A Call to Arms: Quest for a Cryptococcal Vaccine
Open accessAbstract
Cryptococcosis remains a significant cause of morbidity and mortality world-wide, particularly among AIDS patients. Yet, to date, there are no licensed vaccines clinically available to treat or prevent cryptococcosis. In this review, we provide a rationale to support continued investment in Cryptococcus vaccine research, potential challenges that must be overcome along the way, and a literature review of the current progress underway towards developing a vaccine to prevent cryptococcosis.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
This immune response is mediated by production of cytokines including IL-2, IL-12, TNF and IFNγ, which recruit phagocytes that help to clear the infection.
“This immune response is mediated by the production of cytokines, including interleukin-2 (IL-2), IL-12, tumour necrosis factor (TNF) and interferon-γ (IFNγ), which in turn recruit phagocytes that help to clear the infection120,122.”
From Treatment strategies for cryptococcal infection: challenges, advances and future outlook (2021) · cites this paper as [122]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis
Rajasingham, R., Smith, R. M., Park, B. J., Jarvis, J. N., Govender, N. P., Chiller, T. M., Denning, D. W., Loyse, A., & Boulware, D. R. (2017) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(17)30243-8 · Cited by 1,861 · see citing works
Kleinnijenhuis, J., Quintin, J., Preijers, F., Joosten, L. A. B., Ifrim, D. C., Saeed, S., Jacobs, C., van Loenhout, J., de Jong, D., Stunnenberg, H. G., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202870109 · Cited by 1,728 · see citing works
Trained Immunity: A Memory for Innate Host Defense
Netea, M. G., Quintin, J., & van der Meer, J. W. M. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.04.006 · Cited by 1,697 · see citing works
Pappas, P. G., Alexander, B. D., Andes, D. R., Hadley, S., Kauffman, C. A., Freifeld, A., Anaissie, E. J., Brumble, L. M., Herwaldt, L., Ito, J., et al. (2010) · Clinical Infectious Diseases · doi:10.1086/651262 · Cited by 1,570 · see citing works
Quintin, J., Saeed, S., Martens, J. H. A., Giamarellos-Bourboulis, E. J., Ifrim, D. C., Logie, C., Jacobs, L., Jansen, T., Kullberg, B.-J., Wijmenga, C., et al. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.06.006 · Cited by 1,289 · see citing works
Practice Guidelines for the Management of Cryptococcal Disease
Saag, M. S., Graybill, R. J., Larsen, R. A., Pappas, P. G., Perfect, J. R., Powderly, W. G., Sobel, J. D., Dismukes, W. E., & Mycoses Study Group Cryptococcal Subproject (2000) · Clinical Infectious Diseases · doi:10.1086/313757 · Cited by 1,101 · see citing works
Treatment of Cryptococcal Meningitis Associated with the Acquired Immunodeficiency Syndrome
van der Horst, C. M., Saag, M. S., Cloud, G. A., Hamill, R. J., Graybill, J. R., Sobel, J. D., Johnson, P. C., Tuazon, C. U., Kerkering, T. M., Moskovitz, B. L., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199707033370103 · Cited by 808 · see citing works
Hsp90 Potentiates the Rapid Evolution of New Traits: Drug Resistance in Diverse Fungi
Cowen, L. E., & Lindquist, S. (2005) · Science · doi:10.1126/science.1118370 · Cited by 698 · see citing works
Cryptococcus neoformans and Cryptococcus gattii, the etiologic agents of cryptococcosis
Kwon-Chung, K. J., Fraser, J. A., Doering, T. L., Wang, Z. A., Janbon, G., Idnurm, A., & Bahn, Y.-S. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a019760 · Cited by 531 · see citing works
Giaccone, G., Punt, C. J. A., Ando, Y., Ruijter, R., Nishi, N., Peters, M. E. W. J., Blomberg, B. M. E. V., Scheper, R. J., van der Vliet, H. J., van den Eertwegh, A. J. M., et al. (2002) · PubMed · Cited by 506 · see citing works
EPIDEMIOLOGIC DIFFERENCES BETWEEN THE TWO VARIETIES OF CRYPTOCOCCUS NEOFORMANS1
Kwon-Chung, K. J., & Bennett, J. E. (1984) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a113861 · Cited by 474 · see citing works
Chapter 4 The Capsule of the Fungal Pathogen Cryptococcus neoformans
Zaragoza, Ó., Rodrigues, M. L., Jesus, M. D., Frasés, S., Dadachova, E., & Casadevall, A. (2009) · Advances in applied microbiology · doi:10.1016/s0065-2164(09)01204-0 · Cited by 458 · see citing works
Chayakulkeeree, M., & Perfect, J. R. (2006) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2006.07.001 · Cited by 396 · see citing works
Hsp90 Governs Echinocandin Resistance in the Pathogenic Yeast Candida albicans via Calcineurin
Singh, S. D., Robbins, N., Zaas, A. K., Schell, W. A., Perfect, J. R., & Cowen, L. E. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000532 · Cited by 362 · see citing works
Husain, S., Wagener, M. M., & Singh, N. (2001) · Emerging infectious diseases · doi:10.3201/eid0703.010302 · Cited by 328 · see citing works
Husain, S., Wagener, M. M., & Singh, N. (2001) · Emerging infectious diseases · doi:10.3201/eid0703.017302 · Cited by 313 · see citing works
Casadevall, A., Cleare, W., Feldmesser, M., Glatman-Freedman, A., Goldman, D. L., Kozel, T. R., Lendvai, N., Mukherjee, J., Pirofski, L.-A., Rivera, J., et al. (1998) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.42.6.1437 · Cited by 298 · see citing works
Hsp90 Governs Dispersion and Drug Resistance of Fungal Biofilms
Robbins, N., Uppuluri, P., Nett, J., Rajendran, R., Ramage, G., Lopez-Ribot, J. L., Andes, D., & Cowen, L. E. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002257 · Cited by 291 · see citing works
Chronic cryptococcal meningitis: a new experimental model in rabbits.
Perfect, J. R., Lang, S. D. R., & Durack, D. T. (1980) · PubMed · Cited by 283 · see citing works
Cryptococcal Meningitis and AIDS
Powderly, W. G. (1993) · Clinical Infectious Diseases · doi:10.1093/clinids/17.5.837 · Cited by 278 · see citing works
Spread of Cryptococcus gattii into Pacific Northwest Region of the United States
Datta, K., Bartlett, K. H., Baer, R. J., Byrnes, E. J., Galanis, E., Heitman, J., Hoang, L., Leslie, M. J., MacDougall, L., Magill, S. S., et al. (2009) · Emerging infectious diseases · doi:10.3201/eid1508.081384 · Cited by 271 · see citing works
Immunity to a pulmonary Cryptococcus neoformans infection requires both CD4+ and CD8+ T cells.
Huffnagle, G. B., Yates, J. L., & Lipscomb, M. F. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.173.4.793 · Cited by 265 · see citing works
Epidemiology ofCryptococcus gattii, British Columbia, Canada, 1999–2007
Galanis, E., MacDougall, L., Kidd, S. E., Morshed, M., & the British Columbia Cryptococcus gattii Working Group (2010) · Emerging infectious diseases · doi:10.3201/eid1602.090900 · Cited by 262 · see citing works
Singh, N. R., Lortholary, O., Alexander, B. D., Gupta, K. L., John, G. T., Pursell, K. J., Munoz, P., Klintmalm, G. B. G., Stosor, V., Busto, R. D., et al. (2005) · Clinical Infectious Diseases · doi:10.1086/430606 · Cited by 249 · see citing works
Larsen, R. A., Pappas, P. G., Perfect, J., Aberg, J. A., Casadevall, A., Cloud, G. A., James, R., Filler, S., & Dismukes, W. E. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.3.952-958.2005 · Cited by 236 · see citing works
Cryptococcus neoformans Strains and Infection in Apparently Immunocompetent Patients, China
Chen, J., Varma, A., Diaz, M. R., Litvintseva, A. P., Wollenberg, K. R., & Kwon-Chung, K. J. (2008) · Emerging infectious diseases · doi:10.3201/eid1405.071312 · Cited by 231 · see citing works
Saijo, T., Chen, J., Chen, S. C.-A., Rosen, L. B., Yi, J., Sorrell, T. C., Bennett, J. E., Holland, S. M., Browne, S., & Kwon-Chung, K. J. (2014) · mBio · doi:10.1128/mbio.00912-14 · Cited by 226 · see citing works
Immune reconstitution syndrome associated with opportunistic mycoses
Singh, N., & Perfect, J. R. (2007) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(07)70085-3 · Cited by 224 · see citing works
Singh, N., Dromer, F., Perfect, J. R., & Lortholary, O. (2008) · Clinical Infectious Diseases · doi:10.1086/592690 · Cited by 220 · see citing works
Cryptococcal infections in non-HIV-infected patients.
Pappas, P. G. (2013) · PubMed · Cited by 208 · see citing works
Huffnagle, G. B., Lipscomb, M. F., Lovchik, J. A., Hoag, K. A., & Street, N. E. (1994) · Journal of Leukocyte Biology · doi:10.1002/jlb.55.1.35 · Cited by 206 · see citing works
Vaccine development strategies for improving immunization: the role of modern immunology
Levine, M. M., & Sztein, M. B. (2004) · Nature Immunology · doi:10.1038/ni0504-460 · Cited by 198 · see citing works
Epidemiology of HIV-associated cryptococcosis in France (1985–2001)
Dromer, F., Mathoulin‐Pélissier, S., Fontanet, A. L., Ronin, O., Dupont, B., & Lortholary, O. (2004) · AIDS · doi:10.1097/00002030-200402200-00024 · Cited by 193 · see citing works
Wormley, F. L., Perfect, J. R., Steele, C., & Cox, G. M. (2007) · Infection and Immunity · doi:10.1128/iai.00274-06 · Cited by 187 · see citing works
Self-citationDevi, S. J., Schneerson, R., Egan, W., Ulrich, T., Bryla, D., Robbins, J. B., & Bennett, J. E. (1991) · Infection and Immunity · doi:10.1128/iai.59.10.3700-3707.1991 · Cited by 184 · see citing works
Immunoglobulins in Defense, Pathogenesis, and Therapy of Fungal Diseases
Casadevall, A., & Pirofski, L. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.04.004 · Cited by 180 · see citing works
Loyse, A., Thangaraj, H. S., Easterbrook, P., Ford, N. P., Roy, M., Chiller, T. M., Govender, N. P., Harrison, T. S., & Bicanic, T. A. (2013) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(13)70078-1 · Cited by 178 · see citing works
Invasive Fungal Infections in Solid Organ Transplant Recipients
Shoham, S., & Marr, K. A. (2012) · Future Microbiology · doi:10.2217/fmb.12.28 · Cited by 176 · see citing works
Chang, C. C., Crane, M., Zhou, J., Mina, M., Post, J. J., Cameron, B., Lloyd, A. R., Jaworowski, A., French, M. A., & Lewin, S. R. (2013) · Immunological Reviews · doi:10.1111/imr.12063 · Cited by 169 · see citing works
Rachini, A., Pietrella, D., Lupo, P., Torosantucci, A., Chiani, P., Bromuro, C., Proietti, C., Bistoni, F., Cassone, A., & Vecchiarelli, A. (2007) · Infection and Immunity · doi:10.1128/iai.00278-07 · Cited by 165 · see citing works
Mody, C. H., Lipscomb, M. F., Street, N. E., & Toews, G. B. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.144.4.1472 · Cited by 164 · see citing works
The molecular basis for the immunogenicity ofCryptococcus neoformansmannoproteins
Levitz, S. M., & Specht, C. A. (2006) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2006.00071.x · Cited by 154 · see citing works
Litvintseva, A. P., Thakur, R., Reller, L. B., & Mitchell, T. G. (2005) · The Journal of Infectious Diseases · doi:10.1086/432486 · Cited by 153 · see citing works
Devi, S. J. (1996) · Vaccine · doi:10.1016/0264-410x(95)00256-z · Cited by 148 · see citing works
Levitz, S. M., Nong, S.-H., Mansour, M. K., Huang, C., & Specht, C. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.181331398 · Cited by 146 · see citing works
Autochthonous and DormantCryptococcus gattiiInfections in Europe
Hagen, F., Colom, M. F., Swinne, D., Tintelnot, K., Iatta, R., Montagna, M. T., Torres-Rodrı́guez, J. M., Cogliati, M., Velegraki, A., Burggraaf, A., et al. (2012) · Emerging infectious diseases · doi:10.3201/eid1810.120068 · Cited by 142 · see citing works
Huffnagle, G. B., Yates, J. L., & Lipscomb, M. F. (1991) · Infection and Immunity · doi:10.1128/iai.59.4.1423-1433.1991 · Cited by 141 · see citing works
Rosas, Á. L., Nosanchuk, J. D., & Casadevall, A. (2001) · Infection and Immunity · doi:10.1128/iai.69.5.3410-3412.2001 · Cited by 141 · see citing works
Use of Licensed Vaccines for Active Immunization of the Immunocompromised Host
Pirofski, L., & Casadevall, A. (1998) · Clinical Microbiology Reviews · doi:10.1128/cmr.11.1.1 · Cited by 138 · see citing works
Molecular mechanisms of cryptococcal meningitis
Liu, T.-B., Perlin, D. S., & Xue, C. (2012) · Virulence · doi:10.4161/viru.18685 · Cited by 131 · see citing works
Hsp90 orchestrates stress response signaling governing fungal drug resistance
Cowen, L. E. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000471 · Cited by 130 · see citing works
Chau, T. T., Mai, N. H., Phu, N. H., Nghia, H. D. T., Chuong, L. V., Sinh, D. X., Duong, V. A., Diep, P. T., Campbell, J. I., Baker, S. G., et al. (2010) · BMC Infectious Diseases · doi:10.1186/1471-2334-10-199 · Cited by 127 · see citing works
Cell Wall Chitosan Is Necessary for Virulence in the Opportunistic Pathogen Cryptococcus neoformans
Baker, L. G., Specht, C. A., & Lodge, J. K. (2011) · Eukaryotic Cell · doi:10.1128/ec.05138-11 · Cited by 125 · see citing works
Hoag, K. A., Street, N. E., Huffnagle, G. B., & Lipscomb, M. F. (1995) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.13.4.7546779 · Cited by 121 · see citing works
Upadhya, R., Lam, W. C., Maybruck, B. T., Specht, C. A., Levitz, S. M., & Lodge, J. K. (2016) · mBio · doi:10.1128/mbio.00547-16 · Cited by 121 · see citing works
Emergence of Cryptococcus gattii—Pacific Northwest, 2004-2010
(2010) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2010.11.002 · Cited by 119 · see citing works
Antifungal Therapy and Management of Complications of Cryptococcosis due to Cryptococcus gattii
Chen, S. C.-A., Korman, T. M., Slavin, M. A., Marriott, D. J. E., Byth, K., Bak, N., Currie, B. J., Hajkowicz, K. M., Heath, C. H., Kidd, S. E., et al. (2013) · Clinical Infectious Diseases · doi:10.1093/cid/cit341 · Cited by 116 · see citing works
Sorrell, T. C., Juillard, P.-G., Djordjevic, J. T., Kaufman-Francis, K., Dietmann, A., Milonig, A., Combes, V., & Grau, G. E. R. (2016) · Microbes and Infection · doi:10.1016/j.micinf.2015.08.017 · Cited by 113 · see citing works
Fleuridor, R., Lees, A., & Pirofski, L. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.2.1087 · Cited by 112 · see citing works
D, S. S. M., Filler, S. G., Chetchotisakd, P., Pappas, P. G., Nolen, T. L., Manosuthi, W., Anekthananon, T., Morris, M. I., Supparatpinyo, K., Kopetskie, H., et al. (2009) · Clinical Infectious Diseases · doi:10.1086/605497 · Cited by 109 · see citing works
Serological, electrophoretic, and biological properties of Cryptococcus neoformans antigens
Murphy, J. W., Mosley, R. L., Cherniak, R., Reyes, G. H., Kozel, T. R., & Reiss, E. (1988) · Infection and Immunity · doi:10.1128/iai.56.2.424-431.1988 · Cited by 106 · see citing works
Mannoproteins from Cryptococcus neoformans Promote Dendritic Cell Maturation and Activation
Pietrella, D., Corbucci, C., Perito, S., Bistoni, G., & Vecchiarelli, A. (2005) · Infection and Immunity · doi:10.1128/iai.73.2.820-827.2005 · Cited by 102 · see citing works
Huang, C., Nong, S.-H., Mansour, M. K., Specht, C. A., & Levitz, S. M. (2002) · Infection and Immunity · doi:10.1128/iai.70.10.5485-5493.2002 · Cited by 100 · see citing works
Wozniak, K. L., Ravi, S., Macias, S., Young, M. L., Olszewski, M. A., Steele, C., & Wormley, F. L. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006854 · Cited by 99 · see citing works
Self-citationLindell, D. M., Moore, T. A., McDonald, R. A., Toews, G. B., & Huffnagle, G. B. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.12.7920 · Cited by 98 · see citing works
García-Valtanen, P., Guzman‐Genuino, R. M., Williams, D. L., Hayball, J. D., & Diener, K. R. (2017) · Immunology and Cell Biology · doi:10.1038/icb.2017.13 · Cited by 98 · see citing works
Wager, C. M. L., Hole, C. R., Wozniak, K. L., Olszewski, M. A., Mueller, M., & Wormley, F. L. (2015) · Infection and Immunity · doi:10.1128/iai.00935-15 · Cited by 95 · see citing works
Self-citationMechanisms of Cryptococcal Virulence and Persistence
Olszewski, M. A., Zhang, Y., & Huffnagle, G. B. (2010) · Future Microbiology · doi:10.2217/fmb.10.93 · Cited by 94 · see citing works
Rella, A., Mor, V., Farnoud, A. M., Singh, A., Shamseddine, A. A., Ivanova, E., Carpino, N., Montagna, M. T., Luberto, C., & Poeta, M. D. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00836 · Cited by 85 · see citing works
Specht, C. A., Lee, C. K., Huang, H., Tipper, D. J., Shen, Z. T., Lodge, J. K., Leszyk, J., Ostroff, G. R., & Levitz, S. M. (2015) · mBio · doi:10.1128/mbio.01905-15 · Cited by 85 · see citing works
Byrnes, E. J., Li, W., Lewit, Y., Perfect, J. R., Carter, D. A., Cox, G. M., & Heitman, J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005851 · Cited by 80 · see citing works
Zhai, B., Wozniak, K. L., Masso-Silva, J. A., Upadhyay, S., Hole, C. R., Rivera, A., Wormley, F. L., & Lin, X. (2015) · mBio · doi:10.1128/mbio.01433-15 · Cited by 79 · see citing works
Self-citationRodrigues, M. L., Li, S., Barreto‐Bergter, E., Nimrichter, L., Farias, S. E., Rodrigues, E. G., Travassos, L. R., & Nosanchuk, J. D. (2007) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00202-07 · Cited by 77 · see citing works
Protective Immunity against Experimental Pulmonary Cryptococcosis in T Cell-Depleted Mice
Wozniak, K. L., Young, M. L., & Wormley, F. L. (2011) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00036-11 · Cited by 72 · see citing works
Self-citationBuchanan, K. L., & Doyle, H. A. (2000) · Infection and Immunity · doi:10.1128/iai.68.2.456-462.2000 · Cited by 72 · see citing works
Protective Efficacy of Antigenic Fractions in Mouse Models of Cryptococcosis
Mansour, M. K., Yauch, L. E., Rottman, J. B., & Levitz, S. M. (2004) · Infection and Immunity · doi:10.1128/iai.72.3.1746-1754.2004 · Cited by 70 · see citing works
Peptide epitopes recognized by a human anti-cryptococcal glucuronoxylomannan antibody
Zhang, H., Zhong, Z., & Pirofski, L. (1997) · Infection and Immunity · doi:10.1128/iai.65.4.1158-1164.1997 · Cited by 68 · see citing works
Ou, X., Wu, J., Zhu, L., Guan, M., Xu, B., Hu, X., Wang, L., & Weng, X. H. (2011) · The Journal of Infectious Diseases · doi:10.1093/infdis/jir152 · Cited by 66 · see citing works
Specht, C. A., Nong, S., Dan, J. M., Lee, C. K., & Levitz, S. M. (2007) · The Journal of Infectious Diseases · doi:10.1086/520536 · Cited by 63 · see citing works
Dan, J. M., Wang, J. P., Lee, C. K., & Levitz, S. M. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002046 · Cited by 63 · see citing works
Aberg, J. A., Price, R. W., Heeren, D. M., & Bredt, B. M. (2002) · The Journal of Infectious Diseases · doi:10.1086/339680 · Cited by 62 · see citing works
Fc Gamma Receptor 3A Polymorphism and Risk for HIV-Associated Cryptococcal Disease
Rohatgi, S., Gohil, S. K., Kuniholm, M. H., Schultz, H., Dufaud, C. R., Armour, K. L., Badri, S. M., Mailliard, R. B., & Pirofski, L. (2013) · mBio · doi:10.1128/mbio.00573-13 · Cited by 62 · see citing works
Emergence of Cryptococcus gattii-- Pacific Northwest, 2004-2010.
(2010) · PubMed · Cited by 61 · see citing works
Murphy, J. W., Schafer, F. B., Casadevall, A., & Adesina, A. M. (1998) · Infection and Immunity · doi:10.1128/iai.66.6.2632-2639.1998 · Cited by 59 · see citing works
Hu, X., Wu, J., Zhu, L., Wang, X., Xu, B., Wang, R., Ou, X., & Weng, X. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042439 · Cited by 57 · see citing works
Kakeya, H., Udono, H., Maesaki, S., Sasaki, E., Kawamura, S., HOSSAIN, M. A., Yamamoto, Y., Sawai, T., Fukuda, M., Mitsutake, K., et al. (1999) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1999.00821.x · Cited by 56 · see citing works
Cryptococcus gattii: Emergence in Western North America: Exploitation of a Novel Ecological Niche
Datta, K., Bartlett, K. H., & Marr, K. A. (2009) · Interdisciplinary Perspectives on Infectious Diseases · doi:10.1155/2009/176532 · Cited by 56 · see citing works
Lizarazo, J., Escandón, P., Agudelo, C. I., Firacative, C., Meyer, W., & Castañeda, E. (2014) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0003272 · Cited by 54 · see citing works
Kakeya, H., Udono, H., Ikuno, N., Yamamoto, Y., Mitsutake, K., Miyazaki, T., Tomono, K., Koga, H., Tashiro, T., Nakayama, E., et al. (1997) · Infection and Immunity · doi:10.1128/iai.65.5.1653-1658.1997 · Cited by 54 · see citing works
Datta, K., Lees, A., & Pirofski, L. (2008) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00130-08 · Cited by 53 · see citing works
Potent Inhibition of Neutrophil Migration by Cryptococcal Mannoprotein-4-Induced Desensitization
Coenjaerts, F. E. J., Walenkamp, A., Mwinzi, P. N. M., Scharringa, J., Dekker, H. A. T., van Strijp, J. A. G., Cherniak, R., & Hoepelman, A. I. M. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.7.3988 · Cited by 52 · see citing works
Identification and Cloning of a Cryptococcal Deacetylase That Produces Protective Immune Responses
Biondo, C., Beninati, C., Delfino, D., Oggioni, M. R., Mancuso, G., Midiri, A., Bombaci, M., Tomaselli, G., & Teti, G. (2002) · Infection and Immunity · doi:10.1128/iai.70.5.2383-2391.2002 · Cited by 52 · see citing works
Characterization of Two Novel Cryptococcal Mannoproteins Recognized by Immune Sera
Biondo, C., Messina, L., Bombaci, M., Mancuso, G., Midiri, A., Beninati, C., Cusumano, V., Gerace, E., Papasergi, S., & Teti, G. (2005) · Infection and Immunity · doi:10.1128/iai.73.11.7348-7355.2005 · Cited by 50 · see citing works
Vaccine-Mediated Immune Responses to Experimental Pulmonary Cryptococcus gattii Infection in Mice
Chaturvedi, A. K., Hameed, R. S., Wozniak, K. L., Hole, C. R., Wager, C. M. L., Weintraub, S. T., Lopez-Ribot, J. L., & Wormley, F. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104316 · Cited by 45 · see citing works
Self-citationApproaches to Antifungal Therapies and Their Effectiveness among Patients with Cryptococcosis
Bratton, E. W., Husseini, N. E., Chastain, C. A., Lee, M. S., Poole, C., Stürmer, T., Weber, D. J., Juliano, J. J., & Perfect, J. R. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01800-12 · Cited by 42 · see citing works
Yanagisawa, K., Exley, M. A., Jiang, X., Ohkochi, N., Taniguchi, M., & Seino, K.-I. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0944 · Cited by 41 · see citing works
Fatal Disseminated Cryptococcus gattii Infection in New Mexico
Walraven, C. J., Gerstein, W. H., Hardison, S. E., Wormley, F. L., Lockhart, S. R., Harris, J. R., Fothergill, A. W., Wickes, B. L., Gober-Wilcox, J., Massie, L. W., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028625 · Cited by 41 · see citing works
Self-citationA proteomic‐based approach for the identification of immunodominant Cryptococcus neoformans proteins
Young, M. L., Macias, S., Thomas, D. P., & Wormley, F. L. (2009) · PROTEOMICS · doi:10.1002/pmic.200800713 · Cited by 41 · see citing works
Self-citationCryptococcus gattii Infection in Healthy Hosts: A Sentinel for Subclinical Immunodeficiency?
Marr, K. A., Datta, K., Pirofski, L., & Barnes, R. A. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/cir756 · Cited by 40 · see citing works
Immunization of mice with an avirulent pseudohyphal form of Cryptococcus neoformans
Fromtling, R. A., Blackstock, R., Hall, N. K., & Bulmer, G. S. (1979) · Mycopathologia · doi:10.1007/bf00578527 · Cited by 39 · see citing works
Hole, C. R., & Wormley, F. L. (2012) · Frontiers in Microbiology · doi:10.3389/fmicb.2012.00291 · Cited by 35 · see citing works
Self-citationGlycolipid ligands of invariant natural killer T cells as vaccine adjuvants
Kim, S., Lalani, S., Parekh, V. V., Wu, L., & Kaer, L. V. (2008) · Expert Review of Vaccines · doi:10.1586/14760584.7.10.1519 · Cited by 34 · see citing works
Watanabe, T., Ito, T., Goda, H. M., Ishibashi, Y., Miyamoto, T., Ikeda, K., Taguchi, R., Okino, N., & Ito, M. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.616300 · Cited by 34 · see citing works
Chaturvedi, A. K., Weintraub, S. T., Lopez-Ribot, J. L., & Wormley, F. L. (2013) · PROTEOMICS · doi:10.1002/pmic.201300213 · Cited by 30 · see citing works
Self-citationMandel, M. A., Grace, G. G., Orsborn, K. I., Schafer, F. B., Murphy, J. W., Orbach, M. J., & Galgiani, J. N. (2000) · Infection and Immunity · doi:10.1128/iai.68.11.6196-6201.2000 · Cited by 30 · see citing works
TheIn VivoResponse of Invariant Natural Killer T Cells to Glycolipid Antigens
Parekh, V. V., Lalani, S., & Kaer, L. V. (2007) · International Reviews of Immunology · doi:10.1080/08830180601070179 · Cited by 29 · see citing works
The Cell Wall and Membrane ofCryptococcus neoformansPossess a Mitogen for Human T Lymphocytes
Mody, C. H., Wood, C. J., Syme, R., & Spurrell, J. C. L. (1999) · Infection and Immunity · doi:10.1128/iai.67.2.936-941.1999 · Cited by 29 · see citing works
Nussbaum, G., Anandasabapathy, S., Mukherjee, J., Fan, M., Casadevall, A., & Scharff, M. D. (1999) · Infection and Immunity · doi:10.1128/iai.67.9.4469-4476.1999 · Cited by 28 · see citing works
Glucosylceramide Administration as a Vaccination Strategy in Mouse Models of Cryptococcosis
Mor, V., Farnoud, A. M., Singh, A., Rella, A., Tanno, H., Ishii, K., Kawakami, K., Sato, T., & Poeta, M. D. (2016) · PLoS ONE · doi:10.1371/journal.pone.0153853 · Cited by 28 · see citing works
Is Cryptococcus gattii a Primary Pathogen?
Kwon-Chung, K. J., & Saijo, T. (2015) · Journal of Fungi · doi:10.3390/jof1020154 · Cited by 27 · see citing works
Cryptococcus gattii Genotype VGI Infection in New England
McCulloh, R. J., Phillips, R., Perfect, J. R., Byrnes, E. J., Heitman, J., & Dufort, E. M. (2011) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0b013e31822d14fd · Cited by 26 · see citing works
Induction of T Helper Type 1 Responses by a Polysaccharide Deacetylase fromCryptococcus neoformans
Biondo, C., Beninati, C., Bombaci, M., Messina, L., Mancuso, G., Midiri, A., Galbo, R., & Teti, G. (2003) · Infection and Immunity · doi:10.1128/iai.71.9.5412-5417.2003 · Cited by 24 · see citing works
Wormley, F. L., Cox, G. M., & Perfect, J. R. (2005) · Microbial Pathogenesis · doi:10.1016/j.micpath.2004.12.007 · Cited by 23 · see citing works
Self-citationImmunization of mice with stable, acapsular, yeastlike mutants ofCryptococcus neoformans
Fromtling, R. A., Kaplan, A. M., & Shadomy, H. J. (1983) · Medical Mycology · doi:10.1080/00362178385380181 · Cited by 18 · see citing works
Maitta, R. W. (2004) · Vaccine · doi:10.1016/j.vaccine.2004.03.060 · Cited by 15 · see citing works
Carroll, S. F., Lafferty, E. I., Flaczyk, A., Fujiwara, T. M., Homer, R., Morgan, K., Loredo‐Osti, J., & Qureshi, S. T. (2012) · Infection and Immunity · doi:10.1128/iai.00417-12 · Cited by 15 · see citing works
Shourian, M., Flaczyk, A., Angers, I., Mindt, B., Fritz, J. H., & Qureshi, S. (2015) · Infection and Immunity · doi:10.1128/iai.00697-15 · Cited by 10 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Treatment strategies for cryptococcal infection: challenges, advances and future outlook
Iyer, K. R., Revie, N. M., Fu, C., Robbins, N., & Cowen, L. E. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-021-00511-0 · Cited by 363 · see citing works
Induction of memory-like dendritic cell responses in vivo
Hole, C. R., Wager, C. M. L., Castro-Lopez, N., Campuzano, A., Cai, H., Wozniak, K. L., Wang, Y., & Wormley, F. L. (2019) · Nature Communications · doi:10.1038/s41467-019-10486-5 · Cited by 196 · see citing works
Self-citationGeddes‐McAlister, J., & Shapiro, R. S. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13739 · Cited by 159 · see citing works
Vaccines for human fungal diseases: close but still a long way to go
Oliveira, L. V. N., Wang, R., Specht, C. A., & Levitz, S. M. (2021) · npj Vaccines · doi:10.1038/s41541-021-00294-8 · Cited by 135 · see citing works
Cryptococcus extracellular vesicles properties and their use as vaccine platforms
Rizzo, J., Wong, S. S. W., Gazi, A. D., Moyrand, F., Chaze, T., Commère, P., Novault, S., Matondo, M., Pehau‐Arnaudet, G., Reis, F. C. G., et al. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12129 · Cited by 120 · see citing works
Life Cycle ofCryptococcus neoformans
Zhao, Y., Lin, J., Fan, Y., & Lin, X. (2019) · Annual Review of Microbiology · doi:10.1146/annurev-micro-020518-120210 · Cited by 102 · see citing works
Wager, C. M. L., Hole, C. R., Campuzano, A., Castro-Lopez, N., Cai, H., Dyke, M. C. C. V., Wozniak, K. L., Wang, Y., & Wormley, F. L. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1007358 · Cited by 75 · see citing works
Self-citationMechanisms of Pulmonary Escape and Dissemination by Cryptococcus neoformans
Denham, S., & Brown, J. (2018) · Journal of Fungi · doi:10.3390/jof4010025 · Cited by 67 · see citing works
Innate Inspiration: Antifungal Peptides and Other Immunotherapeutics From the Host Immune Response
Mercer, D. K., & O'Neil, D. A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02177 · Cited by 50 · see citing works
Cryptococcus neoformans: Sex, morphogenesis, and virulence
Zhao, Y., & Lin, X. (2021) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2021.104731 · Cited by 51 · see citing works
Guazzelli, L., Crawford, C. J., Ulc, R., Bowen, A. D., McCabe, O., Jedlicka, A. J., Wear, M. P., Casadevall, A., & Oscarson, S. (2020) · Chemical Science · doi:10.1039/d0sc01249a · Cited by 45 · see citing works
Immunotherapies against human bacterial and fungal infectious diseases: A review
Qadri, H., Shah, A. H., Alkhanani, M., Almilaibary, A., & Mir, M. A. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1135541 · Cited by 37 · see citing works
RetractedVaccines and Protective Immune Memory against Cryptococcosis
Ueno, K., Yanagihara, N., Shimizu, K., & Miyazaki, Y. (2020) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b19-00841 · Cited by 34 · see citing works
Immunoprotection against Cryptococcosis Offered by Znf2 Depends on Capsule and the Hyphal Morphology
Lin, J., Pham, T., Hipsher, K., Glueck, N. K., Fan, Y., & Lin, X. (2022) · mBio · doi:10.1128/mbio.02785-21 · Cited by 32 · see citing works
Harnessing the Immune Response to Fungal Pathogens for Vaccine Development
Rivera, A., Lodge, J. K., & Xue, C. (2022) · Annual Review of Microbiology · doi:10.1146/annurev-micro-041020-111511 · Cited by 35 · see citing works
Normile, T. G., Rella, A., & Poeta, M. D. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.739027 · Cited by 30 · see citing works
Limited Role of Mincle in the Host Defense against Infection with Cryptococcus deneoformans
Sato, Y., Sato, K., Yamamoto, H., Kasamatsu, J., Miyasaka, T., Tanno, D., Miyahara, A., Kagesawa, T., Oniyama, A., Kawamura, K., et al. (2020) · Infection and Immunity · doi:10.1128/iai.00400-20 · Cited by 22 · see citing works
Normile, T. G., & Poeta, M. D. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.868523 · Cited by 22 · see citing works
Vaccine protection by Cryptococcus neoformans Δsgl1 is mediated by γδ T cells via TLR2 signaling
Normile, T. G., Chu, T. H., Sheridan, B. S., & Poeta, M. D. (2022) · Mucosal Immunology · doi:10.1038/s41385-022-00570-3 · Cited by 22 · see citing works
iNOS/Arginase-1 expression in the pulmonary tissue over time during Cryptococcus gattii infection
Brito, P. K. M. O., Rezende, C. P., Almeida, F. B. D. R., Roque‐Barreira, M. C., & da Silva, T. A. (2019) · Innate Immunity · doi:10.1177/1753425919869436 · Cited by 22 · see citing works
Crawford, C. J., Cordero, R. J. B., Guazzelli, L., Wear, M. P., Bowen, A. D., Oscarson, S., & Casadevall, A. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.012251 · Cited by 22 · see citing works
Ullah, A., Huang, Y., Zhao, K., Hua, Y., Ullah, S., Rahman, M. U., Wang, J., Wang, Q., Hu, X., & Zheng, L. (2023) · BMC Microbiology · doi:10.1186/s12866-023-02945-3 · Cited by 23 · see citing works
The remarkable complexity of the brain microbiome in health and diseasePreprint
Hu, X., McKenzie, C.-A., Smith, C., Haas, J., & Lathe, R. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.06.527297 · Cited by 20 · see citing works
Semisynthetic Glycoconjugate Vaccine Candidates against Cryptococcus neoformans
Crawford, C. J., Liporagi-Lopes, L., Coelho, C., dos Santos, S. R., Nicola, A. M., Wear, M. P., Vij, R., Oscarson, S., & Casadevall, A. (2024) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.4c00094 · Cited by 17 · see citing works
Synthetic Glycans Reveal Determinants of Antibody Functional Efficacy against a Fungal Pathogen
Crawford, C. J., Guazzelli, L., McConnell, S. A., McCabe, O., d’Errico, C., Greengo, S. D., Wear, M. P., Jedlicka, A., Casadevall, A., & Oscarson, S. (2023) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.3c00447 · Cited by 15 · see citing works
PAMPs and Host Immune Response in Cryptococcal Infection
Sato, K., & Kawakami, K. (2022) · Medical Mycology Journal · doi:10.3314/mmj.22.005 · Cited by 14 · see citing works
Pham, T., Li, Y., Watford, W. T., & Lin, X. (2023) · Infection and Immunity · doi:10.1128/iai.00198-23 · Cited by 14 · see citing works
Differential Effects of Linkers on the Activity of Amphiphilic Tobramycin Antifungals
Fosso, M. Y., Shrestha, S. K., Chandrika, N. T., Dennis, E. K., Green, K. D., & Garneau‐Tsodikova, S. (2018) · Molecules · doi:10.3390/molecules23040899 · Cited by 14 · see citing works
The Overlooked Glycan Components of the Cryptococcus Capsule
Fonseca, F. L., Reis, F. C. G., Sena, B. A. G., Jozefowicz, L. J., Kmetzsch, L., & Rodrigues, M. L. (2018) · Current topics in microbiology and immunology · doi:10.1007/82_2018_140 · Cited by 14 · see citing works
Advances in fungal vaccine development: Progress in the face of emerging challenges
Moses, M., Huang, X., Xue, X., & Chen, C. (2025) · iScience · doi:10.1016/j.isci.2025.114091 · Cited by 13 · see citing works
Wang, K., Espinosa, V., Wang, Y., Lemenze, A. D., Kumamoto, Y., Xue, C., & Rivera, A. (2024) · mBio · doi:10.1128/mbio.01944-24 · Cited by 11 · see citing works
Wang, Y., Wang, K., Rivera, A., & Xue, C. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.04955-22 · Cited by 11 · see citing works
Stempinski, P. R., Irizarry, P. R., McConnell, S. A., Lopes, L. C. L., Santos, S. R. D., Wear, M. P., & Casadevall, A. (2025) · Fungal Biology · doi:10.1016/j.funbio.2025.101544 · Cited by 12 · see citing works
Brito, P. K. M. O., de Campos, G. Y., Guimarães, J. G., da Costa, L. S., de Moura, E. S., Chica, J. E. L., Roque‐Barreira, M. C., & da Silva, T. A. (2022) · Vaccines · doi:10.3390/vaccines10040620 · Cited by 9 · see citing works
Fungal vaccines and adjuvants: a tool to reveal the interaction between host and fungi
Wang, Z., & Shao, J. (2024) · Archives of Microbiology · doi:10.1007/s00203-024-04010-7 · Cited by 9 · see citing works
Elhassan, R. M., Alsony, N. M., Othman, K. M., Izz-Aldin, D. T., Alhaj, T. A., Ali, A. A., Abashir, L. A., Ahmed, O. H., & Hassan, M. A. (2021) · Journal of Immunology Research · doi:10.1155/2021/9921620 · Cited by 13 · see citing works
Diniz-Lima, I., da Fonseca, L. M., dos Reis, J. S., Santos, M. A. R. D. C., da Costa, K. M., Santos, C. A. D. N., Barcelos, P. M., Pinto, K. G., Filardy, A. A., de Lima, M. E. F., et al. (2022) · Medicines · doi:10.3390/medicines9060037 · Cited by 8 · see citing works
Castro-Lopez, N., Campuzano, A., Mdalel, E., Vanegas, D., Chaturvedi, A. K., Nguyen, P. M., Pulse, M., Cardona, A. E., & Wormley, F. L. (2024) · mBio · doi:10.1128/mbio.01483-24 · Cited by 7 · see citing works
Self-citationVernel-Pauillac, F., Laurent‐Winter, C., Fiette, L., Janbon, G., Aimanianda, V., & Dromer, F. (2024) · mBio · doi:10.1128/mbio.02733-24 · Cited by 7 · see citing works
Promising whole‐cell vaccines against cryptococcosis
Ueno, K., Tsuge, S., Shimizu, K., & Miyazaki, Y. (2023) · Microbiology and Immunology · doi:10.1111/1348-0421.13056 · Cited by 6 · see citing works
Dendritic Cells: Multifunctional Roles in Host Defenses to Cryptococcus Infections
Goughenour, K. D., Nair, A. S., Xu, J., Olszewski, M. A., & Wozniak, K. L. (2023) · Journal of Fungi · doi:10.3390/jof9111050 · Cited by 6 · see citing works
Zhu, F., Zhou, Z., Ma, S., Xu, Y., Tan, C., Yang, H., Zhang, P., Qin, R., Luo, Y., Pinhua, P., et al. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112242 · Cited by 5 · see citing works
Elalouf, A., & Yaniv-Rosenfeld, A. (2023) · Journal of Genetic Engineering and Biotechnology · doi:10.1186/s43141-023-00560-3 · Cited by 5 · see citing works
Elhassan, R. M., Alsony, N. M., Othman, K. M., Izz-Aldin, D. T., Alhaj, T. A., Ali, A. A., Abashir, L. A., Ahmed, O. H., & Hassan, M. A. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/534008 · Cited by 5 · see citing works
Khan, M. A. S., Miah, M. I., & Rahman, S. R. (2023) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2023.2258410 · Cited by 4 · see citing works
Chitosan-Deficient Cryptococcus as Whole-Cell Vaccines
Specht, C. A., Lam, W. C., Hester, M. M., Lourenço, D., Levitz, S. M., Lodge, J. K., & Upadhya, R. (2024) · Methods in molecular biology · doi:10.1007/978-1-0716-3722-7_27 · Cited by 4 · see citing works
Adjuvant ArtinM favored the host immunity against Cryptococcus gattii infection in C57BL/6 mice
Brito, P. K. M. O., de Campos, G. Y., Guimarães, J. G., Machado, M. P., da Costa, L. S., Chica, J. E. L., Roque‐Barreira, M. C., & da Silva, T. A. (2024) · Immunotherapy · doi:10.1080/1750743x.2024.2360384 · Cited by 3 · see citing works
Advances in Dendritic-Cell-Based Vaccines against Respiratory Fungal Infections
Kulkarni, N. A., & Nanjappa, S. G. (2024) · Vaccines · doi:10.3390/vaccines12090981 · Cited by 3 · see citing works
Xue, X., Zang, X., Xiao, M., Wang, L., Wu, H., Ma, X., Wu, N., Deng, H., Zhou, M., Pan, L., et al. (2022) · Medical Mycology · doi:10.1093/mmy/myac035 · Cited by 3 · see citing works
Loza, L., & Doering, T. L. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819475-1.00079-1 · Cited by 2 · see citing works
Insights from Mass Spectrometry-Based Proteomics on Cryptococcus neoformans
Betancourt, J. J., & Nielsen, K. (2025) · Journal of Fungi · doi:10.3390/jof11070529 · Cited by 2 · see citing works
mGem: Progress on the development of conjugate vaccines for Cryptococcus neoformans infections
Stempinski, P. R., Santos, S. R. D., & Casadevall, A. (2026) · mBio · doi:10.1128/mbio.03538-25 · Cited by 2 · see citing works
A consensus structural motif for the capsular polysaccharide of Cryptococcus Neoformans by NMR/MD
Prestegard, J. H. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2322413121 · Cited by 2 · see citing works
Xavier, G. A., da Cruz, E. C., de Oliveira, R. S., da Silva, S. H. M., & Siqueira, A. S. (2025) · Journal of Computer-Aided Molecular Design · doi:10.1007/s10822-025-00722-0 · Cited by 1 · see citing works
Crawford, C. J., Guazzelli, L., McConnell, S. A., McCabe, O., d’Errico, C., Greengo, S. D., Wear, M. P., Jedlicka, A. J., Casadevall, A., & Oscarson, S. (2023) · ChemRxiv · doi:10.26434/chemrxiv-2023-nm09n · Cited by 1 · see citing works
Macrophage-mediated innate immunity for the treatment of cryptococcal meningitis
He, Z. (2020) · AIP conference proceedings · doi:10.1063/5.0000307
Dyląg, M. (2022) · Postępy Mikrobiologii - Advancements of Microbiology · doi:10.2478/am-2022-025
Wang, Y., Wang, K., Rivera, A., & Xue, C. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.06.519380
Semi-synthetic glycoconjugate vaccine candidate against Cryptococcus neoformansPreprint
Crawford, C. J., Liporagi-Lopes, L. C., Coelho, C., dos Santos, S. R., Nicola, A. M., Wear, M. P., Vij, R., Oscarson, S., & Casadevall, A. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.02.578725
Criptococose como problema de saúde pública no Distrito Federal
Perazzoni, A. R. D. G., Guimarães, G. V. C., & Silva, R. A. E. (2024) · Programa de Iniciação Científica - PIC/UniCEUB - Relatórios de Pesquisa · doi:10.5102/pic.n0.2022.9557
Design of Cryptococcus neoformans multi-epitope vaccine based on immunoinformatics method
Zhou, Z., Zhu, F., Ma, S., Tan, C., Yang, H., Zhang, P., Xu, Y., Qin, R., Luo, Y., Chen, J., et al. (2024) · Medical Mycology · doi:10.1093/mmy/myae080 · Cited by 1 · see citing works
- Authors
- Caballero Van Dyke, M. C., & Wormley, F. L.
- Affiliations
- The University of Texas at San Antonio (US)
- Corresponding author
- Wormley, Floyd L.
- ORCID
- Wormley, Floyd L.
- Venue
- Trends in Microbiology
- Publisher
- Elsevier BV
- Published
- 2018-05
- Volume
- 26
- Issue
- 5
- Pages
- 436-446
- ISSN
- 0966-842X (ISSN-L)
- PMC
- PMC5910246
- OpenAlex
- W2766300617
- Cited by
- 61
- References
- 117
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 13 · 2023: 11 · 2022: 10 · 2021: 7 · 2020: 6 · 2019: 4 · 2018: 5
- FWCI
- 0.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Trends in Microbiology (acceptedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (NIH) (2RO1 AI071752, 3RO1 AI071752-08S1)
- National Institute of General Medical Sciences (GM060655)
- Topics
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Life Sciences › Immunology and Microbiology › Parasitology › Parasitic Infections and Diagnostics
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Keywords
- cryptococcosis, Cryptococcus, vaccine development, AIDS, cryptococcal meningitis, immunization
- MeSH terms
- Animals, Antigens, Fungal, Cryptococcosis, Cryptococcus neoformans, Disease Models, Animal, Fungal Proteins, Fungal Vaccines, Glycolipids, Humans, Recombinant Proteins, Vaccination, Vaccines, Attenuated, Vaccines, Synthetic, Vaccines, Inactivated, Cryptococcus gattii
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review