Cited by 386Endoplasmic Reticulum Stress and DiseasePancreatic function and diabetesIon Channels and Receptors

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Endoplasmic reticulum stress and pancreatic β-cell death

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Fonseca, Sonya G., Gromada, Jesper, Urano, Fumihiko·2011·Trends in Endocrinology & Metabolism

DOI 10.1016/j.tem.2011.02.008PMC PMC3130122

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Abstract

In pancreatic β-cells, the endoplasmic reticulum (ER) is an important cellular compartment for insulin biosynthesis, which accounts for half of the total protein production in these cells. Protein flux through the ER must be carefully monitored to prevent dysregulation of ER homeostasis and stress. ER stress elicits a signaling cascade known as the unfolded protein response (UPR), which influences both life and death decisions in cells. β-cell loss is a pathological component of both type 1 and type 2 diabetes, and recent findings suggest that ER stress is involved. In this review, we address the transition from the physiological ER stress response to the pathological response, and explore the mechanisms of ER stress-mediated β-cell loss during the progression of diabetes.

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Authors: Fonseca, S. G., Gromada, J., & Urano, F.
Affiliations: University of Massachusetts Chan Medical School (US)
ORCID: Gromada, Jesper
Urano, Fumihiko
Venue: Trends in Endocrinology & Metabolism
Publisher: Elsevier BV
Published: 2011-03
Volume: 22
Issue: 7
Pages: 266-74
ISSN: 1043-2760 (ISSN-L)
DOI: 10.1016/j.tem.2011.02.008
PMC: PMC3130122
OpenAlex: W2039420809
Cited by: 384
References: 100
Citations by year: 2026: 7 · 2025: 14 · 2024: 20 · 2023: 30 · 2022: 34 · 2021: 34 · 2020: 28 · 2019: 35 · 2018: 18 · 2017: 31 · 2016: 23 · 2015: 27 · 2014: 32 · 2013: 21 · 2012: 24
FWCI: 2.26
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
Funders: National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK067493, 5 P30 DK 32520, P30DK032520)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords: endoplasmic reticulum stress, pancreatic beta cells, beta-cell death, unfolded protein response, insulin biosynthesis, type 1 diabetes, type 2 diabetes, ER homeostasis, diabetes pathogenesis
MeSH terms: Animals, Diabetes Mellitus, Endoplasmic Reticulum, Humans, Stress, Physiological, Protein Biosynthesis, Cell Death, Oxidative Stress, Disease Progression, Insulin-Secreting Cells, Unfolded Protein Response, Molecular Targeted Therapy

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Endoplasmic reticulum stress and pancreatic β-cell death

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