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Enabling Technologies for Personalized and Precision Medicine

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Ho, Dean, Quake, Stephen R., McCabe, Edward R.B., Chng, Wee Joo, Chow, Edward K., Ding, Xianting, Gelb, Bruce D., Ginsburg, Geoffrey S., Hassenstab, Jason, Ho, Chih-Ming, Mobley, William C., Nolan, Garry P., Rosen, Steven T., Tan, Patrick, Yen, Yun, Zarrinpar, Ali·2020·Trends in Biotechnology

DOI 10.1016/j.tibtech.2019.12.021PMC PMC7924935

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Abstract

Individualizing patient treatment is a core objective of the medical field. Reaching this objective has been elusive owing to the complex set of factors contributing to both disease and health; many factors, from genes to proteins, remain unknown in their role in human physiology. Accurately diagnosing, monitoring, and treating disorders requires advances in biomarker discovery, the subsequent development of accurate signatures that correspond with dynamic disease states, as well as therapeutic interventions that can be continuously optimized and modulated for dose and drug selection. This work highlights key breakthroughs in the development of enabling technologies that further the goal of personalized and precision medicine, and remaining challenges that, when addressed, may forge unprecedented capabilities in realizing truly individualized patient care.

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Authors: Ho, D., Quake, S. R., McCabe, E. R. B., Chng, W. J., Chow, E. K., Ding, X., Gelb, B. D., Ginsburg, G. S., Hassenstab, J., Ho, C.-M., Mobley, W. C., Nolan, G. P., Rosen, S. T., Tan, P., Yen, Y., & Zarrinpar, A.
Affiliations: National University of Singapore (SG)
Chan Zuckerberg Biohub San Francisco (US)
March of Dimes (US)
Shanghai Jiao Tong University (CN)
Icahn School of Medicine at Mount Sinai (US)
Duke University (US)
Washington University in St. Louis (US)
University of California, Los Angeles (US)
University of California San Diego (US)
Stanford University (US)
City Of Hope National Medical Center (US)
Taipei Medical University (TW)
University of Florida Health (US)
Corresponding author: Ho, Dean
McCabe, Edward R.B.
ORCID: Ho, Dean
Quake, Stephen R.
McCabe, Edward R.B.
Chng, Wee Joo
Chow, Edward K.
Ding, Xianting
Gelb, Bruce D.
Ginsburg, Geoffrey S.
Hassenstab, Jason
Ho, Chih-Ming
Mobley, William C.
Nolan, Garry P.
Rosen, Steven T.
Tan, Patrick
Yen, Yun
Zarrinpar, Ali
Venue: Trends in Biotechnology
Publisher: Elsevier BV
Published: 2020-05
Volume: 38
Issue: 5
Pages: 497-518
ISSN: 0167-7799 (ISSN-L)
DOI: 10.1016/j.tibtech.2019.12.021
PMC: PMC7924935
OpenAlex: W3001878481
Cited by: 517
References: 212
Citations by year: 2026: 97 · 2025: 143 · 2024: 106 · 2023: 67 · 2022: 48 · 2021: 39 · 2020: 17
FWCI: 7.24
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Trends in biotechnology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: V Foundation for Cancer Research
National Research Foundation Singapore
Wallace H. Coulter Foundation
National Institutes of Health
Ministry of Education - Singapore
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Technology and Human Factors in Education and Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced Biosensing Techniques and Applications
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
Keywords: personalized medicine, precision medicine, biomarker discovery, disease signatures, personalized treatment, drug selection, dose optimization, enabling technologies, individualized care
MeSH terms: Artificial Intelligence, Diagnosis, Humans, Therapeutics, Biomarkers, Precision Medicine

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