The DOI matches its Crossref record; 104 of the 104 references it cites were found in a registry or an index.
Alternative cleavage and polyadenylation: the long and short of it
Open accessAbstract
Cleavage and polyadenylation (C/P) of nascent transcripts is essential for maturation of the 3′ ends of most eukaryotic mRNAs. Over the past three decades, biochemical studies have elucidated the machinery responsible for the seemingly simple C/P reaction. Recent genomic analyses have indicated that most eukaryotic genes have multiple cleavage and polyadenylation sites (pAs), leading to transcript isoforms with different coding potentials and/or variable 3′ untranslated regions (UTRs). As such, alternative cleavage and polyadenylation (APA) is an important layer of gene regulation impacting mRNA metabolism. Here, we review our current understanding of APA and recent progress in this field.
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Cites
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“Both modes of action can be elicited by the same protein in different contexts, as shown for the neuronal RBP Nova: its binding near the pA is inhibitory, whereas binding distant from the pA can be enhancing [56].”
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Cited by
Alternative polyadenylation of mRNA precursors
Tian, B., & Manley, J. L. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.116 · Cited by 1,179
Self-citationLinking Long Noncoding RNA Localization and Function
Chen, L.-L. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.07.003 · Cited by 1,052
Regulation by 3′-Untranslated Regions
Mayr, C. (2017) · Annual Review of Genetics · doi:10.1146/annurev-genet-120116-024704 · Cited by 588
Batra, R., Charizanis, K., Manchanda, M., Mohan, A., Li, M., Finn, D. J., Goodwin, M., Zhang, C., Sobczak, K., Thornton, C. A., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.08.027 · Cited by 292
Translation affects mRNA stability in a codon-dependent manner in human cells
Wu, Q., Medina, S. G., Kushawah, G., DeVore, M. L., Castellano, L. A., Hand, J. M., Wright, M., & Bazzini, A. A. (2019) · eLife · doi:10.7554/elife.45396 · Cited by 283
Metadata
- Authors
- Tian, B., & Manley, J. L.
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 2013-06
- Volume
- 38
- Issue
- 6
- Pages
- 312-320
- ISSN
- 0968-0004 (ISSN-L)
- OpenAlex
- W1967637890
- Cited by
- 306
- References
- 104
- FWCI
- 2.77
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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