The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Wnt signaling in axon guidance
Abstract
Recent studies have identified Wnt proteins as conserved axon guidance molecules in vertebrates and invertebrates. Wnt proteins are a large family of diffusible factors that play several important roles, both in embryonic development and in adult function. The signaling mechanisms of Wnt proteins are complex and, because Wnts are newly discovered as axon guidance cues, little is known about how Wnt signaling controls the direction of growth cone navigation - a process that is crucial in development of the nervous system. This review summarizes recent work on the role of Wnts in axon guidance and discusses the possible signaling mechanisms involved in growth cone guidance. Understanding how Wnts regulate axon wiring will not only help us to understand how the nervous system is connected but also provide possible tools for axon regeneration.
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“During axonal guidance, another Wnt pathway via the Ryk receptor and proto-oncoprotein Src regulates repulsion of neurons.104,105”
From Wnt signal transduction pathways (2008) · cites this paper as [105]
Citations
Cites
MECHANISMS OF WNT SIGNALING IN DEVELOPMENT
Wodarz, A., & Nusse, R. (1998) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.14.1.59 · Cited by 2,030
Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation
Heisenberg, C.-P., Tada, M., Rauch, G.-J., Saúde, L., Concha, M. L., Geisler, R., Stemple, D. L., Smith, J. C., & Wilson, S. W. (2000) · Nature · doi:10.1038/35011068 · Cited by 1,013
Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma
Weeraratna, A. T., Jiang, Y., Hostetter, G. H., Rosenblatt, K. P., Duray, P. H., Bittner, M. L., & Trent, J. M. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00045-4 · Cited by 960
Habas, R., Kato, Y., & He, X. (2001) · Cell · doi:10.1016/s0092-8674(01)00614-6 · Cited by 842
Shaping the Vertebrate Body Plan by Polarized Embryonic Cell Movements
Keller, R. E. (2002) · Science · doi:10.1126/science.1079478 · Cited by 731
Usui, T., Shima, Y., Shimada, Y., Hirano, S., Burgess, R. W., Schwarz, T. L., Takeichi, M., & Uemura, T. (1999) · Cell · doi:10.1016/s0092-8674(00)80046-x · Cited by 721
Identification of Vangl2 and Scrb1 as planar polarity genes in mammals
Montcouquiol, M., Rachel, R. A., Lanford, P. J., Copeland, N. G., Jenkins, N. A., & Kelley, M. W. (2003) · Nature · doi:10.1038/nature01618 · Cited by 705
Axonal Remodeling and Synaptic Differentiation in the Cerebellum Is Regulated by WNT-7a Signaling
Hall, A. C., Lucas, F. R., & Salinas, P. C. (2000) · Cell · doi:10.1016/s0092-8674(00)80689-3 · Cited by 699
Anterior-Posterior Guidance of Commissural Axons by Wnt-Frizzled Signaling
Lyuksyutova, A. I., Lu, C.-C., Milanesio, N., King, L. A., Guo, N., Wang, Y., Nathans, J., Tessier‐Lavigne, M., & Zou, Y. (2003) · Science · doi:10.1126/science.1089610 · Cited by 557
Self-citationHuelsken, J., & Behrens, J. (2002) · Journal of Cell Science · doi:10.1242/jcs.00089 · Cited by 537
Cited by
Sorted by citations
Wnt signal transduction pathways
Komiya, Y., & Habas, R. (2008) · Organogenesis · doi:10.4161/org.4.2.5851 · Cited by 1,528
Regulation of salivary gland function by autonomic nerves.
Proctor, G., & Carpenter, G. (2007) · Autonomic Neuroscience: Basic & Clinical · doi:10.1016/j.autneu.2006.10.006 · Cited by 723
“The guidance molecules for nerves in salivary glands are unknown but by comparison with other models (Zou, 2004) Wnt binding to frizzled receptors could be important to axon guidance by acting as both attractants and repellents whilst ectodysplasin A (Eda) and its receptor (EdaR) also have forward and reverse signalli…”
BackgroundWnt/Ca2+ signaling pathway: a brief overview
De, A. (2011) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmr079 · Cited by 565
Dishevelled promotes axon differentiation by regulating atypical protein kinase C
Zhang, X., Zhu, J., Yang, G.-Y., Wang, Q.-J., Qian, L., Chen, Y.-M., Chen, F., Tao, Y., Hu, H.-S., Wang, T., et al. (2007) · Nature Cell Biology · doi:10.1038/ncb1603 · Cited by 220
Wnt signaling in development and disease
Freese, J. L., Pino, D., & Pleasure, S. J. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.09.003 · Cited by 180
Metadata
- Authors
- Zou, Y.
- Affiliations
- University of Chicago (US)
- Corresponding author
- Zou, Yimin
- ORCID
- Zou, Yimin
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2004-09
- Volume
- 27
- Issue
- 9
- Pages
- 528-532
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W1983145618
- Cited by
- 138
- References
- 45
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 9 · 2021: 14 · 2020: 3 · 2019: 9 · 2018: 6 · 2017: 5 · 2016: 4 · 2015: 5 · 2014: 7 · 2013: 7 · 2012: 3
- FWCI
- 0.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS047484)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- Wnt signaling, axon guidance, Wnt proteins, axon guidance cues, brain development, axon regeneration
- MeSH terms
- Animals, Axons, Models, Neurological, Proto-Oncogene Proteins, Signal Transduction, Wnt Proteins
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