The role of acetylcholine in learning and memory

Brain-state- and cell-type-specific firing of hippocampal interneurons in vivo

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A proposed function for hippocampal theta rhythm: separate phases of encoding and retrieval enhance reversal of prior learning

Hasselmo, M. E., Bodelón, C., & Wyble, B. P. (2002) · Neural Computation · doi:10.1162/089976602317318965 · Cited by 875 · see citing works

Nicotinic effects on cognitive function: behavioral characterization, pharmacological specification, and anatomic localization

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Neuromodulation: acetylcholine and memory consolidation

Hasselmo, M. E. (1999) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(99)01365-0 · Cited by 809 · see citing works

Bidirectional synaptic plasticity induced by a single burst during cholinergic theta oscillation in CA1 in vitro

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Differential regulation of neocortical synapses by neuromodulators and activity

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High acetylcholine levels set circuit dynamics for attention and encoding and low acetylcholine levels set dynamics for consolidation

Hasselmo, M. E., & McGaughy, J. (2004) · Progress in Brain Research · doi:10.1016/s0079-6123(03)45015-2 · Cited by 525 · see citing works

Theta band oscillation and synchrony in the hippocampal formation and associated structures: the case for its role in sensorimotor integration

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Laminar selectivity of the cholinergic suppression of synaptic transmission in rat hippocampal region CA1: computational modeling and brain slice physiology

Hasselmo, M., & Schnell, E. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-06-03898.1994 · Cited by 466 · see citing works

Dynamics of learning and recall at excitatory recurrent synapses and cholinergic modulation in rat hippocampal region CA3

Hasselmo, M. E., Schnell, E., & Barkai, E. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-07-05249.1995 · Cited by 463 · see citing works

Low acetylcholine during slow-wave sleep is critical for declarative memory consolidation

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Object and Place Memory in the Macaque Entorhinal Cortex

SUZUKI, W. A., Miller, E. K., & Desimone, R. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.78.2.1062 · Cited by 383 · see citing works

Memory Representation within the Parahippocampal Region

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Selective activation of deep layer (V-VI) retrohippocampal cortical neurons during hippocampal sharp waves in the behaving rat

Chrobak, J. J., & Buzsáki, G. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-10-06160.1994 · Cited by 360 · see citing works

Cholinergic suppression specific to intrinsic not afferent fiber synapses in rat piriform (olfactory) cortex

Hasselmo, M. E., & Bower, J. M. (1992) · Journal of Neurophysiology · doi:10.1152/jn.1992.67.5.1222 · Cited by 358 · see citing works

Cholinergic excitation of GABAergic interneurons in the rat hippocampal slice.

Pitler, T. A., & Alger, B. E. (1992) · The Journal of Physiology · doi:10.1113/jphysiol.1992.sp019119 · Cited by 288 · see citing works

Mechanism of Graded Persistent Cellular Activity of Entorhinal Cortex Layer V Neurons

Fransén, E., Tahvildari, B., Egorov, A. V., Hasselmo, M. E., & Alonso, A. A. (2006) · Neuron · doi:10.1016/j.neuron.2006.01.036 · Cited by 279 · see citing works

Nicotinic Acetylcholine Receptor α7 and α4β2 Subtypes Differentially Control GABAergic Input to CA1 Neurons in Rat Hippocampus

Alkondon, M., & Albuquerque, E. X. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.86.6.3043 · Cited by 240 · see citing works

Involvement of GABAergic and cholinergic medial septal neurons in hippocampal theta rhythm

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Muscarinic Modulation of the Oscillatory and Repetitive Firing Properties of Entorhinal Cortex Layer II Neurons

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Visual Working Memory Is Impaired when the Medial Temporal Lobe Is Damaged

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Nicotinic Modulation of Glutamate and GABA Synaptic Transmission in Hippocampal Neurons

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Nicotinic receptors in the rat prefrontal cortex: increase in glutamate release and facilitation of mediodorsal thalamo‐cortical transmission

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The nucleus basalis and memory codes: Auditory cortical plasticity and the induction of specific, associative behavioral memory

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Blockade of Central Cholinergic Receptors Impairs New Learning and Increases Proactive Interference in a Word Paired-Associate Memory Task.

Atri, A., Sherman, S. J., Norman, K. A., Kirchhoff, B. A., Nicolas, M. M., Greicius, M. D., Cramer, S. C., Breiter, H. C., Hasselmo, M. E., & Stern, C. E. (2004) · Behavioral Neuroscience · doi:10.1037/0735-7044.118.1.223 · Cited by 162 · see citing works

Long-lasting cognitive improvement with nicotinic receptor agonists: mechanisms of pharmacokinetic–pharmacodynamic discordance

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Endogenous acetylcholine lowers the threshold for long‐term potentiation induction in the CA1 area through muscarinic receptor activation: in vivo study

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Cholinergic modulation of excitatory synaptic transmission in the CA3 area of the hippocampus

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Cholinergic Induction of Theta-Frequency Oscillations in Hippocampal Inhibitory Interneurons and Pacing of Pyramidal Cell Firing

Chapman, C. A., & Lacaille, J.-C. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-19-08637.1999 · Cited by 144 · see citing works

Removal of cholinergic input to perirhinal cortex disrupts object recognition but not spatial working memory in the rat

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Cholinergic modulation of the hippocampus during encoding and retrieval

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Simulations of the Role of the Muscarinic-Activated Calcium-Sensitive Nonspecific Cation Current<i>I_NCM</i>in Entorhinal Neuronal Activity during Delayed Matching Tasks

Fransén, E., Alonso, A. A., & Hasselmo, M. E. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-03-01081.2002 · Cited by 137 · see citing works

Scopolamine Reduces Persistent Activity Related to Long-Term Encoding in the Parahippocampal Gyrus during Delayed Matching in Humans

Schon, K., Atri, A., Hasselmo, M. E., Tricarico, M. D., LoPresti, M. L., & Stern, C. E. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1982-05.2005 · Cited by 132 · see citing works

Encoding and Retrieval in the CA3 Region of the Hippocampus: A Model of Theta-Phase Separation

Kunec, S., Hasselmo, M. E., & Kopell, N. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00731.2004 · Cited by 131 · see citing works

Cholinergic Activity Enhances Hippocampal Long-Term Potentiation in CA1 during Walking in Rats

Leung, L.-W. S., Bixia Shen, A., Rajakumar, N., & Ma, J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-28-09297.2003 · Cited by 129 · see citing works

Muscarinic and nicotinic receptor modulation of object and spatial -back working memory in humans

GREEN, A., Ellis, K. A., Ellis, J. R., Bartholomeusz, C., ILIC, S., Croft, R. J., LUANPHAN, K., & NATHAN, P. (2005) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2005.04.010 · Cited by 127 · see citing works

Ionic Mechanism of the Slow Afterdepolarization Induced by Muscarinic Receptor Activation in Rat Prefrontal Cortex

Haj-Dahmane, S., & Andrade, R. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.3.1197 · Cited by 126 · see citing works

Effects of muscarinic blockade in perirhinal cortex during visual recognition

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Theta-Contingent Trial Presentation Accelerates Learning Rate and Enhances Hippocampal Plasticity During Trace Eyeblink Conditioning.

Griffin, A. L., Asaka, Y., Darling, R. D., & Berry, S. D. (2004) · Behavioral Neuroscience · doi:10.1037/0735-7044.118.2.403 · Cited by 117 · see citing works

Muscarinic Receptor Activity Has Multiple Effects on the Resting Membrane Potentials of CA1 Hippocampal Interneurons

McQuiston, A. R., & Madison, D. V. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-14-05693.1999 · Cited by 112 · see citing works

Cell type‐specific dependence of muscarinic signalling in mouse hippocampal stratum oriens interneurones

Lawrence, J. J., Statland, J. M., Grinspan, Z. M., & McBain, C. J. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2005.100875 · Cited by 109 · see citing works

Cholinergic Deafferentation of the Entorhinal Cortex in Rats Impairs Encoding of Novel But Not Familiar Stimuli in a Delayed Nonmatch-to-Sample Task

McGaughy, J. A., Koene, R. A., Eichenbaum, H., & Hasselmo, M. E. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2386-05.2005 · Cited by 103 · see citing works

Action potentials and relations to the theta rhythm of medial septal neurons in vivo

Brazhnik, E. S., & Fox, S. E. (1999) · Experimental Brain Research · doi:10.1007/s002210050794 · Cited by 102 · see citing works

Selective muscarinic regulation of functional glutamatergic Schaffer collateral synapses in rat CA1 pyramidal neurons

de Sevilla, D. F., Cabezas, C., de Prada, A. N. O., Sánchez‐Jiménez, A., & Buño, W. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.029165 · Cited by 100 · see citing works

Cholinergic modulation of cortical function: A hypothetical role in shifting the dynamics in cortical network

Kimura, F. (2000) · Neuroscience Research · doi:10.1016/s0168-0102(00)00151-6 · Cited by 92 · see citing works

Cholinergic Agonist Carbachol Enables Associative Long-Term Potentiation in Piriform Cortex Slices

Patil, M. M., Linster, C., Lubenov, E., & Hasselmo, M. E. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.5.2467 · Cited by 91 · see citing works

Intraseptal muscarinic ligands and galanin: influence on hippocampal acetylcholine and cognition

Elvander-Tottie, E., Schött, P. A., Sandin, J., Bjelke, B., Kehr, J., Yoshitake, T., & Ögren, S. O. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.03.058 · Cited by 89 · see citing works

Effects of intra-hippocampal scopolamine injections in a repeated spatial acquisition task in the rat

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Muscarinic Blockade Slows and Degrades the Location-Specific Firing of Hippocampal Pyramidal Cells

Brazhnik, E. S., Muller, R. U., & Fox, S. E. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-02-00611.2003 · Cited by 78 · see citing works

Effects of cholinergic deafferentation of the rhinal cortex on visual recognition memory in monkeys

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Modulation of Inhibitory Synaptic Potentials in the Piriform Cortex

Patil, M. M., & Hasselmo, M. E. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.81.5.2103 · Cited by 69 · see citing works

Activation of α7 acetylcholine receptors augments stimulation‐induced hippocampal theta oscillation

Siok, C. J., Rogers, J. A., Kocsis, B., & Hajós, M. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04560.x · Cited by 68 · see citing works

Suppression of synaptic transmission may allow combination of associative feedback and self-organizing feedforward connections in the neocortex

Hasselmo, M. E., & Cekic, M. M. (1996) · Behavioural Brain Research · doi:10.1016/0166-4328(96)00010-1 · Cited by 63 · see citing works

Interactions between 192-IgG saporin and intraseptal cholinergic and GABAergic drugs: Role of cholinergic medial septal neurons in spatial working memory.

Pang, K. C. H., & Nocera, R. (1999) · Behavioral Neuroscience · doi:10.1037//0735-7044.113.2.265 · Cited by 63 · see citing works

Presynaptic inhibition of Schaffer collateral synapses by stimulation of hippocampal cholinergic afferent fibres

de Sevilla, D. F., & Buño, W. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02490.x · Cited by 57 · see citing works

Interactions between 192-IgG saporin and intraseptal cholinergic and GABAergic drugs: Role of cholinergic medial septal neurons in spatial working memory.

Pang, K. C. H., & Nocera, R. (1999) · Behavioral Neuroscience · doi:10.1037/0735-7044.113.2.265 · Cited by 57 · see citing works

Enhanced cholinergic suppression of previously strengthened synapses enables the formation of self-organized representations in olfactory cortex

Linster, C., Maloney, M. E., Patil, M. M., & Hasselmo, M. E. (2003) · Neurobiology of Learning and Memory · doi:10.1016/s1074-7427(03)00078-9 · Cited by 53 · see citing works

Nicotinic modulation of glutamatergic synaptic transmission in region CA3 of the hippocampus

Giocomo, L. M., & Hasselmo, M. E. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04316.x · Cited by 52 · see citing works

Muscarinic signaling is required for spike‐pairing induction of long‐term potentiation at rat Schaffer collateral‐CA1 synapses

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Intraseptal infusion of the cholinergic agonist carbachol impairs delayed‐non‐match‐to‐sample radial arm maze performance in the rat

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Synaptic mechanisms and cholinergic regulation in auditory cortex

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Cholinergic modulation of synaptic physiology in deep layer entorhinal cortex of the rat

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Differential modulation by carbachol of four separate excitatory afferent systems to the rat subiculum in vitro

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Hippocampal sharp wave-ripple: A cognitive biomarker for episodic memory and planning

Buzsáki, G. (2015) · Hippocampus · doi:10.1002/hipo.22488 · Cited by 1,759 · see citing works

Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior

Picciotto, M. R., Higley, M. J., & Mineur, Y. S. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.036 · Cited by 1,404 · see citing works

An opportunity cost model of subjective effort and task performance

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Hippocampal replay in the awake state: a potential substrate for memory consolidation and retrieval

Carr, M. F., Jadhav, S. P., & Frank, L. M. (2011) · Nature Neuroscience · doi:10.1038/nn.2732 · Cited by 958 · see citing works

Hippocampal GABAergic Inhibitory Interneurons

Pelkey, K. A., Chittajallu, R., Craig, M. T., Tricoire, L., Wester, J. C., & McBain, C. J. (2017) · Physiological Reviews · doi:10.1152/physrev.00007.2017 · Cited by 889 · see citing works

Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment

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Modes and models of forebrain cholinergic neuromodulation of cognition

Hasselmo, M. E., & Sarter, M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.104 · Cited by 733 · see citing works

The validity of scopolamine as a pharmacological model for cognitive impairment: A review of animal behavioral studies

Klinkenberg, I., & Blokland, A. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.04.001 · Cited by 714 · see citing works

An oscillatory interference model of grid cell firing

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The contribution of sleep to hippocampus-dependent memory consolidation

Marshall, L., & Born, J. (2007) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2007.09.001 · Cited by 667 · see citing works

Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development

Wess, J., Eglen, R. M., & Gautam, D. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2379 · Cited by 637 · see citing works

Pattern separation deficits associated with increased hippocampal CA3 and dentate gyrus activity in nondemented older adults

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Striatal circuits for reward learning and decision-making

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Dendritic Inhibition in the Hippocampus Supports Fear Learning

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Plasticity of Cortical Excitatory-Inhibitory Balance

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Neuromodulated Spike-Timing-Dependent Plasticity, and Theory of Three-Factor Learning Rules

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An optimized acetylcholine sensor for monitoring in vivo cholinergic activity

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Self-organization and neuronal avalanches in networks of dissociated cortical neurons

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Episodic memory in normal aging and Alzheimer disease: Insights from imaging and behavioral studies

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Bifidobacteria modulate cognitive processes in an anxious mouse strain

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An improved neuroanatomical model of the default-mode network reconciles previous neuroimaging and neuropathological findings

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Hierarchical Prediction Errors in Midbrain and Basal Forebrain during Sensory Learning

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Crystal structures of the M1 and M4 muscarinic acetylcholine receptors

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Alzheimer’s disease: Insights and new prospects in disease pathophysiology, biomarkers and disease-modifying drugs

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Acetylcholine and attention

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Eligibility Traces and Plasticity on Behavioral Time Scales: Experimental Support of NeoHebbian Three-Factor Learning Rules

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Toxicity comparison of nano-sized and micron-sized microplastics to Goldfish Carassius auratus Larvae

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Neuromodulatory Influences on Integration and Segregation in the Brain

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Functional significance of axonal Kv7 channels in hippocampal pyramidal neurons

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Pyramidal Cell-Interneuron Circuit Architecture and Dynamics in Hippocampal Networks

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Sublayer-Specific Coding Dynamics during Spatial Navigation and Learning in Hippocampal Area CA1

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Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders

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Cognitive neuroscience-based approaches to measuring and improving treatment effects on cognition in schizophrenia: the CNTRICS initiative.

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Sensorimotor processing in the rodent barrel cortex

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