The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Nuclear lamin functions and disease
Open accessAbstract
Recent studies have shown that premature cellular senescence and normal organ development and function depend on the type V intermediate filament proteins, the lamins, which are major structural proteins of the nucleus. This review presents an up-to-date summary of the literature describing new findings on lamin functions in various cellular processes and emphasizes the relationship between the lamins and devastating diseases ranging from premature aging to cancer. Recent insights into the structure and function of the A- and B- type lamins in normal cells and their dysfunctions in diseased cells are providing novel targets for the development of new diagnostic procedures and disease intervention. We summarize these recent findings, focusing on data from mice and humans, and highlight the expanding knowledge of these proteins in both healthy and diseased cells.
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Citations
Cites
Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome
Liu, G.-H., Barkho, B. Z., Ruiz, S., Diep, D., Qu, J., Yang, S.-L., Panopoulos, A. D., Suzuki, K., Kurian, L., Walsh, C., et al. (2011) · Nature · doi:10.1038/nature09879 · Cited by 575
Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation
Varela, I., Cadiñanos, J., Pendás, A. M., Gutiérrez-Fernández, A., Folgueras, A. R., Sánchez, L. M., Zhou, Z., Rodríguez, F. J., Stewart, C. L., Vega, J. A., et al. (2005) · Nature · doi:10.1038/nature04019 · Cited by 466
Progeria syndromes and ageing: what is the connection?
Burtner, C. R., & Kennedy, B. K. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2944 · Cited by 386
Local translation of extranuclear lamin B promotes axon maintenance
Yoon, B. C., Jung, H., Dwivedy, A., O'Hare, C. M., Zivraj, K. H., & Holt, C. E. (2012) · Cell · doi:10.1016/j.cell.2011.11.064 · Cited by 263
Mouse B-type lamins are required for proper organogenesis but not by embryonic stem cells
Kim, Y., Sharov, A. A., McDole, K., Cheng, M., Hao, H., Fan, C.-M., Gaiano, N., Ko, M. S. H., & Zheng, Y. (2011) · Science · doi:10.1126/science.1211222 · Cited by 247
Krishnan, V., Chow, M. Z. Y., Wang, Z., Zhang, L., Liu, B., Liu, X., & Zhou, Z. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102789108 · Cited by 236
DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A
Liu, Y., Rusinol, A., Sinensky, M., Wang, Y., & Zou, Y. (2006) · Journal of Cell Science · doi:10.1242/jcs.03263 · Cited by 228
Coffinier, C., Jung, H.-J., Nobumori, C., Chang, S., Tu, Y., Barnes, R. H., Yoshinaga, Y., de Jong, P. J., Vergnes, L., Reue, K., et al. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-06-0504 · Cited by 225
Barascu, A., Le Chalony, C., Pennarun, G., Genet, D., Imam, N., Lopez, B., & Bertrand, P. (2012) · The EMBO Journal · doi:10.1038/emboj.2011.492 · Cited by 206 · cited 3×
“Furthermore, lamin B1 protein and mRNA levels are reduced both in normal cellular senescence and in premature senescence induced by oncogenic Ras [20].”
BackgroundLiu, Y., Wang, Y., Rusinol, A. E., Sinensky, M. S., Liu, J., Shell, S. M., & Zou, Y. (2008) · The FASEB Journal · doi:10.1096/fj.07-8598com · Cited by 115
Cited by
Lysosome-mediated processing of chromatin in senescence
Ivanov, A., Pawlikowski, J., Manoharan, I., van Tuyn, J., Nelson, D. M., Rai, T. S., Shah, P. P., Hewitt, G., Korolchuk, V. I., Passos, J. F., et al. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201212110 · Cited by 539
Chromatin and lamin A determine two different mechanical response regimes of the cell nucleus
Stephens, A. D., Banigan, E. J., Adam, S. A., Goldman, R. D., & Marko, J. F. (2017) · Molecular Biology of the Cell · doi:10.1091/mbc.e16-09-0653 · Cited by 473
Self-citationWhen Lamins Go Bad: Nuclear Structure and Disease
Schreiber, K. H., & Kennedy, B. K. (2013) · Cell · doi:10.1016/j.cell.2013.02.015 · Cited by 391
Chromatin histone modifications and rigidity affect nuclear morphology independent of lamins
Stephens, A. D., Liu, P. Z., Banigan, E. J., Almassalha, L. M., Backman, V., Adam, S. A., Goldman, R. D., & Marko, J. F. (2018) · Molecular Biology of the Cell · doi:10.1091/mbc.e17-06-0410 · Cited by 353
Self-citationDrugs that modulate aging: the promising yet difficult path ahead
Kennedy, B. K., & Pennypacker, J. K. (2014) · Translational research · doi:10.1016/j.trsl.2013.11.007 · Cited by 127
Metadata
- Authors
- Butin-Israeli, V., Adam, S. A., Goldman, A. E., & Goldman, R. D.
- Venue
- Trends in Genetics
- Publisher
- Elsevier BV
- Published
- 2012-09
- Volume
- 28
- Issue
- 9
- Pages
- 464-471
- ISSN
- 0168-9525 (ISSN-L)
- OpenAlex
- W2136835005
- Cited by
- 231
- References
- 11
- FWCI
- 1.44
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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