The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Lipid Rafts: Controversies Resolved, Mysteries Remain
Open accessAbstract
The lipid raft hypothesis postulates that lipid-lipid interactions can laterally organize biological membranes into domains of distinct structures, lipid/protein compositions, and functions. This proposal has in equal measure exhilarated and frustrated membrane research for decades. While the physicochemical principles underlying lipid-driven domains has been explored and is well understood, the existence and relevance of such domains in cells remains elusive, despite decades of research. Here, we review the conceptual underpinnings of the raft hypothesis and critically discuss the supporting and contradicting evidence in cells, focusing on why controversies about the composition, properties, and even the very existence of lipid rafts remain unresolved. Finally, we highlight several recent breakthroughs that may resolve existing controversies and suggest general approaches for moving beyond questions of rafts existence and towards understanding of their physiological significance.
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Citations
Cites
Functional rafts in cell membranes
Simons, K., & Ikonen, E. (1997) · Nature · doi:10.1038/42408 · Cited by 9,757 · cited 1×
“The introduction of the raft concept [1] launched a new field and recruited to membrane biology a generation of physical chemists, cell biologists, biophysicists, optical engineers, and computational scientists [2], all to explore the seemingly trivial notion that living membranes are not laterally homogeneous.”
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Cited by
Han, Z., Xiong, D., Schneiter, R., & Tian, C. (2023) · Molecular Plant Pathology · doi:10.1111/mpp.13320 · Cited by 160
Plummer, A. M., Culbertson, A. T., & Liao, M. (2021) · Annual Review of Physiology · doi:10.1146/annurev-physiol-031620-094944 · Cited by 60
Molecular mechanisms of flotillin complexes in organizing membrane microdomains
Lu, M.-A., Qian, Y., Ma, L., Hong, J., Li, X., Yu, L., Guo, Q., & Gao, N. (2026) · Nature Communications · doi:10.1038/s41467-026-69197-3 · Cited by 13
Metadata
- Authors
- Levental, I., Levental, K. R., & Heberle, F. A.
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2020-05
- Volume
- 30
- Issue
- 5
- Pages
- 341-353
- ISSN
- 0962-8924 (ISSN-L)
- OpenAlex
- W3006868374
- Cited by
- 598
- References
- 1
- FWCI
- 6.60
- Type
- journal article
- Language
- en
- Open access
- green
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- Levental, I., Levental, K. R., & Heberle, F. A. (2020). Lipid Rafts: Controversies Resolved, Mysteries Remain. Trends in Cell Biology. https://doi.org/10.1016/j.tcb.2020.01.009
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
