The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Physiological roles of long noncoding RNAs: insight from knockout mice
Open accessAbstract
Long noncoding RNAs (lncRNAs) are a pervasive and recently recognized class of genes. LncRNAs have been proposed to modulate gene expression and nuclear architecture, but their physiological functions are still largely unclear. Several recent efforts to inactivate lncRNA genes in mouse models have shed light on their functions. Different genetic strategies yielded specific lessons about the roles of lncRNA transcription, the lncRNA transcript itself and underlying sequence elements. Current results indicate a function for lncRNAs in organ development, immunity, organismal viability and a connection to human diseases.
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Landscape of transcription in human cells
Djebali, S., Davis, C. A., Merkel, A., Dobin, A., Lassmann, T., Mortazavi, A., Tanzer, A., Lagarde, J., Lin, W., Schlesinger, F., et al. (2012) · Nature · doi:10.1038/nature11233 · Cited by 5,187
Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes
Tsai, M.-C., Manor, O., Wan, Y., Mosammaparast, N., Wang, J. K., Lan, F., Shi, Y., Segal, E., & Chang, H. Y. (2010) · Science · doi:10.1126/science.1192002 · Cited by 3,290 · cited 1×
“HOTAIR interacts with PRC2 and LSD1 complexes and recruits them to specific target genes, and promotes H3K27 methylation and H3K4 demethylation for gene silencing [20-22].”
BackgroundSelf-citationLong Noncoding RNAs: Cellular Address Codes in Development and Disease
Batista, P. J., & Chang, H. Y. (2013) · Cell · doi:10.1016/j.cell.2013.02.012 · Cited by 2,531
Self-citationMost Caenorhabditis elegans microRNAs Are Individually Not Essential for Development or Viability
Miska, E. A., Alvarez-Saavedra, E., Abbott, A. L., Lau, N. C., Hellman, A. B., McGonagle, S. M., Bartel, D. P., Ambros, V. R., & Horvitz, H. R. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030215 · Cited by 484 · cited 1×
“Future studies may reveal a phenotype in organ homeostasis over time or under stress and pathological conditions, as was revealed for many microRNA knockouts [54, 55].”
Background
Cited by
The emerging role of lncRNAs in cancer
Huarte, M. (2015) · Nature Medicine · doi:10.1038/nm.3981 · Cited by 2,702
ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age‐Related Diseases
Davalli, P., Mitic, T., Caporali, A., Lauriola, A., & D’Arca, D. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3565127 · Cited by 1,059
Towards a complete map of the human long non-coding RNA transcriptome
Uszczynska-Ratajczak, B., Lagarde, J., Frankish, A., Guigó, R., & Johnson, R. (2018) · Nature Reviews Genetics · doi:10.1038/s41576-018-0017-y · Cited by 616
Volatile evolution of long noncoding RNA repertoires: mechanisms and biological implications
Kapusta, A., & Feschotte, C. (2014) · Trends in Genetics · doi:10.1016/j.tig.2014.08.004 · Cited by 295
Metadata
- Authors
- Li, L., & Chang, H. Y.
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2014-10
- Volume
- 24
- Issue
- 10
- Pages
- 594-602
- ISSN
- 0962-8924 (ISSN-L)
- OpenAlex
- W2078993607
- Cited by
- 167
- References
- 4
- FWCI
- 1.43
- Type
- journal article
- Language
- en
- Open access
- green
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