Cited by 193Circadian rhythm and melatoninPancreatic function and diabetesDiabetes Treatment and Management

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Melatonin Effects on Glucose Metabolism: Time To Unlock the Controversy

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Garaulet, Marta, Qian, Jingyi, Florez, Jose C., Arendt, Josephine, Saxena, Richa, Scheer, Frank A.J.L.·2020·Trends in Endocrinology & Metabolism

DOI 10.1016/j.tem.2019.11.011PMC PMC7349733

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Abstract

The past decade has witnessed a revival of interest in the hormone melatonin, partly attributable to the discovery that genetic variation in MTNR1B - the melatonin receptor gene - is a risk factor for impaired fasting glucose and type 2 diabetes (T2D). Despite intensive investigation, there is considerable confusion and seemingly conflicting data on the metabolic effects of melatonin and MTNR1B variation, and disagreement on whether melatonin is metabolically beneficial or deleterious, a crucial issue for melatonin agonist/antagonist drug development and dosing time. We provide a conceptual framework - anchored in the dimension of 'time' - to reconcile paradoxical findings in the literature. We propose that the relative timing between elevated melatonin concentrations and glycemic challenge should be considered to better understand the mechanisms and therapeutic opportunities of melatonin signaling in glycemic health and disease.

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Authors: Garaulet, M., Qian, J., Florez, J. C., Arendt, J., Saxena, R., & Scheer, F. A. J. L.
Affiliations: Brigham and Women's Hospital (US)
Broad Institute (US)
Corresponding author: Saxena, Richa
Scheer, Frank A.J.L.
ORCID: Garaulet, Marta
Qian, Jingyi
Saxena, Richa
Scheer, Frank A.J.L.
Venue: Trends in Endocrinology & Metabolism
Publisher: Elsevier BV
Published: 2020-03
Volume: 31
Issue: 3
Pages: 192-204
ISSN: 1043-2760 (ISSN-L)
DOI: 10.1016/j.tem.2019.11.011
PMC: PMC7349733
OpenAlex: W2997273097
Cited by: 193
References: 94
Citations by year: 2026: 28 · 2025: 22 · 2024: 42 · 2023: 32 · 2022: 38 · 2021: 19 · 2020: 12
FWCI: 3.41
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Trends in Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: The Spanish Government of Investigation, Development and Innovation (SAF2017-84135-R)
NIH (R01DK105072, R01DK102696, R01DK107859, R01HL118601, R01DK099512, R01HL140574)
American Diabetes Association (1-17-PDF-103)
NIDDK (P30 DK057521, R01 DK105072, K24 DK110550)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords: melatonin, glucose metabolism, MTNR1B, melatonin receptors, type 2 diabetes, impaired fasting glucose, genetic variation, melatonin receptor agonists, circadian rhythm, drug dosing
MeSH terms: Animals, Blood Glucose, Circadian Rhythm, Diabetes Mellitus, Type 2, Glucose, Humans, Insulin, Melatonin, Genetic Variation, Polymorphism, Single Nucleotide, Receptor, Melatonin, MT2, Carbohydrate Metabolism

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