Piezo1 regulates mechanotransductive release of ATP from human RBCs
Open accessAbstract
Significance: Mechanotransductive release of ATP from RBCs participates in the regulation of microvascular tone and plays essential roles in vascular physiopathology. The mechanism responsible for the release of ATP, however, is poorly understood. We show for the first time, to our knowledge, that Piezo1, the recently identified mechanically activated cation channel, regulates the mechanotransductive release of ATP from RBCs. In particular, we uncover the link between Piezo1, calcium influx, and ATP release and propose a previously unidentified mechanotransductive pathway that modulates the release of ATP from RBCs. The outcome of this study will allow the development of much needed approaches to regulate the release of ATP from RBCs and thus, impact significantly the fields of red cell research, cellular mechanosensing, and Piezo1 channels.
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Shear stress, hypoxia, or pharmacological stimuli such as β-adrenergic receptor stimulation activate signaling cascades leading to release of ATP from RBCs through cystic fibrosis transmembrane conductance regulator or pannexin 1 channels.
“Shear stress, hypoxia, or pharmacological stimuli, such as β-adrenergic receptor stimulation, have been shown to activate signaling cascades leading to release of ATP through cystic fibrosis transmembrane conductance regulator or pannexin 1 channels (36, 53).”
From Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia (2017) · cites this paper as [36]
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- Authors
- Cinar, E., Zhou, S., DeCourcey, J., Wang, Y., Waugh, R. E., & Wan, J.
- Affiliations
- Microsystems Engineering, Rochester Institute of Technology, Rochester, NY 14623;
- Rochester Institute of Technology (US)
- University of Rochester (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2015-09-08
- Volume
- 112
- Issue
- 38
- Pages
- 11783-11788
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4586865
- OpenAlex
- W1684606992
- Cited by
- 206
- References
- 59
- Citations by year
- 2026: 17 · 2025: 17 · 2024: 17 · 2023: 17 · 2022: 30 · 2021: 22 · 2020: 16 · 2019: 22 · 2018: 16 · 2017: 22 · 2016: 10
- FWCI
- 11.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Erythrocyte Function and Pathophysiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- Piezo1, mechanotransduction, ATP release, human erythrocytes, extracellular calcium, hereditary xerocytosis, red cell disorders
- MeSH terms
- Adenosine Triphosphate, Calcium, Calibration, Erythrocyte Membrane, Erythrocytes, Extracellular Space, Humans, Ion Channels, Models, Biological, Shear Strength, Mechanotransduction, Cellular, Microfluidics
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