The DOI matches its Crossref record; 169 of the 169 references it cites were found in a registry or an index.
BMP signalling: agony and antagony in the family
Open accessAbstract
Bone morphogenetic proteins (BMPs) are secreted extracellular matrix (ECM)-associated proteins that regulate a wide range of developmental processes, including limb and kidney formation. A critical element of BMP regulation is the presence of secreted antagonists that bind and inhibit BMP binding to their cognate Ser/Thr kinase receptors at the plasma membrane. Antagonists such as Noggin, Chordin, Gremlin (Grem1), and twisted gastrulation-1 (Twsg1) have been shown to inhibit BMP action in a range of different cell types and developmental stage-specific contexts. Here we review new developments in the field of BMP and BMP antagonist biology during mammalian development and suggest strategies for targeting these proteins in human disease.
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Cites
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Cited by
Contextual determinants of TGFβ action in development, immunity and cancer
David, C. J., & Massagué, J. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0007-0 · Cited by 851
BMP signalling in skeletal development, disease and repair
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Specificity, versatility, and control of TGF-β family signaling
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The interplay of fibroblasts, the extracellular matrix, and inflammation in scar formation
Moretti, L., Stalfort, J., Barker, T. H., & Abebayehu, D. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101530 · Cited by 393
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Metadata
- Authors
- Brazil, D. P., Church, R. H., Surae, S., Godson, C., & Martin, F.
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2015-05
- Volume
- 25
- Issue
- 5
- Pages
- 249-264
- ISSN
- 0962-8924 (ISSN-L)
- OpenAlex
- W2156182988
- Cited by
- 306
- References
- 169
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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