The DOI matches its Crossref record; 335 of the 335 references it cites were found in a registry or an index.
Metabolism of Amino Acids in Cancer
Open accessAbstract
Metabolic reprogramming has been widely recognized as a hallmark of malignancy. The uptake and metabolism of amino acids are aberrantly upregulated in many cancers that display addiction to particular amino acids. Amino acids facilitate the survival and proliferation of cancer cells under genotoxic, oxidative, and nutritional stress. Thus, targeting amino acid metabolism is becoming a potential therapeutic strategy for cancer patients. In this review, we will systematically summarize the recent progress of amino acid metabolism in malignancy and discuss their interconnection with mammalian target of rapamycin complex 1 (mTORC1) signaling, epigenetic modification, tumor growth and immunity, and ferroptosis. Finally, we will highlight the potential therapeutic applications.
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1 retracted
Wang, C., Ruan, P., Zhao, Y., Li, X., Wang, J., Wu, X., Liu, T., Wang, S., Hou, J., Li, Q., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.13582 · Cited by 75
RetractedFerroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691
Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
Stockwell, B. R., Friedmann Angeli, J. P., Bayir, H., Bush, A. I., Conrad, M., Dixon, S. J., Fulda, S., Gascón, S., Hatzios, S. K., Kagan, V. E., et al. (2017) · Cell · doi:10.1016/j.cell.2017.09.021 · Cited by 7,695
mTOR Signaling in Growth, Metabolism, and Disease
Saxton, R. A., & Sabatini, D. M. (2017) · Cell · doi:10.1016/j.cell.2017.02.004 · Cited by 7,555
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Kim, J., Kundu, M., Viollet, B., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2152 · Cited by 7,227
Spencer, P. M., Cameron, J. L., & Lin, L. (2000) · Cited by 7,202
The emerging hallmarks of cancer metabolism
Pavlova, N. N., & Thompson, C. B. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.12.006 · Cited by 5,926 · cited 1×
“Metabolic reprogramming is one of the hallmarks of cancer (Pavlova and Thompson, 2016; Revathidevi and Munirajan, 2019; Faubert et al., 2020; Hoxhaj and Manning, 2020; Leone and Powell, 2020).”
BackgroundAn Integrated Genomic Analysis of Human Glioblastoma Multiforme
Parsons, D. W., Jones, S., Zhang, X., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Siu, I.-M., Gallia, G. L., et al. (2008) · Science · doi:10.1126/science.1164382 · Cited by 5,857
Glutathione Metabolism and Its Implications for Health
Wu, G., Lupton, J. R., Turner, N. D., Fang, Y.-Z., & Yang, S. (2004) · The Journal of Nutrition · doi:10.1093/jn/134.3.489 · Cited by 3,842
The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
Bersuker, K., Hendricks, J. M., Li, Z., Magtanong, L., Ford, B., Tang, P. H., Roberts, M. A., Tong, B., Maimone, T. J., Zoncu, R., et al. (2019) · Nature · doi:10.1038/s41586-019-1705-2 · Cited by 3,703
Cited by
Goodrich, J. A., Walker, D. I., He, J., Lin, X., Baumert, B. O., Hu, X., Alderete, T. L., Chen, Z., Valvi, D., Fuentes, Z. C., et al. (2023) · Environmental Health Perspectives · doi:10.1289/ehp11372 · Cited by 96
Acute Myeloid Leukaemia Drives Metabolic Changes in the Bone Marrow Niche
Maynard, R. S., Hellmich, C., Bowles, K. M., & Rushworth, S. A. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.924567 · Cited by 17
Xu, M., Fei, J., Xiao, Z.-X., & Yi, Y. (2026) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2025106 · Cited by 2
Metadata
- Authors
- Wei, Z., Liu, X., Cheng, C., Yu, W., & Yi, P.
- Venue
- Frontiers in Cell and Developmental Biology
- Publisher
- Frontiers Media SA
- Published
- 2021-01-12
- Volume
- 8
- Pages
- 603837-603837
- ISSN
- 2296-634X (ISSN-L)
- OpenAlex
- W3118575215
- Cited by
- 429
- References
- 335
- FWCI
- 23.11
- Type
- journal article
- Language
- en
- Open access
- gold
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- Wei, Z., Liu, X., Cheng, C., Yu, W., & Yi, P. (2021). Metabolism of Amino Acids in Cancer. Frontiers in Cell and Developmental Biology. https://doi.org/10.3389/fcell.2020.603837
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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