Cited by 316Redox biology and oxidative stressMitochondrial Function and PathologyMetabolism, Diabetes, and Cancer

The DOI matches its Crossref record; 88 of the 89 references it cites were found in a registry or an index.

Linking mitochondrial bioenergetics to insulin resistance via redox biology

Open access

Fisher-Wellman, Kelsey H., Neufer, P. Darrell·2012·Trends in Endocrinology & Metabolism

DOI 10.1016/j.tem.2011.12.008PMC PMC3313496

Open this paper in CoChat — free account

Abstract

Chronic overnutrition and physical inactivity are major risk factors for insulin resistance and type 2 diabetes. Recent research indicates that overnutrition generates an increase in hydrogen peroxide (H(2)O(2)) emission from mitochondria, serving as a release valve to relieve the reducing pressure created by fuel overload, as well as a primary signal that ultimately decreases insulin sensitivity. H(2)O(2) is a major input to cellular redox circuits that link to cysteine residues throughout the entire proteome to regulate cell function. Here we review the principles of mitochondrial bioenergetics and redox systems biology and offer new insight into how H(2)O(2) emission may be linked via redox biology to the etiology of insulin resistance.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.tem.2011.12.008

Cites

88 of 88 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Biochemistry and molecular cell biology of diabetic complications
Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
Bedard, K., & Krause, K.-H. (2007) · Physiological Reviews · doi:10.1152/physrev.00044.2005 · Cited by 6,989
Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism
MITCHELL, P. (1961) · Nature · doi:10.1038/191144a0 · Cited by 4,704
Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple
Schafer, F. Q., & Buettner, G. R. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00480-4 · Cited by 4,587
A central role for JNK in obesity and insulin resistance
Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., Karin, M., & Hotamisligil, G. S. (2002) · Nature · doi:10.1038/nature01137 · Cited by 3,359
Reactive oxygen species have a causal role in multiple forms of insulin resistance
Houstis, N., Rosen, E. D., & Lander, E. S. (2006) · Nature · doi:10.1038/nature04634 · Cited by 2,525
Oxidative Stress and Stress-Activated Signaling Pathways: A Unifying Hypothesis of Type 2 Diabetes
Evans, J. L., Goldfine, I. D., Maddux, B. A., & Grodsky, G. M. (2002) · Endocrine Reviews · doi:10.1210/er.2001-0039 · Cited by 2,232
Mitochondrial dysfunction and type 2 diabetes
Lowell, B. B., & Shulman, G. I. (2005) · Science · doi:10.1126/science.1104343 · Cited by 2,070
Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ
Yuan, M., Konstantopoulos, N., Lee, J., Hansen, L., Li, Z.-W., Karin, M., & Shoelson, S. E. (2001) · Science · doi:10.1126/science.1061620 · Cited by 1,884
The Effect of Insulin on the Disposal of Intravenous Glucose: Results from Indirect Calorimetry and Hepatic and Femoral Venous Catheterization
DeFronzo, R. A., Jacot, E., Jequier, E., Maeder, E., Wahren, J., & Felber, J. P. (1981) · Diabetes · doi:10.2337/diab.30.12.1000 · Cited by 1,770

Flagged first, then by citations

Show all 89 references

1 of the 89 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

Goldstein, 2005, Role of insulin-induced reactive oxygen species in the insulin signaling pathway, Antioxid. Redox Signal., 7, 1021, 10.1089/ars.2005.7.1021 · DOI · Paper page

Sorted by citations

Items 101–200 of 316

Complex II ambiguities—FADH2 in the electron transfer system
Gnaiger, E. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105470 · Cited by 55
Mitochondrial and skeletal muscle health with advancing age
Konopka, A. R., & Nair, K. S. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.05.008 · Cited by 57
“Data from mitochondrial bioenergetics supports the role of altered mitochondrial membrane potential in mediating excess levels of oxidant production (Fisher-Wellman and Neufer, 2012).”
β-Hydroxybutyrate Elicits Favorable Mitochondrial Changes in Skeletal Muscle
Parker, B. A., Walton, C. M., Carr, S. T., Andrus, J. L., Cheung, E. C. K., Duplisea, M. J., Wilson, E. K., Draney, C., Lathen, D. R., Kenner, K. B., et al. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082247 · Cited by 52
Hydrogen peroxide production regulates the mitochondrial function in insulin resistant muscle cells: Effect of catalase overexpression
Barbosa, M. R., Sampaio, I. H., Teodoro, B. G., Sousa, T. A. E., Zoppi, C. C., Queiroz, A. L., Passos, M. A., Alberici, L. C., Teixeira, F. R., Manfiolli, A. O., et al. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.04.029 · Cited by 53
“The oxidation of fatty acid involving the electron transfer by flavoprotein quinone oxidoreductase (ETF-QOR) was observed to increase the rate of ROS production [30–32].”
Background
Mitochondria and Antibiotics: For Good or for Evil?
Suarez-Rivero, J. M., Pastor‐Maldonado, C. J., Povea-Cabello, S., Álvarez-Córdoba, M., Villalón-García, I., Talaverón-Rey, M., Suárez-Carrillo, A., Munuera-Cabeza, M., & Sánchez-Alcázar, J. A. (2021) · Biomolecules · doi:10.3390/biom11071050 · Cited by 52
“Moreover, mitochondrial dysfunction is a key factor on the pathophysiology of T2DM due to its well-established association with insulin resistance [124,125].”
Background
Redox control of non-shivering thermogenesis
Lettieri‐Barbato, D. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.04.002 · Cited by 52
Acute Low-Volume High-Intensity Interval Exercise and Continuous Moderate-Intensity Exercise Elicit a Similar Improvement in 24-h Glycemic Control in Overweight and Obese Adults
Parker, L., Shaw, C. S., Banting, L., Levinger, I., Hill, K. M., McAinch, A. J., & Stepto, N. K. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2016.00661 · Cited by 53
“Postprandial oxidative stress can last for up to 4 h after meal consumption and occurs to a greater extent with larger meals that are higher in lipid content (Tucker et al., 2008; Bloomer et al., 2010; Fisher-Wellman and Bloomer, 2010; Fisher-Wellman and Neufer, 2012; Canale et al., 2014).”
BackgroundInfluential
Reducing the mitochondrial oxidative burden alleviates lipid-induced muscle insulin resistance in humans
Fiorenza, M., Onslev, J., Henríquez‐Olguín, C., Persson, K. W., Hesselager, S. A., Jensen, T. E., Wojtaszewski, J. F. P., Hostrup, M., & Bangsbo, J. (2024) · Science Advances · doi:10.1126/sciadv.adq4461 · Cited by 58
Mitochondrial damage and iron metabolic dysregulation in hepatitis C virus infection
Hino, K., Nishina, S., Sasaki, K., & Hara, Y. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.09.044 · Cited by 49
The role of mitochondrial reactive oxygen species in insulin resistance
Ayer, A., Fazakerley, D. J., James, D. E., & Stocker, R. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.11.007 · Cited by 50
Mitochondrial Activity and Skeletal Muscle Insulin Resistance in Kidney Disease
Carré, J. E., & Affourtit, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112751 · Cited by 46
“Insulin activates its receptor (IR) and receptor substrate (IRS1), which comprise a ‘critical node’ in a branched signalling network that allows interaction with other pathways, for example those induced by cytokines [15]. pathways, for example those induced by cytokines [15 Activation of this node triggers two major…”
BackgroundInfluential
Oxidative stress in muscular dystrophy: from generic evidence to specific sources and targets
Canton, M., Menazza, S., & Lisa, F. D. (2014) · Journal of Muscle Research and Cell Motility · doi:10.1007/s10974-014-9380-2 · Cited by 49
A Perspective on the Link between Mitochondria-Associated Membranes (MAMs) and Lipid Droplets Metabolism in Neurodegenerative Diseases
Fernandes, T., Domingues, M. R., Moreira, P. I., & Pereira, C. (2023) · Biology · doi:10.3390/biology12030414 · Cited by 45
How the mitochondrion was shaped by radical differences in substrates
Speijer, D. (2014) · BioEssays · doi:10.1002/bies.201400033 · Cited by 44
“Recently, my model has also been described in [16].”
Method
The Adaptor Protein p66Shc Inhibits mTOR-Dependent Anabolic Metabolism
Lamming, D. W., Soliman, M. A., Rahman, A. M. A., Birsoy, K., Pawling, J., Frigolet, M. E., Lu, H., Fantus, I. G., Pasculescu, A., Zheng, Y., et al. (2013) · DSpace@MIT (Massachusetts Institute of Technology) · Cited by 44
Cytosolic lipid excess-induced mitochondrial dysfunction is the cause or effect of high fat diet-induced skeletal muscle insulin resistance: a molecular insight
Jana, B. A., Chintamaneni, P. K., Krishnamurthy, P. T., Wadhwani, A., & Mohankumar, S. K. (2018) · Molecular Biology Reports · doi:10.1007/s11033-018-4551-7 · Cited by 45
The effects of 3 weeks of oral glutathione supplementation on whole body insulin sensitivity in obese males with and without type 2 diabetes: a randomized trial
Søndergård, S. D., Cintin, I., Kuhlman, A. B., Morville, T. H., Bergmann, M. L., Kjær, L. K., Poulsen, H. E., Giustarini, D., Rossi, R., Dela, F., et al. (2021) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2020-1099 · Cited by 43
A Descriptive Review of the Action Mechanisms of Berberine, Quercetin and Silymarin on Insulin Resistance/Hyperinsulinemia and Cardiovascular Prevention
Bellavite, P., Fazio, S., & Affuso, F. (2023) · Molecules · doi:10.3390/molecules28114491 · Cited by 46
“High-fat diets increase mitochondrial H2O2 production and cause a reduction in the glutathione (GSH)/glutathione disulfide (GSSG) ratio [122].”
Background
Diversity of mitochondria-dependent dilator mechanisms in vascular smooth muscle of cerebral arteries from normal and insulin-resistant rats
Katakam, P. V. G., Gordon, A. O., Sure, V. N. L. R., Rutkai, I., & Busija, D. W. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00091.2014 · Cited by 43
“Mitochondria act as the sensor of metabolic demand in the cells participating in the neurovascular coupling, and mitochondrial dysfunction has been implicated in the etiology of aging, Alzheimer disease, T2DM, and insulin resistance (11, 21, 47, 56, 57).”
Background
Restoring redox balance enhances contractility in heart trabeculae from type 2 diabetic rats exposed to high glucose
Bhatt, N., Aon, M. A., Tocchetti, C. G., Shen, X., Dey, S., Ramirez‐Correa, G. A., O'Rourke, B. P., Gao, W. D., & Cortassa, S. C. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00378.2014 · Cited by 43
Hepatocyte glutathione peroxidase-1 deficiency improves hepatic glucose metabolism and decreases steatohepatitis in mice
Merry, T. L., Tran, M., Dodd, G. T., Mangiafico, S. P., Wiede, F., Kaur, S., McLean, C., Andrikopoulos, S., & Tiganis, T. (2016) · Diabetologia · doi:10.1007/s00125-016-4084-3 · Cited by 46
“Superoxide (O 2 (cid:129) – ) is a natural byproduct of the single-electron transport chain [14, 15].”
BackgroundInfluential
Reductive stress in striated muscle cells
Bellezza, I., Riuzzi, F., Chiappalupi, S., Arcuri, C., Giambanco, I., Sorci, G., & Donato, R. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03476-0 · Cited by 45
“Indeed, overnutrition increases H2O2 generation by mitochondria to relieve the reducing pressure created by fuel overload [116]; an excess of NADH imposes a stress on the electron transport chain resulting in electron leakage that causes an improper O2 reduction to superoxide anion.”
Background
Metabolic Syndrome and Neuroprotection
Etchegoyen, M., Nobile, M. H., Báez, F., Posesorski, B., González, J., Lago, N. R., Milei, J., & Losada, M. E. O. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00196 · Cited by 44
Type 3 diabetes and metabolic reprogramming of brain neurons: causes and therapeutic strategies
Meng, X., Zhang, H., Zhao, Z., Li, S., Zhang, X., Guo, R., Li, H., Yuan, Y., Li, W., Song, Q., et al. (2025) · Molecular Medicine · doi:10.1186/s10020-025-01101-z · Cited by 47
High-fat load: mechanism(s) of insulin resistance in skeletal muscle
Lark, D. S., Fisher‐Wellman, K. H., & Neufer, P. D. (2012) · International Journal of Obesity Supplements · doi:10.1038/ijosup.2012.20 · Cited by 41
Self-citation
Mitochondrial‐targeted catalase is good for the old mouse proteome, but not for the young: ‘reverse’ antagonistic pleiotropy?
Basisty, N., Dai, D., Gagnidze, A., Gitari, L., Fredrickson, J., Maina, Y., Beyer, R. P., Emond, M. J., Hsieh, E. J., MacCoss, M. J., et al. (2016) · Aging Cell · doi:10.1111/acel.12472 · Cited by 41
“…(ROS) are associated with the progression of a broad spectrum of pathologies including aging (Harman, 1956), neurodegeneration, metabolic syndrome (Fisher-Wellman & Neufer, 2012; Dodson et al., 2013), heart disease (Dai et al., 2013; Wohlgemuth et al., 2014), cancer, and others (Brieger et al.,…”
Background
Integrating the contributions of mitochondrial oxidative metabolism to lipotoxicity and inflammation in NAFLD pathogenesis
Hughey, C. C., Puchalska, P., & Crawford, P. A. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2022.159209 · Cited by 45
Effect of N-acetylcysteine infusion on exercise-induced modulation of insulin sensitivity and signaling pathways in human skeletal muscle
Trewin, A. J., Lundell, L. S., Perry, B. D., Patil, K. V., Chibalin, A., Levinger, I., McQuade, L. R., & Stepto, N. K. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00605.2014 · Cited by 41
“Importantly, these signaling events occur primarily via protein phosphorylation under the control of kinase and phosphatase enzymes, many of which have been shown to be sensitive to reactive oxygen species (ROS) (8).”
Background
Phytochemicals: Targeting Mitophagy to Treat Metabolic Disorders
Su, Z., Guo, Y., Huang, X., Feng, B. C., Tang, L., Zheng, G., & Zhu, Y. J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.686820 · Cited by 40
Central Effects of Beta-Blockers May Be Due to Nitric Oxide and Hydrogen Peroxide Release Independently of Their Ability to Cross the Blood-Brain Barrier
Laurens, C., Abot, A., Delarue, A., & Knauf, C. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00033 · Cited by 39
“Despite its ability to accumulate into the brain, propranolol failed to increase the release of hypothalamic H2O2 that is usually associated with oxidative stress (Fisher-Wellman and Neufer, 2012; Angelova and Abramov, 2018).”
Background
Mechanisms of the protective effects of nitrate and nitrite in cardiovascular and metabolic diseases
Liu, Y., Croft, K. D., Hodgson, J. M., Mori, T., & Ward, N. C. (2020) · Nitric Oxide · doi:10.1016/j.niox.2020.01.006 · Cited by 41
Metabolic master regulators: sharing information among multiple systems
Corkey, B. E., & Shirihai, O. S. (2012) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2012.07.006 · Cited by 37
“Thus, it is important to consider redox as an integrated system that involves linked changes in the pyridine nucleotides, glutathione, thioredoxins, peroxiredoxins, and multiple thiol redox sensitive proteins (67).”
Background
BRCA1 is a novel regulator of metabolic function in skeletal muscle
Jackson, K. C., Gidlund, E., Norrbom, J., Valencia, A. P., Thomson, D. M., Schuh, R. A., Neufer, P. D., & Spangenburg, E. E. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m043851 · Cited by 38
Self-citation
The Central Role of Biometals Maintains Oxidative Balance in the Context of Metabolic and Neurodegenerative Disorders
Pokusa, M., & Trancikova, A. K. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/8210734 · Cited by 37
“This uncontrolled disruption of electron potential is usually associated with ROS generation [61].”
Background
Impact of 17β-estradiol on complex I kinetics and H2O2 production in liver and skeletal muscle mitochondria
Torres, M. J., RYAN, T. E., Lin, C., Zeczycki, T. N., & Neufer, P. D. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.005148 · Cited by 39
“, in excess of demand (49) and/or under various pathological states (50, 51).”
BackgroundSelf-citation
Metabolic remodelling in obesity and type 2 diabetes: pathological or protective mechanisms in response to nutrient excess?
Connor, T., Martin, S. D., Howlett, K. F., & McGee, S. L. (2014) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12315 · Cited by 37
Aerobic capacity mediates susceptibility for the transition from steatosis to steatohepatitis
Morris, E. M., McCoin, C. S., Allen, J., Gastecki, M. L., Koch, L. G., Britton, S. L., Fletcher, J. A., Fu, X., Ding, W., Burgess, S. C., et al. (2017) · The Journal of Physiology · doi:10.1113/jp274281 · Cited by 37
“Chronically reduced NAD+/NADH within the LCR rats is suggestive of greater oxidative stress (Fisher-Wellman & Neufer, 2012), which was further supported by higher hepatic lipid peroxidation (4-HNE) and evidence of hydrogen peroxide handling (GPx1) in the LCR over HCR rats (Fig.”
Background
Mitochondrial oxidants, but not respiration, are sensitive to glucose in adipocytes
Krycer, J. R., Elkington, S. D., Díaz‐Vegas, A., Cooke, K. C., Burchfield, J. G., Fisher‐Wellman, K. H., Cooney, G. J., Fazakerley, D. J., & James, D. E. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.011695 · Cited by 33
“This suggests that mitoROS might represent a mechanistic sensor for nutrient excess (12), particularly in the adipocyte.”
BackgroundSelf-citation
Obesity and Metabolomics: Metallothioneins Protect Against High-Fat Diet-Induced Consequences in Metallothionein Knockout Mice
Lindeque, J. Z., van Rensburg, P. J., Louw, R., van der Westhuizen, F. H., Florit, S., Ramírez, L., Giralt, M., & Hidalgo, J. (2015) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2014.0087 · Cited by 36
“Furthermore, the link between mitochondrial function and insulin resistance is well documented (Fisher-Wellman and Neufer, 2012).”
Role of adipocyte mitochondria in inflammation, lipemia and insulin sensitivity in humans: effects of pioglitazone treatment
Xie, X., Sinha, S., Yi, Z., Langlais, P. R., Madan, M., Bowen, B. P., Willis, W. T., & Meyer, C. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.192 · Cited by 36
Acute HIIE elicits similar changes in human skeletal muscle mitochondrial H2O2 release, respiration, and cell signaling as endurance exercise even with less work
Trewin, A. J., Parker, L., Shaw, C. S., Hiam, D., GARNHAM, A. P., Levinger, I., McConell, G. K., & Stepto, N. K. (2018) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00096.2018 · Cited by 36
“In support of this notion, Chen et al. (8) demonstrated that AMPK phosphorylation only occurred following exercise at 60% V̇O2peak and above but not at 40% V̇O2peak.”
BackgroundInfluential
The effect of exercise-intensity on skeletal muscle stress kinase and insulin protein signaling
Parker, L., Trewin, A. J., Levinger, I., Shaw, C. S., & Stepto, N. K. (2017) · PLoS ONE · doi:10.1371/journal.pone.0171613 · Cited by 36
CoQ imbalance drives reverse electron transport to disrupt liver metabolism
Goncalves, R. L. S., Wang, Z. B., Riveros, J. K., Parlakgül, G., Inouye, K., Lee, G. Y., Fu, X., Saksi, J., Rosique, C., Hui, S. T., et al. (2025) · Nature · doi:10.1038/s41586-025-09072-1 · Cited by 39
“Data are provided in Supplementary Tables 4 and 5.”
Muscle Lipid Droplets: Cellular Signaling to Exercise Physiology and Beyond
Seibert, J. T., Najt, C. P., Heden, T. D., Mashek, D. G., & Chow, L. S. (2020) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2020.08.002 · Cited by 38
“Presumably, ‘lipotoxicity’ arises when increased levels of IMCL enhance production of lipotoxic metabolites, such as DAG [50], ceramides [51], long chain acyl-CoAs [52], and oxidative stress [53], which blunts muscle insulin signaling [49,53], and glucose uptake [49].”
Background
Impaired mitochondrial energy supply coupled to increased H2O2 emission under energy/redox stress leads to myocardial dysfunction during Type I diabetes
Tocchetti, C. G., Stanley, B. A., Sivakumaran, V., Bedja, D., O'Rourke, B. P., Paolocci, N., Cortassa, S. C., & Aon, M. A. (2015) · Clinical Science · doi:10.1042/cs20150204 · Cited by 34
Alterations in fatty acid metabolism and sirtuin signaling characterize early type-2 diabetic hearts of fructose-fed rats
Lou, P., Lucchinetti, E., Scott, K. Y., Huang, Y., Gandhi, M., Hersberger, M., Clanachan, A. S., Lemieux, H., & Zaugg, M. (2017) · Physiological Reports · doi:10.14814/phy2.13388 · Cited by 35
Exercise as a tool to mitigate metabolic disease
Esteves, J. V. D. C., & Stanford, K. I. (2024) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00144.2024 · Cited by 39
High fatty acid oxidation capacity and phosphorylation control despite elevated leak and reduced respiratory capacity in northern elephant seal muscle mitochondria
Chicco, A. J., Le, C. H., Schlater, A. E., Nguyen, A., Kaye, S., Beals, J. W., Scalzo, R. L., Bell, C., Gnaiger, E., da Costa, D. P., et al. (2014) · Journal of Experimental Biology · doi:10.1242/jeb.105916 · Cited by 35
“In humans and rodents, this drives a persistent elevation in mitochondrial ROS that induces UCP3 expression and respiratory uncoupling, but ultimately leads to excessive oxidative stress and the development of muscle insulin resistance (Hesselink et al., 2003; Fisher-Wellman and Neufer, 2012).”
Background
Catalase-dependent H 2 O 2 consumption by cardiac mitochondria and redox-mediated loss in insulin signaling
Rindler, P. M., Cacciola, A., Kinter, M. T., & Szweda, L. I. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00066.2016 · Cited by 32
“oxidative stress (7, 22, 24, 28) and insulin resistance (6, 22, 26,”
Background
NOX2 deficiency exacerbates diet-induced obesity and impairs molecular training adaptations in skeletal muscle
Henríquez‐Olguín, C., Meneses‐Valdés, R., Raun, S. H., Gallero, S., Knudsen, J. R., Li, Z., Li, J., Sylow, L., Jaimovich, E., & Jensen, T. E. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102842 · Cited by 32
Reduced mitochondrial reactive oxygen species production in peripheral nerves of mice fed a ketogenic diet
Cooper, M. A., McCoin, C. S., Pei, D., Thyfault, J. P., Koestler, D. C., & Wright, D. E. (2018) · Experimental Physiology · doi:10.1113/ep087083 · Cited by 31
Association of genetic polymorphisms in SOD2, SOD3, GPX3, and GSTT1 with hypertriglyceridemia and low HDL-C level in subjects with high risk of coronary artery disease
Decharatchakul, N., Settasatian, C., Settasatian, N., Komanasin, N., Kukongviriyapan, U., Intharaphet, P., & Senthong, V. (2019) · PeerJ · doi:10.7717/peerj.7407 · Cited by 32
Exercise and obesity-induced insulin resistance in skeletal muscle
Kwak, H. (2013) · Integrative Medicine Research · doi:10.1016/j.imr.2013.09.004 · Cited by 33
Insulin Modulates the Na+/Mg2+ Exchanger SLC41A1 and Influences Mg2+ Efflux from Intracellular Stores in Transgenic HEK293 Cells
Mastrototaro, L., Tietjen, U., Sponder, G., Vormann, J., Aschenbach, J. R., & Kolísek, M. (2015) · Journal of Nutrition · doi:10.3945/jn.115.213918 · Cited by 30
Mathematical Modeling of Glutathione Status in Type 2 Diabetics with Vitamin B12 Deficiency
Karamshetty, V., Acharya, J. D., Ghaskadbi, S., & Goel, P. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00016 · Cited by 30
“ORIGINAL RESEARCH published: 23 March 2016 doi: 10.3389/fcell.2016.00016 Frontiers in Cell and Developmental Biology | www.frontiersin.org 1 March 2016 | Volume 4 | Article 16 Edited by: Gaetano Santulli, Columbia University in the City of New York, USA Reviewed by: Yves Combarnous, Centre National de la Recherche Sci…”
BackgroundInfluential
Estrogen receptor-α in female skeletal muscle is not required for regulation of muscle insulin sensitivity and mitochondrial regulation
Iñigo, M. R., Amorese, A. J., Tarpey, M. D., Balestrieri, N. P., Jones, K. G., Patteson, D. J., Jackson, K. C., Torres, M. J., Lin, C.-T., Smith, C. D., et al. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2019.12.010 · Cited by 29
“The ability of the mitochondria to regulate energy charge and redox potential has a significant influence on muscle insulin sensitivity [40,41].”
BackgroundSelf-citation
Estimation of kinetic parameters related to biochemical interactions between hydrogen peroxide and signal transduction proteins
de Brito, P. M., & Antunes, F. (2014) · Frontiers in Chemistry · doi:10.3389/fchem.2014.00082 · Cited by 30
“Thus, while H2O2 is an essential component of the insulin signaling pathway, it may also mediate the etiology of insulin resistance (Fisher-Wellman and Neufer, 2012).”
Background
JNK Activation of BIM Promotes Hepatic Oxidative Stress, Steatosis, and Insulin Resistance in Obesity
Litwak, S. A., Pang, L., Galić, S., Igoillo‐Esteve, M., Stanley, W. J., Turatsinze, J., Loh, K., Thomas, H. E., Sharma, A., Trépo, E., et al. (2017) · Diabetes · doi:10.2337/db17-0348 · Cited by 29
“In obesity, reduced fatty acid oxidation and excess free fatty acids generate reducing equivalents that exceed the respiratory demand, resulting in high mitochondrial O2c 2 and H2O2 generation (50,51).”
Background
Acute exercise alters skeletal muscle mitochondrial respiration and H2O2 emission in response to hyperinsulinemic-euglycemic clamp in middle-aged obese men
Trewin, A. J., Levinger, I., Parker, L., Shaw, C. S., Serpiello, F. R., Anderson, M. J., McConell, G. K., Hare, D. L., & Stepto, N. K. (2017) · PLoS ONE · doi:10.1371/journal.pone.0188421 · Cited by 30
AMP deamination is sufficient to replicate an atrophy-like metabolic phenotype in skeletal muscle
Miller, S. G., Hafen, P. S., Law, A. S., Springer, C. B., Logsdon, D. L., O’Connell, T. M., Witczak, C. A., & Brault, J. J. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154864 · Cited by 31
Hepatic DsbA‐L protects mice from diet‐induced hepatosteatosis and insulin resistance
Chen, H., Bai, J., Dong, F., Fang, H., Zhang, Y., Meng, W., Liu, B., Luo, Y., Liu, M., Bai, Y., et al. (2017) · The FASEB Journal · doi:10.1096/fj.201600985r · Cited by 28
“In obese status, the chronic uptake of excess energy substrates, especially lipids, leads to increased ROS production (6).”
Background
Mild Cognitive Impairment and Donepezil Impact Mitochondrial Respiratory Capacity in Skeletal Muscle
Morris, J. K., McCoin, C. S., Fuller, K. N. Z., John, C. S., Wilkins, H., Green, Z. D., Wang, X., Sharma, P., Burns, J. M., Vidoni, E. D., et al. (2021) · Function · doi:10.1093/function/zqab045 · Cited by 26
Obesity impairs leukocyte‐endothelium cell interactions and oxidative stress in humans
López‐Domènech, S., Bañuls, C., Díaz‐Morales, N., Escribano‐López, I., Morillas, C., Veses, S., Orden, S., Álvarez, Á., Víctor, V. M., Hernández‐Mijares, A., et al. (2018) · European Journal of Clinical Investigation · doi:10.1111/eci.12985 · Cited by 27
Genetically increasing flux through β-oxidation in skeletal muscle increases mitochondrial reductive stress and glucose intolerance
Smith, C. D., Lin, C., McMillin, S. L., Weyrauch, L. A., Schmidt, C. A., Smith, C. A., Kurland, I. J., Witczak, C. A., & Neufer, P. D. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00010.2021 · Cited by 25
Self-citation
Short-Term High-Fat Feeding Does Not Alter Mitochondrial Lipid Respiratory Capacity but Triggers Mitophagy Response in Skeletal Muscle of Mice
Ehrlicher, S. E., Stierwalt, H. D., Newsom, S. A., & Robinson, M. M. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.651211 · Cited by 25
“Fatty acid oxidation generates ROS in skeletal muscle mitochondria (17) which play a role in biological signaling (18).”
Background
Pioglitazone treatment restores in vivo muscle oxidative capacity in a rat model of diabetes
Wessels, B., Čiapaitė, J., van den Broek, N. M. A., Houten, S. M., Nicolay, K., & Prompers, J. J. (2014) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12388 · Cited by 25
“Moreover, it has been shown that metabolic intermediates of incomplete FA oxidation accumulate in insulin-resistant muscle [24], indicating that FA oxidation flux outpaces the demand of the respiratory system, which may affect mitochondrial redox state and further promote mitochondrial oxidative stress [25,26].”
Heat therapy: possible benefits for cognitive function and the aging brain
Schulze, A. T. V., Deng, F., Morris, J. K., & Geiger, P. C. (2020) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00168.2020 · Cited by 26
“Mitochondrial dysfunction in skeletal muscle has also been heavily studied as a primary cause of whole body insulin resistance (41, 72, 127), a recognized risk factor for AD (9, 24, 60, 74, 80, 93, 97, 100, 110, 119, 123, 124).”
Background
Mitochondrial Peroxiredoxin 3 Is Rapidly Oxidized and Hyperoxidized by Fatty Acid Hydroperoxides
Cardozo, G., Mastrogiovanni, M., Zeida, A., Viera, N., Radí, R., Reyes, A. M., & Trujillo, M. (2023) · Antioxidants · doi:10.3390/antiox12020408 · Cited by 24
Enhanced Mitochondrial Superoxide Scavenging Does Not Improve Muscle Insulin Action in the High Fat-Fed Mouse
Lark, D. S., Kang, L., Lustig, M. E., Bonner, J. S., James, F. D., Neufer, P. D., & Wasserman, D. H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0126732 · Cited by 24
Self-citation
Translocase of inner mitochondrial membrane 44 alters the mitochondrial fusion and fission dynamics and protects from type 2 diabetes
Wang, Y., Katayama, A., Terami, T., Han, X., Nunoue, T., Zhang, D., Teshigawara, S., Eguchi, J., Nakatsuka, A., Murakami, K., et al. (2015) · Metabolism · doi:10.1016/j.metabol.2015.02.004 · Cited by 24
Mitochondrial reactive oxygen species as a mystery voice in hepatitis C
Hino, K., Hara, Y., & Nishina, S. (2013) · Hepatology Research · doi:10.1111/hepr.12247 · Cited by 24
Colchicine treatment impairs skeletal muscle mitochondrial function and insulin sensitivity in an age‐specific manner
Buch, B. T., Halling, J. F., Ringholm, S., Gudiksen, A., Kjøbsted, R., Olsen, M. A., Wojtaszewski, J. F. P., & Pilegaard, H. (2020) · The FASEB Journal · doi:10.1096/fj.201903113rr · Cited by 24
The “Metabolic Winter” Hypothesis: A Cause of the Current Epidemics of Obesity and Cardiometabolic Disease
Cronise, R. J., Sinclair, D. A., & Bremer, A. A. (2014) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2014.0027 · Cited by 24
N-acetylcysteine alters substrate metabolism during high-intensity cycle exercise in well-trained humans
Trewin, A. J., Petersen, A. C., Billaut, F., McQuade, L. R., McInerney, B. V., & Stepto, N. K. (2013) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2012-0482 · Cited by 23
“Indeed, it is well established that ROS play a fundamental role in cellular signalling and redox homeostasis to facilitate regular physiological function (Fisher-Wellman and Neufer 2012; Powers et al. 2010a).”
BackgroundInfluential
Skeletal muscle bioenergetics in aging and heart failure
Liu, S. Z., & Marcinek, D. J. (2016) · Heart Failure Reviews · doi:10.1007/s10741-016-9586-z · Cited by 25
Mitochondrial dysfunction in human skeletal muscle biopsies of lipid storage disorder
Debashree, B., Kumar, M., Prasad, T. S. K., Natarajan, A., Christopher, R., Nalini, A., Bindu, P., Gayathri, N., & Bharath, M. M. S. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14318 · Cited by 19
Molecular mechanism of ferroptosis and its role in the occurrence and treatment of diabetes
Du, G.-H., Zhang, Q., Huang, X., & Wang, Y. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.1018829 · Cited by 22
“When a large amount of oxidative phosphorylation occurs, the electron transport chain becomes congested, and the electrons return to complex I to generate ROS with oxygen (Fisher-Wellman and Neufer, 2012).”
Background
Emerging roles for the amyloid precursor protein and derived peptides in the regulation of cellular and systemic metabolism
Czeczor, J. K., & McGee, S. L. (2017) · Journal of Neuroendocrinology · doi:10.1111/jne.12470 · Cited by 23
“Mitochondrial ROS production, which is increased in response to excess energy balance (59), also influences APP processing.”
Background
Overexpression of Long-Chain Acyl-CoA Synthetase 5 Increases Fatty Acid Oxidation and Free Radical Formation While Attenuating Insulin Signaling in Primary Human Skeletal Myotubes
Kwak, H., Woodlief, T., Green, T. D., Cox, J. H., Hickner, R. C., Neufer, P. D., & Cortright, R. N. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16071157 · Cited by 23
“If β-oxidation is increased by oversupply of fatty acids without a corresponding increase in energy demand, as likely occurs in the obese human, surplus reducing equivalents are generated, which would result in an increased mitochondrial membrane potential, leading to increased mitochondrial oxidative stress [40,41].”
BackgroundSelf-citation
The manifold role of the mitochondria in skeletal muscle insulin resistance
Cade, W. T. (2018) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000480 · Cited by 21
Tissue Oxygen Demand in Regulation of the Behavior of the Cells in the Vasculature
Barvitenko, N. N., Aslam, M., Filosa, J. A., Matteucci, E., Nikinmaa, M., Pantaleo, A., Saldanha, C., & Baskurt, O. K. (2013) · Microcirculation · doi:10.1111/micc.12052 · Cited by 21
“There is increasing evidence indicating that insulin is a key factor in regulating mitochondrial bioenergetics [186].”
Background
Palmitate-induced changes in energy demand cause reallocation of ATP supply in rat and human skeletal muscle cells
Nisr, R. B., & Affourtit, C. (2016) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2016.04.286 · Cited by 23
“Arguably the most important parameter in cellular bioenergetics is the 1 Abbreviations: AHA, L-azidohomoalanin; 2DG, 2-deoxyglucose; BSA, bovine serum albumin; DMEM, Dulbecco‟s modified Eagle medium; FCCP, trifluorocarbonylcyanide phenylhydrazone; FBS, fetal bovine serum; Hepes, 4-(2-hydroxyethyl)-1-piperazineethanesu…”
Background
Preference and detrimental effects of high fat, sugar, and salt diet in wild‐caught Drosophila simulans are reversed by flight exercise
Murashov, A. K., Pak, E. S., Lin, C., Boykov, I. N., Buddo, K. A., Mar, J. S., Bhat, K. M., & Neufer, P. D. (2020) · FASEB BioAdvances · doi:10.1096/fba.2020-00079 · Cited by 21
Self-citation
Partial skeletal muscle-specific Drp1 knockout enhances insulin sensitivity in diet-induced obese mice, but not in lean mice
Kugler, B. A., Lourie, J., BERGER, N. J. A., Lin, N., Nguyen, P., DosSantos, E., Ali, A. S., Sesay, A., Rosen, H. G., KALEMBA, B. L., et al. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101802 · Cited by 21
“Recent research has indicated that mitochondrial dysfunction, including reduced respiration and/or increased ROS generation (e.g., H 2 O 2 ), is linked to the pathogenesis of skeletal muscle insulin resistance [2,3].”
Background
A Tutorial on Oxidative Stress and Redox Signaling with Application to Exercise and Sedentariness
Buresh, R. J., & Berg, K. E. (2014) · Sports Medicine - Open · doi:10.1186/s40798-014-0003-7 · Cited by 23
“Fisher-Wellman and Neufer [58] explain that the rate at which electrons flow down the ETC. is influenced by energy demand, and not energy availability.”
Influential
The Effect of Aerobic Exercise on the Oxidative Capacity of Skeletal Muscle Mitochondria in Mice with Impaired Glucose Tolerance
Wang, D., Jiang, D.-M., Yu, R.-R., Zhang, L., Liu, Y.-Z., Chen, J.-X., Chen, H., & Liu, Y. (2022) · Journal of Diabetes Research · doi:10.1155/2022/3780156 · Cited by 22
A transient increase in lipid peroxidation primes preadipocytes for delayed mitochondrial inner membrane permeabilization and ATP depletion during prolonged exposure to fatty acids
Rogers, C., Davis, B., Neufer, P. D., Murphy, M. P., Anderson, E. J., & Robidoux, J. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.11.012 · Cited by 21
“Finally, H2O2 itself can alter the activity of redox-sensitive proteins, which include almost all electron transport chain components, the antioxidant systems, and the protein involved in MIM permeabilization and cell death pathways [20, 21].”
BackgroundSelf-citation
Molecularly imprinted electrochemical sensing platform for 2-Aminoadipic acid, a diabetes biomarker
Anirudhan, T. S., Mani, A., & Athira, V. S. (2021) · Reactive and Functional Polymers · doi:10.1016/j.reactfunctpolym.2021.105056 · Cited by 19
Resveratrol metabolites ameliorate insulin resistance in HepG2 hepatocytes by modulating IRS-1/AMPK
Teng, W., Yin, W., Zhao, L., Ma, C., Huang, J., & Ren, F. (2018) · RSC Advances · doi:10.1039/c8ra05092a · Cited by 19
Novel Method for Detection of Reactive Oxygen Species In Vivo in Human Skeletal Muscle
Favor, J. D. L., Anderson, E. J., & Hickner, R. C. (2014) · Physiological Research · doi:10.33549/physiolres.932587 · Cited by 20
Redox Biology in Adipose Tissue Physiology and Obesity
Yu, J., Qiu, J., Zhang, Z., Cui, X., Guo, W., Sheng, M., Gao, M., Wang, D., Xu, L., & Ma, X. (2023) · Advanced Biology · doi:10.1002/adbi.202200234 · Cited by 20
Inhibition of Pyruvate Dehydrogenase in the Heart as an Initiating Event in the Development of Diabetic Cardiomyopathy
Elnwasany, A., Ewida, H. A., Szweda, P. A., & Szweda, L. I. (2023) · Antioxidants · doi:10.3390/antiox12030756 · Cited by 20
Comprehensive Overview of the Effects of Amaranthus and Abelmoschus esculentus on Markers of Oxidative Stress in Diabetes Mellitus
Phoswa, W. N., & Mokgalaboni, K. (2023) · Life · doi:10.3390/life13091830 · Cited by 18
Lipid droplets, autophagy, and ER stress as key (survival) pathways during ischemia‐reperfusion of transplanted grafts
Kamińska, D., & Skrzycki, M. (2024) · Cell Biology International · doi:10.1002/cbin.12114 · Cited by 18
Cardiovasomobility: an integrative understanding of how disuse impacts cardiovascular and skeletal muscle health
Trinity, J. D., Drummond, M. J., Fermoyle, C. C., McKenzie, A. I., Supiano, M. A., & Richardson, R. S. (2022) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00607.2021 · Cited by 18
Veiled Potential of Secretagogin in Diabetes: Correlation or Coincidence?
Sharma, A. K., Khandelwal, R., & Sharma, Y. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.01.007 · Cited by 18
Myogenically differentiated mesenchymal stem cell insulin sensitivity is associated with infant adiposity at 1 and 6 months of age
Jevtovic, F., Zheng, D., Houmard, J. A., Kern, K., Claiborne, A., Lopez, C. A., Broskey, N. T., Isler, C. M., DeVente, J., Newton, E. R., et al. (2023) · Obesity · doi:10.1002/oby.23829 · Cited by 17
Cinnamon intake alleviates the combined effects of dietary-induced insulin resistance and acute stress on brain mitochondria
Couturier, K., Hininger‐Favier, I., Poulet, L., Anderson, R. A., Roussel, A., Canini, F., & Batandier, C. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.10.016 · Cited by 19
Blood glucose regulation in context of infection
Wensveen, F. M., Šestan, M., Wensveen, T. T., & Polić, B. (2021) · Vitamins and hormones · doi:10.1016/bs.vh.2021.06.009 · Cited by 20
The Role of Mitochondrial and Redox Alterations in the Skeletal Myopathy Associated with Chronic Kidney Disease
Thome, T., Kim, K., Dong, G., & RYAN, T. E. (2022) · Antioxidants and Redox Signaling · doi:10.1089/ars.2022.0143 · Cited by 17
“Thus far, 11 sites within the mitochondrion have been identiﬁed to produce ROS directly (Bleier et al, 2015; Brand, 2010; Brand and Nicholls, 2011; Fisher-Wellman and Neufer, 2012; Quinlan et al, 2013; St-Pierre et al, 2002; Tahara et al, 2009; Wong et al, 2017).”
Influential

Authors: Fisher-Wellman, K. H., & Neufer, P. D.
Affiliations: East Carolina University (US)
Corresponding author: Neufer, P. Darrell
ORCID: Neufer, P. Darrell
Venue: Trends in Endocrinology & Metabolism
Publisher: Elsevier BV
Published: 2012-03
Volume: 23
Issue: 3
Pages: 142-153
ISSN: 1043-2760 (ISSN-L)
DOI: 10.1016/j.tem.2011.12.008
PMC: PMC3313496
OpenAlex: W2069466682
Cited by: 316
References: 89
Citations by year: 2026: 17 · 2025: 12 · 2024: 16 · 2023: 22 · 2022: 14 · 2021: 24 · 2020: 16 · 2019: 28 · 2018: 24 · 2017: 25 · 2016: 20 · 2015: 25 · 2014: 29 · 2013: 30 · 2012: 12
FWCI: 2.80
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK073488, R01DK074825)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: mitochondrial bioenergetics, insulin resistance, type 2 diabetes, hydrogen peroxide, mitochondrial reactive oxygen species, redox signaling, cysteine residues, overnutrition, physical inactivity
MeSH terms: Animals, Energy Metabolism, Humans, Hydrogen Peroxide, Insulin Resistance, Mitochondria, Oxidation-Reduction, Signal Transduction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Linking mitochondrial bioenergetics to insulin resistance via redox biology

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks