The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
N6-methyl-adenosine modification in messenger and long non-coding RNA
Open accessAbstract
N6-methyl-Adenosine (m6A) is the most abundant modification in mammalian mRNA and long noncoding RNA. First discovered in 1970s, m6A modification has been proposed to function in mRNA splicing, export, stability and immune tolerance. Interest and excitement in m6A modification has recently been revived based on the discovery of a mammalian enzyme that removes m6A and the application of deep sequencing to localize modification sites. The m6A demethylase FTO controls cellular energy homeostasis and is the first enzyme discovered that reverses an RNA modification. m6A sequencing demonstrates cell type and cell state-dependent m6A patterns, indicating that m6A modifications are highly regulated. This review describes the current knowledge of mammalian m6A modifications and future perspectives on how to push the field forward.
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Cites
Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons
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N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
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Self-citationALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility
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Cited by
Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase
Ping, X.-L., Sun, B.-F., Wang, L., Xiao, W., Yang, X., Wang, W.-J., Adhikari, S., Shi, Y., Lv, Y., Chen, Y.-S., et al. (2014) · Cell Research · doi:10.1038/cr.2014.3 · Cited by 2,375
Zhou, S., Bai, Z., Xia, D., Zhao, Z., Zhao, R., Wang, Y., & Zhe, H. (2018) · Molecular Carcinogenesis · doi:10.1002/mc.22782 · Cited by 365
Durbin, A. F., Wang, C., Marcotrigiano, J., & Gehrke, L. (2016) · mBio · doi:10.1128/mbio.00833-16 · Cited by 238
Metadata
- Authors
- Pan, T.
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 2013-04
- Volume
- 38
- Issue
- 4
- Pages
- 204-209
- ISSN
- 0968-0004 (ISSN-L)
- OpenAlex
- W2075160563
- Cited by
- 208
- References
- 10
- FWCI
- 1.12
- Type
- journal article
- Language
- en
- Open access
- green
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