Vaccines for human fungal diseases: close but still a long way to go

Hidden Killers: Human Fungal Infections

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Of Mice and Not Men: Differences between Mouse and Human Immunology

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Global and Multi-National Prevalence of Fungal Diseases-Estimate Precision

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Defining trained immunity and its role in health and disease

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Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis

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The Fungal Cell Wall: Structure, Biosynthesis, and Function

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The Fungal Cell Wall: Candida, Cryptococcus, and Aspergillus Species

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Global burden of recurrent vulvovaginal candidiasis: a systematic review

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The how’s and what’s of vaccine reactogenicity

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Aspergillus fumigatus morphology and dynamic host interactions

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A novel glyco-conjugate vaccine against fungal pathogens

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Estimation of Direct Healthcare Costs of Fungal Diseases in the United States

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Transferring functional immune responses to pathogens after haploidentical hematopoietic transplantation

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The Eukaryotic Tree of Life from a Global Phylogenomic PerspectivePreprint

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The global burden of fungal diseases

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Dimorphism and virulence in fungi

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Bioengineering T cells to target carbohydrate to treat opportunistic fungal infection

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The capsule of Cryptococcus neoformans

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A dendritic cell vaccine against invasive aspergillosis in allogeneic hematopoietic transplantation

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NDV-3, a recombinant alum-adjuvanted vaccine for Candida and Staphylococcus aureus, is safe and immunogenic in healthy adults

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Dynamic Fungal Cell Wall Architecture in Stress Adaptation and Immune Evasion

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Pattern recognition receptors in fungal immunity

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Synthetic glycopeptide vaccines combining β-mannan and peptide epitopes induce protection against candidiasis

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A Fungal Immunotherapeutic Vaccine (NDV-3A) for Treatment of Recurrent Vulvovaginal Candidiasis—A Phase 2 Randomized, Double-Blind, Placebo-Controlled Trial

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Host Control of Fungal Infections: Lessons from Basic Studies and Human Cohorts

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Vaccine development strategies for improving immunization: the role of modern immunology

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Induction of memory-like dendritic cell responses in vivo

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Protection against Cryptococcosis by Using a Murine Gamma Interferon-Producing <i>Cryptococcus neoformans</i> Strain

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An Anti-β-Glucan Monoclonal Antibody Inhibits Growth and Capsule Formation of Cryptococcus neoformans In Vitro and Exerts Therapeutic, Anticryptococcal Activity In Vivo

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Evaluation of the Protective Efficacy of the Killed Coccidioides immitis Spherule Vaccine in Humans

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Preclinical efficacy of a glucuronoxylomannan-tetanus toxoid conjugate vaccine of Cryptococcus neoformans in a murine model

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Beyond Empiricism: Informing Vaccine Development through Innate Immunity Research

Levitz, S. M., & Golenbock, D. T. (2012) · Cell · doi:10.1016/j.cell.2012.02.012 · Cited by 140 · see citing works

Fungal vaccines, mechanism of actions and immunology: A comprehensive review

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A virosomal vaccine against candidal vaginitis: immunogenicity, efficacy and safety profile in animal models.

de Bernardis, F., Amacker, M., Arancia, S., Sandini, S., Gremion, C., Zurbriggen, R., Moser, C., & Cassone, A. (2012) · Vaccine · doi:10.1016/j.vaccine.2012.04.069 · Cited by 128 · see citing works

Induction of Protective Immunity to Cryptococcal Infection in Mice by a Heat-Killed, Chitosan-Deficient Strain of Cryptococcus neoformans

Upadhya, R., Lam, W. C., Maybruck, B. T., Specht, C. A., Levitz, S. M., & Lodge, J. K. (2016) · mBio · doi:10.1128/mbio.00547-16 · Cited by 121 · see citing works

Cryptococcus extracellular vesicles properties and their use as vaccine platforms

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Beta-glucan-CRM197 conjugates as candidates antifungal vaccines

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Relative Contributions of Dectin-1 and Complement to Immune Responses to Particulate β-Glucans

Huang, H., Ostroff, G. R., Lee, C. K., Agarwal, S., Ram, S., Rice, P. A., Specht, C. A., & Levitz, S. M. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200603 · Cited by 110 · see citing works

Vaccination of immunocompromised patients

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Innate Defense against Fungal PathogensPreprint

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Development of vaccines for Candida albicans: fighting a skilled transformer

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Protective effect of fungal extracellular vesicles against murine candidiasis

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Vaccination with Recombinant <i>Cryptococcus</i> Proteins in Glucan Particles Protects Mice against Cryptococcosis in a Manner Dependent upon Mouse Strain and Cryptococcal Species

Specht, C. A., Lee, C. K., Huang, H., Hester, M. M., Liu, J., Luckie, B. A., Torres Santana, M. A., Mirza, Z., Khoshkenar, P., Abraham, A., et al. (2017) · mBio · doi:10.1128/mbio.01872-17 · Cited by 91 · see citing works

Characterization and Optimization of the Glucan Particle-Based Vaccine Platform

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Protection against Experimental Cryptococcosis following Vaccination with Glucan Particles ContainingCryptococcusAlkaline Extracts

Specht, C. A., Lee, C. K., Huang, H., Tipper, D. J., Shen, Z. T., Lodge, J. K., Leszyk, J., Ostroff, G. R., & Levitz, S. M. (2015) · mBio · doi:10.1128/mbio.01905-15 · Cited by 85 · see citing works

Role of Sterylglucosidase 1 (Sgl1) on the pathogenicity of Cryptococcus neoformans: potential applications for vaccine development

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Construction and Evaluation of a Novel Recombinant T Cell Epitope-Based Vaccine against Coccidioidomycosis

Hurtgen, B. J., Hung, C.-Y., Ostroff, G. R., Levitz, S. M., & Cole, G. T. (2012) · Infection and Immunity · doi:10.1128/iai.00566-12 · Cited by 80 · see citing works

The Elusive Anti-Candida Vaccine: Lessons From the Past and Opportunities for the Future

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Development of Protective Inflammation and Cell-Mediated Immunity against Cryptococcus neoformans after Exposure to Hyphal Mutants

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Cryptococcus gattii Infection Dampens Th1 and Th17 Responses by Attenuating Dendritic Cell Function and Pulmonary Chemokine Expression in the Immunocompetent Hosts

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Exploiting fungal cell wall components in vaccines

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Candida vaginitis: virulence, host response and vaccine prospects

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Protective Efficacy of Antigenic Fractions in Mouse Models of Cryptococcosis

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Calnexin Induces Expansion of Antigen-Specific CD4+ T Cells that Confer Immunity to Fungal Ascomycetes via Conserved Epitopes

Wüthrich, M., Brandhorst, T. T., Sullivan, T. D., Filutowicz, H. I., Sterkel, A., Stewart, D. A., Li, M., Lerksuthirat, T., LeBert, V., Shen, Z. T., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.02.009 · Cited by 69 · see citing works

Extracellular vesicles of human pathogenic fungi

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Monoclonal Immunoglobulin G1 Directed againstAspergillus fumigatusCell Wall Glycoprotein Protects against Experimental Murine Aspergillosis

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A Heat-Killed Cryptococcus Mutant Strain Induces Host Protection against Multiple Invasive Mycoses in a Murine Vaccine Model

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Immune responses induced by heat killed Saccharomyces cerevisiae: A vaccine against fungal infection

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A Call to Arms: Quest for a Cryptococcal Vaccine

Caballero Van Dyke, M. C., & Wormley, F. L. (2018) · Trends in Microbiology · doi:10.1016/j.tim.2017.10.002 · Cited by 61 · see citing works

In silico Design of a Multivalent Vaccine Against Candida albicans

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Vaccination with Heat Shock Protein 60 Induces a Protective Immune Response against ExperimentalParacoccidioides brasiliensisPulmonary Infection

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Multivalent Recombinant Protein Vaccine against Coccidioidomycosis

Tarcha, E. J., Basrur, V., Hung, C.-Y., Gardner, M. J., & Cole, G. T. (2006) · Infection and Immunity · doi:10.1128/iai.00961-06 · Cited by 55 · see citing works

Glucan-Chitin Particles Enhance Th17 Response and Improve Protective Efficacy of a Multivalent Antigen (rCpa1) against Pulmonary Coccidioides posadasii Infection

Hung, C.-Y., Zhang, H., Castro-Lopez, N., Ostroff, G. R., Khoshlenar, P., Abraham, A., Cole, G. T., Negron, A. J., Forsthuber, T. G., Peng, T., et al. (2018) · Infection and Immunity · doi:10.1128/iai.00070-18 · Cited by 54 · see citing works

Therapeutic Efficacy of a Conjugate Vaccine Containing a Peptide Mimotope of Cryptococcal Capsular Polysaccharide Glucuronoxylomannan

Datta, K., Lees, A., & Pirofski, L. (2008) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00130-08 · Cited by 53 · see citing works

Protection of mice against experimental cryptococcosis using glucan particle-based vaccines containing novel recombinant antigens

Hester, M. M., Lee, C. K., Abraham, A., Khoshkenar, P., Ostroff, G. R., Levitz, S. M., & Specht, C. A. (2019) · Vaccine · doi:10.1016/j.vaccine.2019.10.051 · Cited by 52 · see citing works

The Rise of Coccidioides: Forces Against the Dust Devil Unleashed

Dyke, M. C. C. V., Thompson, G. R., Galgiani, J. N., & Barker, B. M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02188 · Cited by 50 · see citing works

Multispecific Aspergillus T Cells Selected by CD137 or CD154 Induce Protective Immune Responses Against the Most Relevant Mold Infections

Stuehler, C., Nowakowska, J., Bernardini, C., Topp, M. S., Battegay, M., Passweg, J. R., & Khanna, N. (2014) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiu607 · Cited by 48 · see citing works

Vaccine-Mediated Immune Responses to Experimental Pulmonary Cryptococcus gattii Infection in Mice

Chaturvedi, A. K., Hameed, R. S., Wozniak, K. L., Hole, C. R., Wager, C. M. L., Weintraub, S. T., Lopez-Ribot, J. L., & Wormley, F. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104316 · Cited by 45 · see citing works

Heat Shock Proteins in Histoplasma and Paracoccidioides

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Whole glucan particles as a vaccine against murine aspergillosis

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DNA immunization using a secreted cell wall antigen Mp1p is protective against Penicillium marneffei infection

WONG, L. (2002) · Vaccine · doi:10.1016/s0264-410x(02)00234-7 · Cited by 41 · see citing works

Current trends to control fungal pathogens: exploiting our knowledge in the host–pathogen interaction

García-Carnero, L. C., Pérez-García, L. A., Martínez-Álvarez, J. A., Reyes-Martínez, J. E., & Mora-Montes, H. M. (2018) · Infection and Drug Resistance · doi:10.2147/idr.s170337 · Cited by 38 · see citing works

Aspergillusvaccines: Hardly worth studying or worthy of hard study?: Table 1.

Levitz, S. M. (2016) · Medical Mycology · doi:10.1093/mmy/myw081 · Cited by 37 · see citing works

Vaccination with an alkaline extract of Histoplasma capsulatum packaged in glucan particles confers protective immunity in mice

Deepe, G. S., Buesing, W. R., Ostroff, G. R., Abraham, A., Specht, C. A., Huang, H., & Levitz, S. M. (2018) · Vaccine · doi:10.1016/j.vaccine.2018.04.047 · Cited by 36 · see citing works

Vaccines and Protective Immune Memory against Cryptococcosis

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Adjuvants and delivery systems for antifungal vaccines: Current state and future developments

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A dendritic cell-based systemic vaccine induces long-lived lung-resident memory Th17 cells and ameliorates pulmonary mycosis

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Identification and characterization of C ryptococcus neoformans protein fractions that induce protective immune responses

Chaturvedi, A. K., Weintraub, S. T., Lopez-Ribot, J. L., & Wormley, F. L. (2013) · PROTEOMICS · doi:10.1002/pmic.201300213 · Cited by 30 · see citing works

Safety, Tolerability, and Immunogenicity of a Recombinant, Genetically Engineered, Live-Attenuated Vaccine against Canine Blastomycosis

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Candida albicans Niche Specialization: Features That Distinguish Biofilm Cells from Commensal Cells

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Antibodies Generated against Streptococci Protect in a Mouse Model of Disseminated Aspergillosis

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Cellular and molecular insights on the regulation of innate immune responses to experimental aspergillosis in chicken and turkey poults

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Non-lethal Candida albicans cph1/cph1 efg1/efg1 mutant partially protects mice from systemic infections by lethal wild-type cells

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A Therapeutic Vaccine for Recurrent Vulvovaginal Candidiasis

Casadevall, A., & Pirofski, L. (2018) · Clinical Infectious Diseases · doi:10.1093/cid/ciy188 · Cited by 14 · see citing works

Fungal immunology in clinical practice: Magical realism or practical reality?

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