Impact of circadian disruption on glucose metabolism: implications for type 2 diabetes
Open accessAbstract
The circadian system generates endogenous rhythms of approximately 24 h, the synchronisation of which are vital for healthy bodily function. The timing of many physiological processes, including glucose metabolism, are coordinated by the circadian system, and circadian disruptions that desynchronise or misalign these rhythms can result in adverse health outcomes. In this review, we cover the role of the circadian system and its disruption in glucose metabolism in healthy individuals and individuals with type 2 diabetes mellitus. We begin by defining circadian rhythms and circadian disruption and then we provide an overview of circadian regulation of glucose metabolism. We next discuss the impact of circadian disruptions on glucose control and type 2 diabetes. Given the concurrent high prevalence of type 2 diabetes and circadian disruption, understanding the mechanisms underlying the impact of circadian disruption on glucose metabolism may aid in improving glycaemic control.
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Recent work has recognised the importance of understanding the impact of chronodisruption on glucose metabolism.
“Recent work has recognised the importance of understanding the impact of chronodisruption on glucose metabolism ( 16 ),”
From Dynamic modulation of glucose utilisation by glucocorticoid rhythms in health and disease (2020) · cites this paper as [16]
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Melatonin effects on glucose metabolism: time to unlock the controversy
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- Authors
- Mason, I. C., Qian, J., Adler, G. K., & Scheer, F. A. J. L.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Scheer, Frank A. J. L.
- Venue
- Diabetologia
- Published
- 2020-01-08
- Volume
- 63
- Issue
- 3
- Pages
- 462-472
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- PMC
- PMC7002226
- OpenAlex
- W3000654447
- Cited by
- 359
- References
- 19
- Citations by year
- 2026: 49 · 2025: 72 · 2024: 73 · 2023: 60 · 2022: 51 · 2021: 36 · 2020: 17 · 2018: 1
- FWCI
- 5.53
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Diabetologia (publishedVersion, cc-by)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR002541)
- National Heart, Lung, and Blood Institute (R01HL140574, R01HL118601, T32HL007609, K24HL103845, T32HL007901)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK099512, R01DK105072, R01DK102696)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Keywords
- circadian rhythm disruption, circadian rhythm, glucose metabolism, type 2 diabetes, glycemic control
- MeSH terms
- Animals, Blood Glucose, Circadian Rhythm, Diabetes Mellitus, Type 2, Glucose, Humans, Risk Factors, Sleep, Chronobiology Disorders, Carbohydrate Metabolism, Insulin-Secreting Cells
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