The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Force Matters: Biomechanical Regulation of Cell Invasion and Migration in Disease
Open accessAbstract
Atherosclerosis, cancer and various chronic fibrotic conditions are characterized by an increase in the migratory behavior of resident cells and the enhanced invasion of assorted exogenous cells across a stiffened extracellular matrix. This stiffened scaffold aberrantly engages cellular mechanosignaling networks in cells, which promotes the assembly of invadosomes and lamella for cell invasion and migration. Accordingly, deciphering the conserved molecular mechanisms whereby matrix stiffness fosters invadosome and lamella formation could identify therapeutic targets to treat fibrotic conditions, and reducing extracellular matrix stiffness could ameliorate disease progression.
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Cites
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Cited by
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Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment
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The Extracellular Matrix Modulates the Metastatic Journey
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Metadata
- Authors
- Kai, F., Laklai, H., & Weaver, V. M.
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2016-07
- Volume
- 26
- Issue
- 7
- Pages
- 486-497
- ISSN
- 0962-8924 (ISSN-L)
- OpenAlex
- W2337230445
- Cited by
- 243
- References
- 11
- FWCI
- 3.15
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kai, F., Laklai, H., & Weaver, V. M. (2016). Force Matters: Biomechanical Regulation of Cell Invasion and Migration in Disease. Trends in Cell Biology. https://doi.org/10.1016/j.tcb.2016.03.007
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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