MYC and tumor metabolism: chicken and egg

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197 · see citing works

The Warburg Effect: How Does it Benefit Cancer Cells?

Liberti, M. V., & Locasale, J. W. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2015.12.001 · Cited by 5,150 · see citing works

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

DeBerardinis, R. J., Lum, J. J., Hatzivassiliou, G., & Thompson, C. B. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.002 · Cited by 4,088 · see citing works

MYC on the Path to Cancer

Dang, C. V. (2012) · Cell · doi:10.1016/j.cell.2012.03.003 · Cited by 3,390 · see citing works

Endoplasmic reticulum stress: cell life and death decisions

Xu, C. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26373 · Cited by 2,260 · see citing works

The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation

Wang, R., Dillon, C. P., Shi, L. Z., Milasta, S., Carter, R., Finkelstein, D., McCormick, L. L., Fitzgerald, P., Chi, H., Munger, J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.021 · Cited by 2,140 · cited 2× · see citing works

Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins

Castello, A., Fischer, B., Eichelbaum, K., Horos, R., Beckmann, B. M., Strein, C., Davey, N. E., Humphreys, D. T., Preiss, T., Steinmetz, L. M., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.031 · Cited by 2,132 · see citing works

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

Gao, P., Tchernyshyov, I., Chang, T.-C., Lee, Y.-S., Kita, K., Ochi, T., Zeller, K. I., De Marzo, A. M., Van Eyk, J. E., Mendell, J. T., et al. (2009) · Nature · doi:10.1038/nature07823 · Cited by 2,124 · see citing works

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

Wise, D. R., DeBerardinis, R. J., Mancuso, A., Sayed, N., Zhang, X.-Y., Pfeiffer, H. K., Nissim, I., Daikhin, E., Yudkoff, M., McMahon, S. B., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810199105 · Cited by 2,001 · see citing works

Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

Nicklin, P., Bergman, P., Zhang, B., Triantafellow, E., Wang, H., Nyfeler, B., Yang, H., Hild, M., Kung, C., Wilson, C., et al. (2009) · Cell · doi:10.1016/j.cell.2008.11.044 · Cited by 1,798 · see citing works

PI3K and cancer: lessons, challenges and opportunities

Fruman, D. A., & Rommel, C. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4204 · Cited by 1,716 · see citing works

The pentose phosphate pathway and cancer

Patra, K. C., & Hay, N. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2014.06.005 · Cited by 1,444 · see citing works

Intrinsic tumour suppression

Lowe, S. W., Cepero, E., & Evan, G. I. (2004) · Nature · doi:10.1038/nature03098 · Cited by 1,309 · see citing works

HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

David, C. J., Chen, M., Assanah, M., Canoll, P., & Manley, J. L. (2010) · Nature · doi:10.1038/nature08697 · Cited by 1,179 · see citing works

Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells

Le, A., Lane, A. N., Hamaker, M., Bose, S., Gouw, A., Barbi, J., Tsukamoto, T., Rojas, C. J., Slusher, B. S., Zhang, H., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2011.12.009 · Cited by 1,095 · see citing works

FOXOs: signalling integrators for homeostasis maintenance

Eijkelenboom, A., & Burgering, B. M. T. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3507 · Cited by 1,081 · see citing works

AU-rich elements and associated factors: are there unifying principles?

Barreau, C. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki1012 · Cited by 1,033 · see citing works

Serine and one-carbon metabolism in cancer

Yang, M., & Vousden, K. H. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.81 · Cited by 992 · see citing works

MYC as a regulator of ribosome biogenesis and protein synthesis

van Riggelen, J., Yetil, A., & Felsher, D. W. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2819 · Cited by 956 · see citing works

Reversible tumorigenesis by MYC in hematopoietic lineages.

Felsher, D., & Bishop, J. (1999) · Molecules and Cells · doi:10.1016/s1097-2765(00)80367-6 · Cited by 917 · see citing works

Deregulation of Glucose Transporter 1 and Glycolytic Gene Expression by c-Myc

Osthus, R. C., Shim, H., Kim, S., Li, Q., Reddy, R., Mukherjee, M., Xu, Y., Wonsey, D. R., Lee, L. A., & Dang, C. V. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000023200 · Cited by 876 · see citing works

MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer

Shachaf, C. M., Kopelman, A. M., Arvanitis, C., Karlsson, Å., Beer, S., Mandl, S., Bachmann, M. H., Borowsky, A. D., Ruebner, B., Cardiff, R. D., et al. (2004) · Nature · doi:10.1038/nature03043 · Cited by 874 · see citing works

Nucleotide deficiency promotes genomic instability in early stages of cancer development

Bester, A. C., Roniger, M., Oren, Y. S., Im, M. M., Sarni, D., Chaoat, M., Bensimon, A., Zamir, G., Shewach, D. S., & Kerem, B. (2011) · Cell · doi:10.1016/j.cell.2011.03.044 · Cited by 858 · see citing works

p53 represses c-Myc through induction of the tumor suppressor miR-145

Sachdeva, M., Zhu, S., Wu, F., Wu, H., Walia, V., Kumar, S. R., Elble, R. C., Watabe, K., & Mo, Y. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808042106 · Cited by 841 · see citing works

Modelling Myc inhibition as a cancer therapy

Soucek, L., Whitfield, J. R., Martins, C. P., Finch, A. J., Murphy, D. J., Sodir, N. M., Karnezis, A. N., Swigart, L. B., Nasi, S., & Evan, G. I. (2008) · Nature · doi:10.1038/nature07260 · Cited by 822 · see citing works

The Energy Sensor AMP-activated Protein Kinase Directly Regulates the Mammalian FOXO3 Transcription Factor

Greer, E. L., Oskoui, P. R., Banko, M. R., Maniar, J. M., Gygi, M. P., Gygi, S. P., & Brunet, A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705325200 · Cited by 820 · see citing works

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

Ben-Sahra, I., Hoxhaj, G., Ricoult, S. J. H., Asara, J. M., & Manning, B. D. (2016) · Science · doi:10.1126/science.aad0489 · Cited by 795 · see citing works

The ornithine decarboxylase gene is a transcriptional target of c-Myc.

Bello-Fernández, C., Packham, G., & Cleveland, J. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.16.7804 · Cited by 783 · see citing works

Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1

Ben-Sahra, I., Howell, J. J., Asara, J. M., & Manning, B. D. (2013) · Science · doi:10.1126/science.1228792 · Cited by 739 · see citing works

Environment impacts the metabolic dependencies of Ras-driven non-small cell lung cancer

Davidson, S. M., Papagiannakopoulos, T., Olenchock, B. A., Heyman, J. E., Keibler, M. A., Luengo, A., Bauer, M. R., Jha, A. K., O’Brien, J. P., Pierce, K. A., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.01.007 · Cited by 737 · see citing works

Nutrient sensing and TOR signaling in yeast and mammals

González, A., & Hall, M. N. (2017) · The EMBO Journal · doi:10.15252/embj.201696010 · Cited by 725 · see citing works

Glutaminolysis Activates Rag-mTORC1 Signaling

Durán, R. V., Oppliger, W., Robitaille, A. M., Heiserich, L., Skendaj, R., Gottlieb, E., & Hall, M. N. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.05.043 · Cited by 723 · see citing works

Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells

Yuneva, M., Zamboni, N., Oefner, P., Sachidanandam, R., & Lazebnik, Y. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200703099 · Cited by 690 · cited 2× · see citing works

The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type

Yuneva, M. O., Fan, T. W. M., Allen, T. D., Higashi, R. M., Ferraris, D. V., Tsukamoto, T., Matés, J. M., Alonso, F. J., Wang, C., Seo, Y., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2011.12.015 · Cited by 639 · see citing works

Reexamining cancer metabolism: lactate production for carcinogenesis could be the purpose and explanation of the Warburg Effect

San-Millán, I., & Brooks, G. A. (2016) · Carcinogenesis · doi:10.1093/carcin/bgw127 · Cited by 613 · see citing works

MYC, Metabolism, Cell Growth, and TumorigenesisPreprint

Dang, C. V. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014217 · Cited by 600 · see citing works

Pyruvate kinase: Function, regulation and role in cancer

Israelsen, W. J., & Heiden, M. G. V. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.08.004 · Cited by 593 · see citing works

The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis

Ruggero, D., Montanaro, L., Ma, L., Xu, W. G., Londei, P., Cordon‐Cardo, C., & Pandolfi, P. P. (2004) · Nature Medicine · doi:10.1038/nm1042 · Cited by 592 · see citing works

Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer

Camarda, R., Zhou, A. Y., Kohnz, R. A., Balakrishnan, S., Mahieu, C. I., Anderton, B. N., Eyob, H., Kajimura, S., Tward, A. D., Krings, G., et al. (2016) · Nature Medicine · doi:10.1038/nm.4055 · Cited by 530 · see citing works

MYC: Connecting selective transcriptional control to global RNA production

Kress, T. R., Sabò, A., & Amati, B. (2015) · Nature reviews. Cancer · doi:10.1038/nrc3984 · Cited by 521 · see citing works

Polyamines in aging and disease

Minois, N., Carmona‐Gutiérrez, D., & Madeo, F. (2011) · Aging · doi:10.18632/aging.100361 · Cited by 516 · see citing works

Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC

Liu, W., Le, A., Hancock, C., Lane, A. N., Dang, C. V., Fan, T. W.-M., & Phang, J. M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1203244109 · Cited by 483 · see citing works

Glioblastoma Cells Require Glutamate Dehydrogenase to Survive Impairments of Glucose Metabolism or Akt Signaling

Yang, C., Sudderth, J., Dang, T. T., Bachoo, R. G., McDonald, J. G., & DeBerardinis, R. J. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-2266 · Cited by 425 · see citing works

Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis

Xiang, Y., Stine, Z. E., Xia, J., Lu, Y., O’Connor, R. S., Altman, B. J., Hsieh, A. L., Gouw, A. M., Thomas, A. G., Gao, P., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci75836 · Cited by 409 · see citing works

mTOR Complex 2 Controls Glycolytic Metabolism in Glioblastoma through FoxO Acetylation and Upregulation of c-Myc

Masui, K., Tanaka, K., Akhavan, D., Babic, I., Gini, B., Matsutani, T., Iwanami, A., Liu, F., Villa, G. R., Gu, Y., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.09.013 · Cited by 407 · see citing works

Blocking Lactate Export by Inhibiting the Myc Target MCT1 Disables Glycolysis and Glutathione Synthesis

Doherty, J. R., Yang, C., Scott, K. E. N., Cameron, M. D., Fallahi, M., Li, W., Hall, M. A., Amelio, A. L., Mishra, J. K., Li, F., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-2034 · Cited by 399 · see citing works

ATF4 Regulates MYC-Mediated Neuroblastoma Cell Death upon Glutamine Deprivation

Qing, G., Li, B., Vu, A., Skuli, N., Walton, Z. E., Liu, X., Mayes, P. A., Wise, D. R., Thompson, C. B., Maris, J. M., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.09.021 · Cited by 375 · see citing works

Evaluation of myc E-box phylogenetic footprints in glycolytic genes by chromatin immunoprecipitation assays

Kim, J.-W., Zeller, K. I., Wang, Y., Jegga, A. G., Aronow, B. J., O'Donnell, K. A., & Dang, C. V. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.13.5923-5936.2004 · Cited by 371 · see citing works

Glutamine transporters in mammalian cells and their functions in physiology and cancer

Bhutia, Y. D., & Ganapathy, V. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.12.017 · Cited by 326 · see citing works

Global Regulation of Nucleotide Biosynthetic Genes by c-Myc

Liu, Y.-C., Li, F., Handler, J., Huang, C. R. L., Xiang, Y., Neretti, N., Sedivy, J. M., Zeller, K. I., & Dang, C. V. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002722 · Cited by 317 · see citing works

cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions

Sun, L., Song, L., Wan, Q., Wu, G., Li, X., Wang, Y., Wang, J., Liu, Z., Zhong, X., He, X., et al. (2015) · Cell Research · doi:10.1038/cr.2015.33 · Cited by 311 · see citing works

FOXO3a regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression

Ferber, E. C., Peck, B., Delpuech, O., Bell, G. P., East, P., & Schulze, A. (2011) · Cell Death and Differentiation · doi:10.1038/cdd.2011.179 · Cited by 307 · see citing works

O-GlcNAc Transferase Integrates Metabolic Pathways to Regulate the Stability of c-MYC in Human Prostate Cancer Cells

Itkonen, H. M., Minner, S. J. P., Guldvik, I. J., Sandmann, M. J., Tsourlakis, M. C., Berge, V., Svindland, A., Schlomm, T., & Mills, I. G. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-0549 · Cited by 293 · see citing works

Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers

Pourdehnad, M., Truitt, M., Siddiqi, I. N., Ducker, G. S., Shokat, K. M., & Ruggero, D. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1310230110 · Cited by 288 · see citing works

A unique glucose-dependent apoptotic pathway induced by c-Myc

Shim, H., Chun, Y. S., Lewis, B. C., & Dang, C. V. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.4.1511 · Cited by 286 · see citing works

Glutamine synthetase is a genetic determinant of cell type-specific glutamine independence in breast epithelia

Kung, H.-N., Marks, J. R., & Chi, J.-T. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002229 · Cited by 277 · see citing works

Deregulated MYC expression induces dependence upon AMPK-related kinase 5

Liu, L., Ulbrich, J., Müller, J., Wüstefeld, T., Aeberhard, L., Kress, T. R., Muthalagu, N., Rycak, L., Rudalska, R., Moll, R., et al. (2012) · Nature · doi:10.1038/nature10927 · Cited by 276 · see citing works

Metabolic Enzymes Enjoying New Partnerships as RNA-Binding Proteins

Castelló, A., Hentze, M. W., & Preiß, T. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.09.012 · Cited by 274 · see citing works

O-GlcNAcylation in Cancer Biology: Linking Metabolism and Signaling

Ferrer, C. M., Sodi, V. L., & Reginato, M. J. (2016) · Journal of Molecular Biology · doi:10.1016/j.jmb.2016.05.028 · Cited by 268 · see citing works

Protein and nucleotide biosynthesis are coupled by a single rate-limiting enzyme, PRPS2, to drive cancer

Cunningham, J. T., Moreno, M. V., Lodi, A., Ronen, S. M., & Ruggero, D. (2014) · Cell · doi:10.1016/j.cell.2014.03.052 · Cited by 260 · see citing works

Oncogenic Myc Induces Expression of Glutamine Synthetase through Promoter Demethylation

Bott, A. J., Peng, I., Fan, Y., Faubert, B., Zhao, L. H., Li, J., Neidler, S., Sun, Y., Jaber, N. L., Krokowski, D., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.09.025 · Cited by 259 · see citing works

Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells

Mannava, S., Grachtchouk, V., Wheeler, L. J., Im, M., Zhuang, D., Slavina, E. G., Mathews, C. K., Shewach, D. S., & Nikiforov, M. A. (2008) · Cell Cycle · doi:10.4161/cc.6390 · Cited by 257 · cited 11× · see citing works

MYC oncogene overexpression drives renal cell carcinoma in a mouse model through glutamine metabolism

Shroff, E. H., Eberlin, L. S., Dang, V. M., Gouw, A. M., Gabay, M., Adam, S. J., Bellovin, D. I., Tran, P. T., Philbrick, W. M., Garcia-Ocana, A., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1507228112 · Cited by 255 · see citing works

13C-Pyruvate Imaging Reveals Alterations in Glycolysis that Precede c-Myc-Induced Tumor Formation and Regression

Hu, S., Balakrishnan, A., Bok, R. A., Anderton, B., Larson, P. E. Z., Nelson, S. J., Kurhanewicz, J., Vigneron, D. B., & Goga, A. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.04.012 · Cited by 245 · see citing works

Activation of the AMPK-FOXO3 Pathway Reduces Fatty Acid–Induced Increase in Intracellular Reactive Oxygen Species by Upregulating Thioredoxin

Li, X., Song, J., Zhang, L., LeMaire, S. A., Hou, X., Zhang, C., Coselli, J. S., Chen, L., Wang, X. L., Zhang, Y., et al. (2009) · Diabetes · doi:10.2337/db08-1512 · Cited by 237 · see citing works

Myc-Nick: A Cytoplasmic Cleavage Product of Myc that Promotes α-Tubulin Acetylation and Cell Differentiation

Conacci‐Sorrell, M., Ngouenet, C., & Eisenman, R. N. (2010) · Cell · doi:10.1016/j.cell.2010.06.037 · Cited by 219 · see citing works

Metabolic reprogramming in triple-negative breast cancer through Myc suppression of TXNIP

Shen, L., O’Shea, J. M., Kaadige, M. R., Cunha, S., Wilde, B. R., Cohen, A. L., Welm, A. L., & Ayer, D. E. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1501555112 · Cited by 212 · see citing works

Myc‐induced proliferation and transformation require Akt‐mediated phosphorylation of FoxO proteins

Bouchard, C., Marquardt, J., Brás, A., Medema, R. H., & Eilers, M. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600279 · Cited by 211 · see citing works

Targeting ornithine decarboxylase in Myc-induced lymphomagenesis prevents tumor formation

Nilsson, J. A., Keller, U. B., Baudino, T. A., Yang, C., Norton, S., Old, J. B., Nilsson, L. M., Neale, G. A. M., Kramer, D. L., Porter, C. W., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.03.036 · Cited by 210 · see citing works

Deregulated Myc Requires MondoA/Mlx for Metabolic Reprogramming and Tumorigenesis

Carroll, P. A., Diolaiti, D., McFerrin, L. G., Gu, H., Djukovic, D., Du, J., Cheng, P. F., Anderson, S., Ulrich, M. L., Hurley, J. B., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2014.11.024 · Cited by 202 · see citing works

A Functional Screen for Myc-Responsive Genes Reveals Serine Hydroxymethyltransferase, a Major Source of the One-Carbon Unit for Cell Metabolism

Nikiforov, M. A., Chandriani, S. J., O’Connell, B. C., Petrenko, O., Kotenko, I., Beavis, A. J., Sedivy, J. M., & Cole, M. D. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.16.5793-5800.2002 · Cited by 201 · see citing works

Myc inhibition is effective against glioma and reveals a role for Myc in proficient mitosis

Annibali, D., Whitfield, J. R., Favuzzi, E., Jauset, T., Serrano, E., Cuartas, I., Redondo-Campos, S., Folch, G., Gonzàlez-Juncà, A., Sodir, N. M., et al. (2014) · Nature Communications · doi:10.1038/ncomms5632 · Cited by 200 · see citing works

Targeting polyamine metabolism for cancer therapy and prevention

Stewart, T. M., Woster, P. M., & Casero, R. A. (2016) · Biochemical Journal · doi:10.1042/bcj20160383 · Cited by 190 · see citing works

Translational induction of the c-myc oncogene via activation of the FRAP/TOR signalling pathway

West, M. J., Stoneley, M., & Willis, A. E. (1998) · Oncogene · doi:10.1038/sj.onc.1201990 · Cited by 183 · see citing works

Targeting Glutamine Metabolism in Breast Cancer with Aminooxyacetate

Korangath, P., Teo, W. W., Sadik, H., Han, L., Mori, N., Huijts, C. M., Wildes, F., Bharti, S., Zhang, Z., Santa-Maria, C. A., et al. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-1200 · Cited by 182 · see citing works

c-Myc and eIF4F Are Components of a Feedforward Loop that Links Transcription and Translation

Lin, C.-J., Cencic, R., Mills, J. R., Robert, F., & Pelletier, J. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5876 · Cited by 180 · see citing works

p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication

Cannell, I. G., Kong, Y. W., Johnston, S. J., Chen, M. L., Collins, H. M., Dobbyn, H. C., Elia, A., Kress, T. R., Dickens, M., Clemens, M. J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910015107 · Cited by 171 · see citing works

Proline biosynthesis augments tumor cell growth and aerobic glycolysis: involvement of pyridine nucleotides

Liu, W., Hancock, C. N., Fischer, J. W., Harman, M., & Phang, J. M. (2015) · Scientific Reports · doi:10.1038/srep17206 · Cited by 171 · see citing works

Myc and Ras oncogenes engage different energy metabolism programs and evoke distinct patterns of oxidative and DNA replication stress

Maya‐Mendoza, A., Ostráková, J., Košař, M., Hall, A., Dušková, P., Mistrík, M., Merchut‐Maya, J. M., Hodný, Z., Bártková, J., Christensen, C., et al. (2014) · Molecular Oncology · doi:10.1016/j.molonc.2014.11.001 · Cited by 170 · see citing works

c-Myc activates multiple metabolic networks to generate substrates for cell-cycle entry

Morrish, F. M., Isern, N., Sadı́lek, M., Jeffrey, M., & Hockenbery, D. M. (2009) · Oncogene · doi:10.1038/onc.2009.112 · Cited by 164 · see citing works

Induction of Mxi1-SRα by FOXO3a Contributes to Repression of Myc-Dependent Gene Expression

Delpuech, O., Griffiths, B. L., East, P., Essafi, A., Lam, E. W. ‐., Burgering, B. M. T., Downward, J., & Schulze, A. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01789-06 · Cited by 160 · see citing works

ATF4 and N‐Myc coordinate glutamine metabolism in MYCN ‐amplified neuroblastoma cells through ASCT2 activation

Ren, P., Yue, M., Xiao, D., Xiu, R., Gan, L., Liu, H., & Qing, G. (2014) · The Journal of Pathology · doi:10.1002/path.4429 · Cited by 156 · see citing works

The B55α Subunit of PP2A Drives a p53-Dependent Metabolic Adaptation to Glutamine Deprivation

Reid, M. A., Wang, W.-I., Rosales, K. R., Welliver, M. X., Pan, M., & Kong, M. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.02.008 · Cited by 154 · see citing works

Myc-dependent Mitochondrial Generation of Acetyl-CoA Contributes to Fatty Acid Biosynthesis and Histone Acetylation during Cell Cycle Entry

Morrish, F. M., Noonan, J., Olsen, C. P., Gafken, P. R., Fitzgibbon, M., Kelleher, J. K., VanGilst, M., & Hockenbery, D. M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.141606 · Cited by 152 · see citing works

mTOR/MYC Axis Regulates O-GlcNAc Transferase Expression and O-GlcNAcylation in Breast Cancer

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The MK5/PRAK Kinase and Myc Form a Negative Feedback Loop that Is Disrupted during Colorectal Tumorigenesis

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FoxOs Enforce a Progression Checkpoint to Constrain mTORC1-Activated Renal Tumorigenesis

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PKM2 promotes glucose metabolism and cell growth in gliomas through a mechanism involving a let-7a/c-Myc/hnRNPA1 feedback loop

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Alteration of the lipid profile in lymphomas induced by MYC overexpression

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A MYC-Driven Change in Mitochondrial Dynamics Limits YAP/TAZ Function in Mammary Epithelial Cells and Breast Cancer

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Myc-induced AMPK-phospho p53 pathway activates Bak to sensitize mitochondrial apoptosis

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Control of Cell Survival and Proliferation by Mammalian Eukaryotic Initiation Factor 4B

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Taming of the beast: shaping Myc-dependent amplification

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AKT1 and MYC Induce Distinctive Metabolic Fingerprints in Human Prostate Cancer

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FoxO3A promotes metabolic adaptation to hypoxia by antagonizing Myc function

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Akt and c-Myc Differentially Activate Cellular Metabolic Programs and Prime Cells to Bioenergetic Inhibition

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c-Myc Programs Fatty Acid Metabolism and Dictates Acetyl-CoA Abundance and Fate

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Polyamines Regulate c-Myc Translation through Chk2-dependent HuR Phosphorylation

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Downregulation of c-MYC Protein Levels Contributes to Cancer Cell Survival under Dual Deficiency of Oxygen and Glucose

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Regulation of OGT by URI in Response to Glucose Confers c-MYC-Dependent Survival Mechanisms

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Tumor induction by the c-Myc target genes rcl and lactate dehydrogenase A.

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Isotopically nonstationary 13C flux analysis of Myc-induced metabolic reprogramming in B-cells

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miR-16 and miR-26a target checkpoint kinases Wee1 and Chk1 in response to p53 activation by genotoxic stress

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c-Myc is crucial for the expression of LAT1 in MIA Paca-2 human pancreatic cancer cells

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Nature and Nurture: What Determines Tumor Metabolic Phenotypes?

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c‐Myc primed mitochondria determine cellular sensitivity to TRAIL‐induced apoptosis

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Inhibition of p38α unveils an AMPK-FoxO3A axis linking autophagy to cancer-specific metabolism

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MYC‐driven inhibition of the glutamate‐cysteine ligase promotes glutathione depletion in liver cancer

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The MYC mRNA 3′‐UTR couples RNA polymerase II function to glutamine and ribonucleotide levels

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Caspase-mediated Cleavage of RNA-binding Protein HuR Regulates c-Myc Protein Expression after Hypoxic Stress

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Metabolic changes in cancer cells upon suppression of MYC

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c-Myc Sensitization to Oxygen Deprivation-induced Cell Death Is Dependent on Bax/Bak, but Is Independent of p53 and Hypoxia-inducible Factor-1

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Polyamine Metabolism Is Sensitive to Glycolysis Inhibition in Human Neuroblastoma Cells

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Overexpression of c ‐myc in the liver prevents obesity and insulin resistance

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MYC Degradation under Low O 2 Tension Promotes Survival by Evading Hypoxia-Induced Cell Death

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Characterization of MYC-Induced Tumorigenesis by in situ Lipid Profiling

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Critical Roles of Myc-ODC Axis in the Cellular Transformation Induced by Myeloproliferative Neoplasm-Associated JAK2 V617F Mutant

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Repression of SRF target genes is critical for Myc‐dependent apoptosis of epithelial cells

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Coordination of glucose and glutamine utilization by an expanded Myc network

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Abstract 5277: MicroRNA expression profile of astrocytoma in archived formalin-fixed paraffin-embedded brain tumor samples.

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c-MYC responds to glucose deprivation in a cell-type-dependent manner

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Activation of glutamate dehydrogenase by l-leucine

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The c‐myc gene regulates the polyamine pathway in DMSO‐induced apoptosis.

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Non-immunosuppressive triazole-based small molecule induces anticancer activity against human hormone-refractory prostate cancers: the role in inhibition of PI3K/AKT/mTOR and c-Myc signaling pathways

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The anti-cancer effect of quercetin: molecular implications in cancer metabolism

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PKM2, function and expression and regulation

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R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6A/PFKP/LDHB axis

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The metabolic landscape of RAS-driven cancers from biology to therapy

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Immunity, Hypoxia, and Metabolism–the Ménage à Trois of Cancer: Implications for Immunotherapy

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The MYC transcription factor network: balancing metabolism, proliferation and oncogenesis

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Metabolic reprogramming in triple-negative breast cancer

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Polyamine synthesis as a target of MYC oncogenes

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The Metabolic Fates of Pyruvate in Normal and Neoplastic Cells

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c-Myc-Targeting PROTAC Based on a TNA-DNA Bivalent Binder for Combination Therapy of Triple-Negative Breast Cancer

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ASCT2 (SLC1A5)-dependent glutamine uptake is involved in the progression of head and neck squamous cell carcinoma

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Metabolic reprogramming and the role of mitochondria in polycystic kidney disease

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Computer-aided drug repurposing for cancer therapy: Approaches and opportunities to challenge anticancer targets

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Dissection of metabolic reprogramming in polycystic kidney disease reveals coordinated rewiring of bioenergetic pathways

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Signaling, metabolism, and cancer: An important relationship for therapeutic intervention

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Epstein–Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis

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Protein phosphatase 2A as a therapeutic target in inflammation and neurodegeneration

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The role of Wnt signaling pathway in tumor metabolic reprogramming

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Starve Cancer Cells of Glutamine: Break the Spell or Make a Hungry Monster?

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Metabolic flexibility in melanoma: A potential therapeutic target

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Elevated Polyamines in Saliva of Pancreatic Cancer

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Deubiquitination of MYC by OTUB1 contributes to HK2 mediated glycolysis and breast tumorigenesis

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The long noncoding RNA glycoLINC assembles a lower glycolytic metabolon to promote glycolysis

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Metabolic Plasticity of Tumor Cell Mitochondria

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High OGT activity is essential for MYC-driven proliferation of prostate cancer cells

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Glutamine and cancer: metabolism, immune microenvironment, and therapeutic targets

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LncRNA PDIA3P interacts with c-Myc to regulate cell proliferation via induction of pentose phosphate pathway in multiple myeloma

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MTR4 drives liver tumorigenesis by promoting cancer metabolic switch through alternative splicing

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Glutamine as an Essential Amino Acid for KRas-Driven Cancer Cells

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Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage

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Contractile activity-specific transcriptome response to acute endurance exercise and training in human skeletal muscle

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Salivary metabolomics with alternative decision tree-based machine learning methods for breast cancer discrimination

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LncRNA FTO-IT1 promotes glycolysis and progression of hepatocellular carcinoma through modulating FTO-mediated N6-methyladenosine modification on GLUT1 and PKM2

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Berberine Inhibits Growth of Liver Cancer Cells by Suppressing Glutamine Uptake

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Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases

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Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence

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Short-term activation of the Jun N-terminal kinase pathway in apoptosis-deficient cells of Drosophila induces tumorigenesis

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Long Noncoding RNA DCST1-AS1 Promotes Cell Proliferation and Metastasis in Triple-negative Breast Cancer by Forming a Positive Regulatory Loop with miR-873-5p and MYC

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Homeodomain‐interacting protein kinase 2 suppresses proliferation and aerobic glycolysis via ERK/cMyc axis in pancreatic cancer

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Perturbations of cancer cell metabolism by the antidiabetic drug canagliflozin

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The role of metabolic checkpoint regulators in B cell survival and transformation

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Targeting IGF1R signaling enhances the sensitivity of cisplatin by inhibiting proline and arginine metabolism in oesophageal squamous cell carcinoma under hypoxia

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Beyond Brooding on Oncometabolic Havoc in IDH-Mutant Gliomas and AML: Current and Future Therapeutic Strategies

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Radioactive nano-oxygen generator enhance anti-tumor radio-immunotherapy by regulating tumor microenvironment and reducing proliferation

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De novo pyrimidine synthesis fuels glycolysis and confers chemoresistance in gastric cancer

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Matrine Promotes Human Myeloid Leukemia Cells Apoptosis Through Warburg Effect Mediated by Hexokinase 2

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Regulation of PI3K signaling in cancer metabolism and PI3K-targeting therapy

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The molecular chaperone TRAP1 in cancer: From the basics of biology to pharmacological targeting

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Inhibition of fatty acid synthesis induces differentiation and reduces tumor burden in childhood neuroblastoma

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Emerging therapies for autosomal dominant polycystic kidney disease with a focus on cAMP signaling

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AMPK promotes survival of c‐Myc‐positive melanoma cells by suppressing oxidative stress

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Exploring the metabolic alterations in cervical cancer induced by HPV oncoproteins: From mechanisms to therapeutic targets

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TAZ functions as a tumor suppressor in multiple myeloma by downregulating MYC

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Role ofMycProto-Oncogene as a Transcriptional Hub to Regulate the Expression of Regeneration-Associated Genes following Preconditioning Peripheral Nerve Injury

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Targeting RAS mutants in malignancies: successes, failures, and reasons for hope

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Dihydroartemisinin and artesunate inhibit aerobic glycolysis via suppressing c-Myc signaling in non-small cell lung cancer

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Molecular Mediators of Metabolic Reprogramming in Cancer: Mechanisms, Regulatory Networks, and Therapeutic Strategies

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Glycine decarboxylase is a transcriptional target of MYCN required for neuroblastoma cell proliferation and tumorigenicity

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Prognostic implications of metabolism-associated gene signatures in colorectal cancer

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mTORC1-c-Myc pathway rewires methionine metabolism for HCC progression through suppressing SIRT4 mediated ADP ribosylation of MAT2A

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c-Myc directly targets an over-expression of pyruvate carboxylase in highly invasive breast cancer

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N-Myc-induced metabolic rewiring creates novel therapeutic vulnerabilities in neuroblastoma

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Polydatin Inhibits Cell Viability, Migration, and Invasion Through Suppressing the c-Myc Expression in Human Cervical Cancer

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The Myc Family and the Metastasis Suppressor NDRG1: Targeting Key Molecular Interactions with Innovative Therapeutics

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Immunosurveillance encounters cancer metabolism

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Salivary metabolomics for cancer detection

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Metabolic reprogramming as an emerging mechanism of resistance to endocrine therapies in prostate cancer

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A Potential “Anti-Warburg Effect” in Circulating Tumor Cell-mediated Metastatic Progression?

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CDK9 Inhibitor Induces the Apoptosis of B-Cell Acute Lymphocytic Leukemia by Inhibiting c-Myc-Mediated Glycolytic Metabolism

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Elevated ATGL in colon cancer cells and cancer stem cells promotes metabolic and tumorigenic reprogramming reinforced by obesity

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Tumor suppression by the EGR1, DMP1, ARF, p53, and PTEN Network

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MYCN and PRC1 cooperatively repress docosahexaenoic acid synthesis in neuroblastoma via ELOVL2

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MYC Ran Up the Clock: The Complex Interplay between MYC and the Molecular Circadian Clock in Cancer

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METTL13 inhibits progression of clear cell renal cell carcinoma with repression on PI3K/AKT/mTOR/HIF-1α pathway and c-Myc expression

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MYC Drives mRNA Pseudouridylation to Mitigate Proliferation-Induced Cellular Stress during Cancer Development

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Tumor Metabolism as a Regulator of Tumor–Host Interactions in the B-Cell Lymphoma Microenvironment—Fueling Progression and Novel Brakes for Therapy

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Metabolic Roles of Androgen Receptor and Tip60 in Androgen-Dependent Prostate Cancer

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c-Myc protects hepatocellular carcinoma cell from ferroptosis induced by glutamine deprivation via upregulating GOT1 and Nrf2

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A novel MYC-ZNF706-SLC7A11 regulatory circuit contributes to cancer progression and redox balance in human hepatocellular carcinoma

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Natural Products and Altered Metabolism in Cancer: Therapeutic Targets and Mechanisms of Action

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A Computational Framework for Prediction and Analysis of Cancer Signaling Dynamics from RNA Sequencing Data—Application to the ErbB Receptor Signaling Pathway

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Crosstalk between oncogenic MYC and noncoding RNAs in cancer

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Polyamine metabolism and anti-tumor immunity

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c-Myc plays a key role in IFN-γ-induced persistence of Chlamydia trachomatis

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Pharmacological inhibition of Lin28 promotes ketogenesis and restores lipid homeostasis in models of non-alcoholic fatty liver disease

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MYC modulators in cancer: a patent review

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Inhibition of hepatocellular carcinoma by metabolic normalization

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Transcriptomics and Metabolomics Integration Reveals Redox-Dependent Metabolic Rewiring in Breast Cancer Cells

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Metabolism in Cancer Stem Cells: Targets for Clinical Treatment

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MYC as a Target for Cancer Treatment: from Undruggable to Druggable?

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c-MYC and HIF1α promoter G-quadruplexes dependent metabolic regulation mechanism of berberine in colon cancer

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TIPE3 promotes non-small cell lung cancer progression via the protein kinase B/extracellular signal-regulated kinase 1/2-glycogen synthase kinase 3β-β-catenin/Snail axis

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Discovery and Synthesis of a Pyrimidine-Based Aurora Kinase Inhibitor to Reduce Levels of MYC Oncoproteins

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Metabolomics: A New Era in the Diagnosis or Prognosis of B-Cell Non-Hodgkin’s Lymphoma

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Regulation of cancer cell metabolism: Oncogenic MYC in the driver’s seat

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Rewired Metabolism Caused by the Oncogenic Deregulation of MYC as an Attractive Therapeutic Target in Cancers

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