The DOI matches its Crossref record; 123 of the 123 references it cites were found in a registry or an index.
Neuromodulatory Influences on Integration and Segregation in the Brain
Abstract
Cognitive function relies on the dynamic cooperation of specialized regions of the brain; however, the elements of the system responsible for coordinating this interaction remain poorly understood. In this Opinion article I argue that this capacity is mediated in part by competitive and cooperative dynamic interactions between two prominent metabotropic neuromodulatory systems - the cholinergic basal forebrain and the noradrenergic locus coeruleus (LC). I assert that activity in these projection nuclei regulates the amount of segregation and integration within the whole brain network by modulating the activity of a diverse set of specialized regions of the brain on a timescale relevant for cognition and attention.
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Citations
Cites
Complex brain networks: graph theoretical analysis of structural and functional systems
Bullmore, E., & Sporns, O. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2575 · Cited by 11,820
Aston-Jones, G., & Cohen, J. D. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.061604.135709 · Cited by 4,472
The economy of brain network organization
Bullmore, E., & Sporns, O. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3214 · Cited by 3,284
Mesulam, M. (1998) · Brain · doi:10.1093/brain/121.6.1013 · Cited by 3,072
Bassett, D. S., & Bullmore, E. (2006) · The Neuroscientist · doi:10.1177/1073858406293182 · Cited by 2,600
Bassett, D. S., & Sporns, O. (2017) · Nature Neuroscience · doi:10.1038/nn.4502 · Cited by 2,398
Rich-club organization of the human connectome
van den Heuvel, M. P., & Sporns, O. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3539-11.2011 · Cited by 2,354
The functional role of cross-frequency coupling
Canolty, R. T., & Knight, R. T. (2010) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.09.001 · Cited by 2,101
Uncertainty, Neuromodulation, and Attention
Yu, A. J., & Dayan, P. (2005) · Neuron · doi:10.1016/j.neuron.2005.04.026 · Cited by 1,774 · cited 2×
“Together, these studies suggest that the noradrenergic circuitry, at least when working within its normal limits [56], promotes integrative capacities, such as cognitive control and attention [62,64], which typically require coordinated activity between otherwise segregated circuitry [17].”
The role of acetylcholine in learning and memory
Hasselmo, M. E. (2006) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2006.09.002 · Cited by 1,693
Cited by
Hansen, J. Y., Shafiei, G., Markello, R. D., Smart, K., Cox, S. M. L., Nørgaard, M., Beliveau, V., Wu, Y., Gallezot, J.-D., Aumont, É., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01186-3 · Cited by 797
Self-citationQuestions and controversies in the study of time-varying functional connectivity in resting fMRI
Lurie, D. J., Kessler, D., Bassett, D. S., Betzel, R. F., Breakspear, M., Kheilholz, S., Kucyi, A., Liégeois, R., Lindquist, M. A., McIntosh, A. R., et al. (2020) · Network Neuroscience · doi:10.1162/netn_a_00116 · Cited by 648
Self-citationIntegrative frontal-parietal dynamics supporting cognitive control
Nee, D. E. (2021) · eLife · doi:10.7554/elife.57244 · Cited by 112
Multivariate information theory uncovers synergistic subsystems of the human cerebral cortex
Varley, T. F., Pope, M., Faskowitz, J., & Sporns, O. (2023) · Communications Biology · doi:10.1038/s42003-023-04843-w · Cited by 101
Apical drive-A cellular mechanism of dreaming?
Aru, J., Siclari, F., Phillips, W. A., & Storm, J. F. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.09.018 · Cited by 74
Metadata
- Authors
- Shine, J. M.
- Venue
- Trends in Cognitive Sciences
- Publisher
- Elsevier BV
- Published
- 2019-07
- Volume
- 23
- Issue
- 7
- Pages
- 572-583
- ISSN
- 1364-6613 (ISSN-L)
- OpenAlex
- W2944341921
- Cited by
- 317
- References
- 123
- FWCI
- 3.69
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
