Mapk signal specificity: The right place at the right time

Murphy, Leon O.; Blenis, John

doi:10.1016/j.tibs.2006.03.009

Cited by 707Protein Kinase Regulation and GTPase SignalingMelanoma and MAPK PathwaysProtein Tyrosine Phosphatases

Mapk signal specificity: The right place at the right time

Murphy, Leon O., Blenis, John·2006·Trends in Biochemical Sciences

DOI 10.1016/j.tibs.2006.03.009

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Abstract

Although the mechanisms that lead to activation of the Ras, extracellular-signal-regulated kinase mitogen-activated protein kinase (Ras/ERK-MAPK) signaling pathway have been studied intensively, the fundamental principles that determine how activation of ERK signaling can result in distinct biological outcomes have only recently received attention. Factors such as cell-surface receptor density, expression of scaffolding proteins, the surrounding extracellular matrix, and the interplay between kinases and phosphatases modulate the strength and duration of ERK signaling. Furthermore, the spatial distribution and temporal qualities of ERK can markedly alter the qualitative and quantitative features of downstream signaling to immediate early genes (IEG) and the expression of IEG-encoded protein products. As a result, IEG products provide a molecular interpretation of ERK dynamics, enabling the cell to program an appropriate biological response.

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Authors: Murphy, L. O., & Blenis, J.
Affiliations: Harvard University (US)
Corresponding author: Blenis, John
ORCID: Blenis, John
Venue: Trends in Biochemical Sciences
Publisher: Elsevier BV
Published: 2006-05
Volume: 31
Issue: 5
Pages: 268-275
ISSN: 0968-0004 (ISSN-L)
DOI: 10.1016/j.tibs.2006.03.009
OpenAlex: W2009707997
Cited by: 707
References: 82
Citations by year: 2026: 18 · 2025: 6 · 2024: 24 · 2023: 20 · 2022: 21 · 2021: 20 · 2020: 21 · 2019: 28 · 2018: 29 · 2017: 37 · 2016: 34 · 2015: 27 · 2014: 45 · 2013: 43 · 2012: 47
FWCI: 4.80
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Biochemical Sciences (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Cancer Institute (R01-CA46595, R01CA046595)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
Keywords: MAPK signaling, ERK signaling, Ras/ERK pathway, signaling specificity, immediate early genes, scaffold proteins, extracellular matrix, kinases and phosphatases, downstream gene expression
MeSH terms: Animals, Enzyme Activation, Humans, Models, Biological, Signal Transduction, Genes, Immediate-Early, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3

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