The DOI matches its Crossref record; 93 of the 93 references it cites were found in a registry or an index.
Spatiotemporal Control of Acetyl-CoA Metabolism in Chromatin Regulation
Open accessAbstract
The epigenome is sensitive to the availability of metabolites that serve as substrates of chromatin-modifying enzymes. Links between acetyl-CoA metabolism, histone acetylation, and gene regulation have been documented, although how specificity in gene regulation is achieved by a metabolite has been challenging to answer. Recent studies suggest that acetyl-CoA metabolism is tightly regulated both spatially and temporally, to elicit responses to nutrient availability and signaling cues. Here we discuss evidence that acetyl-CoA production is distinctly regulated in the nucleus and cytosol in mammalian cells. Recent findings indicate that acetyl-CoA availability for site-specific histone acetylation is influenced through post-translational modification of acetyl-CoA producing enzymes, as well as through dynamic regulation of the nuclear localization and chromatin recruitment of these enzymes.
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Martínez-Reyes, I., & Chandel, N. S. (2020) · Nature Communications · doi:10.1038/s41467-019-13668-3 · Cited by 2,813
Functions and mechanisms of non-histone protein acetylation
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Metabolism of Amino Acids in Cancer
Wei, Z., Liu, X., Cheng, C., Yu, W., & Yi, P. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.603837 · Cited by 429
Mitochondria as a Cellular Hub in Infection and Inflammation
Andrieux, P., Chevillard, C., Cunha-Neto, E., & Nunes, J. P. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111338 · Cited by 346
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Metadata
- Authors
- Sivanand, S., Viney, I., & Wellen, K. E.
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 43
- Issue
- 1
- Pages
- 61-74
- ISSN
- 0968-0004 (ISSN-L)
- OpenAlex
- W2770715322
- Cited by
- 357
- References
- 93
- FWCI
- 1.87
- Type
- journal article
- Language
- en
- Open access
- bronze
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