Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons

Coffinier, Catherine; Jung, Hea-Jin; Nobumori, Chika; Chang, Sandy; Tu, Yiping; Barnes, Richard H.; Yoshinaga, Yuko; de Jong, Pieter J.; Vergnes, Laurent; Reue, Karen; Fong, Loren G.; Young, Stephen G.

doi:10.1091/mbc.e11-06-0504

Cited by 225Nuclear Structure and FunctionNeurogenesis and neuroplasticity mechanismsSkin and Cellular Biology Research

Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons

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Coffinier, Catherine, Jung, Hea-Jin, Nobumori, Chika, Chang, Sandy, Tu, Yiping, Barnes, Richard H., Yoshinaga, Yuko, de Jong, Pieter J. +4 more·2011·Molecular Biology of the Cell

DOI 10.1091/mbc.e11-06-0504PMC PMC3226484

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Abstract

Neuronal migration is essential for the development of the mammalian brain. Here, we document severe defects in neuronal migration and reduced numbers of neurons in lamin B1–deficient mice. Lamin B1 deficiency resulted in striking abnormalities in the nuclear shape of cortical neurons; many neurons contained a solitary nuclear bleb and exhibited an asymmetric distribution of lamin B2. In contrast, lamin B2 deficiency led to increased numbers of neurons with elongated nuclei. We used conditional alleles for Lmnb1 and Lmnb2 to create forebrain-specific knockout mice. The forebrain-specific Lmnb1- and Lmnb2-knockout models had a small forebrain with disorganized layering of neurons and nuclear shape abnormalities, similar to abnormalities identified in the conventional knockout mice. A more severe phenotype, complete atrophy of the cortex, was observed in forebrain-specific Lmnb1/Lmnb2 double-knockout mice. This study demonstrates that both lamin B1 and lamin B2 are essential for brain development, with lamin B1 being required for the integrity of the nuclear lamina, and lamin B2 being important for resistance to nuclear elongation in neurons.

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Loss of lamin B1 has been associated with cognitive decline and neurodegenerative pathology.
“Loss of lamin B1 has been associated with cognitive decline and neurodegenerative pathology [20, 56].”
From DNA repair deficiency and senescence in concussed professional athletes involved in contact sports (2019) · cites this paper as [20]

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Abnormal development of the cerebral cortex and cerebellum in the setting of lamin B2 deficiency
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Reciprocal knock-in mice to investigate the functional redundancy of lamin B1 and lamin B2
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An absence of lamin B1 in migrating neurons causes nuclear membrane ruptures and cell death
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Nuclear envelope and lamin B2 function in the central nervous system
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Authors: Coffinier, C., Jung, H.-J., Nobumori, C., Chang, S., Tu, Y., Barnes, R. H., Yoshinaga, Y., de Jong, P. J., Vergnes, L., Reue, K., Fong, L. G., & Young, S. G.
Affiliations: University of California, Los Angeles (US)
Children's Hospital Oakland Research Institute, Oakland, CA 94609
Corresponding author: Coffinier, Catherine
ORCID: Chang, Sandy
Tu, Yiping
Yoshinaga, Yuko
Vergnes, Laurent
Reue, Karen
Fong, Loren G.
Young, Stephen G.
Venue: Molecular Biology of the Cell
Publisher: American Society for Cell Biology (ASCB)
Published: 2011-12
Volume: 22
Issue: 23
Pages: 4683-4693
ISSN: 1059-1524 (ISSN-L)
1939-4586
DOI: 10.1091/mbc.e11-06-0504
PMC: PMC3226484
OpenAlex: W1978257498
Cited by: 225
References: 41
Citations by year: 2026: 11 · 2025: 16 · 2024: 9 · 2023: 13 · 2022: 17 · 2021: 23 · 2020: 14 · 2019: 11 · 2018: 12 · 2017: 8 · 2016: 20 · 2015: 12 · 2014: 21 · 2013: 19 · 2012: 14
FWCI: 7.54
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: cc-by-nc-sa
Locations: Molecular Biology of the Cell (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion, cc-by-nc-sa)
PubMed (publishedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Science Foundation (0722519)
Ellison Medical Foundation
March of Dimes Foundation
American Heart Association
National Institutes of Health
University of California, Los Angeles
U.S. Public Health Service (CJX1-44385-WS-29646)
National Institute on Aging (R01AG035626)
National Heart, Lung, and Blood Institute (HL89781, R01HL076839, R01HL086683, HL-86683, HL76839, R01HL089781)
National Institute of General Medical Sciences (GM66152, R01GM066152)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR050200, AR 050200)
National Center for Research Resources (CHE-0722519)
Division of Chemistry (CHE-0722519)
California NanoSystems Institute
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
Keywords: lamin B1, lamin B2, neuronal migration, brain development, nuclear lamina, cortical neurons, cortical atrophy, forebrain development, conditional knockout mice
MeSH terms: Animals, Brain, Neurons, Prosencephalon, Mice, Knockout, Nuclear Lamina, Lamin Type B, Mice

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Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons

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