Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: Differences in expression, subunit interaction, and evolution

Analysis of the genome sequence of the flowering plant Arabidopsis thaliana

Initiative, T. A. G. (2000) · Nature · doi:10.1038/35048692 · Cited by 9,301 · see citing works

Antibodies: A laboratory manual

J.L. (1989) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(89)90307-1 · Cited by 5,141 · see citing works

Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

Janssens, V., & Goris, J. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3530417 · Cited by 1,890 · see citing works

Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

Janssens, V., & Goris, J. (2001) · Biochemical Journal · doi:10.1042/bj3530417 · Cited by 1,392 · see citing works

Proteins: Structures and molecular properties

Rb, F. (1985) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(85)90239-7 · Cited by 669 · see citing works

Protein serine/threonine phosphatases: structure, regulation, and functions in cell growth

Mumby, M. C., & Walter, G. (1993) · Physiological Reviews · doi:10.1152/physrev.1993.73.4.673 · Cited by 661 · see citing works

Protein phosphatases come of age

Cohen, P. T. W., & Cohen, P. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)88197-6 · Cited by 604 · see citing works

Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A

Pallas, D. C., Shahrik, L. K., Martin, B. L., Jaspers, S. R., Miller, T. B., Brautigan, D. L., & Roberts, T. M. (1990) · Cell · doi:10.1016/0092-8674(90)90726-u · Cited by 573 · see citing works

The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs

Groves, M. R., Hanlon, N., Turowski, P., Hemmings, B. A., & Barford, D. (1999) · Cell · doi:10.1016/s0092-8674(00)80963-0 · Cited by 442 · see citing works

The B56 Family of Protein Phosphatase 2A (PP2A) Regulatory Subunits Encodes Differentiation-induced Phosphoproteins That Target PP2A to Both Nucleus and Cytoplasm

McCright, B., Rivers, A. M., Audlin, S., & Virshup, D. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.36.22081 · Cited by 382 · see citing works

Alterations of the PPP2R1B Gene in Human Lung and Colon Cancer

Wang, S. S., Esplin, E. D., Li, J. L., Huang, L., Gazdar, A. F., Minna, J. D., & Evans, G. A. (1998) · Science · doi:10.1126/science.282.5387.284 · Cited by 363 · see citing works

A mutation in protein phosphatase 2A regulatory subunit A affects auxin transport in Arabidopsis.

Garbers, C., DeLong, A., Deruère, J., Bernasconi, P., & Söll, D. G. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00565.x · Cited by 264 · see citing works

Control of Protein Phosphatase 2A by Simian Virus 40 Small-t Antigen

Yang, S., Lickteig, R. L., Estes, R., Rundell, K., Walter, G., & Mumby, M. C. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.4.1988-1995.1991 · Cited by 246 · see citing works

Alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure

Hemmings, B. A., Adams-Pearson, C., Maurer, F., Mueller, P., Goris, J., Merlevede, W., Hofsteenge, J., & Stone, S. R. (1990) · Biochemistry · doi:10.1021/bi00465a002 · Cited by 243 · see citing works

Human glioblastoma cells release interleukin 6 in vivo and in vitro.

Meir, E. G. V., Sawamura, Y., Diserens, A. C., Hamou, M., & de Tribolet, N. (1990) · PubMed · Cited by 235 · see citing works

Identification of Members of the Protein Phosphatase 1 Gene Family in the Rat and Enhanced Expression of Protein Phosphatase 1α Gene in Rat Hepatocellular Carcinomas

Sasaki, K., Shima, H., Kitagawa, Y., Irino, S., Sügimura, T., & Nagao, M. (1990) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1990.tb02690.x · Cited by 225 · see citing works

Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Cα

Götz, J., Probst, A., Ehler, E., Hemmings, B., & Kues, W. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.21.12370 · Cited by 220 · see citing works

Low frequency of alterations of the α (PPP2R1A) and β (PPP2R1B) isoforms of the subunit A of the serine-threonine phosphatase 2A in human neoplasms

Calin, G. A., di Iasio, M. G., Caprini, E., Vorechovsky, I., Natali, P. G., Sozzi, G., Croce, C. M., Barbanti-Brodano, G., Russo, G., & Negrini, M. (2000) · Oncogene · doi:10.1038/sj.onc.1203389 · Cited by 219 · see citing works

Association of protein phosphatase 2A with polyoma virus medium tumor antigen.

Walter, G., Ruediger, R., Slaughter, C. A., & Mumby, M. C. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.7.2521 · Cited by 209 · see citing works

Separation of PP2A core enzyme and holoenzyme with monoclonal antibodies against the regulatory A subunit: abundant expression of both forms in cells

Kremmer, E., Ohst, K., Kiefer, J., Brewis, N., & Walter, G. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.3.1692 · Cited by 175 · see citing works

Disruption of protein phosphatase 2A subunit interaction in human cancers with mutations in the Aα subunit gene

Ruediger, R., Pham, H. T., & Walter, G. (2001) · Oncogene · doi:10.1038/sj.onc.1204059 · Cited by 149 · see citing works

Molecular model of the A subunit of protein phosphatase 2A: interaction with other subunits and tumor antigens

Ruediger, R., Hentz, M., Fait, J., Mumby, M. C., & Walter, G. (1994) · Journal of Virology · doi:10.1128/jvi.68.1.123-129.1994 · Cited by 142 · see citing works

Identification of Binding Sites on the Regulatory A Subunit of Protein Phosphatase 2A for the Catalytic C Subunit and for Tumor Antigens of Simian Virus 40 and Polyomavirus

Ruediger, R., Roeckel, D., Fait, J., Bergqvist, A., Magnusson, G., & Walter, G. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.11.4872 · Cited by 136 · see citing works

[21] Progressive alignment of amino acid sequences and construction of phylogenetic trees from them

Feng, D.-F., & Doolittle, R. F. (1996) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(96)66023-6 · Cited by 127 · see citing works

Alterations in protein phosphatase 2A subunit interaction in human carcinomas of the lung and colon with mutations in the Aβ subunit gene

Ruediger, R., Pham, H. T., & Walter, G. (2001) · Oncogene · doi:10.1038/sj.onc.1204279 · Cited by 125 · see citing works

Identification of a Novel Protein Phosphatase 2A Regulatory Subunit Highly Expressed in Muscle

Tehrani, M. A., Mumby, M. C., & Kamibayashi, C. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.9.5164 · Cited by 122 · see citing works

The RCN1‐encoded A subunit of protein phosphatase 2A increases phosphatase activity in vivo

Deruère, J., Jackson, K. M., Garbers, C., Söll, D., & DeLong, A. (1999) · The Plant Journal · doi:10.1046/j.1365-313x.1999.00607.x · Cited by 120 · see citing works

Different Oligomeric Forms of Protein Phosphatase 2A Activate and Inhibit Simian Virus 40 DNA Replication

Cegielska, A., Shaffer, S. A., Derua, R., Goris, J., & Virshup, D. M. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.7.4616 · Cited by 108 · see citing works

Alterations of the PPP2R1B gene located at 11q23 in human colorectal cancers

Takagi, Y., Futamura, M., Yamaguchi, K., Aoki, S., Takahashi, T., & Saji, S. (2000) · Gut · doi:10.1136/gut.47.2.268 · Cited by 90 · see citing works

Constant Expression and Activity of Protein Phosphatase 2A in Synchronized Cells

Ruediger, R., Hood, J., Mumby, M. C., & Walter, G. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.8.4282-4285.1991 · Cited by 89 · see citing works

Distinct role of protein phosphatase 2A subunit Cα in the regulation of E-cadherin and β-catenin during development

Götz, J., Probst, A., Mistl, C., Nitsch, R. M., & Ehler, E. (2000) · Mechanisms of Development · doi:10.1016/s0925-4773(00)00267-7 · Cited by 88 · see citing works

Molecular cloning of a calmodulin-dependent phosphatase from murine testis: identification of a developmentally expressed nonneural isoenzyme.

Muramatsu, T., Giri, P. R., Higuchi, S., & Kincaid, R. L. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.2.529 · Cited by 85 · see citing works

Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A

Li, X., & Virshup, D. M. (2002) · European Journal of Biochemistry · doi:10.1046/j.0014-2956.2001.02680.x · Cited by 83 · see citing works

Molecular cloning and sequence of cDNA encoding polyoma medium tumor antigen-associated 61-kDa protein.

Walter, G., Ferre, F., Espiritu, O., & Carbone, A. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.22.8669 · Cited by 73 · see citing works

Reduced expression of the A? subunit of protein phosphatase 2A in human gliomas in the absence of mutations in the A? and A? subunit genes

Colella, S., Ohgaki, H., Ruediger, R., Yang, F., Nakamura, M., Fujisawa, H., Kleihues, P., & Walter, G. (2001) · International Journal of Cancer · doi:10.1002/ijc.1423 · Cited by 59 · see citing works

Effects of Regulatory Subunits on the Kinetics of Protein Phosphatase 2A

Price, N. E., & Mumby, M. C. (2000) · Biochemistry · doi:10.1021/bi0008478 · Cited by 57 · see citing works

Protein phosphatases possibly involved in rat spermatogenesis

Kitagawa, Y., Sasaki, K., Shima, H., Shibuya, M., Sügimura, T., & Nagao, M. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)91381-2 · Cited by 52 · see citing works

Identification of Binding Sites on the Regulatory A Subunit of Protein Phosphatase 2A for the Catalytic C Subunit and for Tumor Antigens of Simian Virus 40 and Polyomavirus

Ruediger, R., Eckel, D. R., Fait, J., et al. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.11.4872-4882.1992 · Cited by 46 · see citing works

Different Oligomeric Forms of Protein Phosphatase 2A Activate and Inhibit Simian Virus 40 DNA Replication

Cegielska, A., Shaffer, S. A., Derua, R., et al. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.7.4616-4623.1994 · Cited by 40 · see citing works

The PR55 and PR65 Subunits of Protein Phosphatase 2A from Xenopus laevis. Molecular Cloning and Developmental Regulation of Expression

Bosch, M., Cayla, X., Hoof, C. A. V., Hemmings, B. A., Ozon, R., Merlevede, W. J., & Goris, J. (1995) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1995.tb20653.x · Cited by 37 · see citing works

Expression of PP2A B regulatory subunit β isotype in rat testis

Hatano, Y., Shima, H., Haneji, T., MIURA, A. B., Sügimura, T., & Nagao, M. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)81535-8 · Cited by 33 · see citing works

Differentiation of spinous synapses in the mouse organ of corti

Sobkowicz, H. M., Slapnick, S. M., & August, B. K. (2002) · Synapse · doi:10.1002/syn.10080 · Cited by 13 · see citing works

Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer

Seshacharyulu, P., Pandey, P., Datta, K., & Batra, S. K. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.02.036 · Cited by 479 · see citing works

PP2A holoenzyme assembly: In cauda venenum (the sting is in the tail)

Janssens, V., Longin, S., & Goris, J. (2008) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2007.12.004 · Cited by 390 · see citing works

Multiple pathways regulated by the tumor suppressor PP2A in transformation

Westermarck, J., & Hahn, W. C. (2008) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2008.02.001 · Cited by 344 · see citing works

Involvement of PP2A in viral and cellular transformation

Arroyo, J. D., & Hahn, W. C. (2005) · Oncogene · doi:10.1038/sj.onc.1209038 · Cited by 237 · see citing works

The Tumor Suppressor PP2A Aβ Regulates the RalA GTPase

Sablina, A. A., Chen, W., Arroyo, J. D., Corral, L. G., Hector-Greene, M., Bulmer, S. E., DeCaprio, J. A., & Hahn, W. C. (2007) · Cell · doi:10.1016/j.cell.2007.03.047 · Cited by 203 · see citing works

Lessons in Signaling and Tumorigenesis from Polyomavirus Middle T Antigen

Fluck, M. M., & Schaffhausen, B. S. (2009) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00009-09 · Cited by 176 · see citing works

Cellular transformation by Simian Virus 40 and Murine Polyoma Virus T antigens

Cheng, J., DeCaprio, J. A., Fluck, M. M., & Schaffhausen, B. S. (2009) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2009.03.002 · Cited by 152 · see citing works

Critical Role for Protein Phosphatase 2A Heterotrimers in Mammalian Cell Survival*

Strack, S., Cribbs, J., & Gomez, L. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408015200 · Cited by 160 · see citing works

Protein phosphatase 2A regulatory subunits and cancer

Eichhorn, P. J. A., Creyghton, M. P., & Bernards, R. (2009) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2008.05.005 · Cited by 513 · see citing works

PP2A impaired activity is a common event in acute myeloid leukemia and its activation by forskolin has a potent anti-leukemic effect

Cristóbal, I., García-Ortí, L., Cirauqui, C., Alonso, M. M., Calasanz, M. J., & Odero, M. D. (2011) · Leukemia · doi:10.1038/leu.2010.294 · Cited by 138 · see citing works

Subtype‐specific mutation of PPP2R1A in endometrial and ovarian carcinomas

McConechy, M. K., Anglesio, M. S., Kalloger, S. E., Yang, W., Senz, J., Chow, C., Heravi‐Moussavi, A., Morin, G. B., Mes‐Masson, A., Chenevix‐Trench, G., et al. (2011) · The Journal of Pathology · doi:10.1002/path.2848 · Cited by 131 · see citing works

PP2A Inhibition Is a Common Event in Colorectal Cancer and Its Restoration Using FTY720 Shows Promising Therapeutic Potential

Cristóbal, I., Manso, R., Rincón, R., Caramés, C., Senin, C., Borrero‐Palacios, A., Martínez‐Useros, J., Rodriguez, M., Zazo, S., Aguilera, O., et al. (2014) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-13-0150 · Cited by 124 · see citing works

Disparate Roles for the Regulatory A Subunit Isoforms in Arabidopsis Protein Phosphatase 2A

Zhou, H., Nussbaumer, C., Chao, Y. L., & DeLong, A. (2004) · The Plant Cell · doi:10.1105/tpc.018994 · Cited by 114 · see citing works

Human cancer-associated mutations in the Aα subunit of protein phosphatase 2A increase lung cancer incidence in Aα knock-in and knockout mice

Ruediger, R., Ruiz, J., & Walter, G. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05744-11 · Cited by 98 · see citing works

SV40 small T antigen and PP2A phosphatase in cell transformation

Sablina, A. A., & Hahn, W. C. (2008) · Cancer and Metastasis Reviews · doi:10.1007/s10555-008-9116-0 · Cited by 95 · see citing works

PP2A holoenzymes, substrate specificity driving cellular functions and deregulation in cancer

(2019) · Advances in Cancer Research · doi:10.1016/bs.acr.2019.03.009 · Cited by 93 · see citing works

Specificity of RCN1-Mediated Protein Phosphatase 2A Regulation in Meristem Organization and Stress Response in Roots

Blakeslee, J. J., Zhou, H., Heath, J. T., Skottke, K. R., Barrios, J. A. R., Liu, S.-Y., & DeLong, A. (2007) · PLANT PHYSIOLOGY · doi:10.1104/pp.107.112995 · Cited by 91 · see citing works

Molecular Mechanisms Underlying Cardiac Protein Phosphatase 2A Regulation in Heart

DeGrande, S. T., Little, S. C., Nixon, D. J., Wright, P., Snyder, J. S., Dun, W., Murphy, N. P., Kılıç, A., Higgins, R. S. D., Binkley, P. F., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.426957 · Cited by 92 · see citing works

PP2A: The Wolf in Sheep’s Clothing?

Bailey‐Whyte, M., & Kiely, P. (2015) · Cancers · doi:10.3390/cancers7020648 · Cited by 78 · see citing works

Protein phosphatase 2A – structure, function and role in neurodevelopmental disorders

Sandal, P., Jong, C. J., Merrill, R. A., Song, J., & Strack, S. (2021) · Journal of Cell Science · doi:10.1242/jcs.248187 · Cited by 72 · see citing works

The basic biology of PP2A in hematologic cells and malignancies

Haesen, D., Sents, W., Lemaire, K., Hoorne, Y., & Janssens, V. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00347 · Cited by 73 · see citing works

PP2A targeting by viral proteins: A widespread biological strategy from DNA/RNA tumor viruses to HIV-1

Guergnon, J., Godet, A. N., Galioot, A., Falanga, P. B., Colle, J., Cayla, X., & Garcı́a, A. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.07.001 · Cited by 58 · see citing works

Protein phosphatase 2A subunit PR70 interacts with pRb and mediates its dephosphorylation

Magenta, A., Fasanaro, P., Romani, S., Di Stefano, V., Capogrossi, M. C., & Martelli, F. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00480-07 · Cited by 58 · see citing works

Dephosphorylation of JC virus agnoprotein by protein phosphatase 2A: Inhibition by small t antigen

Sariyer, I. K., Khalili, K., & Safak, M. (2008) · Virology · doi:10.1016/j.virol.2008.02.020 · Cited by 57 · see citing works

The role of serine/threonine protein phosphatases in exocytosis

Sim, A. T. R., Baldwin, M. L., Rostas, J. A. P., Holst, J., & Ludowyke, R. I. (2003) · Biochemical Journal · doi:10.1042/bj20030484 · Cited by 56 · see citing works

Redox inhibition of protein phosphatase PP2A: Potential implications in oncogenesis and its progression

Raman, D., & Pervaiz, S. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101105 · Cited by 54 · see citing works

Lessons from polyoma middle T antigen on signaling and transformation: A DNA tumor virus contribution to the war on cancer

Schaffhausen, B. S., & Roberts, T. M. (2008) · Virology · doi:10.1016/j.virol.2008.09.042 · Cited by 50 · see citing works

PPP2R5D-Related Intellectual Disability and Neurodevelopmental Delay: A Review of the Current Understanding of the Genetics and Biochemical Basis of the Disorder

Biswas, D., Cary, W., & Nolta, J. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041286 · Cited by 49 · see citing works

Scaffold Subunit Aalpha of PP2A Is Essential for Female Meiosis and Fertility in Mice1

Hu, M.-W., Wang, Z.-B., Jiang, Z.-Z., Qi, S.-T., Huang, L., Liang, Q.-X., Schatten, H., & Sun, Q.-Y. (2014) · Biology of Reproduction · doi:10.1095/biolreprod.114.120220 · Cited by 48 · see citing works

Inactivation of PP2A by a recurrent mutation drives resistance to MEK inhibitors

O’Connor, C. M., Leonard, D., Wiredja, D., Avelar, R. A., Wang, Z., Schlatzer, D., Bryson, B., Tokala, E., Taylor, S. E., Upadhyay, A., et al. (2020) · Oncogene · doi:10.1038/s41388-019-1012-2 · Cited by 48 · see citing works

The Role of PP2A A Subunits in Tumor Suppression

Sablina, A. A., & Hahn, W. C. (2007) · Cell Adhesion & Migration · doi:10.4161/cam.1.3.4986 · Cited by 47 · see citing works

The NMR‐based characterization of the FTY720‐SET complex reveals an alternative mechanism for the attenuation of the inhibitory SET‐PP2A interaction

Palma, R. M. D., Parnham, S. R., Li, Y., Oaks, J. J., Peterson, Y. K., Szulc, Z. M., Roth, B. M., Xing, Y., & Öğretmen, B. (2019) · The FASEB Journal · doi:10.1096/fj.201802264r · Cited by 43 · see citing works

Phosphatase Type 2A-dependent and -independent Pathways for ATR Phosphorylation of Chk1

Li, G., Elder, R. T., Qin, K., Park, H. U., Liang, D., & Zhao, Y. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m607951200 · Cited by 43 · see citing works

Protein Phosphatase 2A: a Double-Faced Phosphatase of Cellular System and Its Role in Neurodegenerative Disorders

Nematullah, M., Hoda, M. N., & Khan, F. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0444-3 · Cited by 42 · see citing works

The glycine 90 to aspartate alteration in the Aβ subunit of PP2A (PPP2R1B) associates with breast cancer and causes a deficit in protein function

Esplin, E. D., Ramos, P., Martinez, B., Tomlinson, G. E., Mumby, M. C., & Evans, G. A. (2005) · Genes Chromosomes and Cancer · doi:10.1002/gcc.20284 · Cited by 40 · see citing works

Mouse model for probing tumor suppressor activity of protein phosphatase 2A in diverse signaling pathways

Walter, G., & Ruediger, R. (2012) · Cell Cycle · doi:10.4161/cc.11.3.19057 · Cited by 37 · see citing works

Role for PP2A in ARF signaling to p53

Moule, M. G., Collins, C. H., McCormick, F. P., & Fried, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405533101 · Cited by 37 · see citing works

The protein phosphatase 2A represents a novel cellular target for hepatitis C virus NS5A protein

Georgopoulou, U., Tsitoura, P., Kalamvoki, M., & Mavromara, P. (2006) · Biochimie · doi:10.1016/j.biochi.2005.12.003 · Cited by 36 · see citing works

PP2A: more than a reset switch to activate pRB proteins during the cell cycle and in response to signaling cues

Kurimchak, A., & Graña, X. (2014) · Cell Cycle · doi:10.4161/15384101.2014.985069 · Cited by 33 · see citing works

Perturbation of Specific Signaling Pathways Is Involved in Initiation of Mouse Liver Fibrosis

Chen, L., Guo, P., Li, W., Fang, F., Zhu, W., Fan, J., Wang, F., Gao, Y., Zhao, Q., Wang, Q., et al. (2020) · Hepatology · doi:10.1002/hep.31457 · Cited by 31 · see citing works

Functional importance of PP2A regulatory subunit loss in breast cancer

Watt, L. F., Panicker, N., Mannan, A., Copeland, B., Kahl, R. G. S., Dun, M. D., Young, B., Roselli, S., & Verrills, N. M. (2017) · Breast Cancer Research and Treatment · doi:10.1007/s10549-017-4403-5 · Cited by 29 · see citing works

The Formation and Activity of PP2A Holoenzymes Do Not Depend on the Isoform of the Catalytic Subunit

Zhou, J., Pham, H. T., & Walter, G. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211181200 · Cited by 29 · see citing works

Comparisons between Murine Polyomavirus and Simian Virus 40 Show Significant Differences in Small T Antigen Function

Andrabi, S., Hwang, J. H., Choe, J. K., Roberts, T. M., & Schaffhausen, B. S. (2011) · Journal of Virology · doi:10.1128/jvi.05034-11 · Cited by 27 · see citing works

Benzene-induced mouse hematotoxicity is regulated by a protein phosphatase 2A complex that stimulates transcription of cytochrome P4502E1

Chen, L., Guo, P., Zhang, H., Li, W., Gao, C., Huang, Z., Fan, J., Zhang, Y., Li, X., Liu, X., et al. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.006319 · Cited by 27 · see citing works

The Cell Cycle Checkpoint System MAST(L)-ENSA/ARPP19-PP2A is Targeted by cAMP/PKA and cGMP/PKG in Anucleate Human Platelets

Kumm, E. J., Pagel, O., Gambaryan, S. P., Walter, U., Zahedi, R. P., Smolenski, A., & Jurk, K. (2020) · Cells · doi:10.3390/cells9020472 · Cited by 26 · see citing works

Protein Phosphatase 2A Isoforms Utilizing Aβ Scaffolds Regulate Differentiation through Control of Akt Protein

Hwang, J. H., Jiang, T., Kulkarni, S., Faure, N., & Schaffhausen, B. S. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.497644 · Cited by 25 · see citing works

Mast cell function: Regulation of degranulation by serine/threonine phosphatases

Sim, A. T. R., Ludowyke, R. I., & Verrills, N. M. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.04.011 · Cited by 25 · see citing works

Polymerized Collagen Inhibits Fibroblast Proliferation via a Mechanism Involving the Formation of a β1 Integrin-Protein Phosphatase 2A-Tuberous Sclerosis Complex 2 Complex That Suppresses S6K1 Activity

Hong, X., Nho, R. S., Kleidon, J., Kahm, J., & Henke, C. A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m707489200 · Cited by 24 · see citing works

Protein phosphatase 4 regulates apoptosis in leukemic and primary human T-cells

Mourtada‐Maarabouni, M., & Williams, G. T. (2009) · Leukemia Research · doi:10.1016/j.leukres.2009.05.013 · Cited by 24 · see citing works

The tumor suppressor phosphatase PP2A-B56α regulates stemness and promotes the initiation of malignancies in a novel murine model

Janghorban, M., Langer, E. M., Wang, X., Zachman, D., Daniel, C. J., Hooper, J., Fleming, W. H., Agarwal, A., & Sears, R. C. (2017) · PLoS ONE · doi:10.1371/journal.pone.0188910 · Cited by 19 · see citing works

PPP2R1B is modulated by ubiquitination and is essential for spermatogenesis

Du, M., Yuan, L., Zhang, Z., Zhang, C., Zhu, M., Zhang, Z., Li, R., Zhao, X., Liang, H., Li, Y., et al. (2021) · The FASEB Journal · doi:10.1096/fj.202002810r · Cited by 20 · see citing works

Quantitative proteomics reveals novel protein interaction partners of PP2A catalytic subunit in pancreatic β-cells

Zhang, X., Damacharla, D., Ma, D., Qi, Y. A., Tagett, R., Drăghici, S., Kowluru, A., & Yi, Z. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.01.008 · Cited by 19 · see citing works

Phosphorylated protein phosphatase 2A determines poor outcome in patients with metastatic colorectal cancer

Cristóbal, I., Manso, R., Rincón, R., Caramés, C., Zazo, S., del Pulgar, T. G., Cebrián, A., Madoz‐Gúrpide, J., Rojo, F., & García‐Foncillas, J. (2014) · British Journal of Cancer · doi:10.1038/bjc.2014.376 · Cited by 17 · see citing works

Structural and Biochemical Characterization of Human PR70 in Isolation and in Complex with the Scaffolding Subunit of Protein Phosphatase 2A

Dovega, R., Tsutakawa, S. E., Quistgaard, E. M., Anandapadamanaban, M., Löw, C., & Nordlund, P. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101846 · Cited by 14 · see citing works

Protein phosphatase 2A Aα regulates Aβ protein expression and stability

O’Connor, C. M., Hoffa, M. T., Taylor, S. E., Avelar, R. A., & Narla, G. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.007593 · Cited by 15 · see citing works

Protein phosphatase 2A dephosphorylates phosphoserines in nucleocytoplasmic shuttling and secretion of high mobility group box 1

Taira, J., Kida, Y., Kuwano, K., & Higashimoto, Y. (2013) · The Journal of Biochemistry · doi:10.1093/jb/mvt056 · Cited by 14 · see citing works

The PP2A-Aβ Gene is Regulated by Multiple Transcriptional Factors Including Ets-1, SP1/SP3, and RXRα /β

Liu, J., Ji, W., Sun, S., Zhang, L., Chen, H., Mao, Y., Liu, L., Zhang, X., Gong, L., Deng, M., et al. (2012) · Current Molecular Medicine · doi:10.2174/156652412802480916 · Cited by 14 · see citing works

A Cancer-Associated Missense Mutation in PP2A-Aα Increases Centrosome Clustering during Mitosis

Antao, N. V., Marcet-Ortega, M., Cifani, P., Kentsis, A., & Foley, E. A. (2019) · iScience · doi:10.1016/j.isci.2019.07.018 · Cited by 13 · see citing works

Virus–Host Interactions in Retrovirus Integration

Engelman, A. N., & Maertens, G. N. (2018) · Retrovirus-Cell Interactions · doi:10.1016/b978-0-12-811185-7.00004-2 · Cited by 12 · see citing works

The role of PP2A /NLRP3 signaling pathway in ambient particulate matter 2.5 induced lung injury

Han, B., Liu, Q., Su, X., Zhou, L., Zhang, B., Kang, H., Ning, J., Li, C., Zhao, B., Niu, Y., et al. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.135794 · Cited by 11 · see citing works

Induction of Cancer-Specific Cell Death by the Adenovirus E4orf4 Protein

Kleinberger, T. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-1-4471-6458-6_4 · Cited by 10 · see citing works

Protein phosphatase 2A is essential to maintain active Wnt signaling and its Aβ tumor suppressor subunit is not expressed in colon cancer cells

Figueroa‐Aldariz, M. C., Castañeda‐Patlán, M. C., Santoyo‐Ramos, P., Zentella‐Dehesa, A., & Robles‐Flores, M. (2014) · Molecular Carcinogenesis · doi:10.1002/mc.22217 · Cited by 10 · see citing works

Recent insights into Protein Phosphatase 2A structure and regulation: the reasons why PP2A is no longer considered as a lazy passive housekeeping enzyme

Martin, M., Kettmann, R., & Dequiedt, S. (2010) · ORBi (University of Liège) · Cited by 10 · see citing works

Effects of phosphatase and proteasome inhibitors on Borealin phosphorylation and degradation

Date, D. A., Dreier, M. R., Borton, M. T., Bekier, M. E., & Taylor, W. R. (2012) · The Journal of Biochemistry · doi:10.1093/jb/mvs015 · Cited by 9 · see citing works

ATM phosphorylates PP2A subunit A resulting in nuclear export and spatiotemporal regulation of the DNA damage response

Sule, A. D., Golding, S. E., Ahmad, S. F., Watson, J., Ahmed, M. H., Kellogg, G. E., Bernaś, T., Koebley, S. R., Reed, J. C., Povirk, L. F., et al. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04550-5 · Cited by 9 · see citing works

Targeting PP2A in cancer: an underrated option

Sarais, F., Krempien, F., Koehn, C., Brewing, L., Classen, C. F., Walter, M., & Shokraie, O. (2025) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-025-03560-y · Cited by 8 · see citing works

cAMP/PKA signaling promotes AKT deactivation by reducing CIP2A expression, thereby facilitating decidualization

Zhao, W., Xu, C., Peng, L., Ma, L., & Du, M. (2023) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2023.111946 · Cited by 8 · see citing works

Sphingosine simultaneously inhibits nuclear import and activates PP2A by binding importins and PPP2R1A

Jayashankar, V., Kubiniok, P., McCracken, A. N., Gentry, R. G., Eckenstein, K. H., Sernissi, L., Vece, V., Garsi, J.-B., Valles, S. Y., Jung, S., et al. (2025) · The EMBO Journal · doi:10.1038/s44318-025-00490-5 · Cited by 5 · see citing works

Expression and mechanism of regulation of PP2A/Pr65 in ameloblastoma

Gao, X., Wang, G., Zhang, Y., & Zhong, M. (2013) · The Surgeon · doi:10.1016/j.surge.2013.07.003 · Cited by 5 · see citing works

siRNA Screen Identifies the Phosphatase Acting on the G Protein-Coupled Thyrotropin-Releasing Hormone Receptor

Gehret, A. U., & Hinkle, P. M. (2012) · ACS Chemical Biology · doi:10.1021/cb3004513 · Cited by 5 · see citing works

Sodium butyrate ameliorates renal tubular lipid accumulation through a protein phosphatase 2A/transcription factor EB axis in diabetic nephropathy

Tao, J., Ai, S., Wang, Y., Liu, Y., Zhou, J., Liu, Q., Wang, X., Li, D., Li, X., Wang, L., et al. (2025) · British Journal of Pharmacology · doi:10.1111/bph.70261 · Cited by 3 · see citing works

Ser/Thr Phosphatases: The New Frontier for Myeloid Leukemia Therapy?

Amanda, M., Kathryn, G., & Nicole, M. (2011) · InTech eBooks · doi:10.5772/26425 · Cited by 3 · see citing works

Role of PP2A in Cancer and Signal Transduction

Walter, G. (2003) · Elsevier eBooks · doi:10.1016/b978-012124546-7/50465-4 · Cited by 3 · see citing works

Regulatory mechanisms of PP2A complex assembly driven by physicochemical differences in A-subunit isoforms

Day, A., Huang, W., Léonard, D., O’Connor, C. M., Narla, G., & Taylor, D. J. (2025) · Structure · doi:10.1016/j.str.2025.06.013 · Cited by 2 · see citing works

Identification of Autoantibodies in a Patient With Testicular Cancer and Concurrent Inflammatory Bowel Disease

Gao, J. J., Maricque, B. B., Morse, M. D., Huang, W. Q., & McNeel, D. G. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2010.30.2893 · Cited by 2 · see citing works

SIV-Mediated Synaptic Dysfunction Is Associated with an Increase in Synapsin Site 1 Phosphorylation and Impaired PP2A Activity

Shekarabi, M., Robinson, J. A., Smith, M. D., & Burdo, T. H. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.0178-19.2019 · Cited by 2 · see citing works

Structural and functional studies of proteins in cell signaling and cancer

Dovega, R. (2014) · Figshare · Cited by 2 · see citing works

Protein kinase involvement in wild-type and mutant calcium-sensing receptor signalling

Khayat, B., & Ezuan, M. (2016) · Cited by 2 · see citing works

Purification of PP2A Holoenzymes by Sequential Immunoprecipitation with Anti-Peptide Antibodies

Walter, G., Zhou, J., & Ruediger, R. (2007) · Humana Press eBooks · doi:10.1385/1-59745-267-x:113 · Cited by 1 · see citing works

Regulation of tyrosine hydroxylase by protein phosphatase 2A

Saraf, A. (2008) · doi:10.17077/etd.9lhm4w05 · Cited by 1 · see citing works

Protein phosphatase 2A: A multifunctional regulator of cell signaling

Mumby, M. C. (2003) · Topics in current genetics · doi:10.1007/978-3-540-40035-6_3 · Cited by 1 · see citing works

CHK2 is Negatively Regulated by Protein Phosphatase 2A

Freeman, A. K. (2010) · Digital Commons - University of South Florida (University of South Florida)

Entwicklung von zellulären Indikatorsystemen zur Identifikation von Modulatoren der HIV-1 Genexpression

Wolff, H. (2004) · doi:10.5282/edoc.2005

Merkel Cell Polyomavirus Small T Antigen Perturbs the Cellular DNA Damage Response

Yoon, R. (2015) · Digital Access to Scholarship at Harvard (DASH) (Harvard University)

Mise en evidence et caractérisation d'une interaction fonctionnelle entre la kinase Aurora-A et la phosphatase PP2A

Horn, V. (2005) · HAL

Regulation of nerve growth factor signaling by protein phosphatase 2A

Kanegan, M. J. V. (2008) · doi:10.17077/etd.23exfh2c

IDENTIFICATION AND CHARACTERIZATION OF CIP2A AS A NOVEL ONCOGENIC INHIBITOR OF PP2A

Niemelä, M. (2012) · UTUPub (University of Turku)

EFFECT OF MICROCYSTIN LR ON PP2A IN HL7702 CELL

Zheng, Q., Liang, J. L., & Xu, L. (2011) · Acta Hydrobiologica Sinica · doi:10.3724/sp.j.1035.2011.00313

Caracterización de nuevos perfiles moleculares en carcinoma de endometrio esporádico

Cieza-Borrella, C. (2013) · doi:10.14201/gredos.124099

Composition, regulation, and function of protein serine/threonine phosphatase.kinase signaling modules

Mazalouskas, M. D. (2014)

A Tale of a ‘Tail’ – Understanding the Role of Ku80 C-terminal Region in Non-Homologous End Joining

Radhakrishnan, S. K. (2015) · Libraries and Cultural Resources (University of Calgary) · doi:10.11575/prism/25052

Protein Phosphatase 2a Interactions In Islet And Human Skeletal Muscle In Diabetes

Damacharla, D. (2017) · Human Biology

Identification et caractérisation des premiers substrats de la protéine kinase Greatwall et étude de leur implication au cours du cycle cellulaire

Gharbi-Ayachi, A. (2013) · theses.fr (ABES) · doi:10.70675/bffa905ez75e5z47a1zae33z615ed770a93a

Mutagenesis and Expression of the Scaffolding Aα and Aβ Subunits of PP2A: Assays for Measuring Defects in Binding of Cancer-Related Aα and Aβ Mutants to the Regulatory B and Catalytic C Subunits

Ruediger, R., Zhou, J., & Walter, G. (2007) · Humana Press eBooks · doi:10.1385/1-59745-267-x:85 · Cited by 1 · see citing works

High Complexity in the Expression of the B′ Subunit of Protein Phosphatase 2A0

Csoŕtos, C., Zołnierowicz, S., Bakó, É., Durbin, S. D., & DePaoli-Roach, A. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.5.2578 · Cited by 163 · see citing works

Identification and Characterization of an Alternatively Spliced Isoform of the Human Protein Phosphatase 2Aα Catalytic Subunit

Smetana, J. H. C., Migueleti, D. L. D. S., Nunes, H. F., Kobarg, J., & Zanchin, N. I. T. (2012) · The FASEB Journal · doi:10.1096/fasebj.26.1_supplement.lb181

Diversity in the Regulatory B-Subunits of Protein Phosphatase 2A: Identification of a Novel Isoform Highly Expressed in Brain

Zołnierowicz, S., Csoŕtos, C., Bondor, J., Verin, A. D., Mumby, M. C., & DePaoli-Roach, A. A. (1994) · Biochemistry · doi:10.1021/bi00205a023 · Cited by 114 · see citing works

The three Type 2A protein phosphatases, PP2Ac, PP4c and PP6c, are differentially regulated by Alpha4

Lenoue-Newton, M. L., Wadzinski, B. E., & Spiller, B. W. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.05.036 · Cited by 13 · see citing works