Mitochondrial quality control: an integrated network of pathways

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

Narendra, D., Tanaka, A., Suen, D.-F., & Youle, R. J. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200809125 · Cited by 4,026

ROS as signalling molecules: Mechanisms that generate specificity in ROS homeostasis

D'Autréaux, B., & Toledano, M. B. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2256 · Cited by 3,642

Mechanisms of mitophagy

Youle, R. J., & Narendra, D. P. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3028 · Cited by 3,273

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

Twig, G., Elorza, A., Molina, A. J. A., Mohamed, H., Wikstrom, J. D., Walzer, G., Stiles, L., Haigh, S. E., Katz, S., Las, G., et al. (2008) · The EMBO Journal · doi:10.1038/sj.emboj.7601963 · Cited by 3,082

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

Narendra, D. P., Jin, S. M., Tanaka, A., Suen, D.-F., Gautier, C. A., Shen, J., Cookson, M. R., & Youle, R. J. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000298 · Cited by 2,944

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

Geisler, S., Holmström, K. M., Skujat, D., Fiesel, F. C., Rothfuss, O. C., Kahle, P. J., & Springer, W. (2010) · Nature Cell Biology · doi:10.1038/ncb2012 · Cited by 2,835

The Biologic Clock: The Mitochondria?

Harman, D. (1972) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1972.tb00787.x · Cited by 2,026

Mitochondrial fusion and fission in cell life and death

Westermann, B. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3013 · Cited by 2,002

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

Matsuda, N., Sato, S., Shiba, K., Okatsu, K., Saisho, K., Gautier, C. A., Sou, Y.-S., Saiki, S., Kawajiri, S., Sato, F., et al. (2010) · Journal of Cell Biology · doi:10.1083/jcb.200910140 · Cited by 1,969

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

Vives-Bauza, C., Zhou, C., Huang, Y., Cui, M., de Vries, R. L. A., Kim, J., May, J., Tocilescu, M. A., Liu, W., Ko, H. S., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911187107 · Cited by 1,616

The mitochondrial translocase of the inner membrane PaTim54 is involved in defense response and longevity in Podospora anserina

Mercier, A., Clairet, C., Debuchy, R., Morais, D., Silar, P., & Brun, S. (2019) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2019.103257 · Cited by 5

MAMs and Mitochondrial Quality Control: Overview and Their Role in Alzheimer’s Disease

Luo, J.-S., Zhai, W.-H., Ding, L.-L., Zhang, X.-J., Han, J., Ning, J., Chen, X.-M., Jiang, W., Yan, R., & Chen, M. (2024) · Neurochemical Research · doi:10.1007/s11064-024-04205-w · Cited by 4

Transcriptome profiles of latently- and reactivated HIV-1 infected primary CD4+ T cells: A pooled data-analysis

Inderbitzin, A., Loosli, T., Opitz, L., Rusert, P., & Metzner, K. J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.915805 · Cited by 4

The proteasome activity reporter GFP-Cl1 is degraded by autophagy in the aging model Podospora anserina

Wiemer, M., & Osiewacz, H. D. (2014) · F1000Research · doi:10.12688/f1000research.5337.1 · Cited by 4

Substrate Profiling of Mitochondrial Caseinolytic Protease P via a Site‐Specific Photocrosslinking Approach

Nguyen, T., Gronauer, T. F., Nast‐Kolb, T., Sieber, S. A., & Lang, K. (2021) · Angewandte Chemie · doi:10.1002/ange.202111085 · Cited by 4

STUDY OF THE CHEMISTRY OF MODIFIED SILICA SURFACE BY DYE ADSORPTION

Khokhlova, T. D., Nikitin, Y. S., & Detistova, A. L. (1991) · Russian Journal of Physical Chemistry A · Cited by 4

Tooth Loss Leads to Cognitive Impairment and Mitochondrial Disturbance in Wistar Rats

Meng, S., Lu, Y., Hu, J., Luo, B., Sun, X., Wang, X., & Jiang, Q. (2025) · International Dental Journal · doi:10.1016/j.identj.2025.03.027 · Cited by 3

Heat Shock Factor HSFA6b Mediates Mitochondrial Unfolded Protein Response in Arabidopsis thaliana

Yu, G., Huang, Z., Guo, C., Li, J., Wang, X., Wang, Y., & Wang, X. (2024) · Plants · doi:10.3390/plants13223116 · Cited by 3

Cuproptosis genes in predicting the occurrence of allergic rhinitis and pharmacological treatment

Yi, T. (2025) · PLoS ONE · doi:10.1371/journal.pone.0318511 · Cited by 3

Mitochondrial Abnormalities in Down Syndrome: Pathogenesis, Effects and Therapeutic Approaches

Izzo, A., Mollo, N., Cicatiello, R., Genesio, R., Paladino, S., Conti, A. M. F., & Nitsch, L. (2018) · InTech eBooks · doi:10.5772/intechopen.71059 · Cited by 3

An impedimetric assay for the identification of abnormal mitochondrial dynamics in living cells

Dona, K. N. U. G., Du, E., & Wei, J. (2020) · Electrophoresis · doi:10.1002/elps.202000125 · Cited by 3

Growth differentiation factor 15: a valuable biomarker for the diagnosis and prognosis of late-onset form of multiple Acyl-CoA dehydrogenation deficiency

Sun, Y., Tang, S., Jingwei, L., Bing, W., Xu, J., Busu, L., Zhao, B. T., Ji, K., & Yan, C. (2025) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-025-03651-1 · Cited by 2

Rett syndrome: Pathogenicity and regulation of MECP2 (human) and Mecp2 (mouse) genes and their protein products through various molecular mechanisms

Ahmad, B., Dumbuya, J. S., Tang, J., Li, W., Chen, X., & Lu, J. (2025) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2025.108553 · Cited by 2

The yeast ALA synthase C‐terminus positively controls enzyme structure and function

Tran, J. U., & Brown, B. L. (2023) · Protein Science · doi:10.1002/pro.4600 · Cited by 2

Analysis of Autophagy in Penicillium chrysogenum by Using Starvation Pads in Combination With Fluorescence Microscopy

Scheckhuber, C. Q. (2015) · Journal of Visualized Experiments · doi:10.3791/52577 · Cited by 2

Autophagic responses compensate mitochondrial impairments

Henkel, V., Warnsmann, V., & Osiewacz, H. D. (2017) · Aging · doi:10.18632/aging.101292 · Cited by 2

High Throughput Volume Flow Cytometry (parallel-iLIFE) Resolves Mitochondrial Network On the GoPreprint

Kumar, P., Joshi, P., Basumatary, J., & Mondal, P. P. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.10.14.334466 · Cited by 2

Barth syndrome cellular models have dysregulated respiratory chain complex I and mitochondrial quality control due to abnormal cardiolipinPreprint

Anzmann, A. F., Carney, O. S., Pado, A. M., Busa, V. F., Vaz, F. M., Kreimer, S. D., Cole, R. N., Le, A., Kirsch, B. J., Claypool, S. M., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.01.06.425502 · Cited by 2

Special Issue “Signal Transductions in Fungi”

Kück, U. (2022) · Journal of Fungi · doi:10.3390/jof8050528 · Cited by 2

A new subset of mitochondrial-derived vesicles perform inter-mitochondrial communications

Adla, P., Bshivakumar, V., Pathak, D., Mattam, U., Tammineni, P., Krishnamoorthy, T., & Sepuri, N. B. V. (2025) · Molecular Biology of the Cell · doi:10.1091/mbc.e25-04-0188 · Cited by 1

Migrasome-driven mitocytosis relieves mitochondrial damage induced by chikungunya virus TF and 6K

Wang, S., Zhang, D., & Zhang, L. (2026) · hLife · doi:10.1016/j.hlife.2025.12.002 · Cited by 1

Use of methods for determining cell viability in cryobiological research

An, S., & Maiorova, O. (2025) · Problems of Cryobiology and Cryomedicine · doi:10.15407/cryo35.04.181 · Cited by 1

Human iPSC‐NSC‐Derived Extracellular Vesicles Can Alleviate Alzheimer's Disease‐Linked Impairments in Mitochondria, mTOR Signaling, Autophagy, and Hippocampal Neurogenesis

Madhu, L. N., Attaluri, S., Kotian, S., Upadhya, R., Somayaji, Y., Rao, S., Tarale, P., Ganesh, S. V., Huard, C., Kodali, M., et al. (2026) · Aging Cell · doi:10.1111/acel.70590 · Cited by 1

Novel insights into genetic associations and drug targets of mitochondria-associated proteins with major depressive disorder.

Sun, W.-X., Pan, X., Yang, H.-D., Wang, X.-Y., Zhang, X.-Y., Pan, S.-M., Li, Z., & Zhang, X.-B. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120122 · Cited by 1

Translating Genetic Data into Actionable Clinical Guidelines: Succinate Dehydrogenase Subunit A Variants of Unknown Significance in Gastrointestinal Stromal Tumors

Bannon, A. E. (2017) · doi:10.6083/hh63sw55h · Cited by 1

Mitochondrial pathways in bipolar disorder: Mechanisms and implications

Scaini, G., Andrews, T., Benevenuto, D., & Quevedo, J. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819182-8.00005-3 · Cited by 1

Mitophagy Impairments as Culprit of Alzheimer’s Disease

Mani, S., Swargiary, G., Singh, M., & Rawal, M. (2022) · Springer eBooks · doi:10.1007/978-981-16-7606-2_5 · Cited by 1

Impaired renal ischemia reperfusion recovery after bilateral renal artery ligation in rats treated with adenine: role of renal mitochondria

Prem, P. N., Chellappan, D. R., & Kurian, G. A. (2023) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-023-09974-7 · Cited by 1

Involvement of Mitochondrial Dysfunction on the Toxic Effects Caused by Drugs of Abuse and Addiction

Barbosa, D. J., Capela, J. P., Bastos, M. D. L., & Carvalho, F. D. (2018) · Wiley eBooks · doi:10.1002/9781119329725.ch32 · Cited by 1

ROS regulation of axonal mitochondrial transport

Liao, P. (2016) · Purdue e-Pubs (Purdue University System)

Role of Autophagy in Age-Related Vascular Dysfunction

LaRocca, T. J. (2012) · CU Scholar (University of Colorado Boulder)

Caracterização funcional da peroxirredoxina mitocondrial (Prx1) na fisiologia redox de Saccharomyces cerevisiae

Gomes, F. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.41.2017.tde-13032017-160422

Expression of Nutmeg Seed Extract in Integral Membrane Protein and Synaptic Vesicle: Younger Vs Aging

Veronica, F., Fitri, L. L., Ganiem, A. R., Ambrosius, P., Gunawan, H., Supratman, U., & Lesmana, R. (2020) · Systematic Reviews in Pharmacy

МЕХАНИЗМЫ ВОЗНИКНОВЕНИЯ И РАЗВИТИЯ ТОКСИЧЕСКОЙ КАРДИОМИОПАТИИ

РФ, Ф. В. «. Г. М. У. М., Daguf, V., Filonov, A., РФ, Ф. В. «. Г. М. У. М., Гребенникова, М. А., & РФ, Ф. В. «. Г. М. У. М. (2021) · ICSP «NEW SCIENCE» eBooks · doi:10.46916/21122021-2-978-5-00174-416-0

Mitohormesis

Machado, I. F., Teodoro, J. S., Castela, A. C., Palmeira, C. M., & Rolo, A. P. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821562-3.00035-6

Yaşlanmada tiyol/disülfür Homeostazisi ve Bazı Mineraller

Acı, R., Çiftçi, G., Ümit, F., Kar, P., Ermiş, M., & Çaka, Ö. (2024) · Journal of Anatolian Environmental and Animal Sciences · doi:10.35229/jaes.1436383

Systems biology approach in the detection of neuronal disorders

Rao, D., Yadav, S., Chandra, N., Muthamma, T., Sivamani, Y., Pokkuluri, K. S., & Elayaperumal, S. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-33351-4.00016-7

ZK53 enhances tumor cell susceptibility to ferroptosis via ClpP-mediated mitochondrial dysfunction

Dai, S., Zhang, T., Dai, X., Zheng, K., Qian, H., Tong, Z., & Zhang, Q. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1594840

Antioxidant, cytotoxic and apoptosis-inducing properties Carissa carandas L. against lung carcinoma cells: Insights from leaf, young & ripe fruit extracts

Sargara, P., NATARAJ, M., Subramanian, R. B., & Thakkar, A. B. (2025) · Pharmacological Research - Natural Products · doi:10.1016/j.prenap.2025.100385

A novel strategy for the treatment of Obesity using the small molecule ABX300, a modulator of the LMNA gene splicing

Herrera, C. L. (2015) · theses.fr (ABES) · doi:10.70675/d09d7e9cz079fz4faaz985aza9cd4fc18f18

Role of alphaOGG1 in the Maintenance of Mitochondrial Physiology

Lia, D. (2018) · theses.fr (ABES) · doi:10.70675/679004d9z93c1z48b3zbba9zf7828ee3d37a

LRRK2 et fonction mitochondriale dans la maladie de Parkinson : rôle dans la régulation de la mitophagie dépendante de la voie PINK1/Parkine

Bonello, F. (2018) · theses.fr (ABES) · doi:10.70675/e43ece04z57d0z4e13z96dez05a00e151822

Role of Mitochondria in Mechanisms of Fungal Senescence and Longevity

Osiewacz, H. D. (2026) · The mycota · doi:10.1007/978-3-032-15548-1_4

Deubiquitinases in mitophagy: therapeutic control of mitochondrial quality

Xu, Y., Behrouz, B., Lee, A., Xin, G., & Sun, N. (2026) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2026.08.009

Poly(methyl methacrylate) micro- and nanoplastics induce early mitochondrial dysfunction and cellular perturbations in Drosophila melanogaster

Hamdan, M., Elkady, E. F., Abass, D., Alaraby, M., Marcos, R., & Hernández, A. (2026) · Environmental Chemistry and Ecotoxicology · doi:10.1016/j.enceco.2026.09.008

Mitochondrial dysfunction in microglia: a novel perspective of depression pathogenesis

Jia, Y., Zhao, S., Miao, F., Yang, Z., Zhao, S., Wu, Q., Wang, Y., & Xia, X. (2026) · Inflammation and Regeneration · doi:10.1186/s41232-026-00444-2

Mitochondrial quality control pathways as determinants of metabolic health

Held, N. M., & Houtkooper, R. H. (2015) · BioEssays · doi:10.1002/bies.201500013 · Cited by 133

The mechanism of mammalian mitochondrial quality control system

Khan, S. U., & Khan, M. U. (2021) · Journal of Chemistry and Nutritional Biochemistry · doi:10.48185/jcnb.v2i2.387 · Cited by 6

Impaired quality control of mitochondria: Aging from a new perspective

Weber, T. A., & Reichert, A. S. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.03.018 · Cited by 112

Mitochondria as a Key Player in Aging

Banerjee, R., & Rath, P. C. (2020) · Springer eBooks · doi:10.1007/978-981-32-9005-1_10

Autophagic responses compensate mitochondrial impairments

Henkel, V., Warnsmann, V., & Osiewacz, H. D. (2017) · Aging · doi:10.18632/aging.101292 · Cited by 2