PP2A holoenzyme assembly: in cauda venenum (the sting is in the tail)

Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

Janssens, V., & Goris, J. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3530417 · Cited by 1,927

A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells

Yeh, E., Cunningham, M., Arnold, H., Chasse, D., Monteith, T., Ivaldi, G., Hahn, W. C., Stukenberg, P. T., Shenolikar, S., Uchida, T., et al. (2004) · Nature Cell Biology · doi:10.1038/ncb1110 · Cited by 791

CIP2A inhibits PP2A in human malignancies

Junttila, M. R., Puustinen, P., Niemelä, M., Ahola, R., Arnold, H., Böttzauw, T., Ala-aho, R., Nielsen, C., Ivaska, J., Taya, Y., et al. (2007) · Cell · doi:10.1016/j.cell.2007.04.044 · Cited by 677

Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation

Chen, J., Martin, B. L., & Brautigan, D. L. (1992) · Science · doi:10.1126/science.1325671 · Cited by 601

The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein

Neviani, P., Santhanam, R., Trotta, R., Notari, M., Blaser, B. W., Liu, S., Mao, H. C., Chang, J. S., Galietta, A., Uttam, A., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.10.015 · Cited by 481

Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme

Cho, U. S., & Xu, W. (2007) · Nature · doi:10.1038/nature05351 · Cited by 459

Structure of the Protein Phosphatase 2A Holoenzyme

Xu, Y., Xing, Y., Chen, Y., Chao, Y., Lin, Z., Fan, E., Yu, J. W., Strack, S., Jeffrey, P. D., & Shi, Y. (2006) · Cell · doi:10.1016/j.cell.2006.11.033 · Cited by 450

The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs

Groves, M. R., Hanlon, N., Turowski, P., Hemmings, B. A., & Barford, D. (1999) · Cell · doi:10.1016/s0092-8674(00)80963-0 · Cited by 442

PP2A: the expected tumor suppressor

Janssens, V., Goris, J., & Van Hoof, C. (2005) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2004.12.004 · Cited by 426

Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast

Jiang, Y., & Broach, J. (1999) · EMBO Journal · doi:10.1093/emboj/18.10.2782 · Cited by 363

Molecular mechanisms of theprotein serine/threonine phosphatases

Barford, D. (1996) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(96)10060-8 · Cited by 357

Multiple pathways regulated by the tumor suppressor PP2A in transformation

Westermarck, J., & Hahn, W. C. (2008) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2008.02.001 · Cited by 344

Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins

Xing, Y., Xu, Y., Chen, Y., Jeffrey, P. D., Chao, Y., Lin, Z., Li, Z., Strack, S., Stock, J. B., & Shi, Y. (2006) · Cell · doi:10.1016/j.cell.2006.09.025 · Cited by 334

Protein phosphatase 2A: the Trojan Horse of cellular signaling

Sontag, E. (2001) · Cellular Signalling · doi:10.1016/s0898-6568(00)00123-6 · Cited by 330

Identification of specific PP2A complexes involved in human cell transformation

Chen, W., Possemato, R., Campbell, K. T., Plattner, C. A., Pallas, D. C., & Hahn, W. C. (2004) · Cancer Cell · doi:10.1016/s1535-6108(04)00026-1 · Cited by 325

Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites

Ory, S., Zhou, M., Conrads, T. P., Veenstra, T. D., & Morrison, D. K. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00535-9 · Cited by 296

Actions of PP2A on the MAP kinase pathway and apoptosis are mediated by distinct regulatory subunits

Silverstein, A. M., Barrow, C. A., Davis, A. J., & Mumby, M. C. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.072071699 · Cited by 276

Carboxyl methylation regulates phosphoprotein phosphatase 2A by controlling the association of regulatory B subunits

Tolstykh, T., Lee, J., Vafai, S. B., & Stock, J. B. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5682 · Cited by 239

Involvement of PP2A in viral and cellular transformation

Arroyo, J. D., & Hahn, W. C. (2005) · Oncogene · doi:10.1038/sj.onc.1209038 · Cited by 237

Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation

Sontag, E., Nunbhakdi-Craig, V., Sontag, J.-M., Diaz-Arrastia, R., Ogris, E., Dayal, S., Lentz, S. R., Arning, E., & Bottiglieri, T. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3316-06.2007 · Cited by 225

B56‐containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX‐1 and ERK

Letourneux, C., Rocher, G., & Porteu, F. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7600980 · Cited by 224

Cyclin G2 Associates with Protein Phosphatase 2A Catalytic and Regulatory B′ Subunits in Active Complexes and Induces Nuclear Aberrations and a G1/S Phase Cell Cycle Arrest

Bennin, D. A., Don, A. S. A., Brake, T., McKenzie, J. L., Rosenbaum, H., Ortiz, L., DePaoli-Roach, A. A., & Horne, M. C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111693200 · Cited by 215

Cyclin G Recruits PP2A to Dephosphorylate Mdm2

Okamoto, K., Li, H., Jensen, M. R., Zhang, T., Taya, Y., Thorgeirsson, S. S., & Prives, C. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00504-x · Cited by 215

The Tumor Suppressor PP2A Aβ Regulates the RalA GTPase

Sablina, A. A., Chen, W., Arroyo, J. D., Corral, L. G., Hector-Greene, M., Bulmer, S. E., DeCaprio, J. A., & Hahn, W. C. (2007) · Cell · doi:10.1016/j.cell.2007.03.047 · Cited by 207

Downregulation of Protein Phosphatase 2A Carboxyl Methylation and Methyltransferase May Contribute to Alzheimer Disease Pathogenesis

Sontag, E., Hladik, C. L., Montgomery, L. G., Luangpirom, A., Mudrak, I., Ogris, E., & White, C. L. (2004) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/63.10.1080 · Cited by 195

WD40 Repeat Proteins Striatin and S/G2 Nuclear Autoantigen Are Members of a Novel Family of Calmodulin-binding Proteins That Associate with Protein Phosphatase 2A

Moreno, C. S., Park, S., Nelson, K., Ashby, D., Hubalek, F., Lane, W. S., & Pallas, D. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.8.5257 · Cited by 194

A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A

Ogris, E., Du, X., Nelson, K. C., Mak, E. K., Yu, X. X., Lane, W. S., & Pallas, D. C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.20.14382 · Cited by 191

Role for the PP2A/B56δ Phosphatase in Regulating 14-3-3 Release from Cdc25 to Control Mitosis

Margolis, S. S., Perry, J. A., Forester, C. M., Nutt, L. K., Guo, Y., Jardim, M. J., Thomenius, M. J., Freel, C. D., Darbandi, R., Ahn, J., et al. (2006) · Cell · doi:10.1016/j.cell.2006.10.035 · Cited by 187

Carboxyl methylation of the phosphoprotein phosphatase 2A catalytic subunit promotes its functional association with regulatory subunits in vivo

Wu, J., Tolstykh, T., Lee, J., Boyd, K., Stock, J. B., & Broach, J. R. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5672 · Cited by 186

Selection of protein phosphatase 2A regulatory subunits is mediated by the C terminus of the catalytic Subunit

Longin, S., Zwaenepoel, K., Louis, J. V., Dilworth, S., Goris, J., & Janssens, V. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704059200 · Cited by 184

Separation of PP2A core enzyme and holoenzyme with monoclonal antibodies against the regulatory A subunit: abundant expression of both forms in cells

Kremmer, E., Ohst, K., Kiefer, J., Brewis, N., & Walter, G. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.3.1692 · Cited by 175

Dynamic nucleosomes and gene transcription

Mellor, J. (2006) · Trends in Genetics · doi:10.1016/j.tig.2006.03.008 · Cited by 174

Methylated C-terminal leucine residue of PP2A catalytic subunit is important for binding of regulatory Bα subunit

BRYANT, J. C., Westphal, R. S., & Wadzinski, B. E. (1999) · Biochemical Journal · doi:10.1042/bj3390241 · Cited by 173

Autophosphorylation-activated protein kinase phosphorylates and inactivates protein phosphatase 2A.

Guo, H., & Damuni, Z. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.6.2500 · Cited by 161

Methylation of the Protein Phosphatase 2A Catalytic Subunit Is Essential for Association of Bα Regulatory Subunit But Not SG2NA, Striatin, or Polyomavirus Middle Tumor Antigen

Yu, X. X., Du, X., Moreno, C. S., Green, R. E., Ogris, E., Feng, Q., Chou, L., McQuoid, M. J., & Pallas, D. C. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.1.185 · Cited by 160

Disruption of protein phosphatase 2A subunit interaction in human cancers with mutations in the Aα subunit gene

Ruediger, R., Pham, H. T., & Walter, G. (2001) · Oncogene · doi:10.1038/sj.onc.1204059 · Cited by 153

Purification of Porcine Brain Protein Phosphatase 2A Leucine Carboxyl Methyltransferase and Cloning of the Human Homologue,

BAERE, I. D., Derua, R., Janssens, V., Hoof, C. A. V., Waelkens, E., Merlevede, W. J., & Goris, J. (1999) · Biochemistry · doi:10.1021/bi991646a · Cited by 145

Critical Role for Protein Phosphatase 2A Heterotrimers in Mammalian Cell Survival

Strack, S., Cribbs, J. T., & Gomez, L. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408015200 · Cited by 144

B56-Associated Protein Phosphatase 2A Is Required For Survival and Protects from Apoptosis in Drosophila melanogaster

Li, X., Scuderi, A., Letsou, A., & Virshup, D. M. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.11.3674-3684.2002 · Cited by 137

Protein phosphatase 2A subunit assembly: The catalytic subunit carboxy terminus is important for binding cellular B subunit but not polyomavirus middle tumor antigen

Ogris, E., Gibson, D. M., & Pallas, D. C. (1997) · Oncogene · doi:10.1038/sj.onc.1201259 · Cited by 134

Carboxymethylation of the PP2A Catalytic Subunit in Saccharomyces cerevisiae Is Required for Efficient Interaction with the B-type Subunits Cdc55p and Rts1p

Wei, H., Ashby, D. G., Moreno, C. S., Ogris, E., Yeong, F. M., Corbett, A. H., & Pallas, D. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008694200 · Cited by 128

Alterations in protein phosphatase 2A subunit interaction in human carcinomas of the lung and colon with mutations in the Aβ subunit gene

Ruediger, R., Pham, H. T., & Walter, G. (2001) · Oncogene · doi:10.1038/sj.onc.1204279 · Cited by 127

Structural Basis of PP2A Inhibition by Small t Antigen

Cho, U., Morrone, S. R., Sablina, A. A., Arroyo, J. D., Hahn, W. C., & Xu, W. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050202 · Cited by 124

Drosophila mutants in the 55 kDa regulatory subunit of protein phosphatase 2A show strongly reduced ability to dephosphorylate substrates of p34cdc2

Mayer-Jaekel, R. E., Ohkura, H., Ferrigno, P. K., Andjelković, N., Shiomi, K., Uemura, T., Glover, D. M., & Hemmings, B. A. (1994) · Journal of Cell Science · doi:10.1242/jcs.107.9.2609 · Cited by 107

An inactive protein phosphatase 2A population is associated with methylesterase and can be re-activated by the phosphotyrosyl phosphatase activator

Longin, S., Jordens, J., MARTENS, E., Stevens, I., Janssens, V., Rondelez, E., BAERE, I. D., Derua, R., Waelkens, E., Goris, J., et al. (2004) · Biochemical Journal · doi:10.1042/bj20031643 · Cited by 106

A novel and essential mechanism determining specificity and activity of protein phosphatase 2A (PP2A) in vivoPreprint

Fellner, T., Lackner, D. H., Hombauer, H., Piribauer, P., Mudrak, I., Zaragoza, K., Juno, C., & Ogris, E. (2003) · Genes & Development · doi:10.1101/gad.259903 · Cited by 105

Specificity of the polycation‐stimulated (type‐2A) and ATP, Mg‐dependent (type‐1) protein phosphatases toward substrates phosphorylated by P34cdc2 kinase

Agostinis, P., Derua, R., Sarno, S., Goris, J., & Merlevede, W. J. (1992) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1992.tb16774.x · Cited by 105

The Protein Phosphatase 2A Phosphatase Activator Is a Novel Peptidyl-Prolyl cis/trans-Isomerase

Jordens, J., Janssens, V., Longin, S., Stevens, I., Martens, E., Bultynck, G., Engelborghs, Y., Lescrinier, E., Waelkens, E., Goris, J., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507760200 · Cited by 105

The B″/PR72 subunit mediates Ca 2+ -dependent dephosphorylation of DARPP-32 by protein phosphatase 2A

Ahn, J., Sung, J. Y., McAvoy, T., Nishi, A., Janssens, V., Goris, J., Greengard, P., & Nairn, A. C. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703589104 · Cited by 102

Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: Differences in expression, subunit interaction, and evolution

ZHOU, J., PHAM, H. T., RUEDIGER, R., & WALTER, G. (2003) · Biochemical Journal · doi:10.1042/bj20021244 · Cited by 95

Mutation of Tyr307 and Leu309 in the Protein Phosphatase 2A Catalytic Subunit Favors Association with the α4 Subunit Which Promotes Dephosphorylation of Elongation Factor-2

Chung, H., Nairn, A. C., Murata, K., & Brautigan, D. L. (1999) · Biochemistry · doi:10.1021/bi990902g · Cited by 90

Structural and biochemical insights into the regulation of protein phosphatase 2A by small t antigen of SV40

Chen, Y., Xu, Y., Bao, Q., Xing, Y., Li, Z., Lin, Z., Stock, J. B., Jeffrey, P. D., & Shi, Y. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1254 · Cited by 89

Identification and functional analysis of two Ca2+-binding EF-hand motifs in the B″/PR72 subunit of protein phosphatase 2A

Janssens, V., Jordens, J., Stevens, I., Van Hoof, C., Martens, E., De Smedt, H., Engelborghs, Y., Waelkens, E., & Goris, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211717200 · Cited by 89

Generation of Active Protein Phosphatase 2A Is Coupled to Holoenzyme Assembly

Hombauer, H., Weismann, D., Mudrak, I., Stanzel, C., Fellner, T., Lackner, D. H., & Ogris, E. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050155 · Cited by 88

Structure of Protein Phosphatase Methyltransferase 1 (PPM1), a Leucine Carboxyl Methyltransferase Involved in the Regulation of Protein Phosphatase 2A Activity

Leulliot, N., Quevillon‐Chéruel, S., Sorel, I., de la Sierra-Gallay, I. L., Collinet, B., Graille, M., Blondeau, K., Bettache, N., Anne Poupon, B., Janin, J., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311484200 · Cited by 86

Protein Phosphatase 2A Holoenzyme Assembly

Strack, S., Ruediger, R., Walter, G., Dagda, R. K., Barwacz, C. A., & Cribbs, J. T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202992200 · Cited by 83

Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A

Li, X., & Virshup, D. M. (2002) · European Journal of Biochemistry · doi:10.1046/j.0014-2956.2001.02680.x · Cited by 83

Identification of a PP2A-interacting protein that functions as a negative regulator of phosphatase activity in the ATM/ATR signaling pathway

McConnell, J. L., Gomez, R. J., McCorvey, L. R. A., Law, B. K., & Wadzinski, B. E. (2007) · Oncogene · doi:10.1038/sj.onc.1210406 · Cited by 80

Localization ofSaccharomyces cerevisiaeProtein Phosphatase 2A Subunits throughout Mitotic Cell Cycle

Gentry, M. S., & Hallberg, R. L. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.02-05-0065 · Cited by 78

Expression of protein phosphatase 2A mutants and silencing of the regulatory Bα subunit induce a selective loss of acetylated and detyrosinated microtubules

Nunbhakdi‐Craig, V., Schüchner, S., Sontag, J., Montgomery, L. G., Pallas, D. C., Juno, C., Mudrak, I., Ogris, E., & Sontag, E. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04503.x · Cited by 72

Spatial control of protein phosphatase 2A (de)methylation

Longin, S., Zwaenepoel, K., Martens, E., Louis, J. V., Rondelez, E., Goris, J., & Janssens, V. (2007) · Experimental Cell Research · doi:10.1016/j.yexcr.2007.07.030 · Cited by 59

Genomic organisation, chromosomal localisation tissue distribution and developmental regulation of the PR61/B′ regulatory subunits of protein phosphatase 2A in mice

Martens, E., Stevens, I., Janssens, V., Vermeesch, J., Götz, J., Goris, J., & Van Hoof, C. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2003.12.047 · Cited by 57

Crystal Structure of the PP2A Phosphatase Activator: Implications for Its PP2A-Specific PPIase Activity

Leulliot, N., Vicentini, G., Jordens, J., Quevillon‐Chéruel, S., Schiltz, M., Barford, D., TILBEURGH, H. V., & Goris, J. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.07.008 · Cited by 52

Binding Specificity of Protein Phosphatase 2A Core Enzyme for Regulatory B Subunits and T Antigens

Ruediger, R., Fields, K., & Walter, G. (1999) · Journal of Virology · doi:10.1128/jvi.73.1.839-842.1999 · Cited by 49

Mutation of the C-terminal leucine residue of PP2Ac inhibits PR55/B subunit binding and confers supersensitivity to microtubule destabilization in Saccharomyces cerevisiae

Evans, D. R., & Hemmings, B. A. (2000) · Molecular Genetics and Genomics · doi:10.1007/s004380000302 · Cited by 47

A Novel Assay for Protein Phosphatase 2A (PP2A) Complexes In Vivo Reveals Differential Effects of Covalent Modifications on Different Saccharomyces cerevisiae PP2A Heterotrimers

Gentry, M. S., Li, Y., Wei, H., Syed, F. F., Patel, S. H., Hallberg, R. L., & Pallas, D. C. (2005) · Eukaryotic Cell · doi:10.1128/ec.4.6.1029-1040.2005 · Cited by 45

ATM-dependent Dissociation of B55 Regulatory Subunit from Nuclear PP2A in Response to Ionizing Radiation

Guo, C. Y., Brautigan, D. L., & Larner, J. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110092200 · Cited by 43

The Structure of Tap42/α4 Reveals a Tetratricopeptide Repeat-like Fold and Provides Insights into PP2A Regulation,

Yang, J., Roe, S. M., Prickett, T. D., Brautigan, D. L., & Barford, D. (2007) · Biochemistry · doi:10.1021/bi7007118 · Cited by 39

MCM3-binding GANP DNA-primase is associated with a novel phosphatase component G5PR

Kono, Y., Maeda, K., Kuwahara, K., Yamamoto, H., Miyamoto, E., Yonezawa, K., Takagi, K., & Sakaguchi, N. (2002) · Genes to Cells · doi:10.1046/j.1365-2443.2002.00562.x · Cited by 35

Methylation of the C-terminal leucine residue of the PP2A catalytic subunit is unnecessary for the catalytic activity and the binding of regulatory subunit (PR55/B)

Ikehara, T., Ikehara, S., Imamura, S., Shinjo, F., & Yasumoto, T. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.01.085 · Cited by 33

The Formation and Activity of PP2A Holoenzymes Do Not Depend on the Isoform of the Catalytic Subunit

Zhou, J., Pham, H. T., & Walter, G. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211181200 · Cited by 30

The Scaffolding A/Tpd3 Subunit and High Phosphatase Activity Are Dispensable for Cdc55 Function in the Saccharomyces cerevisiae Spindle Checkpoint and in Cytokinesis

Koren, R. N., Rainis, L., & Kleinberger, T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409359200 · Cited by 28

Identification and characterization of B′′‐subunits of protein phosphatase 2 A in Xenopus laevis oocytes and adult tissues

Stevens, I., Janssens, V., Martens, E., Dilworth, S., Goris, J., & HOOF, C. V. (2003) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2003.03398.x · Cited by 24

Domains Necessary for Gα12 Binding and Stimulation of Protein Phosphatase-2A (PP2A): Is Gα12 a Novel Regulatory Subunit of PP2A?

Zhu, D., Tate, R. I., Ruediger, R., Meigs, T. E., & Denker, B. M. (2007) · Molecular Pharmacology · doi:10.1124/mol.106.033555 · Cited by 22

11 Reversible methylation of protein phosphatase 2A

Longin, S., & Goris, J. (2006) · The Enzymes · doi:10.1016/s1874-6047(06)80013-2 · Cited by 8

Serine/threonine phosphatases: mechanism through structure

Shi, Y. (2009) · Cell · doi:10.1016/j.cell.2009.10.006 · Cited by 1,488

Wnt/β-catenin signaling in cancers and targeted therapies

Yu, F., Yu, C., Li, F., Zuo, Y., Wang, Y., Yao, L., Wu, C., Wang, C., & Ye, L. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00701-5 · Cited by 734

From Promiscuity to Precision: Protein Phosphatases Get a Makeover

Virshup, D. M., & Shenolikar, S. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.02.015 · Cited by 643

Brassinosteroid Signal Transduction: From Receptor Kinase Activation to Transcriptional Networks Regulating Plant Development

Clouse, S. D. (2011) · The Plant Cell · doi:10.1105/tpc.111.084475 · Cited by 573

The extended PP1 toolkit: designed to create specificity

Bollen, M., Peti, W., Ragusa, M. J., & Beullens, M. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.03.002 · Cited by 524

Structural Genetics to Understand Holoenzyme Assembly and Substrate Selection of Diverse Multimeric Serine-threonine Phosphatases

Huang, W., Veis, J., Day, A., Cui, S., Leonard, D., Narla, G., Ogris, E., & Taylor, D. J. (2024) · Microscopy and Microanalysis · doi:10.1093/mam/ozae044.354

Determinants for Substrate Specificity of Protein Phosphatase 2A

Slupe, A. M., Merrill, R. A., & Strack, S. (2011) · Enzyme Research · doi:10.4061/2011/398751 · Cited by 91

Recent insights into Protein Phosphatase 2A structure and regulation: the reasons why PP2A is no longer considered as a lazy passive housekeeping enzyme

Martin, M., Kettmann, R., & Dequiedt, S. (2010) · Open Repository and Bibliography (University of Liège) · Cited by 10

The biogenesis of active protein phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificity

Sents, W., Ivanova, E., Lambrecht, C., Haesen, D., & Janssens, V. (2013) · The FEBS Journal · doi:10.1111/j.1742-4658.2012.08579.x · Cited by 204

Assembly and structure of protein phosphatase 2A

Shi, Y. (2009) · Science in China Series C Life Sciences · doi:10.1007/s11427-009-0018-3 · Cited by 56