The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Obesity and leptin resistance: distinguishing cause from effect
Open accessAbstract
Because leptin reduces food intake and body weight, the coexistence of elevated leptin levels with obesity is widely interpreted as evidence of “leptin resistance.” Indeed, obesity promotes multiple cellular processes that attenuate leptin signaling (referred to here as “cellular leptin resistance”), and which amplify the extent of weight gain induced by genetic and environmental factors. As commonly employed, however, the term “leptin resistance” embraces a range of phenomena that are distinct with respect both to underlying mechanisms and pathophysiological implications. Moreover, the induction of cellular leptin resistance by obesity complicates efforts to distinguish the mechanisms that predispose to weight gain from those that result from it. We suggest a framework for approaching these issues and important avenues for future investigation.
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Cites
Central nervous system control of food intake
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Self-citationRole of leptin in the neuroendocrine response to fasting
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Leptin-Replacement Therapy for Lipodystrophy
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STAT3 signalling is required for leptin regulation of energy balance but not reproduction
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“of genetic lesions that impair specific leptin-regulated pathways may produce selective leptin resistance, these represent a different case than DIO (39,56).”
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Cited by
Obesity is associated with hypothalamic injury in rodents and humans.
Thaler, J. P., Yi, C.-X., Schur, E. A., Guyenet, S. J., Hwang, B. H., Dietrich, M. O., Zhao, X., Sarruf, D. A., Izgur, V., Maravilla, K. R., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59660 · Cited by 1,857
Self-citationThe role of estrogens in control of energy balance and glucose homeostasis
Mauvais-Jarvis, F., Clegg, D. J., & Hevener, A. L. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1055 · Cited by 1,329
Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons
Vong, L., Ye, C., Yang, Z., Choi, B., Chua, S., & Lowell, B. B. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.028 · Cited by 1,235
Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders
Choe, S. S., Huh, J. Y., Hwang, I. J., Kim, J. I., & Kim, J. B. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00030 · Cited by 1,206
Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks
Magnuson, B., Ekim, B., & Fingar, D. C. (2012) · Biochemical Journal · doi:10.1042/bj20110892 · Cited by 1,015
Metadata
- Authors
- Myers, M. G., Leibel, R. L., Seeley, R. J., & Schwartz, M. W.
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2010-11
- Volume
- 21
- Issue
- 11
- Pages
- 643-651
- ISSN
- 1043-2760 (ISSN-L)
- OpenAlex
- W2039749588
- Cited by
- 901
- References
- 26
- FWCI
- 2.88
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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