Cited by 316Redox biology and oxidative stressMitochondrial Function and PathologyMetabolism, Diabetes, and Cancer

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Linking mitochondrial bioenergetics to insulin resistance via redox biology

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Fisher-Wellman, Kelsey H., Neufer, P. Darrell·2012·Trends in Endocrinology & Metabolism

DOI 10.1016/j.tem.2011.12.008PMC PMC3313496

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Abstract

Chronic overnutrition and physical inactivity are major risk factors for insulin resistance and type 2 diabetes. Recent research indicates that overnutrition generates an increase in hydrogen peroxide (H(2)O(2)) emission from mitochondria, serving as a release valve to relieve the reducing pressure created by fuel overload, as well as a primary signal that ultimately decreases insulin sensitivity. H(2)O(2) is a major input to cellular redox circuits that link to cysteine residues throughout the entire proteome to regulate cell function. Here we review the principles of mitochondrial bioenergetics and redox systems biology and offer new insight into how H(2)O(2) emission may be linked via redox biology to the etiology of insulin resistance.

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The evolution of insulin resistance in muscle of the glucose infused rat
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Goldstein, 2005, Role of insulin-induced reactive oxygen species in the insulin signaling pathway, Antioxid. Redox Signal., 7, 1021, 10.1089/ars.2005.7.1021 · DOI · Paper page

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Mechanisms of Insulin Action and Insulin Resistance
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BackgroundInfluential
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Authors: Fisher-Wellman, K. H., & Neufer, P. D.
Affiliations: East Carolina University (US)
Corresponding author: Neufer, P. Darrell
ORCID: Neufer, P. Darrell
Venue: Trends in Endocrinology & Metabolism
Publisher: Elsevier BV
Published: 2012-03
Volume: 23
Issue: 3
Pages: 142-153
ISSN: 1043-2760 (ISSN-L)
DOI: 10.1016/j.tem.2011.12.008
PMC: PMC3313496
OpenAlex: W2069466682
Cited by: 316
References: 89
Citations by year: 2026: 17 · 2025: 12 · 2024: 16 · 2023: 22 · 2022: 14 · 2021: 24 · 2020: 16 · 2019: 28 · 2018: 24 · 2017: 25 · 2016: 20 · 2015: 25 · 2014: 29 · 2013: 30 · 2012: 12
FWCI: 2.80
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK073488, R01DK074825)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: mitochondrial bioenergetics, insulin resistance, type 2 diabetes, hydrogen peroxide, mitochondrial reactive oxygen species, redox signaling, cysteine residues, overnutrition, physical inactivity
MeSH terms: Animals, Energy Metabolism, Humans, Hydrogen Peroxide, Insulin Resistance, Mitochondria, Oxidation-Reduction, Signal Transduction

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Linking mitochondrial bioenergetics to insulin resistance via redox biology

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