Cited by 323Cellular transport and secretionUbiquitin and proteasome pathwaysAutophagy in Disease and Therapy

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ALIX and the multivesicular endosome: ALIX in Wonderland

Bissig, Christin, Gruenberg, Jean·2014·Trends in Cell Biology

DOI 10.1016/j.tcb.2013.10.009

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Abstract

In yeast and mammalian cells, endosomal sorting complexes required for transport (ESCRT) assist in sorting ubiquitinated proteins into intralumenal vesicles (ILVs) of multivesicular endosomes (MVEs) for degradation in the lysosome/vacuole. In mammalian cells, ESCRTs also drive other topologically identical membrane deformation processes, including cytokinesis, exosome release, and virus budding. Although the ESCRT-associated protein ALIX regulates these mammalian cell-specific functions, it was believed to be dispensable for receptor sorting into ILVs, unlike its yeast homolog Bro1. Despite these differences, recent evidence suggests ALIX and Bro1 share common properties in cargo sorting and ILV formation. We review these commonalities and discuss the role of ALIX in operating 'behind the mirror' during ILV back-fusion with the limiting membrane. We also propose models of how ALIX and some ESCRTs regulate the back-fusion process.

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Authors: Bissig, C., & Gruenberg, J.
Affiliations: University of Geneva (CH)
ORCID: Gruenberg, Jean
Venue: Trends in Cell Biology
Publisher: Elsevier BV
Published: 2014-01
Volume: 24
Issue: 1
Pages: 19-25
ISSN: 0962-8924 (ISSN-L)
DOI: 10.1016/j.tcb.2013.10.009
OpenAlex: W2154203178
Cited by: 323
References: 66
Citations by year: 2026: 16 · 2025: 21 · 2024: 29 · 2023: 19 · 2022: 20 · 2021: 29 · 2020: 35 · 2019: 28 · 2018: 33 · 2017: 18 · 2016: 36 · 2015: 24 · 2014: 15
FWCI: 2.88
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Cell Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Keywords: Alix, multivesicular endosomes, ESCRT, intralumenal vesicles, ubiquitin-dependent protein degradation, membrane deformation, limiting membrane, exosome secretion, viral budding, cytokinesis
MeSH terms: Animals, Calcium-Binding Proteins, Cell Membrane, Humans, Cell Cycle Proteins, Protein Transport, Transport Vesicles, Saccharomyces cerevisiae Proteins, Endosomal Sorting Complexes Required for Transport, Multivesicular Bodies, Ubiquitinated Proteins

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ALIX and the multivesicular endosome: ALIX in Wonderland

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