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Regulation of lipid droplets by autophagy
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Dyshomeostasis of lipid transport and/or dysfunction of autophagy may play a role in CE dysregulation.
“Studies suggest the dyshomeostasis of lipid transport35,36 and/or the dysfunction of autophagy may play a role in CE dysregulation37,38.”
From GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau (2025) · cites this paper as [38]
Aster proteins, as well as lipids and lipid droplets, can also be regulated by autophagy.
“Aster proteins, as well as lipids and lipid droplets, can also be regulated by autophagy37,38.”
From GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau (2025) · cites this paper as [38]
Degradation of both lipids and tau protein is regulated by autophagy.
“Given the degradation of both lipids and tau protein is regulated by autophagy37,38”
From GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau (2025) · cites this paper as [38]
Growing evidence demonstrates that dysfunctions in autophagy, lipid metabolism, and tau clearance are interconnected.
“Growing evidence demonstrates that dysfunctions in autophagy, lipid metabolism, and tau clearance are interconnected37,38”
From GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau (2025) · cites this paper as [38]
CE accumulation could be due to the dyshomeostasis of lipid transport and/or the dysfunction of autophagy to degrade CE.
“CE accumulation could be due to the dyshomeostasis of lipid transport35,36 and/or the dysfunction of autophagy to degrade CE37,38.”
From GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau (2025) · cites this paper as [38]
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Citations
Cites
Autophagy fights disease through cellular self-digestion
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Autophagy regulates lipid metabolism
Singh, R., Kaushik, S., Wang, Y., Xiang, Y., Novak, I., Komatsu, M., Tanaka, K., Cuervo, A. M., & Czaja, M. J. (2009) · Nature · doi:10.1038/nature07976 · Cited by 3,975
Self-citationSuppression of basal autophagy in neural cells causes neurodegenerative disease in mice
Hara, T., Nakamura, K., Matsui, M., Yamamoto, A., Nakahara, Y., Suzuki-Migishima, R., Yokoyama, M., Mishima, K., Saito, I., Okano, H., et al. (2006) · Nature · doi:10.1038/nature04724 · Cited by 3,882
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Nix is a selective autophagy receptor for mitochondrial clearance
Novak, I., Kirkin, V., McEwan, D. G., Zhang, J., Wild, P., Rozenknop, A., Rogov, V., Löhr, F., Popovic, D., Occhipinti, A., et al. (2010) · The EMBO Reports · doi:10.1038/embor.2009.256 · Cited by 1,309 · cited 1×
“Nix binds proteins required for autophagosome membrane formation [33], presumably recruiting the components necessary to assemble an autophagosome around mitochondria.”
Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance
Yang, L., Li, P., Fu, S., Calay, E. S., & Hotamisligil, G. S. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.04.005 · Cited by 1,274
Cargo recognition failure is responsible for inefficient autophagy in Huntington’s disease
Martinez-Vicente, M., Talloczy, Z., Wong, E., Tang, G., Koga, H., Kaushik, S., de Vries, R., Arias, E., Harris, S., Sulzer, D., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2528 · Cited by 885
Autophagy and aging: The importance of maintaining "clean" cells
Cuervo, A. M., Bergamini, E., Brunk, U. T., Dröge, W., Ffrench, M., & Terman, A. (2005) · Autophagy · doi:10.4161/auto.1.3.2017 · Cited by 792
PpAtg30 Tags Peroxisomes for Turnover by Selective Autophagy
Farré, J.-C., Manjithaya, R., Mathewson, R. D., & Subramani, S. (2008) · Developmental Cell · doi:10.1016/j.devcel.2007.12.011 · Cited by 331
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Sorted by citations
GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau
Acosta Ingram, D., Turkes, E., Kim, T. Y., Vo, S., Sweeney, N., Bonte, M.-A., Rutherford, R., Julian, D. L., Pan, M., Marsh, J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-58585-w · Cited by 12
Metadata
- Authors
- Dong, H., & Czaja, M. J.
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2011-06
- Volume
- 22
- Issue
- 6
- Pages
- 234-240
- ISSN
- 1043-2760
- PMC
- PMC3118855
- Cited by
- 197
- References
- 9
- Language
- en
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