The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Rebuilding Chromosomes After Catastrophe: Emerging Mechanisms of Chromothripsis
Open accessAbstract
Cancer genome sequencing has identified chromothripsis, a complex class of structural genomic rearrangements involving the apparent shattering of an individual chromosome into tens to hundreds of fragments. An initial error during mitosis, producing either chromosome missegregation into a micronucleus or chromatin bridge interconnecting two daughter cells, can trigger the catastrophic pulverization of the spatially isolated chromosome. The resultant chromosomal fragments are re-ligated in random order by DNA double-strand break repair during the subsequent interphase. Chromothripsis scars the cancer genome with localized DNA rearrangements that frequently generate extensive copy number alterations, oncogenic gene fusion products, and/or tumor suppressor gene inactivation. Here we review emerging mechanisms underlying chromothripsis with a focus on the contribution of cell division errors caused by centromere dysfunction.
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Cites
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Cited by
Chromothripsis as an on-target consequence of CRISPR–Cas9 genome editing
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Metadata
- Authors
- Ly, P., & Cleveland, D. W.
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2017-12
- Volume
- 27
- Issue
- 12
- Pages
- 917-930
- ISSN
- 0962-8924 (ISSN-L)
- OpenAlex
- W2753782648
- Cited by
- 205
- References
- 15
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- green
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