The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Rethinking WNT signaling
Abstract
Recent research on the WNT signaling pathway warrants a reassessment of the basic mechanism that transmits signal from the membrane-bound receptor to the nucleus. This article incorporates these findings into a revised model for pathway activation. We propose that the control of Axin stability, rather than the control of ZW3 phosphorylation of the Armadillo protein, is the key step in signaling. Axin degradation is controlled by a stabilizing effect of ZW3-dependent phosphorylation, and a destabilizing effect of active Arrow. Removing Axin enables Armadillo to accumulate and re-localize to the nucleus. We argue that nuclear localization of Armadillo is required for transcriptional pathway activity. Finally, we speculate on the effects this revision will have on the major questions facing the WNT field of research.
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“At the same time, GSK-3β also controls cell survival through regulation of β-catenin, 1 of the key molecules in Wnt signaling (11), and inhibition of Akt suppresses the Wnt pathway by activation of GSK-3β and degradation of ß-catenin (51).”
From Anabolic effect of plant brassinosteroid (2011) · cites this paper as [11]
Citations
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1 retracted
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RetractedPolakis, P. (2000) · Genes & Development · doi:10.1101/gad.14.15.1837 · Cited by 3,183
MECHANISMS OF WNT SIGNALING IN DEVELOPMENT
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LDL-receptor-related proteins in Wnt signal transduction
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Items 101–150 of 150
Kalderon, D. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-470-4_8 · Cited by 16
Liquid–liquid phase separation drives the β‐catenin destruction complex formation
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“Several models have been proposed for Wnt-triggered inactivation of the destruction complex,[2,48] including targeting Axin for degradation,[55] direct inhibition of GSK3β by phosphorylated LRP5/6,[56] inhibition of Axin homo-polymerization and the Axin-APC interaction byDvl via theAxin-Dvl hetero-polymerization.”
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Tolwinski, N. S. (2009) · Genetics · doi:10.1534/genetics.108.098236 · Cited by 14
“It was further shown that Axin was the ratelimiting component, and its levels were regulated through proteasomal degradation in a signal-dependent manner (Lee et al. 2003; Tolwinski et al. 2003; Tolwinski and Wieschaus 2004b).”
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Parker, D. S., Blauwkamp, T. A., & Cadigan, K. M. (2007) · Advances in developmental biology · doi:10.1016/s1574-3349(06)17001-5 · Cited by 14
Membrane Bound GSK-3 Activates Wnt Signaling through Disheveled and Arrow
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“Many good review papers have been published in recent years (Korswagen & Clevers 1999; Moon et al. 2002; Karim et al. 2004; Logan & Nusse 2004; Nelson & Nusse 2004; Tolwinski & Wieschaus 2004).”
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Filhol, O., Deshière, A., & Cochet, C. (2013) · doi:10.1002/9781118482490.ch14 · Cited by 10
Membrane Targeting of Disheveled Can Bypass the Need for Arrow/LRP5
Kaur, P., Lam, V. Y. M., Mannava, A. G., Suresh, J., Jenny, A., & Tolwinski, N. S. (2017) · Scientific Reports · doi:10.1038/s41598-017-04414-0 · Cited by 10
Self-citationRegulatory role of miRNAs in Wnt signaling pathway linked with cardiovascular diseases
Behera, J. K., Bhattacharya, M., Mishra, P. K., Mishra, A., Dash, A. A., Kar, N. B., Behera, B., & Patra, B. C. (2022) · Current Research in Pharmacology and Drug Discovery · doi:10.1016/j.crphar.2022.100133 · Cited by 6
“It also noted that the Wnt signaling mechanism is absent to result in phosphorylation of cytoplasmic β-catenin degraded by destruction complex with Axin, β-catenin, adenomatous polyposis coli (APC), Ser/Thr kinases GSK-3β and casein kinase I α (CKIα) protein subunit (MacDonald and Tamai, 2009; Tolwinski and Wieschaus,…”
BackgroundMolecular Genetics of Lung and Pleural Neoplasms
Cagle, P. T., Jagirdar, J. S., & Popper, H. (2008) · Springer eBooks · doi:10.1007/978-0-387-72114-9_2 · Cited by 4
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Sun, S., Gong, Y., Kang, J. S., Dong, M., & Choi, Y. (2024) · Medical Oncology · doi:10.1007/s12032-024-02314-8 · Cited by 1
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Receptors, Signaling Pathways, Cell Cycle, and DNA Damage Repair
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2. Mise en place du plan d’organisation de la drosophile
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Metadata
- Authors
- Tolwinski, N. S., & Wieschaus, E.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Wieschaus, Eric
- Venue
- Trends in Genetics
- Publisher
- Elsevier BV
- Published
- 2004-04
- Volume
- 20
- Issue
- 4
- Pages
- 177-181
- ISSN
- 0168-9525 (ISSN-L)
- OpenAlex
- W1965204519
- Cited by
- 151
- References
- 40
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2022: 2 · 2021: 1 · 2020: 2 · 2017: 5 · 2016: 3 · 2015: 3 · 2014: 5 · 2013: 9 · 2012: 7
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Javna Agencija za Raziskovalno Dejavnost RS
- National Cancer Institute (P01CA041086, P01CA41086)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- Wnt signaling, armadillos, arrows, signal transduction, transcriptional activation
- MeSH terms
- Animals, Cell Membrane, Cell Nucleus, Models, Biological, Phosphorylation, Protein Binding, Proto-Oncogene Proteins, Signal Transduction, Zebrafish Proteins, Wnt Proteins
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