Interpreting infective microbiota: the importance of an ecological perspective
Open accessAbstract
Complex microbiota are being reported increasingly across a range of chronic infections, including those of the cystic fibrosis airways. Such diversity fits poorly into classical models of sterile tissue infections, which generally involve one species, and where microbe-outcome associations usually imply causality. It has been suggested that microbiota at sites of infection could represent pathogenic entities, analogous to individual species. We argue that our ability to identify causality in microbiota-disease associations is, however, inherently confounded. Although particular microbiota may be associated with clinical outcomes, niche characteristics at sites of infection will shape microbiota composition through exerting selective pressures. Here, we suggest that ecological theory can inform clinical understanding.
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Impaired airway clearance due to intrinsic or extrinsic factors leads to the proliferation of bacterial species that can exploit this growth opportunity.
“Impaired airway clearance due to intrinsic or extrinsic factors leads to the proliferation of bacterial species that can exploit this growth opportunity”
From Respiratory viral infection-induced microbiome alterations and secondary bacterial pneumonia. (2018) · cites this paper as [82]
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Respiratory viral infection-induced microbiome alterations and secondary bacterial pneumonia.
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- Authors
- Rogers, G. B., Hoffman, L. R., Carroll, M. P., & Bruce, K. D.
- Affiliations
- King's College London (GB)
- University of Washington (US)
- University Hospital Southampton NHS Foundation Trust (GB)
- Corresponding author
- Rogers, Geraint B.
- Venue
- Trends in Microbiology
- Publisher
- Elsevier BV
- Published
- 2013-06
- Volume
- 21
- Issue
- 6
- Pages
- 271-276
- ISSN
- 0966-842X (ISSN-L)
- PMC
- PMC3880558
- OpenAlex
- W2015961680
- Cited by
- 76
- References
- 44
- Citations by year
- 2026: 2 · 2024: 2 · 2023: 4 · 2021: 6 · 2020: 16 · 2019: 3 · 2018: 7 · 2017: 8 · 2016: 7 · 2015: 7 · 2014: 12 · 2013: 2
- FWCI
- 0.88
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- National Heart, Lung, and Blood Institute (K02HL105543)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Physical Sciences › Environmental Science › Ecology › Microbial Community Ecology and Physiology
- Keywords
- chronic infection, cystic fibrosis, airway microbiome, ecological theory, niche characteristics, microbial diversity, host-microbe interactions
- MeSH terms
- Cystic Fibrosis, Humans, Lung, Pseudomonas aeruginosa, Pseudomonas Infections, Ecosystem, Microbiota
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