, K., Bhagat, G., & Rai, A. J. (2020) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.14611 · Cited by 31

Evidence of Extracellular Vesicles Biogenesis and Release in Mouse Embryonic Stem Cells

Cruz, L., Romero, J. A. A., Prado, M. B., Santos, T. G., & Lopes, M. H. (2017) · Stem Cell Reviews and Reports · doi:10.1007/s12015-017-9776-7 · Cited by 28

Extracellular Vesicles for Therapeutic Nucleic Acid Delivery: Loading Strategies and Challenges

Oshchepkova, A. L., Аркадьевна, З. М., & Vlassov, V. V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087287 · Cited by 35

Functionally overlapping intra- and extralysosomal pathways promote bis(monoacylglycero)phosphate synthesis in mammalian cells

Bulfon, D., Breithofer, J., Grabner, G. F., Fawzy, N., Pirchheim, A., Wolinski, H., Kolb, D., Hartig, L., Tischitz, M., Zitta, C., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-54213-1 · Cited by 33

Dengue virus requires apoptosis linked gene-2-interacting protein X (ALIX) for viral propagation

Thepparit, C., Khongwichit, S., Ketsuwan, K., Libsittikul, S., Auewarakul, P., & Smith, D. R. (2018) · Virus Research · doi:10.1016/j.virusres.2018.12.015 · Cited by 28

The Role of Exosomes in Thyroid Cancer and Their Potential Clinical Application

Feng, K., Ma, R., Zhang, L., Li, H., Tang, Y., Du, G., Niu, D., & Yin, D. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.596132 · Cited by 28

Advances in oral mesenchymal stem cell-derived extracellular vesicles in health and disease

Luo, H., Birjandi, A. A., Ren, F., Sun, T., Sharpe, P. T., Sun, H., & An, Z. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2023.03.015 · Cited by 28

Stress-induced EGF receptor signaling through STAT3 and tumor progression in triple-negative breast cancer

Balanis, N. G., & Carlin, C. R. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.01.013 · Cited by 28

Lipids in Entamoeba histolytica: Host-Dependence and Virulence Factors

Castellanos‐Castro, S., Bolaños, J., & Orozco, E. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00075 · Cited by 30

Phosphorylation of PKCδ by FER tips the balance from EGFR degradation to recycling

Lonic, A., Gehling, F., Belle, L., Li, X., Schieber, N. L., Nguyen, E. V., Goodall, G. J., Parton, R. G., Daly, R. J., & Khew‐Goodall, Y. (2021) · The Journal of Cell Biology · doi:10.1083/jcb.201902073 · Cited by 27

Exosome Secretion — More Than Simple Waste Disposal? Implications for Physiology, Diagnostics and Therapeutics

Nagarajah, S. (2016) · Journal of Circulating Biomarkers · doi:10.5772/62975 · Cited by 27

The Role of Exosomes/Extracellular Vesicles in Neural Signal Transduction

Kawahara, H., & Hanayama, R. (2018) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b18-00167 · Cited by 28

The open architecture of HD-PTP phosphatase provides new insights into the mechanism of regulation of ESCRT function

Gahloth, D., Heaven, G., Jowitt, T. A., Mould, A. P., Bella, J., Baldock, C., Woodman, P. G., & Tabernero, L. (2017) · Scientific Reports · doi:10.1038/s41598-017-09467-9 · Cited by 27

Annexins: Ca2+ Effectors Determining Membrane Trafficking in the Late Endocytic Compartment

Enrich, C., Rentero, C., Meneses‐Salas, E., Tebar, F., & Grewal, T. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-55858-5_14 · Cited by 26

Targeting the LMP1‐ALIX axis in EBV + nasopharyngeal carcinoma inhibits immunosuppressive small extracellular vesicle secretion and boosts anti‐tumor immunity

He, F., Gong, Y. Q., Tao, G., Zhang, J., Wu, Q., Tan, Y., Cheng, Y., Wang, C., Yang, J., Han, L., et al. (2024) · 癌症：英文版 · doi:10.1002/cac2.12619 · Cited by 25

Salvianolic acid A inhibits tumor-associated angiogenesis by blocking GRP78 secretion

Yang, Y., Zhang, L., La, X., Li, Z., Li, H., & Guo, S. (2018) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-018-1585-2 · Cited by 25

Structural Basis for Selective Interaction between the ESCRT Regulator HD-PTP and UBAP1

Gahloth, D., Levy, C., Heaven, G., Stefani, F., Wunderley, L., Mould, A. P., Cliff, M. J., Bella, J., Fielding, A. J., Woodman, P. G., et al. (2016) · Structure · doi:10.1016/j.str.2016.10.006 · Cited by 30

Biosensor-based methods for exosome detection with applications to disease diagnosis

Ge, W., Mu, Z., Yang, S., Zeng, Y., Deng, Y., Lin, Y., Xie, P., & Li, G. (2025) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2025.117362 · Cited by 26

Drug-Induced Lysosomal Impairment Is Associated with the Release of Extracellular Vesicles Carrying Autophagy Markers

Sagini, K., Buratta, S., Delo, F., Pellegrino, R. M., Giovagnoli, S., Urbanelli, L., & Emiliani, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312922 · Cited by 25

VPS32, a member of the ESCRT complex, modulates adherence to host cells in the parasite Trichomonas vaginalis by affecting biogenesis and cargo sorting of released extracellular vesicles

Salas, N., Cóceres, V. M., Melo, T. D. S., Pereira‐Neves, A., Maguire, V. G., Rodriguez, T. M., Sabatke, B., Ramirez, M. I., Sha, J., Wohlschlegel, J. A., et al. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-04083-3 · Cited by 24

Exosome-mediated aptamer S58 reduces fibrosis in a rat glaucoma filtration surgery model

Lin, Q., Leng, Y., Zhu, X., Tang, M., Lin, Y., Luo, W., Jiang, B., Chen, X., & Xie, L. (2022) · International Journal of Ophthalmology · doi:10.18240/ijo.2022.05.02 · Cited by 25

Thermotolerance in S. cerevisiae as a model to study extracellular vesicle biology

Logan, C. J., Staton, C. C., Oliver, J., Bouffard, J., Kazmirchuk, T. D. D., Magi, M., & Brett, C. L. (2024) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12431 · Cited by 25

Reduced urinary release of AQP1‐ and AQP2‐bearing extracellular vesicles in patients with advanced chronic kidney disease

Oshikawa, S., Yokota‐Ikeda, N., Sonoda, H., Sasaki, Y., & Ikeda, M. (2021) · Physiological Reports · doi:10.14814/phy2.15005 · Cited by 23

Nonlytic cellular release of hepatitis A virus requires dual capsid recruitment of the ESCRT-associated Bro1 domain proteins HD-PTP and ALIX

Shirasaki, T., Feng, H., Duyvesteyn, H. M. E., Fusco, W. G., McKnight, K. L., Xie, L., Boyce, M., Kumar, S., Barouch‐Bentov, R., González‐López, O., et al. (2022) · PLoS Pathogens · doi:10.1371/journal.ppat.1010543 · Cited by 22

The Charcot Marie Tooth disease protein LITAF is a zinc-binding monotopic membrane protein

Qin, W., Wunderley, L., Barrett, A. L., High, S., & Woodman, P. G. (2016) · Biochemical Journal · doi:10.1042/bcj20160657 · Cited by 21

The DUF582 Proteins of Chlamydia trachomatis Bind to Components of the ESCRT Machinery, Which Is Dispensable for Bacterial Growth In vitro

Vromman, F., Perrinet, S., Gehre, L., & Subtil, A. (2016) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2016.00123 · Cited by 22

Role of Gasdermin E in the Biogenesis of Apoptotic Cell–Derived Exosomes

Hur, J., Kim, Y. J., Choi, D. A., Kang, D. W., Kim, J., Yoo, H. S., Shahriyar, S. A., Mustajab, T., Kim, J., Han, K. R., et al. (2023) · The Journal of Immunology · doi:10.4049/jimmunol.2200342 · Cited by 22

Extracellular Vesicles: Subcellular Organelles With the Potential to Spread Cancer Resistance

Ender, F., von Bubnoff, N. C. C., & Gieseler, F. (2019) · Anticancer Research · doi:10.21873/anticanres.13483 · Cited by 21

MicroRNAs as sentinels and protagonists of carotid artery thromboembolism

Raju, S., Fish, J. E., & Howe, K. L. (2020) · Clinical Science · doi:10.1042/cs20190651 · Cited by 22

Gap junction internalization and processing in vivo : a 3D immuno-electron microscopy study

Norris, R. P., & Terasaki, M. R. (2020) · Journal of Cell Science · doi:10.1242/jcs.252726 · Cited by 20

Membrane Destabilization Induced by Lipid Species Increases Activity of Phosphorothioate-Antisense Oligonucleotides

Wang, S., Allen, N., Liang, X., & Crooke, S. T. (2018) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2018.10.011 · Cited by 20

Extracellular Vesicle Mobility in Collagen I Hydrogels Is Influenced by Matrix-Binding Integrins

Tam, N. W., Becker, A., Mangiarotti, A., Cipitria, A., & Dimova, R. (2024) · ACS Nano · doi:10.1021/acsnano.4c07186 · Cited by 23

Delta opioid receptors recycle to the membrane after sorting to the degradation path

Charfi, I., Abdallah, K., Gendron, L., & Piñeyro, G. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2732-5 · Cited by 20

New Insights to Adenovirus-Directed Innate Immunity in Respiratory Epithelial Cells

Carlin, C. R. (2019) · Microorganisms · doi:10.3390/microorganisms7080216 · Cited by 19

Extracellular Vesicles as Unique Signaling Messengers: Role in Lung Diseases

Gao, Y., & Raj, J. U. (2020) · Comprehensive physiology · doi:10.1002/cphy.c200006 · Cited by 21

Vacuole-inducing compounds that disrupt endolysosomal trafficking stimulate production of exosomes by glioblastoma cells

Li, Z., Mbah, N. E., & Maltese, W. A. (2017) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-017-3130-x · Cited by 18

Adenovirus early region 3 RIDα protein limits NFκB signaling through stress-activated EGF receptors

Zeng, X., & Carlin, C. R. (2019) · PLoS Pathogens · doi:10.1371/journal.ppat.1008017 · Cited by 18

Recent Advances in the Delivery Carriers and Chemical Conjugation Strategies for Nucleic Acid Drugs

Oyama, S., Yamamoto, T., & Yamayoshi, A. (2021) · Cancers · doi:10.3390/cancers13153881 · Cited by 20

Extracellular vesicles: from bench to bedside

Chen, Y., & Yu, L. (2022) · Current Medicine · doi:10.1007/s44194-022-00001-2 · Cited by 16

PDCD6IP , encoding a regulator of the ESCRT complex, is mutated in microcephaly

Khan, A. U., Alaamery, M. A., Massadeh, S., Obaid, A., Kashgari, A. A., Walsh, C. A., & Eyaid, W. (2020) · Clinical Genetics · doi:10.1111/cge.13756 · Cited by 17

Biological role and clinical relevance of extracellular vesicles as key mediators of cell communication in cancer

Mantile, F., Franco, P., Stoppelli, M. P., & Liguori, G. L. (2020) · Advances in biomembranes and lipid self-assembly · doi:10.1016/bs.abl.2020.05.006 · Cited by 22

The endocytic pathways of a secretory granule membrane protein in HEK293 cells: PAM and EGF traverse a dynamic multivesicular body network together

Bäck, N., Kanerva, K., Kurutihalli, V., Yanik, A., Ikonen, E., Mains, R. E., & Eipper, B. A. (2017) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2017.03.007 · Cited by 17

Centrosomal ALIX regulates mitotic spindle orientation by modulating astral microtubule dynamics

Malerød, L., Borgne, R. L., Lie-Jensen, A., Eikenes, Å. H., Brech, A., Liestøl, K., Stenmark, H., & Haglund, K. (2018) · The EMBO Journal · doi:10.15252/embj.201797741 · Cited by 18

Epithelial Cells Expressing EhADH, An Entamoeba histolytica Adhesin, Exhibit Increased Tight Junction Proteins

Betanzos, A., Zanatta, D., Bañuelos, C., Hernández-Nava, E., Cuéllar, P., & Orozco, E. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00340 · Cited by 17

Prospect of extracellular vesicles in tumor immunotherapy

Xia, W., Tan, Y., Liu, Y., Xie, N., & Zhu, H. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1525052 · Cited by 19

Heterodimerization of theEntamoeba histolyticaEhCPADH virulence complex through molecular dynamics and protein–protein docking

Montaño, S., Orozco, E., Correa‐Basurto, J., Bello, M., Chávez‐Munguía, B., & Betanzos, A. (2016) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2016.1151831 · Cited by 16

PAM: diverse roles in neuroendocrine cells, cardiomyocytes, and green algae

Bäck, N., Mains, R. E., & Eipper, B. A. (2021) · FEBS Journal · doi:10.1111/febs.16049 · Cited by 15

Role of Exosomes in Human Retroviral Mediated Disorders

Anderson, M. R., Kashanchi, F., & Jacobson, S. (2018) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-018-9784-7 · Cited by 17

Regulation of ESCRT endosomal recruitment by the lipid-binding protein ALIX

Larios, J. (2018) · Archive ouverte UNIGE (University of Geneva) · doi:10.13097/archive-ouverte/unige:106922 · Cited by 1

ALIX- and ESCRT-III–dependent sorting of tetraspanins to exosomes

Larios, J., Mercier, V., Roux, A., & Gruenberg, J. (2020) · Journal of Cell Biology · doi:10.1083/jcb.201904113 · Cited by 422

Bro1 family proteins harmonize cargo sorting with vesicle formation

Tseng, C., Piper, R. C., & Katzmann, D. J. (2022) · BioEssays · doi:10.1002/bies.202100276 · Cited by 7

Bro1 stimulates Vps4 activity to promote Intralumenal Vesicle Formation during Multivesicular Body biogenesisPreprint

Tseng, C., Dean, S., Davies, B. A., Azmi, I. F., Pashkova, N., Payne, J. A., Staffenhagen, J., West, M., Piper, R. C., Odorizzi, G., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.27.223255

Bro1 stimulates Vps4 to promote intralumenal vesicle formation during multivesicular body biogenesis

Tseng, C., Dean, S., Davies, B. A., Azmi, I. F., Pashkova, N., Payne, J. A., Staffenhagen, J., West, M., Piper, R. C., Odorizzi, G., et al. (2021) · The Journal of Cell Biology · doi:10.1083/jcb.202102070 · Cited by 22