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The human Mediator complex: a versatile, genome-wide regulator of transcription
Open accessAbstract
The Mediator complex interacts extensively with the RNA polymerase II enzyme and regulates its ability to express protein-coding genes. The mechanisms by which Mediator regulates gene expression remain poorly understood, in part because Mediator structure and even its composition can change, depending upon the promoter context. Combined with the sheer size of the human Mediator complex (26 subunits, 1.2 MDa), this structural adaptability bestows seemingly unlimited regulatory potential within the complex. Recent efforts to understand Mediator structure and function have identified expanded roles that include control of both pre- and post-initiation events; it is also evident that Mediator performs both general and gene-specific roles to regulate gene expression.
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Cites
Transcription regulation and animal diversity
Levine, M., & Tjian, R. (2003) · Nature · doi:10.1038/nature01763 · Cited by 1,309
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Alarcón, C., Zaromytidou, A.-I., Xi, Q., Gao, S., Yu, J., Fujisawa, S., Barlas, A., Miller, A. N., Manova-Todorova, K., Macias, M. J., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.035 · Cited by 719
An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis
Yang, F., Vought, B. W., Satterlee, J. S., Walker, A. K., Jim Sun, Z.-Y., Watts, J. L., DeBeaumont, R., Mako Saito, R., Hyberts, S. G., Yang, S., et al. (2006) · Nature · doi:10.1038/nature04942 · Cited by 405
Complexity in Transcription Control at the Activation Domain–Mediator Interface
Balamotis, M. A., Pennella, M. A., Stevens, J. L., Wasylyk, B., Belmont, A. S., & Berk, A. J. (2009) · Science Signaling · doi:10.1126/scisignal.1164302 · Cited by 84
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Metadata
- Authors
- Taatjes, D. J.
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 35
- Issue
- 6
- Pages
- 315-322
- ISSN
- 0968-0004 (ISSN-L)
- OpenAlex
- W2008027677
- Cited by
- 326
- References
- 4
- FWCI
- 2.71
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
