PP2A: the expected tumor suppressor

Janssens, Veerle; Goris, Jozef; Van Hoof, Christine

doi:10.1016/j.gde.2004.12.004

Cited by 426Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase SignalingCancer-related Molecular Pathways

PP2A: the expected tumor suppressor

Janssens, Veerle, Goris, Jozef, Van Hoof, Christine·2005·Current Opinion in Genetics & Development

DOI 10.1016/j.gde.2004.12.004

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Abstract

PP2A is one of the few serine/threonine-specific phosphatases in the cell, and its complex structure and regulation guarantees its many different functions. Some viruses have chosen to target this enzyme system in order to manage the host cell machinery for their own profit and to program cells into a malignant state. Suppression of PR61/B'gamma, a specific third regulatory subunit of PP2A, can substitute for the viral SV40 protein small t antigen in causing tumorigenic transformation of several human cell lines -- provided that telomerase, SV40 large T antigen and oncogenic Ras are also present. Accumulation of c-Myc seems to be the common denominator.

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The tumor suppressive role of specific PP2A complexes had been inferred from okadaic acid experiments, in vitro transformation assays, and clinical data, but convincing in vivo data were lacking for some time.
“Although the tumor suppressive role of specific PP2A complexes had already been inferred for a relatively long time, from experiments with the tumor promotor and pharmacologic PP2A inhibitor okadaic acid [100], from in vitro cell transformation assays in a large variety of epithelial cells [101], and from a plethora of clinical data supporting PP2A dysfunction in many different cancer types [5,102”
From Physiologic functions of PP2A: Lessons from genetically modified mice (2019) · cites this paper as [100]
PP2A is a trimeric complex of catalytic, scaffold, and regulatory B subunits; different B subunits produce holoenzymes with unique substrates and functions.
“PP2A is a trimeric protein complex consisting of a catalytic subunit (PP2Ac or C), a scaffold subunit (PR65 or A), and one of several regulatory B subunits. Such variability in PP2A composition results in heterogeneity in the composition of active PP2A holoenzymes, each with unique substrates and functions (Janssens et al., 2005).”
From Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis (2019) · cites this paper as Janssens et al., 2005
PP2A is a tumor suppressor.
“PP2A has been established as a tumor suppressor”
From Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis (2019) · cites this paper as Janssens et al., 2005
Inactivation of PP2A is an important step toward full-blown transformation.
“the inactivation of PP2A has become widely accepted as an important step toward full-blown transformation.”
From Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis (2019) · cites this paper as Janssens et al., 2005
Genetic and/or functional inactivation of different PP2A subunits, and loss of its phosphatase activity, have been found in several types of tumors.
“Indeed, genetic and/or functional inactivation of different PP2A subunits, and, therefore, loss of its phosphatase activity, have been found in several types of tumors (Janssens et al., 2005; Mumby, 2007).”
From Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis (2019) · cites this paper as Janssens et al., 2005

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Authors: Janssens, V., Goris, J., & Van Hoof, C.
Affiliations: KU Leuven (BE)
Corresponding author: Goris, Jozef
ORCID: Janssens, Veerle
Venue: Current Opinion in Genetics & Development
Publisher: Elsevier BV
Published: 2005-02
Volume: 15
Issue: 1
Pages: 34-41
ISSN: 0959-437X (ISSN-L)
DOI: 10.1016/j.gde.2004.12.004
OpenAlex: W1981076681
Cited by: 426
References: 55
Citations by year: 2026: 3 · 2025: 9 · 2024: 7 · 2023: 9 · 2022: 8 · 2021: 16 · 2020: 17 · 2019: 12 · 2018: 15 · 2017: 17 · 2016: 8 · 2015: 20 · 2014: 32 · 2013: 28 · 2012: 25
FWCI: 2.10
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Current Opinion in Genetics & Development (publishedVersion)
PubMed (publishedVersion)
Lirias (submittedVersion)
Funders: Fonds Wetenschappelijk Onderzoek
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords: protein phosphatase 2A, tumor suppressor, serine/threonine phosphatase, PP2A regulatory subunit, SV40 small t antigen, viral oncogenesis, tumorigenic transformation, telomerase, oncogenic Ras, c-Myc, protein dephosphorylation
MeSH terms: Animals, Cell Cycle, Humans, Neoplasms, Phosphoprotein Phosphatases, Tumor Suppressor Proteins

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PP2A: the expected tumor suppressor

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