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Nursing our microbiota: molecular linkages between bifidobacteria and milk oligosaccharides
Open accessAbstract
As the sole nutrition provided to infants, bioactive molecules dissolved in milk influence the development of our gut microbiota. Accordingly, human milk oligosaccharides (HMOs) are minimally digested by the infant and persist to negatively and positively regulate gut microbiota. Infant-type bifidobacteria utilize these soluble carbohydrate oligomers by convergent mechanisms. Bifidobacterium longum subsp. infantis efficiently consumes several small mass HMOs and possesses a large gene cluster and other loci dedicated to HMO metabolism. In contrast, adult-associated bifidobacteria such as the closely related B. longum subsp. longum are deficient for HMO utilization, although they retain the capacity to ferment plant oligosaccharides and constituent pentose sugars. Thus, the ability to subsist on HMO could demark infant-associated ecotypes potentially adapted to colonize the nursing infant.
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“This bacteria grows exceptionally well in the presence of complex milk oligosaccharides to the exclusion of other potentially harmful bacteria [27–29].”
From Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms (2019) · cites this paper as [28]
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Metadata
- Authors
- Sela, D. A., & Mills, D. A.
- Affiliations
- University of California, Davis (US)
- Corresponding author
- Mills, David A.
- Venue
- Trends in Microbiology
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 18
- Issue
- 7
- Pages
- 298-307
- ISSN
- 0966-842X (ISSN-L)
- PMC
- PMC2902656
- OpenAlex
- W1998628730
- Cited by
- 468
- References
- 82
- Citations by year
- 2026: 16 · 2025: 14 · 2024: 26 · 2023: 28 · 2022: 29 · 2021: 42 · 2020: 33 · 2019: 28 · 2018: 40 · 2017: 33 · 2016: 35 · 2015: 35 · 2014: 31 · 2013: 29 · 2012: 30
- FWCI
- 2.80
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (T32GM008799, T32GM08799)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD061923, R01HD059127)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- human milk oligosaccharides, Bifidobacterium, Bifidobacterium longum subsp. infantis, Bifidobacterium longum subsp. longum, infant gut microbiota, infant nutrition, pentoses
- MeSH terms
- Bifidobacterium, Humans, Infant, Infant, Newborn, Milk, Human, Oligosaccharides, Gastrointestinal Tract, Metabolic Networks and Pathways
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