The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
RNA pseudouridylation: new insights into an old modification
Open accessAbstract
Pseudouridine is the most abundant posttranscriptionally modified nucleotide in various stable RNAs of all organisms. Pseudouridine is derived from uridine via base-specific isomerization, resulting in an extra hydrogen bond donor that distinguishes it from other nucleotides. In eukaryotes, uridine-to-pseudouridine isomerization is catalyzed primarily by box H/ACA RNPs, ribonucleoproteins that act as pseudouridylases. When introduced into RNA, pseudouridine contributes significantly to RNA-mediated cellular processes. It was recently discovered that pseudouridylation can be induced by stress, suggesting a regulatory role for pseudouridine. It has also been reported that pseudouridine can be artificially introduced into mRNA by box H/ACA RNPs and that such introduction can mediate nonsense-to-sense codon conversion, thus demonstrating a new means of generating coding/protein diversity.
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Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation
Anderson, B. R., Muramatsu, H., Nallagatla, S. R., Bevilacqua, P. C., Sansing, L. H., Weissman, D., & Karikó, K. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq347 · Cited by 682
A Human Telomerase Holoenzyme Protein Required for Cajal Body Localization and Telomere Synthesis
Venteicher, A. S., Abreu, E. B., Meng, Z., McCann, K. E., Terns, R. M., Veenstra, T. D., Terns, M. P., & Artandi, S. E. (2009) · Science · doi:10.1126/science.1165357 · Cited by 522
A Conserved WD40 Protein Binds the Cajal Body Localization Signal of scaRNP Particles
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Cited by
Andries, O., Mc Cafferty, S., De Smedt, S. C., Weiss, R., Sanders, N. N., & Kitada, T. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.08.051 · Cited by 701
Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem Cells
Guzzi, N., Cieśla, M., Ngoc, P. C. T., Lang, S., Arora, S., Dimitriou, M., Pimková, K., Sommarin, M. N. E., Munita, R., Lubas, M., et al. (2018) · Cell · doi:10.1016/j.cell.2018.03.008 · Cited by 518
iRNA-PseU: Identifying RNA pseudouridine sites
Chen, W., Tang, H., Ye, J., Lin, H., & Chou, K.-C. (2016) · Molecular Therapy - Nucleic Acids · doi:10.1038/mtna.2016.37 · Cited by 291
Synthetic modified messenger RNA for therapeutic applications
Gao, M., Zhang, Q., Feng, X.-H., & Liu, J. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.06.020 · Cited by 89
Role of RNA modifications in brain and behavior
Jung, Y., & Goldman, D. (2018) · Genes, Brain and Behavior · doi:10.1111/gbb.12444 · Cited by 66
“Ψ is an isomer of uridine that does not affect Watson-Crick base pairing.(29) Ψ is generated by the action of 2 enzymes: H/ACA box snoRNAs(30) and by pseudouridine synthase (PUS).”
Background
Metadata
- Authors
- Ge, J., & Yu, Y.-T.
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 2013-04
- Volume
- 38
- Issue
- 4
- Pages
- 210-218
- ISSN
- 0968-0004 (ISSN-L)
- OpenAlex
- W2065898700
- Cited by
- 274
- References
- 5
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- green
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