The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
CRISPR/Cas Systems towards Next-Generation Biosensing
Abstract
Beyond its remarkable genome editing ability, the CRISPR/Cas9 effector has also been utilized in biosensing applications. The recent discovery of the collateral RNA cleavage activity of the Cas13a effector has sparked even greater interest in developing novel biosensing technologies for nucleic acid detection and promised significant advances in CRISPR diagnostics. Now, along with the discovery of Cas12 collateral cleavage activities on single-stranded DNA (ssDNA), several CRISPR/Cas systems have been established for detecting various targets, including bacteria, viruses, cancer mutations, and others. Based on key Cas effectors, we provide a detailed classification of CRISPR/Cas biosensing systems and propose their future utility. As the field continues to mature, CRISPR/Cas systems have the potential to become promising candidates for next-generation diagnostic biosensing platforms.
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Cites
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Self-citationUltrasensitive and Highly Specific Lateral Flow Assays for Point-of-Care Diagnosis
Liu, Y., Zhan, L., Qin, Z., Sackrison, J., & Bischof, J. C. (2021) · ACS Nano · doi:10.1021/acsnano.0c10035 · Cited by 626
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de Puig, H., Lee, R. A., Najjar, D., Tan, X., Soenksen, L. R., Angenent-Mari, N. M., Donghia, N. M., Weckman, N. E., Ory, A., Ng, C. F., et al. (2021) · Science Advances · doi:10.1126/sciadv.abh2944 · Cited by 325
Metadata
- Authors
- Li, Y., Li, S., Wang, J., & Liu, G.
- Venue
- Trends in Biotechnology
- Publisher
- Elsevier BV
- Published
- 2019-07
- Volume
- 37
- Issue
- 7
- Pages
- 730-743
- ISSN
- 0167-7799 (ISSN-L)
- OpenAlex
- W2910181162
- Cited by
- 917
- References
- 54
- FWCI
- 7.49
- Type
- journal article
- Language
- en
- Open access
- closed
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