Cited by 85Cancer, Hypoxia, and MetabolismAmino Acid Enzymes and MetabolismPI3K/AKT/mTOR signaling in cancer

Glutamine as an Essential Amino Acid for KRas-Driven Cancer Cells

Bernfeld, Elyssa, Foster, David A.·2019·Trends in Endocrinology & Metabolism

Abstract

Cancer cells consume glutamine, a nonessential amino acid (NEAA), at exceedingly high rates to fulfill their energetic and biosynthetic requirements for proliferation. Glutamine plays distinct roles from essential amino acids in cell cycle progression and in the activation of mammalian target of rapamycin (mTOR). Furthermore, the need of cancer cells for glutamine can be exploited therapeutically - especially those driven by KRas. In this review we explore several distinct cellular roles for glutamine that contribute to glutamine addiction in KRas-driven cancer cells and discuss opportunities for therapeutic intervention created by glutamine addiction.

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Crossref · 10.1016/j.tem.2019.03.003

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88 of 88 references verified0 citation errors · 0 not checkable

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  • K-Ras-driven cells have increased expression of GOT1 and GOT2.

    “Additionally, K-Ras-driven cells are characterized by increased expression of GOT1 and GOT2182,183.”

    From Glutamine reliance in cell metabolism (2020) · cites this paper as [182]

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Authors
Bernfeld, E., & Foster, D. A.
Affiliations
The Graduate Center, CUNY (US)
Corresponding author
Foster, David A.
Venue
Trends in Endocrinology & Metabolism
Publisher
Elsevier BV
Published
2019-06
Volume
30
Issue
6
Pages
357-368
ISSN
1043-2760 (ISSN-L)
OpenAlex
W2941734641
Cited by
85
References
89
Citations by year
2026: 5 · 2025: 18 · 2024: 11 · 2023: 11 · 2022: 18 · 2021: 16 · 2020: 4 · 2019: 2
FWCI
0.96
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (R01-CA046677, R01-CA179542)
  • National Center for Research Resources (RP-03037)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Keywords
glutamine, glutamine addiction, KRAS-driven cancers, non-essential amino acids, mTOR, cell cycle progression, cancer metabolism, glutamine metabolism, cancer therapy
MeSH terms
Amino Acids, Essential, Animals, Glutamine, Humans, Neoplasms, Proto-Oncogene Proteins p21(ras), TOR Serine-Threonine Kinases

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