The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Touch, Tension, and Transduction – The Function and Regulation of Piezo Ion Channels
Open accessAbstract
In 2010, two proteins, Piezo1 and Piezo2, were identified as the long-sought molecular carriers of an excitatory mechanically activated current found in many cells. This discovery has opened the floodgates for studying a vast number of mechanotransduction processes. Over the past six years, groundbreaking research has identified Piezos as ion channels that sense light touch, proprioception, and vascular blood flow, ruled out roles for Piezos in several other mechanotransduction processes, and revealed the basic structural and functional properties of the channel. Here, we review these findings and discuss the many aspects of Piezo function that remain mysterious, including how Piezos convert a variety of mechanical stimuli into channel activation and subsequent inactivation, and what molecules and mechanisms modulate Piezo function.
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Citations
Cites
Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells
Pathak, M. M., Nourse, J. L., Tran, T., Hwe, J., Arulmoli, J., Le, D. T. T., Bernardis, E., Flanagan, L. A., & Tombola, F. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1409802111 · Cited by 657
PIP 2 Is a Necessary Cofactor for Ion Channel Function: How and Why?
Suh, B.-C., & Hille, B. (2008) · Annual Review of Biophysics · doi:10.1146/annurev.biophys.37.032807.125859 · Cited by 646
The Mechanosensitive Ion Channel Piezo1 Is Inhibited by the Peptide GsMTx4
Bae, C., Sachs, F., & Gottlieb, P. A. (2011) · Biochemistry · doi:10.1021/bi200770q · Cited by 566
Cox, C. D., Bae, C., Ziegler, L., Hartley, S., Nikolova-Krstevski, V., Rohde, P. R., Ng, C.-A., Sachs, F., Gottlieb, P. A., & Martinac, B. (2016) · Nature Communications · doi:10.1038/ncomms10366 · Cited by 528
Piezo1 regulates mechanotransductive release of ATP from human RBCs
Cinar, E., Zhou, S., DeCourcey, J., Wang, Y., Waugh, R. E., & Wan, J. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1507309112 · Cited by 206
Cited by
Structure of the mechanically activated ion channel Piezo1
Saotome, K., Murthy, S. E., Kefauver, J. M., Whitwam, T., Patapoutian, A., & Ward, A. B. (2018) · Nature · doi:10.1038/nature25453 · Cited by 649
Piezos thrive under pressure: mechanically activated ion channels in health and disease
Murthy, S. E., Dubin, A. E., & Patapoutian, A. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.92 · Cited by 582
Structure-based membrane dome mechanism for Piezo mechanosensitivity
Guo, Y. R., & MacKinnon, R. (2017) · eLife · doi:10.7554/elife.33660 · Cited by 446
Force-induced conformational changes in PIEZO1
Lin, Y.-C., Guo, Y. R., Miyagi, A., Levring, J., MacKinnon, R., & Scheuring, S. (2019) · Nature · doi:10.1038/s41586-019-1499-2 · Cited by 433
Mechanisms and impact of altered tumour mechanics
Mohammadi, H., & Sahai, E. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0131-2 · Cited by 336
Metadata
- Authors
- Wu, J., Lewis, A. H., & Grandl, J.
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 2017-01
- Volume
- 42
- Issue
- 1
- Pages
- 57-71
- ISSN
- 0968-0004 (ISSN-L)
- OpenAlex
- W2530833951
- Cited by
- 570
- References
- 5
- FWCI
- 5.41
- Type
- journal article
- Language
- en
- Open access
- green
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- Wu, J., Lewis, A. H., & Grandl, J. (2017). Touch, Tension, and Transduction – The Function and Regulation of Piezo Ion Channels. Trends in Biochemical Sciences. https://doi.org/10.1016/j.tibs.2016.09.004
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