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Cited by 96Antibiotic Resistance in BacteriaInfection Control in HealthcareEscherichia coli research studies

Animal Model To Study Klebsiella pneumoniae Gastrointestinal Colonization and Host-to-Host Transmission

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Young, Taylor M., Bray, Andrew S., Nagpal, Ravinder K., Caudell, David L., Yadav, Hariom, Zafar, M. Ammar·2020·Infection and Immunity
DOI 10.1128/iai.00071-20PMC PMC7573435

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Abstract

An important yet poorly understood facet of the life cycle of a successful pathogen is host-to-host transmission. Hospital-acquired infections (HAI) resulting from the transmission of drug-resistant pathogens affect hundreds of millions of patients worldwide. Klebsiella pneumoniae , a Gram-negative bacterium, is notorious for causing HAI, with many of these infections difficult to treat, as K. pneumoniae has become multidrug resistant. Epidemiological studies suggest that K. pneumoniae host-to-host transmission requires close contact and generally occurs through the fecal-oral route.

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  • Klebsiella pneumoniae is naturally present in the respiratory and gastrointestinal tracts of humans and has a lower occurrence in animals, possibly due to diet, competition with other bacteria, or genetic virulence factors.

    “Klebsiella pneumoniae is naturally present in the respiratory and gastrointestinal tracts of humans and has a lower occurrence in animals, possibly due to diet, competition with other bacteria, or genetic virulence factors [70,71,72].”

    From A Systematic Review on Antimicrobial Resistance in Ghana from a One Health Perspective (2024) · cites this paper as [72]

    The Introduction (page not provided) identifies the oropharynx and gastrointestinal tract as natural sites of colonization, and the Discussion reports gastrointestinal colonization in mice. The paper does not compare occurrence in humans and animals or attribute a lower occurrence in animals to diet, bacterial competition, or genetic virulence factors; it discusses microbiota and genetic variation in relation to colonization, not that comparison. (LLM, conf=0.86)

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Cited by

Sorted by citations

Authors
Young, T. M., Bray, A. S., Nagpal, R. K., Caudell, D. L., Yadav, H., & Zafar, M. A.
Affiliations
Wake Forest University Health Sciences (US)
Corresponding author
Zafar, M. Ammar
ORCID
Venue
Infection and Immunity
Publisher
American Society for Microbiology
Published
2020-10-19
Volume
88
Issue
11
ISSN
  • 0019-9567 (ISSN-L)
  • 1098-5522
DOI
10.1128/iai.00071-20
PMC
PMC7573435
OpenAlex
W3080611838
Cited by
96
References
4
Citations by year
2026: 15 · 2025: 22 · 2024: 19 · 2023: 12 · 2022: 15 · 2021: 13
FWCI
3.34
Type
journal article
Language
en
Open access
Licence
Locations
  • Infection and Immunity (publishedVersion, cc-by)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • HHS | NIH | National Institute of Allergy and Infectious Diseases (5T32AI007401-28)
  • WFU | Wake Forest School of Medicine (Startup funds)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
  • Health Sciences › Medicine › Infectious Diseases › Infection Control in Healthcare
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
Keywords
Klebsiella pneumoniae, intestinal colonization, host-to-host transmission, nosocomial infections, multidrug resistance, animal models, fecal-oral transmission, pathogen life cycle, Gram-negative bacteria
MeSH terms
Animals, Disease Models, Animal, Gastrointestinal Diseases, Klebsiella Infections, Klebsiella pneumoniae, Mice

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