Madecassoside alleviates PM2.5-induced skin cell damage
Abstract
With accelerated urbanization, air pollution has become an environmental problem that requires urgent resolution. Intensified inflammation, atopic dermatitis, and itchy skin have been reported in humans exposed to increasing PM 2.5 concentrations. PM 2.5 is the particulate matter whose aerodynamic equivalent diameter is less than or equal to 2.5 μm in ambient air. Madecassoside, a pentacyclic triterpenoid active component, which is found in and extracted from the plant Centella Asiatica, possesses unique pharmacological properties, such as anti-inflammatory activity, which are used to treat skin wounds. This study investigated the effects of madecassoside in terms of pyroptosis antagonism, cell membrane repair promotion, and skin barrier repair using THP-1 and HaCaT cells stimulated with PM 2.5 . We measured IL-1β and LDH contents in culture supernatants of THP-1 cells. The expressions of the proteins related to cell membrane repair and skin barrier repair were detected by western blotting, quantitative reverse transcription PCR and immunofluorescence. We found that madecassoside reduced the release of the inflammatory factor IL-1β and the lytic cell death marker lactate dehydrogenase and repaired PM 2.5 -induced gasdermin D-mediated cell membrane damage. Further, madecassoside may have the potential to promote skin barrier repair by alleviating skin barrier-related protein damage and nuclear transfer. Therefore, madecassoside possesses anti-PM 2.5 stimulating activity throug…
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Asiaticoside and madecassoside activate the TGF-β/Smad pathway to drive extracellular matrix synthesis, thereby enhancing collagen deposition and improving skin elasticity and hydration.
“At the molecular signaling level, asiaticoside and madecassoside activate the TGF-β/Smad pathway to drive extracellular matrix synthesis, thereby enhancing collagen deposition and improving skin elasticity and hydration (Shen et al. 2019; Kim et al. 2021; Tai et al. 2025).”
From Centella asiatica (L.) Urb. in skin health and cosmeceuticals: mechanisms, clinical evidence, and advanced delivery systems (2025) · cites this paper as Tai et al. 2025
Cites
Piao, M. J., Ahn, M. J., Kang, K. A., Ryu, Y. S., Hyun, Y. J., Shilnikova, K., Zhen, A. X., Jeong, J. W., Choi, Y. H., Kang, H. K., et al. (2018) · Archives of Toxicology · doi:10.1007/s00204-018-2197-9 · Cited by 339 · see citing works
Ming, L., Jin, L. N., Li, J., Fu, P., Yang, W., Liu, D., Zhang, G., Wang, Z., & Li, X. D. (2017) · Environmental Pollution · doi:10.1016/j.envpol.2017.01.013 · Cited by 315 · see citing works
The filaggrin story: novel insights into skin-barrier function and disease
McGrath, J. A., & Uitto, J. (2007) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.10.006 · Cited by 224 · see citing works
Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review
Bandopadhyay, S., Mandal, S., Ghorai, M., Jha, N. K., Kumar, M., Radha, Ghosh, A., Proćków, J., Pérez de la Lastra, J. M., & Dey, A. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17635 · Cited by 220 · see citing works
Dijkhoff, I. M., Drasler, B., Karakocak, B. B., Petri-Fink, A., Valacchi, G., Eeman, M., & Rothen-Rutishauser, B. (2020) · Particle and Fibre Toxicology · doi:10.1186/s12989-020-00366-y · Cited by 202 · see citing works
Liquid-liquid phase separation drives skin barrier formation
Quiroz, F. G., Fiore, V. F., Levorse, J. M., Polak, L., Wong, E., Pasolli, H. A., & Fuchs, E. V. (2020) · Science · doi:10.1126/science.aax9554 · Cited by 200 · see citing works
Particulate matter causes skin barrier dysfunction.
Kim, B. E., Kim, J., Goleva, E., Berdyshev, E., Lee, J., Vang, K. A., Lee, U. H., Han, S., Leung, S., Hall, C. F., et al. (2021) · JCI insight · doi:10.1172/jci.insight.145185 · Cited by 173 · see citing works
Acute health effects of urban fine and ultrafine particles on children with atopic dermatitis.
Song, S., Lee, K., Lee, Y.-M., Lee, J.-H., Il Lee, S., Yu, S.-D., & Paek, D. (2011) · Environmental Research · doi:10.1016/j.envres.2010.10.010 · Cited by 162 · see citing works
Systematic Review and Meta-Analysis of Human Skin Diseases Due to Particulate Matter
Ngoc, L., Park, D., Lee, Y., & Lee, Y.-C. (2017) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph14121458 · Cited by 159 · see citing works
Punching Holes in Cellular Membranes: Biology and Evolution of Gasdermins
De Schutter, E., Roelandt, R., Riquet, F. B., Van Camp, G., Wullaert, A., & Vandenabeele, P. (2021) · Trends in Cell Biology · doi:10.1016/j.tcb.2021.03.004 · Cited by 158 · see citing works
Ryu, Y. S., Kang, K. A., Piao, M. J., Ahn, M. J., Yi, J. M., Hyun, Y., Kim, S. H., Ko, M. K., Park, C. O., & Hyun, J. W. (2018) · Redox Biology · doi:10.1016/j.redox.2018.101080 · Cited by 147 · see citing works
Research progresses of molecular mechanism of pyroptosis and its related diseases
Gong, W., Shi, Y., & Ren, J. (2019) · Immunobiology · doi:10.1016/j.imbio.2019.11.019 · Cited by 95 · see citing works
Hu, R., Xie, X., Xu, S., Wang, Y., Jiang, M., Wen, L.-R., Lai, W., & Guan, L. (2017) · Chinese Medical Journal · doi:10.4103/0366-6999.212942 · Cited by 76 · see citing works
Adult atopic dermatitis and exposure to air pollutants—a nationwide population-based study
Tang, K.-T., Ku, K.-C., Chen, D.-Y., Lin, C.-H., Tsuang, B.-J., & Chen, Y.-H. (2017) · Annals of Allergy, Asthma & Immunology · doi:10.1016/j.anai.2016.12.005 · Cited by 73 · see citing works
Wei, H., Li, H., Wan, S., Zeng, Q., Cheng, L.-X., Jiang, L.-L., & Peng, Y.-D. (2017) · Medical Science Monitor · doi:10.12659/msm.902196 · Cited by 56 · see citing works
Guo, M., An, F., Yu, H., Wei, X., Hong, M., & Lü, Y. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.09.097 · Cited by 56 · see citing works
Self-citationAlcohol accumulation promotes esophagitis via pyroptosis activation
Wang, F., Li, G., Ning, J., Chen, L., Xu, H., Kong, X., Bu, J., Zhao, W., Li, Z., Wang, X., et al. (2018) · International Journal of Biological Sciences · doi:10.7150/ijbs.24347 · Cited by 54 · see citing works
Shen, X., Guo, M., Yu, H., Liu, D., Lu, Z., & Lu, Y. (2019) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2018.1547627 · Cited by 54 · see citing works
Self-citationMadecassoside Inhibits Melanin Synthesis by Blocking Ultraviolet-Induced Inflammation
Jung, E., Lee, J.-A., Shin, S., Roh, K.-B., Kim, J.-H., & Park, D. (2013) · Molecules · doi:10.3390/molecules181215724 · Cited by 52 · see citing works
Keratinocytes oxidative damage mechanisms related to airbone particle matter exposure
Romani, A., Cervellati, C., Muresan, X. M., Belmonte, G., Pecorelli, A., Cervellati, F., Benedusi, M., Evelson, P., & Valacchi, G. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.11.007 · Cited by 52 · see citing works
Analysis of PM 2.5 -induced cytotoxicity in human HaCaT cells based on a microfluidic system
Zhang, Y., Zheng, L., Tuo, J., Liu, Q., Zhang, X., Xu, Z., Liu, S., & Sui, G. (2017) · Toxicology in Vitro · doi:10.1016/j.tiv.2017.04.018 · Cited by 45 · see citing works
Skin inflammation induced by ambient particulate matter in China
Dong, Y., Liao, L.-Y., Li, L., Yi, F., Meng, H., He, Y., & Guo, M. (2019) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2019.05.155 · Cited by 39 · see citing works
Self-citationFu, X., Hong, W., Li, S., Chen, Z., Zhou, W., Dai, J., Deng, X., Zhou, H., Li, B., & Ran, P. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.135726 · Cited by 37 · see citing works
Lu, W., Luo, D., Chen, D., Zhang, S., Chen, X., Zhou, H. W., Liu, Q., Chen, S., & Liu, W. (2023) · Molecules · doi:10.3390/molecules28135275 · Cited by 25 · see citing works
YU, W.-G., SHEN, Y., WU, J.-Z., GAO, Y.-B., & ZHANG, L.-X. (2018) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(18)30064-5 · Cited by 21 · see citing works
dos Santos, M. M., Fei, M. T. P., Li, C., Jia, S., & Snyder, S. A. (2022) · Environment International · doi:10.1016/j.envint.2022.107403 · Cited by 19 · see citing works
Development of Imiquimod-induced HaCaT-THP-1 co-culture for modeling of psoriasis
Váradi, J., Oláh, B., Hosszú, D., Fenyvesi, F., Remenyik, J., Homoki, J. R., Nagy, B., Fejes, Z., Bácskay, I., & Klusóczki, Á. (2024) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2024.106846 · Cited by 12 · see citing works
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Handayani, R., Febriyanti, R. M., Muhaimin, M., & Chearunisaa, A. Y. (2025) · Pharmacia · doi:10.3897/pharmacia.72.e167217 · Cited by 5 · see citing works
Xu, X., Wei, S., Shan, Q., Chen, C., Liu, S., & Ma, J. (2026) · Journal of Environmental Sciences · doi:10.1016/j.jes.2026.03.061 · Cited by 1 · see citing works
Jerzyńska, O., Kałachurska, M., Rozek, M., Nowakowska, M. K., Kowalewska-Kurek, A., Lisowska, A., Nowak, B., Sierant, M., Gural, M., & Guy, C. E. (2026) · International Journal of Innovative Technologies in Social Science · doi:10.31435/ijitss.1(49).2026.4800
Cai, J., Xu, Y., Ping, W., Ya, H., Guo, Y., Zhang, X., & Lv, X. (2026) · Colloid & Polymer Science · doi:10.1007/s00396-026-05733-3
- Authors
- Tai, M., He, Q., Lv, P., Li, W., Ling, X., Li, L., & Guo, M.
- Affiliations
- Infinitus (China) (CN)
- Beijing Technology and Business University (CN)
- Corresponding author
- Guo, Miaomiao
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2025-07
- Volume
- 770
- Pages
- 151977
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W4410301411
- Cited by
- 4
- References
- 28
- Citations by year
- 2026: 3 · 2025: 1
- FWCI
- 3.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Keywords
- madecassoside, PM2.5, particulate matter, skin barrier repair, pyroptosis, gasdermin D, cell membrane damage, IL-1β, anti-inflammatory activity, Centella asiatica, HaCaT keratinocytes, THP-1 macrophages, air pollution, skin inflammation
- MeSH terms
- Pyroptosis, THP-1 Cells, HaCaT Cells, Anti-Inflammatory Agents, Cell Line, Humans, L-Lactate Dehydrogenase, Skin, Triterpenes, Particulate Matter, Interleukin-1beta
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