The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Nascent Connections: R-Loops and Chromatin Patterning
Open accessAbstract
RNA molecules such as long non-coding RNAs play critical roles in regulating gene expression, chromosome architecture, and the modification states of chromatin. Recent developments suggest that RNA may also influence gene expression and chromatin patterns through the interaction of nascent transcripts with their DNA template via the formation of co-transcriptional R-loop structures. R-loop formation over specific, conserved, hotspots occurs at thousands of genes in mammalian genomes and represents an important and dynamic feature of mammalian chromatin. Here, focusing primarily on mammalian systems, I describe the accumulating connections and possible mechanisms linking R-loop formation and chromatin patterning. The possible contribution of aberrant R-loops to pathological conditions is also discussed.
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Shilatifard, A. (2012) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-051710-134100 · Cited by 1,091
CpG islands influence chromatin structure via the CpG-binding protein Cfp1
Thomson, J. P., Skene, P. J., Selfridge, J., Clouaire, T., Guy, J., Webb, S., Kerr, A. R. W., Deaton, A., Andrews, R., James, K. D., et al. (2010) · Nature · doi:10.1038/nature08924 · Cited by 625
Ayrapetov, M. K., Gursoy-Yuzugullu, O., Xu, C., Xu, Y., & Price, B. D. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1403565111 · Cited by 391
Cited by
R-Loops as Cellular Regulators and Genomic Threats
Crossley, M. P., Bocek, M., & Cimprich, K. A. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.01.024 · Cited by 746
Mechanisms of Oncogene-Induced Replication Stress: Jigsaw Falling into Place
Kotsantis, P., Petermann, E., & Boulton, S. J. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-1461 · Cited by 416
Chen, L., Chen, J.-Y., Zhang, X., Gu, Y., Xiao, R., Shao, C., Tang, P., Qian, H., Luo, D., Li, H., et al. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.10.008 · Cited by 375
De Magis, A., Manzo, S. G., Russo, M., Marinello, J., Morigi, R., Sordet, O., & Capranico, G. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1810409116 · Cited by 332
R-Loop Mediated trans Action of the APOLO Long Noncoding RNA
Ariel, F., Lucero, L., Christ, A., Mammarella, M. F., Jegu, T., Veluchamy, A., Mariappan, K., Latrasse, D., Blein, T., Liu, C., et al. (2020) · Molecular Cell · doi:10.1016/j.molcel.2019.12.015 · Cited by 287
Metadata
- Authors
- Chédin, F.
- Venue
- Trends in Genetics
- Publisher
- Elsevier BV
- Published
- 2016-12
- Volume
- 32
- Issue
- 12
- Pages
- 828-838
- ISSN
- 0168-9525 (ISSN-L)
- OpenAlex
- W2534058863
- Cited by
- 207
- References
- 3
- FWCI
- 1.48
- Type
- journal article
- Language
- en
- Open access
- green
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