Cited by 172Adipokines, Inflammation, and Metabolic DiseasesMetabolism, Diabetes, and CancerDiet, Metabolism, and Disease

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cJun NH2-terminal kinase 1 (JNK1): roles in metabolic regulation of insulin resistance

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Sabio, Guadalupe, Davis, Roger J.·2010·Trends in Biochemical Sciences

DOI 10.1016/j.tibs.2010.04.004PMC PMC2975251

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Abstract

The cJun NH(2)-terminal kinase isoform JNK1 is implicated in the mechanism of obesity-induced insulin resistance. Feeding a high-fat diet causes activation of the JNK1 signaling pathway, insulin resistance, and obesity in mice. Germ-line ablation of Jnk1 prevents both diet-induced obesity and insulin resistance. Genetic analysis indicates that the effects of JNK1 on insulin resistance can be separated from effects of JNK1 on obesity. Emerging research indicates that JNK1 plays multiple roles in the regulation of insulin resistance, including altered gene expression, hormone/cytokine production, and lipid metabolism. Together, these studies establish JNK1 as a potential pharmacological target for the development of drugs that might be useful for the treatment of insulin resistance, metabolic syndrome, and type 2 diabetes.

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Authors: Sabio, G., & Davis, R. J.
Affiliations: Consejo Superior de Investigaciones Científicas (ES)
Howard Hughes Medical Institute (US)
Corresponding author: Davis, Roger J.
ORCID: Sabio, Guadalupe
Davis, Roger J.
Venue: Trends in Biochemical Sciences
Publisher: Elsevier BV
Published: 2010-09
Volume: 35
Issue: 9
Pages: 490-496
ISSN: 0968-0004 (ISSN-L)
DOI: 10.1016/j.tibs.2010.04.004
PMC: PMC2975251
OpenAlex: W2123557018
Cited by: 170
References: 71
Citations by year: 2026: 5 · 2025: 13 · 2024: 10 · 2023: 8 · 2022: 9 · 2021: 6 · 2020: 11 · 2019: 11 · 2018: 7 · 2017: 13 · 2016: 17 · 2015: 12 · 2014: 10 · 2013: 15 · 2012: 15
FWCI: 1.42
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Biochemical Sciences (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
Funders: National Cancer Institute (CA065861, R01CA065861)
National Institute of Diabetes and Digestive and Kidney Diseases (P01DK080665, P30DK032520, DK080665, P30-DK32520)
National Institute of Neurological Disorders and Stroke (NS054948, R01NS054948)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords: JNK1, c-Jun N-terminal kinase, insulin resistance, obesity, high-fat diet, metabolic regulation, lipid metabolism, gene expression regulation, cytokine production, metabolic syndrome, type 2 diabetes, therapeutic target
MeSH terms: Animals, Diet, Humans, Insulin Resistance, Obesity, Mitogen-Activated Protein Kinase 8, Insulin-Secreting Cells, Mice

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cJun NH2-terminal kinase 1 (JNK1): roles in metabolic regulation of insulin resistance

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