Cited by 139Axon Guidance and Neuronal SignalingWnt/β-catenin signaling in development and cancerDevelopmental Biology and Gene Regulation

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Wnt signaling in axon guidance

Zou, Yimin·2004·Trends in Neurosciences

DOI 10.1016/j.tins.2004.06.015

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Abstract

Recent studies have identified Wnt proteins as conserved axon guidance molecules in vertebrates and invertebrates. Wnt proteins are a large family of diffusible factors that play several important roles, both in embryonic development and in adult function. The signaling mechanisms of Wnt proteins are complex and, because Wnts are newly discovered as axon guidance cues, little is known about how Wnt signaling controls the direction of growth cone navigation - a process that is crucial in development of the nervous system. This review summarizes recent work on the role of Wnts in axon guidance and discusses the possible signaling mechanisms involved in growth cone guidance. Understanding how Wnts regulate axon wiring will not only help us to understand how the nervous system is connected but also provide possible tools for axon regeneration.

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Authors: Zou, Y.
Affiliations: University of Chicago (US)
Corresponding author: Zou, Yimin
ORCID: Zou, Yimin
Venue: Trends in Neurosciences
Publisher: Elsevier BV
Published: 2004-09
Volume: 27
Issue: 9
Pages: 528-532
ISSN: 0166-2236 (ISSN-L)
DOI: 10.1016/j.tins.2004.06.015
OpenAlex: W1983145618
Cited by: 138
References: 45
Citations by year: 2026: 4 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 9 · 2021: 14 · 2020: 3 · 2019: 9 · 2018: 6 · 2017: 5 · 2016: 4 · 2015: 5 · 2014: 7 · 2013: 7 · 2012: 3
FWCI: 0.75
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Neurosciences (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Neurological Disorders and Stroke (R01NS047484)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: Wnt signaling, axon guidance, Wnt proteins, axon guidance cues, brain development, axon regeneration
MeSH terms: Animals, Axons, Models, Neurological, Proto-Oncogene Proteins, Signal Transduction, Wnt Proteins

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Wnt signaling in axon guidance

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