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Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

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Gasdermin E suppresses tumour growth by activating anti-tumour immunity

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Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells

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Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death

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PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis

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GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

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Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection

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NINJ1 mediates plasma membrane rupture during lytic cell death

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Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation

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Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis

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Gasdermin D plays a vital role in the generation of neutrophil extracellular traps

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Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis

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ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation

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ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences

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Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis

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Noncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular traps

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Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis

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Pyroptosis and Apoptosis Pathways Engage in Bidirectional Crosstalk in Monocytes and Macrophages

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Cleavage of GSDME by caspase-3 determines lobaplatin-induced pyroptosis in colon cancer cells

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Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death

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N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis

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Nonsyndromic hearing impairment is associated with a mutation in DFNA5

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Extrinsic and intrinsic apoptosis activate pannexin‐1 to drive NLRP3 inflammasome assembly

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Innate immune priming in the absence of TAK1 drives RIPK1 kinase activity–independent pyroptosis, apoptosis, necroptosis, and inflammatory disease

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Single-cell analysis of pyroptosis dynamics reveals conserved GSDMD-mediated subcellular events that precede plasma membrane rupture

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Cryo-EM structure of the gasdermin A3 membrane pore

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MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation

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Mutations in the gene encoding pejvakin, a newly identified protein of the afferent auditory pathway, cause DFNB59 auditory neuropathy

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GSDME mediates caspase-3-dependent pyroptosis in gastric cancer

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Structure insight of GSDMD reveals the basis of GSDMD autoinhibition in cell pyroptosis

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Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation

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Molecular Targeted Therapies Elicit Concurrent Apoptotic and GSDME-Dependent Pyroptotic Tumor Cell Death

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Caspase-8–dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality

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Hypervulnerability to Sound Exposure through Impaired Adaptive Proliferation of Peroxisomes

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GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation

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Gasdermin-B Promotes Invasion and Metastasis in Breast Cancer Cells

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Gasdermin C Is Upregulated by Inactivation of Transforming Growth Factor β Receptor Type II in the Presence of Mutated Apc, Promoting Colorectal Cancer Proliferation

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A functional splice variant associated with decreased asthma risk abolishes the ability of gasdermin B to induce epithelial cell pyroptosis

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GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity

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Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 Inflammasome

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GASDERMIN, suppressed frequently in gastric cancer, is a target of LMO1 in TGF-β-dependent apoptotic signalling

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Enterovirus 71 Inhibits Pyroptosis through Cleavage of Gasdermin D

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Coral gasdermin triggers pyroptosis

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The DFNA5 gene, responsible for hearing loss and involved in cancer, encodes a novel apoptosis-inducing protein

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ASC- and caspase-8-dependent apoptotic pathway diverges from the NLRC4 inflammasome in macrophages

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Teleost Gasdermin E Is Cleaved by Caspase 1, 3, and 7 and Induces Pyroptosis

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Pejvakin-mediated pexophagy protects auditory hair cells against noise-induced damage

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Loss of conserved Gsdma3 self-regulation causes autophagy and cell death

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Zebrafish GSDMEb Cleavage-Gated Pyroptosis Drives Septic Acute Kidney Injury In Vivo

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The zebrafish NLRP3 inflammasome has functional roles in ASC-dependent interleukin-1β maturation and gasdermin E–mediated pyroptosis

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The Characterization of GSDMB Splicing and Backsplicing Profiles Identifies Novel Isoforms and a Circular RNA That Are Dysregulated in Multiple Sclerosis

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Intrinsic repair protects cells from pore-forming toxins by microvesicle shedding

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The dominant alopecia phenotypes Bareskin, Rex-denuded, and Reduced Coat 2 are caused by mutations in gasdermin 3

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Mutations in Gasdermin 3 Cause Aberrant Differentiation of the Hair Follicle and Sebaceous Gland

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The zebrafish NLRP3 inflammasome has functional roles in ASC-dependent interleukin-1β maturation and gasdermin E–mediated pyroptosis

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Structural Insight of Gasdermin Family Driving Pyroptotic Cell Death

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Inner ear development in cyclostomes and evolution of the vertebrate semicircular canals

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Light Triggered “Bacterial Bomb” to Amplify Tumor Pyroptosis

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Non‐viral Gene Therapy for Melanoma Using Lysenin from Eisenia Foetida

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RIPK1 and RIPK3 in antibacterial defence

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Precise Orchestration of Gasdermins' Pore-Forming Function by Posttranslational Modifications in Health and Disease

Jiang, H., Liu, P., Kang, J., Wu, J., Gong, W., Li, X., Li, Y., Liu, J., Li, W., Ni, C., et al. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.86869 · Cited by 7 · see citing works

Lenvatinib promotes hepatocellular carcinoma pyroptosis by regulating GSDME palmitoylation

Yuan, Y., Wang, M.-R., Ding, Y., Lin, Y., Xu, T., He, X., & Li, P. (2025) · Cancer Biology & Therapy · doi:10.1080/15384047.2025.2532217 · Cited by 6 · see citing works

For Better or Worse: The Impact of Necrotic Cell Death Modalities

Vandenabeele, P., Conrad, M., & Wahida, A. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-92785-0_8 · Cited by 7 · see citing works

The Evolution of NLR Inflammasome and Its Mediated Pyroptosis in Metazoa

Sun, J., Leng, J., & Song, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252011167 · Cited by 6 · see citing works

Paralichthys olivaceus GSDME-mediated pyroptosis is regulated by multiple caspases in different manners

Hao, K., Yuan, L., Yu, C., Xu, H., & Sun, L. (2024) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2024.110002 · Cited by 6 · see citing works

Microbial gasdermins: More than a billion years of pyroptotic-like cell death

Zheng, Q. T., & Daskalov, A. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101813 · Cited by 6 · see citing works

Regulatory T cell death in inflammation and tumor immunity: Focus on necroptosis, pyroptosis and ferroptosis

Zhao, C., & Wang, X. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.112159 · Cited by 5 · see citing works

Integrative Analysis of a Pyroptosis-Related Signature of Clinical and Biological Value in Multiple Myeloma

Wang, H., Shao, R., Lu, S., Bai, S., Fu, B., Lai, R.-C., & Lu, Y. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.845074 · Cited by 5 · see citing works

Targeting VDAC1 to protect against mitochondria-linked cell death pathways: apoptosis, pyroptosis, ferroptosis, and associated diseases

Shteinfer‐Kuzmine, A., Nivedita, A. K., Santhanam, M., Trishna, S., Swerdlow, R. H., Pan, J., & Shoshan‐Barmatz, V. (2026) · APOPTOSIS · doi:10.1007/s10495-025-02217-7 · Cited by 4 · see citing works

Functional Materials Targeted Regulation of Gasdermins: From Fundamentals to Functionalities and Applications

Tian, L., Piao, S., Li, X., Guo, L., Huang, L., & Gao, W. (2025) · Advanced Science · doi:10.1002/advs.202500873 · Cited by 4 · see citing works

Madecassoside alleviates PM2.5-induced skin cell damage

Tai, M., He, Q., Lv, P., Li, W., Ling, X., Li, L., & Guo, M. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.151977 · Cited by 4 · see citing works

Decay of Skin-Specific Gene Modules in Pangolins

Pinto, B., Valente, R., Caramelo, F., Ruivo, R., & Castro, L. F. C. (2023) · Journal of Molecular Evolution · doi:10.1007/s00239-023-10118-z · Cited by 4 · see citing works

Targeting PAK4 promotes Gemcitabine-induced pyroptosis in pancreatic cancer via NLRP1/caspase-3/GSDME axis

Lu, T., Song, Y., Liang, K., Zhang, Z., Li, Y., Tan, X., Li, X., & Li, F. (2026) · Communications Biology · doi:10.1038/s42003-026-09538-6 · Cited by 3 · see citing works

Gasdermin B modulates intestinal epithelial homeostasis via regulating hyperactive unfolded protein response in Crohn’s disease

Gong, W., Liu, P., Liu, J., Li, Y., Jiang, H., Li, W., Kang, J., Jiao, F., Wu, X., Zhao, Y., et al. (2025) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjaf012 · Cited by 3 · see citing works

Erianin induces apoptosis and pyroptosis via MAPK/ERK and PI3K/Akt pathways and synergizes with anlotinib in anaplastic thyroid carcinoma

Zhang, Q., Qiu, M., Liu, J., Gao, Z., Liu, Y., Wang, Y., Liu, R., Yang, Z., Hao, J., & Gao, M. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1596873 · Cited by 3 · see citing works

Evolutive aspects of inflammasomes

Hikima, J.-I., & Morimoto, N. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91802-2.00013-x · Cited by 3 · see citing works

Pyroptosis: A promising target for lung cancer therapy

Zhou, W., Zhao, L., Wang, H., Liu, X., Liu, Y., Xu, K., Yu, H., Suda, K., & He, Y. (2023) · Chinese Medical Journal - Pulmonary and Critical Care Medicine · doi:10.1016/j.pccm.2023.03.001 · Cited by 3 · see citing works

The Versatile Gasdermin Family: Their Function and Roles in Diseases

Zou, J., Zheng, Y., Huang, Y., Tang, D., Kang, R., & Chen, R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.751533 · Cited by 150 · see citing works

New insights into the evolutionary dynamic and lineage divergence of gasdermin E in metazoa

Yuan, Z., Jiang, S., Qin, K., & Sun, L. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.952015 · Cited by 46 · see citing works

Gasdermins: pore-forming activities and beyond

Zheng, Z., Deng, W., Lou, X., Bai, Y., Wang, J., Zeng, H., Gong, S., & Liu, X. (2020) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmaa016 · Cited by 42 · see citing works

Molecular mechanisms of gasdermin D pore-forming activity

Devant, P., & Kagan, J. C. (2023) · Nature Immunology · doi:10.1038/s41590-023-01526-w · Cited by 267 · see citing works

Licensed to pore: Gasdermins in action

Ketelut-Carneiro, N., Mathur, A., & Fitzgerald, K. A. (2026) · Cell chemical biology · doi:10.1016/j.chembiol.2026.05.001