Mechanisms of the protective effects of nitrate and nitrite in cardiovascular and metabolic diseases

Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation

Cosby, K., Partovi, K. S., Crawford, J. H., Patel, R. P., Reiter, C. D., Martyr, S., Yang, B. K., Waclawiw, M. A., Zalos, G., Xu, X., et al. (2003) · Nature Medicine · doi:10.1038/nm954 · Cited by 1,807 · see citing works

Nitrate, bacteria and human health

Lundberg, J. O., Weitzberg, E., Cole, J. A., & Benjamin, N. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro929 · Cited by 739 · see citing works

Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver

Duranski, M. R., Greer, J. J. M., Dejam, A., Jaganmohan, S., Hogg, N., Langston, W., Patel, R. P., Yet, S.-F., Wang, X., Kevil, C. G., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci22493 · Cited by 674 · see citing works

Stomach NO synthesis

Benjamin, N., O'Driscoll, F., Dougall, H., Duncan, C., Smith, L., Golden, M., & McKenzie, H. (1994) · Nature · doi:10.1038/368502a0 · Cited by 665 · see citing works

Inorganic Nitrate Supplementation Lowers Blood Pressure in Humans: Role for Nitrite-Derived NO

Kapil, V., Milsom, A. B., Okorie, M., Maleki-Toyserkani, S., Akram, F., Rehman, F., Arghandawi, S., Pearl, V., Benjamin, N., Loukogeorgakis, S., et al. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.153536 · Cited by 621 · see citing works

Reduction of nitrite to nitric oxide during ischemia protects against myocardial ischemia–reperfusion damage

Webb, A., Bond, R., McLean, P., Uppal, R., Benjamin, N., & Ahluwalia, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402927101 · Cited by 608 · see citing works

Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transfer

Shiva, S., Sack, M. N., Greer, J. J., Duranski, M., Ringwood, L. A., Burwell, L., Wang, X., MacArthur, P. H., Shoja, A., Raghavachari, N., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070198 · Cited by 555 · see citing works

Specialized metabolites from the microbiome in health and disease

Sharon, G., Garg, N., Debelius, J., Knight, R., Dorrestein, P. C., & Mazmanian, S. K. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.10.016 · Cited by 544 · see citing works

Nitrate and periplasmic nitrate reductases

Sparacino-Watkins, C., Stolz, J. F., & Basu, P. (2014) · Chem. Soc. Rev. · doi:10.1039/c3cs60249d · Cited by 426 · see citing works

Nitrite reductase activity of myoglobin regulates respiration and cellular viability in myocardial ischemia-reperfusion injury

Hendgen-Cotta, U. B., Merx, M. W., Shiva, S., Schmitz, J., Becher, S., Klare, J. P., Steinhoff, H.-J., Goedecke, A., Schrader, J., Gladwin, M. T., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801336105 · Cited by 418 · see citing works

Mitochondrial dysfunction in cardiovascular disease

Ballinger, S. W. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.02.014 · Cited by 405 · see citing works

Dietary inorganic nitrate reverses features of metabolic syndrome in endothelial nitric oxide synthase-deficient mice

Carlström, M., Larsen, F. J., Nyström, T., Hezel, M., Borniquel, S., Weitzberg, E., & Lundberg, J. O. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1008872107 · Cited by 382 · see citing works

Evaluation of bacterial nitrate reduction in the human oral cavity

Doel, J. J., Benjamin, N., Hector, M. P., Rogers, M., & Allaker, R. P. (2005) · European Journal of Oral Sciences · doi:10.1111/j.1600-0722.2004.00184.x · Cited by 362 · see citing works

Vascular effects of dietary nitrate (as found in green leafy vegetables and beetroot) via the nitrate-nitrite-nitric oxide pathway

Lidder, S., & Webb, A. J. (2013) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2012.04420.x · Cited by 360 · see citing works

Nitrite Infusion in Humans and Nonhuman Primates: Endocrine Effects, Pharmacokinetics, and Tolerance Formation

Dejam, A., Hunter, C. J., Tremonti, C., Pluta, R. M., Hon, Y. Y., Grimes, G., Partovi, K., Pelletier, M. M., Oldfield, E. H., Cannon, R. O., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.712133 · Cited by 334 · see citing works

Linking mitochondrial bioenergetics to insulin resistance via redox biology

Fisher-Wellman, K. H., & Neufer, P. D. (2012) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2011.12.008 · Cited by 316 · see citing works

Nitrate reduction to nitrite, nitric oxide and ammonia by gut bacteria under physiological conditions

Tiso, M., & Schechter, A. N. (2015) · PLOS ONE · doi:10.1371/journal.pone.0119712 · Cited by 311 · see citing works

Human neuroglobin functions as a redox-regulated nitrite reductase

Tiso, M., Tejero, J., Basu, S., Azarov, I., Wang, X., Simplaceanu, V., Frizzell, S., Jayaraman, T., Geary, L., Shapiro, C., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.159541 · Cited by 287 · see citing works

Nitrite Reductase Function of Deoxymyoglobin: Oxygen Sensor and Regulator of Cardiac Energetics and Function

Rassaf, T., Flögel, U., Drexhage, C., Hendgen-Cotta, U., Kelm, M., & Schrader, J. (2007) · Circulation Research · doi:10.1161/circresaha.107.152488 · Cited by 284 · see citing works

S-Nitrosation of the Insulin Receptor, Insulin Receptor Substrate 1, and Protein Kinase B/Akt

Carvalho-Filho, M. A., Ueno, M., Hirabara, S. M., Seabra, A. B., Carvalheira, J. B. C., de Oliveira, M. G., Velloso, L. A., Curi, R., & Saad, M. J. A. (2005) · Diabetes · doi:10.2337/diabetes.54.4.959 · Cited by 277 · see citing works

Metagenomic analysis of nitrate-reducing bacteria in the oral cavity: implications for nitric oxide homeostasis

Hyde, E. R., Andrade, F., Vaksman, Z., Parthasarathy, K., Jiang, H., Parthasarathy, D. K., Torregrossa, A. C., Tribble, G., Kaplan, H. B., Petrosino, J. F., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088645 · Cited by 275 · see citing works

Cytoglobin is a respiratory protein in connective tissue and neurons, which is up-regulated by hypoxia

Schmidt, M., Gerlach, F., Avivi, A., Laufs, T., Wystub, S., Simpson, J. C., Nevo, E., Saaler-Reinhardt, S., Reuss, S., Hankeln, T., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310540200 · Cited by 222 · see citing works

Enhanced Vasodilator Activity of Nitrite in Hypertension: Critical Role for Erythrocytic Xanthine Oxidoreductase and Translational Potential

Ghosh, S. M., Kapil, V., Fuentes-Calvo, I., Bubb, K. J., Pearl, V., Milsom, A. B., Khambata, R., Maleki-Toyserkani, S., Yousuf, M., Benjamin, N., et al. (2013) · Hypertension · doi:10.1161/hypertensionaha.111.00933 · Cited by 218 · see citing works

Nitrite supplementation reverses vascular endothelial dysfunction and large elastic artery stiffness with aging: Sodium nitrite and vascular dysfunction with aging

Sindler, A. L., Fleenor, B. S., Calvert, J. W., Marshall, K. D., Zigler, M. L., Lefer, D. J., & Seals, D. R. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00679.x · Cited by 218 · see citing works

Nitrite reductase activity of cytochrome c

Basu, S., Azarova, N. A., Font, M. D., King, S. B., Hogg, N., Gladwin, M. T., Shiva, S., & Kim-Shapiro, D. B. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806934200 · Cited by 214 · see citing works

Mechanisms Underlying Erythrocyte and Endothelial Nitrite Reduction to Nitric Oxide in Hypoxia: Role for Xanthine Oxidoreductase and Endothelial Nitric Oxide Synthase

Webb, A. J., Milsom, A. B., Rathod, K. S., Chu, W. L., Qureshi, S., Lovell, M. J., Lecomte, F. M. J., Perrett, D., Raimondo, C., Khoshbin, E., et al. (2008) · Circulation Research · doi:10.1161/circresaha.108.175810 · Cited by 203 · see citing works

Nitrite regulates hypoxic vasodilation via myoglobin-dependent nitric oxide generation

Totzeck, M., Hendgen-Cotta, U. B., Luedike, P., Berenbrink, M., Klare, J. P., Steinhoff, H.-J., Semmler, D., Shiva, S., Williams, D., Kipar, A., et al. (2012) · Circulation · doi:10.1161/circulationaha.111.087155 · Cited by 202 · see citing works

Antibacterial Mouthwash Blunts Oral Nitrate Reduction and Increases Blood Pressure in Treated Hypertensive Men and Women

Bondonno, C. P., Liu, A. H., Croft, K. D., Considine, M. J., Puddey, I. B., Woodman, R. J., & Hodgson, J. M. (2015) · American Journal of Hypertension · doi:10.1093/ajh/hpu192 · Cited by 190 · see citing works

Nitrite Anion Provides Potent Cytoprotective and Antiapoptotic Effects as Adjunctive Therapy to Reperfusion for Acute Myocardial Infarction

Gonzalez, F. M., Shiva, S., Vincent, P. S., Ringwood, L. A., Hsu, L.-Y., Hon, Y. Y., Aletras, A. H., Cannon, R. O., Gladwin, M. T., & Arai, A. E. (2008) · Circulation · doi:10.1161/circulationaha.107.748814 · Cited by 175 · see citing works

Endothelial nitric oxide synthase reduces nitrite anions to NO under anoxia

Gautier, C., van Faassen, E., Mikula, I., Martasek, P., & Slama-Schwok, A. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.01.031 · Cited by 143 · see citing works

Dietary Nitrate, Nitric Oxide, and Cardiovascular Health

Bondonno, C. P., Croft, K. D., & Hodgson, J. M. (2016) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2013.811212 · Cited by 141 · see citing works

Nitrite confers protection against myocardial infarction: Role of xanthine oxidoreductase, NADPH oxidase and KATP channels

Baker, J. E., Su, J., Fu, X., Hsu, A., Gross, G. J., Tweddell, J. S., & Hogg, N. (2007) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2007.07.057 · Cited by 137 · see citing works

Characterization of the Mechanism and Magnitude of Cytoglobin-mediated Nitrite Reduction and Nitric Oxide Generation under Anaerobic Conditions

Li, H., Hemann, C., Abdelghany, T. M., El-Mahdy, M. A., & Zweier, J. L. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.342378 · Cited by 132 · see citing works

Salivary nitrite production is elevated in individuals with a higher abundance of oral nitrate-reducing bacteria

Burleigh, M. C., Liddle, L., Monaghan, C., Muggeridge, D. J., Sculthorpe, N., Butcher, J. P., Henriquez, F. L., Allen, J. D., & Easton, C. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.03.023 · Cited by 127 · see citing works

Characterization of the magnitude and mechanism of aldehyde oxidase-mediated nitric oxide production from nitrite

Li, H., Kundu, T. K., & Zweier, J. L. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.019125 · Cited by 126 · see citing works

The effects of dietary nitrate on blood pressure and endothelial function: a review of human intervention studies

Hobbs, D. A., George, T. W., & Lovegrove, J. A. (2013) · Nutrition Research Reviews · doi:10.1017/s0954422413000188 · Cited by 114 · see citing works

Antiplatelet effects of dietary nitrate in healthy volunteers: Involvement of cGMP and influence of sex

Velmurugan, S., Kapil, V., Ghosh, S. M., Davies, S., McKnight, A., Aboud, Z., Khambata, R. S., Webb, A. J., Poole, A., & Ahluwalia, A. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.06.031 · Cited by 114 · see citing works

Heme proteins mediate the conversion of nitrite to nitric oxide in the vascular wall

Alzawahra, W. F., Talukder, M. A. H., Liu, X., Samouilov, A., & Zweier, J. L. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00374.2008 · Cited by 111 · see citing works

A comparison of organic and inorganic nitrates/nitrites

Omar, S. A., Artime, E., & Webb, A. J. (2012) · Nitric Oxide · doi:10.1016/j.niox.2012.03.008 · Cited by 106 · see citing works

The ingestion of inorganic nitrate increases gastric S-nitrosothiol levels and inhibits platelet function in humans

Richardson, G., Hicks, S. L., O'Byrne, S., Frost, M. T., Moore, K., Benjamin, N., & McKnight, G. M. (2002) · Nitric Oxide · doi:10.1016/s1089-8603(02)00010-1 · Cited by 101 · see citing works

Dietary nitrate and nitrite modulate blood and organ nitrite and the cellular ischemic stress response

Raat, N. J. H., Noguchi, A. C., Liu, V. B., Raghavachari, N., Liu, D., Xu, X., Shiva, S., Munson, P. J., & Gladwin, M. T. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.05.015 · Cited by 97 · see citing works

Reduction of<i>N</i>ω-hydroxy-<scp>L</scp>-arginine by the mitochondrial amidoxime reducing component (mARC)

Kotthaus, J., Wahl, B., Havemeyer, A., Kotthaus, J., Schade, D., Garbe-Schönberg, D., Mendel, R., Bittner, F., & Clement, B. (2011) · Biochemical Journal · doi:10.1042/bj20100960 · Cited by 88 · see citing works

Sulfite Oxidase Catalyzes Single-Electron Transfer at Molybdenum Domain to Reduce Nitrite to Nitric Oxide

Wang, J., Krizowski, S., Fischer-Schrader, K., Niks, D., Tejero, J., Sparacino-Watkins, C., Wang, L., Ragireddy, V., Frizzell, S., Kelley, E. E., et al. (2015) · Antioxidants &amp; Redox Signaling · doi:10.1089/ars.2013.5397 · Cited by 84 · see citing works

Myocardial protection by nitrite

Calvert, J. W., & Lefer, D. J. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp079 · Cited by 82 · see citing works

The effects of chronic nitrate supplementation and the use of strong and weak antibacterial agents on plasma nitrite concentration and exercise blood pressure

McDonagh, S., Wylie, L., Winyard, P., Vanhatalo, A., & Jones, A. (2015) · International Journal of Sports Medicine · doi:10.1055/s-0035-1554700 · Cited by 79 · see citing works

Low-dose sodium nitrite vasodilates hypoxic human pulmonary vasculature by a means that is not dependent on a simultaneous elevation in plasma nitrite

Ingram, T. E., Pinder, A. G., Bailey, D. M., Fraser, A. G., & James, P. E. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00583.2009 · Cited by 78 · see citing works

Nitrite signaling in pulmonary hypertension: mechanisms of bioactivation, signaling, and therapeutics

Bueno, M., Wang, J., Mora, A. L., & Gladwin, M. T. (2013) · Antioxidants &amp; Redox Signaling · doi:10.1089/ars.2012.4833 · Cited by 68 · see citing works

Inorganic nitrite supplementation for healthy arterial aging

Sindler, A. L., DeVan, A. E., Fleenor, B. S., & Seals, D. R. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01100.2013 · Cited by 68 · see citing works

Dietary nitrate increases arginine availability and protects mitochondrial complex I and energetics in the hypoxic rat heart

Ashmore, T., Fernandez, B. O., Branco‐Price, C., West, J. A., Cowburn, A. S., Heather, L. C., Griffin, J. L., Johnson, R. S., Feelisch, M., & Murray, A. J. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2014.275263 · Cited by 58 · see citing works

Isoform-specific differences in the nitrite reductase activity of nitric oxide synthases under hypoxia

Mikula, I., Durocher, S., Martasek, P., Mutus, B., & Slama-Schwok, A. (2009) · Biochemical Journal · doi:10.1042/bj20080987 · Cited by 51 · see citing works

Impact of dietary nitrate on age-related diastolic dysfunction

Rammos, C., Hendgen-Cotta, U. B., Totzeck, M., Pohl, J., Lüdike, P., Flögel, U., Deenen, R., Köhrer, K., French, B. A., Gödecke, A., et al. (2016) · European Journal of Heart Failure · doi:10.1002/ejhf.535 · Cited by 31 · see citing works

Nitrite-mediated renal vasodilatation is increased during ischemic conditions via cGMP-independent signaling

Liu, M., Zollbrecht, C., Peleli, M., Lundberg, J. O., Weitzberg, E., & Carlström, M. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.03.025 · Cited by 30 · see citing works

Acute administration of l-arginine restores nitric oxide-mediated relaxation in isolated pulmonary arteries from pulmonary hypertensive exercise trained rats

Goret, L., Tanguy, S., Guiraud, I., Dauzat, M., & Obert, P. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.11.037 · Cited by 24 · see citing works

Dietary Nitrate-Rich Vegetables as Natural Modulators of Health: Mechanisms and Benefits in Ageing Populations

Kurhaluk, N., Kołodziejska, R., Buyun, L., Kamiński, P., & Tkaczenko, H. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27083461 · Cited by 3 · see citing works