Cited by 61Fungal Infections and StudiesParasitic Infections and DiagnosticsBacterial Infections and Vaccines

A Call to Arms: Quest for a Cryptococcal Vaccine

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Caballero Van Dyke, Marley C., Wormley, Floyd L.·2018·Trends in Microbiology

Abstract

Cryptococcosis remains a significant cause of morbidity and mortality world-wide, particularly among AIDS patients. Yet, to date, there are no licensed vaccines clinically available to treat or prevent cryptococcosis. In this review, we provide a rationale to support continued investment in Cryptococcus vaccine research, potential challenges that must be overcome along the way, and a literature review of the current progress underway towards developing a vaccine to prevent cryptococcosis.

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Crossref · 10.1016/j.tim.2017.10.002

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  • This immune response is mediated by production of cytokines including IL-2, IL-12, TNF and IFNγ, which recruit phagocytes that help to clear the infection.

    “This immune response is mediated by the production of cytokines, including interleukin-2 (IL-2), IL-12, tumour necrosis factor (TNF) and interferon-γ (IFNγ), which in turn recruit phagocytes that help to clear the infection120,122.”

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Authors
Caballero Van Dyke, M. C., & Wormley, F. L.
Affiliations
The University of Texas at San Antonio (US)
Corresponding author
Wormley, Floyd L.
Venue
Trends in Microbiology
Publisher
Elsevier BV
Published
2018-05
Volume
26
Issue
5
Pages
436-446
ISSN
0966-842X (ISSN-L)
OpenAlex
W2766300617
Cited by
61
References
117
Citations by year
2026: 1 · 2025: 4 · 2024: 13 · 2023: 11 · 2022: 10 · 2021: 7 · 2020: 6 · 2019: 4 · 2018: 5
FWCI
0.54
Type
journal article
Language
en
Open access
Locations
  • Trends in Microbiology (acceptedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (NIH) (2RO1 AI071752, 3RO1 AI071752-08S1)
  • National Institute of General Medical Sciences (GM060655)
Topics
  • Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
  • Life Sciences › Immunology and Microbiology › Parasitology › Parasitic Infections and Diagnostics
  • Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
Keywords
cryptococcosis, Cryptococcus, vaccine development, AIDS, cryptococcal meningitis, immunization
MeSH terms
Animals, Antigens, Fungal, Cryptococcosis, Cryptococcus neoformans, Disease Models, Animal, Fungal Proteins, Fungal Vaccines, Glycolipids, Humans, Recombinant Proteins, Vaccination, Vaccines, Attenuated, Vaccines, Synthetic, Vaccines, Inactivated, Cryptococcus gattii

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