The DOI matches its Crossref record; 98 of the 98 references it cites were found in a registry or an index.
Revisiting the role of persistent neural activity during working memory
Open accessAbstract
What are the neural mechanisms underlying working memory (WM)? One influential theory posits that neurons in lateral prefrontal cortex (lPFC) store WM information via persistent activity. In this review, we critically evaluate recent findings that together indicate that this model of WM needs revision. We argue that sensory cortex, not lPFC, maintains high-fidelity representations of WM content. In contrast, lPFC simultaneously maintains representations of multiple goal-related variables that serve to bias stimulus-specific activity in sensory regions. This work highlights multiple neural mechanisms supporting WM, including temporally dynamic population coding in addition to persistent activity. These new insights focus the question on understanding how the mechanisms that underlie WM are related, interact, and are coordinated in lPFC and sensory cortices.
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Cited by
The Cognitive Neuroscience of Working Memory
D'Esposito, M., & Postle, B. R. (2015) · Annual Review of Psychology · doi:10.1146/annurev-psych-010814-015031 · Cited by 1,653
Self-citationThe Distributed Nature of Working Memory
Christophel, T. B., Klink, P. C., Spitzer, B., Roelfsema, P. R., & Haynes, J.-D. (2017) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2016.12.007 · Cited by 882
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Stokes, M. G. (2015) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2015.05.004 · Cited by 850
Hierarchical process memory: memory as an integral component of information processing
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The mechanisms and functions of synaptic facilitation.
Jackman, S. L., & Regehr, W. G. (2017) · Neuron · doi:10.1016/j.neuron.2017.02.047 · Cited by 489
Metadata
- Authors
- Sreenivasan, K. K., Curtis, C. E., & D’Esposito, M.
- Venue
- Trends in Cognitive Sciences
- Publisher
- Elsevier BV
- Published
- 2014-02
- Volume
- 18
- Issue
- 2
- Pages
- 82-89
- ISSN
- 1364-6613 (ISSN-L)
- OpenAlex
- W1996507113
- Cited by
- 441
- References
- 98
- FWCI
- 4.21
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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