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When bigger is better: the role of polyploidy in organogenesis
Open accessAbstract
Defining how organ size is regulated, a process controlled by not only the number of cells but also the size of the cells, is a frontier in developmental biology. Large cells are produced by increasing DNA content or ploidy, a developmental strategy employed throughout the plant and animal kingdoms. The wide-spread use of polyploidy during cell differentiation makes it important to define how this hypertrophy contributes to organogenesis. I discuss here examples from a variety of animals and plants in which polyploidy controls organ size, the size and function of specific tissues within an organ, or the differentiated properties of cells. In addition, I highlight how polyploidy functions in wound healing and tissue regeneration.
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Cites
Mammalian heart renewal by pre-existing cardiomyocytes
Senyo, S. E., Steinhauser, M. L., Pizzimenti, C. L., Yang, V. K., Cai, L., Wang, M., Wu, T.-D., Guerquin-Kern, J.-L., Lechene, C. P., & Lee, R. T. (2013) · Nature · doi:10.1038/nature11682 · Cited by 1,343
Direct observation of mammalian cell growth and size regulation
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Polyploidization in Liver Tissue
Gentric, G., & Desdouets, C. (2014) · The American Journal of Pathology · doi:10.1016/j.ajpath.2013.06.035 · Cited by 192
E2F8 is essential for polyploidization in mammalian cells
Pandit, S. K., Westendorp, B., Nantasanti, S., van Liere, E., Tooten, P. C. J., Cornelissen, P. W. A., Toussaint, M. J. M., Lamers, W. H., & de Bruin, A. (2012) · Nature Cell Biology · doi:10.1038/ncb2585 · Cited by 168 · cited 1×
“A confounding observation is that conditional knock out of these genes did not apparently affect hepatocyte differentiation or liver regeneration [65].”
BackgroundCanonical and atypical E2Fs regulate the mammalian endocycle
Chen, H.-Z., Ouseph, M. M., Li, J., Pécot, T., Chokshi, V., Kent, L., Bae, S., Byrne, M., Duran, C., Comstock, G., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2595 · Cited by 161
Cited by
The broken cycle: E2F dysfunction in cancer
Kent, L. N., & Leone, G. (2019) · Nature Reviews Cancer · doi:10.1038/s41568-019-0143-7 · Cited by 800
RNA contributions to the form and function of biomolecular condensates
Roden, C., & Gladfelter, A. S. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0264-6 · Cited by 655
Myocardial Polyploidization Creates a Barrier to Heart Regeneration in Zebrafish
González-Rosa, J. M., Sharpe, M., Field, D., Soonpaa, M. H., Field, L. J., Burns, C. E., & Burns, C. G. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.01.021 · Cited by 264
Matsumoto, T., Wakefield, L., Tarlow, B. D., & Grompe, M. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2019.11.014 · Cited by 194
Polyploidy in liver development, homeostasis and disease
Donne, R., Saroul-Aïnama, M., Cordier, P., Celton-Morizur, S., & Desdouets, C. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0284-x · Cited by 188
Metadata
- Authors
- Orr-Weaver, T. L.
- Venue
- Trends in Genetics
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 31
- Issue
- 6
- Pages
- 307-315
- ISSN
- 0168-9525 (ISSN-L)
- OpenAlex
- W2094964240
- Cited by
- 283
- References
- 5
- FWCI
- 2.76
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
